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Items: 40

1.

Bifidenone: Structure-Activity Relationship and Advanced Preclinical Candidate.

Huang Z, Williams RB, Martin SM, Lawrence JA, Norman VL, O'Neil-Johnson M, Harding J, Mangette JE, Liu S, Guzzo PR, Starks CM, Eldridge GR.

J Med Chem. 2018 Aug 9;61(15):6736-6747. doi: 10.1021/acs.jmedchem.7b01644. Epub 2018 Jul 25.

PMID:
29995409
2.

Discovery of UDP-Glycosyltransferases and BAHD-Acyltransferases Involved in the Biosynthesis of the Antidiabetic Plant Metabolite Montbretin A.

Irmisch S, Jo S, Roach CR, Jancsik S, Man Saint Yuen M, Madilao LL, O'Neil-Johnson M, Williams R, Withers SG, Bohlmann J.

Plant Cell. 2018 Aug;30(8):1864-1886. doi: 10.1105/tpc.18.00406. Epub 2018 Jul 2.

3.

A Total Synthesis of Bifidenone.

Huang Z, Williams RB, O'Neil-Johnson M, Eldridge GR, Mangette JE, Starks CM.

J Org Chem. 2017 Apr 21;82(8):4235-4241. doi: 10.1021/acs.joc.7b00202. Epub 2017 Mar 31.

PMID:
28351141
4.

Isolation and Identification of the Novel Tubulin Polymerization Inhibitor Bifidenone.

Williams RB, Martin SM, Lawrence JA, Norman VL, O'Neil-Johnson M, Eldridge GR, Starks CM.

J Nat Prod. 2017 Mar 24;80(3):616-624. doi: 10.1021/acs.jnatprod.6b00893. Epub 2016 Nov 14.

PMID:
28335606
5.

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4.

Biggs BW, Rouck JE, Kambalyal A, Arnold W, Lim CG, De Mey M, O'Neil-Johnson M, Starks CM, Das A, Ajikumar PK.

ACS Chem Biol. 2016 May 20;11(5):1445-51. doi: 10.1021/acschembio.5b00968. Epub 2016 Mar 16.

PMID:
26930136
6.

Dereplication of natural products using minimal NMR data inputs.

Williams RB, O'Neil-Johnson M, Williams AJ, Wheeler P, Pol R, Moser A.

Org Biomol Chem. 2015 Oct 21;13(39):9957-62. doi: 10.1039/c5ob01713k.

PMID:
26381222
7.

Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum.

Williams RB, Norman VL, O'Neil-Johnson M, Woodbury S, Eldridge GR, Starks CM.

J Nat Prod. 2015 Aug 28;78(8):2074-86. doi: 10.1021/acs.jnatprod.5b00394. Epub 2015 Aug 19.

PMID:
26287548
8.

Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.

Chemler JA, Tripathi A, Hansen DA, O'Neil-Johnson M, Williams RB, Starks C, Park SR, Sherman DH.

J Am Chem Soc. 2015 Aug 26;137(33):10603-9. doi: 10.1021/jacs.5b04842. Epub 2015 Aug 13.

9.

Exploring diterpene metabolism in non-model species: transcriptome-enabled discovery and functional characterization of labda-7,13E-dienyl diphosphate synthase from Grindelia robusta.

Zerbe P, Rodriguez SM, Mafu S, Chiang A, Sandhu HK, O'Neil-Johnson M, Starks CM, Bohlmann J.

Plant J. 2015 Sep;83(5):783-93. doi: 10.1111/tpj.12925. Epub 2015 Jul 23.

10.

Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells.

Augustin MM, Ruzicka DR, Shukla AK, Augustin JM, Starks CM, O'Neil-Johnson M, McKain MR, Evans BS, Barrett MD, Smithson A, Wong GK, Deyholos MK, Edger PP, Pires JC, Leebens-Mack JH, Mann DA, Kutchan TM.

Plant J. 2015 Jun;82(6):991-1003. doi: 10.1111/tpj.12871.

11.

Antibacterial activity of Taxodium ascendens diterpenes against methicillin-resistant Staphylococcus aureus.

Starks CM, Norman VL, Williams RB, Goering MG, Rice SM, O'Neil-Johnson M, Eldridge GR.

Nat Prod Commun. 2014 Aug;9(8):1129-30.

PMID:
25233589
12.

Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus.

Kilgore MB, Augustin MM, Starks CM, O'Neil-Johnson M, May GD, Crow JA, Kutchan TM.

PLoS One. 2014 Jul 25;9(7):e103223. doi: 10.1371/journal.pone.0103223. eCollection 2014.

13.

In situ natural product discovery via an artificial marine sponge.

La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P.

PLoS One. 2014 Jul 8;9(7):e100474. doi: 10.1371/journal.pone.0100474. eCollection 2014.

14.

Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare.

Zerbe P, Chiang A, Dullat H, O'Neil-Johnson M, Starks C, Hamberger B, Bohlmann J.

Plant J. 2014 Sep;79(6):914-27. doi: 10.1111/tpj.12589. Epub 2014 Jul 23.

15.

Diterpenes from the endangered goldenrod Solidago shortii.

Williams RB, Du L, Norman VL, Goering MG, O'Neil-Johnson M, Woodbury S, Albrecht MA, Powell DR, Cichewicz RH, Eldridge GR, Starks CM.

J Nat Prod. 2014 Jun 27;77(6):1438-44. doi: 10.1021/np500178s. Epub 2014 Jun 12.

PMID:
24922615
16.

Antibacterial chromene and chromane stilbenoids from Hymenocardia acida.

Starks CM, Williams RB, Norman VL, Rice SM, O'Neil-Johnson M, Lawrence JA, Eldridge GR.

Phytochemistry. 2014 Feb;98:216-22. doi: 10.1016/j.phytochem.2013.11.012. Epub 2013 Dec 19.

PMID:
24361290
17.

Acetylated dammarane-type bisdesmosides from Combretum inflatum.

Williams RB, Norman VL, Goering MG, O'Neil-Johnson M, Eldridge GR, Starks CM.

J Nat Prod. 2013 Sep 27;76(9):1592-7. doi: 10.1021/np4002652. Epub 2013 Aug 26.

PMID:
23978065
18.

Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity.

Starks CM, Williams RB, Norman VL, Lawrence JA, O'Neil-Johnson M, Eldridge GR.

Phytochemistry. 2012 Oct;82:172-5. doi: 10.1016/j.phytochem.2012.06.017. Epub 2012 Jul 16.

19.

Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia.

Williams RB, Martin SM, Hu JF, Norman VL, Goering MG, Loss S, O'Neil-Johnson M, Eldridge GR, Starks CM.

J Nat Prod. 2012 Jul 27;75(7):1319-25. doi: 10.1021/np300241d. Epub 2012 Jul 3.

20.

Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis.

Starks CM, Williams RB, Rice SM, Norman VL, Lawrence JA, Goering MG, O'Neil-Johnson M, Hu JF, Eldridge GR.

Phytochemistry. 2012 Feb;74:185-9. doi: 10.1016/j.phytochem.2011.10.014. Epub 2011 Nov 24.

21.

Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family.

Williams RB, Martin SM, Hu JF, Garo E, Rice SM, Norman VL, Lawrence JA, Hough GW, Goering MG, O'Neil-Johnson M, Eldridge GR, Starks CM.

Planta Med. 2012 Jan;78(2):160-5. doi: 10.1055/s-0031-1280293. Epub 2011 Oct 14.

PMID:
22002852
22.

Novel pentadecenyl tetrazole enhances susceptibility of methicillin-resistant Staphylococcus aureus biofilms to gentamicin.

Olson KM, Starks CM, Williams RB, O'Neil-Johnson M, Huang Z, Ellis M, Reilly JE, Eldridge GR.

Antimicrob Agents Chemother. 2011 Aug;55(8):3691-5. doi: 10.1128/AAC.00302-11. Epub 2011 Jun 6.

23.

Abronione, a rotenoid from the desert annual Abronia villosa.

Starks CM, Williams RB, Norman VL, Lawrence JA, Goering MG, O'Neil-Johnson M, Hu JF, Rice SM, Eldridge GR.

Phytochem Lett. 2011 Jun 15;4(2):72-74.

24.

Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework.

Williams RB, Hu JF, Olson KM, Norman VL, Goering MG, O'Neil-Johnson M, Eldridge GR, Starks CM.

J Nat Prod. 2010 May 28;73(5):1008-11. doi: 10.1021/np1001225.

PMID:
20405845
25.

Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea).

Starks CM, Williams RB, Goering MG, O'Neil-Johnson M, Norman VL, Hu JF, Garo E, Hough GW, Rice SM, Eldridge GR.

Phytochemistry. 2010 Jan;71(1):104-9. doi: 10.1016/j.phytochem.2009.09.032. Epub 2009 Oct 24.

PMID:
19857881
26.

Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius.

Ye M, Zhao Y, Norman VL, Starks CM, Rice SM, Goering MG, O'Neil-Johnson M, Eldridge GR, Hu JF.

Phytother Res. 2010 May;24(5):778-81. doi: 10.1002/ptr.2992.

PMID:
19827017
27.

Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus.

Garo E, Hung CS, Williams RB, Olson KM, Hu JF, Rice SM, Hough GW, Goering MG, O'Neil-Johnson M, Eldridge GR, Starks CM.

Planta Med. 2009 Apr;75(5):541-3. doi: 10.1055/s-0029-1185310. Epub 2009 Jan 30.

PMID:
19184969
28.

New guaiane sesquiterpenes and furanocoumarins from Notopterygium incisum.

Wu SB, Zhao Y, Fan H, Hu YH, Hamann MT, Peng JN, Starks CM, O'Neil-Johnson M, Hu JF.

Planta Med. 2008 Dec;74(15):1812-7. doi: 10.1055/s-0028-1088326. Epub 2008 Nov 7.

29.

Stilbenes from the Orchid Phragmipedium sp.

Garo E, Hu JF, Goering M, Hough G, O'Neil-Johnson M, Eldridge G.

J Nat Prod. 2007 Jun;70(6):968-73. Epub 2007 May 31.

PMID:
17536858
30.

Anti-HCV bioactivity of pseudoguaianolides from Parthenium hispitum.

Hu JF, Patel R, Li B, Garo E, Hough GW, Goering MG, Yoo HD, O'neil-Johnson M, Eldridge GR.

J Nat Prod. 2007 Apr;70(4):604-7. Epub 2007 Feb 10.

PMID:
17291045
31.

Antibacterial, partially acetylated oligorhamnosides from Cleistopholis patens.

Hu JF, Garo E, Hough GW, Goering MG, O'Neil-Johnson M, Eldridge GR.

J Nat Prod. 2006 Apr;69(4):585-90.

PMID:
16643031
32.

Bacterial biofilm inhibitors from Diospyros dendo.

Hu JF, Garo E, Goering MG, Pasmore M, Yoo HD, Esser T, Sestrich J, Cremin PA, Hough GW, Perrone P, Lee YS, Le NT, O'Neil-Johnson M, Costerton JW, Eldridge GR.

J Nat Prod. 2006 Jan;69(1):118-20.

PMID:
16441080
33.

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.

Peti W, Page R, Moy K, O'Neil-Johnson M, Wilson IA, Stevens RC, W├╝thrich K.

J Struct Funct Genomics. 2005 Dec;6(4):259-67. Epub 2005 Nov 9.

PMID:
16283429
34.

Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods.

Hu JF, Garo E, Yoo HD, Cremin PA, Goering MG, O'Neil-Johnson M, Eldridge GR.

Phytochemistry. 2005 May;66(9):1077-82.

PMID:
15896378
35.

Application of capillary-scale NMR for the structure determination of phytochemicals.

Hu JF, Garo E, Yoo HD, Cremin PA, Zeng L, Goering MG, O'Neil-Johnson M, Eldridge GR.

Phytochem Anal. 2005 Mar-Apr;16(2):127-33.

PMID:
15881121
36.

Miniaturization of the structure elucidation of novel natural products--two trace antibacterial acylated caprylic alcohol glycosides from Arctostaphylos pumila.

Hu JF, Yoo HD, Williams CT, Garo E, Cremin PA, Zeng L, Vervoort HC, Lee CM, Hart SM, Goering MG, O'Neil-Johnson M, Eldridge GR.

Planta Med. 2005 Feb;71(2):176-80.

PMID:
15729628
37.

Suaveolindole, a new mass-limited antibacterial indolosesquiterpene from Greenwayodendron suaveolens obtained via high-throughput natural products chemistry methods.

Yoo HD, Cremin PA, Zeng L, Garo E, Williams CT, Lee CM, Goering MG, O'Neil-Johnson M, Eldridge GR, Hu JF.

J Nat Prod. 2005 Jan;68(1):122-4.

PMID:
15679334
38.

Microflow NMR: concepts and capabilities.

Olson DL, Norcross JA, O'Neil-Johnson M, Molitor PF, Detlefsen DJ, Wilson AG, Peck TL.

Anal Chem. 2004 May 15;76(10):2966-74.

PMID:
15144211
39.

Biomolecular NMR using a microcoil NMR probe--new technique for the chemical shift assignment of aromatic side chains in proteins.

Peti W, Norcross J, Eldridge G, O'Neil-Johnson M.

J Am Chem Soc. 2004 May 12;126(18):5873-8.

PMID:
15125680
40.

High-throughput method for the production and analysis of large natural product libraries for drug discovery.

Eldridge GR, Vervoort HC, Lee CM, Cremin PA, Williams CT, Hart SM, Goering MG, O'Neil-Johnson M, Zeng L.

Anal Chem. 2002 Aug 15;74(16):3963-71.

PMID:
12199561

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