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Items: 45


Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography.

Wang M, Zhan Y, O'Neil SP, Harris S, Henson C, McEwen A, Webster R, O'Hara DM.

Bioanalysis. 2018 Sep 1;10(18):1487-1500. doi: 10.4155/bio-2018-0046. Epub 2018 Sep 10.


Accidental and Programmed Cell Death in Investigative and Toxicologic Pathology.

Radi ZA, Stewart ZS, O'Neil SP.

Curr Protoc Toxicol. 2018 May;76(1):e51. doi: 10.1002/cptx.51. Epub 2018 Apr 30.


Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy.

Wang M, Zhan Y, Chen J, Rong H, O'Neil SP, Ghosh B, Nguyen V, Owens J, Li X, O'Hara DM.

Int J Mol Imaging. 2016;2016:5768312. doi: 10.1155/2016/5768312. Epub 2016 Dec 6.


Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease.

Sharif MN, Campanholle G, Nagiec EE, Wang J, Syed J, O'Neil SP, Zhan Y, Brenneman K, Homer B, Neubert H, Karim R, Pullen N, Evans SM, Fleming M, Chockalingam P, Lin LL.

PLoS One. 2016 May 12;11(5):e0155368. doi: 10.1371/journal.pone.0155368. eCollection 2016.


Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study.

Krueger J, Clark JD, Suárez-Fariñas M, Fuentes-Duculan J, Cueto I, Wang CQ, Tan H, Wolk R, Rottinghaus ST, Whitley MZ, Valdez H, von Schack D, O'Neil SP, Reddy PS, Tatulych S; A3921147 Study Investigators.

J Allergy Clin Immunol. 2016 Apr;137(4):1079-1090. doi: 10.1016/j.jaci.2015.12.1318.


Monoclonal antibody against macrophage colony-stimulating factor suppresses circulating monocytes and tissue macrophage function but does not alter cell infiltration/activation in cutaneous lesions or clinical outcomes in patients with cutaneous lupus erythematosus.

Masek-Hammerman K, Peeva E, Ahmad A, Menon S, Afsharvand M, Peng Qu R, Cheng JB, Syed J, Zhan Y, O'Neil SP, Pleasic-Williams S, Cox LA, Beidler D.

Clin Exp Immunol. 2016 Feb;183(2):258-70. doi: 10.1111/cei.12705. Epub 2015 Nov 9.


Identification of Promising Urinary MicroRNA Biomarkers in Two Rat Models of Glomerular Injury.

Nassirpour R, Homer BL, Mathur S, Li Y, Li Z, Brown T, Carraher D, Warneke J, Bailey S, Percival K, O'Neil SP, Whiteley LO.

Toxicol Sci. 2015 Nov;148(1):35-47. doi: 10.1093/toxsci/kfv167. Epub 2015 Aug 7.


Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms.

Nassirpour R, Mathur S, Gosink MM, Li Y, Shoieb AM, Wood J, O'Neil SP, Homer BL, Whiteley LO.

BMC Genomics. 2014 Jun 18;15:485. doi: 10.1186/1471-2164-15-485.


Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.

Brenneman KA, Ramaiah SK, Rohde CM, Messing DM, O'Neil SP, Gauthier LM, Stewart ZS, Mantena SR, Shevlin KM, Leonard CG, Sokolowski SA, Lin H, Carraher DC, Jesson MI, Tomlinson L, Zhan Y, Bobrowski WF, Bailey SA, Vogel WM, Morris DL, Whiteley LO, Davis JW 2nd.

Toxicol Pathol. 2014 Jan;42(1):229-42. doi: 10.1177/0192623313508851. Epub 2013 Nov 13.


Diffusion tensor imaging detects treatment effects of FTY720 in experimental autoimmune encephalomyelitis mice.

Wang X, Brieland JK, Kim JH, Chen YJ, O'Neal J, O'Neil SP, Tu TW, Trinkaus K, Song SK.

NMR Biomed. 2013 Dec;26(12):1742-50. doi: 10.1002/nbm.3012. Epub 2013 Aug 13.


Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers.

Martinot AJ, Meythaler M, Pozzi LA, Dalecki Boisvert K, Knight H, Walsh D, Westmoreland S, Anderson DC, Kaur A, O'Neil SP.

PLoS One. 2013;8(3):e57785. doi: 10.1371/journal.pone.0057785. Epub 2013 Mar 5.


CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain.

Ratai EM, Pilkenton S, He J, Fell R, Bombardier JP, Joo CG, Lentz MR, Kim WK, Burdo TH, Autissier P, Annamalai L, Curran E, O'Neil SP, Westmoreland SV, Williams KC, Masliah E, Gilberto González R.

J Med Primatol. 2011 Oct;40(5):300-9. doi: 10.1111/j.1600-0684.2011.00475.x. Epub 2011 Apr 4.


Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.

Meythaler M, Wang Z, Martinot A, Pryputniewicz S, Kasheta M, McClure HM, O'Neil SP, Kaur A.

J Immunol. 2011 May 1;186(9):5151-61. doi: 10.4049/jimmunol.1004110. Epub 2011 Mar 25.


Myocarditis in CD8-depleted SIV-infected rhesus macaques after short-term dual therapy with nucleoside and nucleotide reverse transcriptase inhibitors.

Annamalai L, Westmoreland SV, Domingues HG, Walsh DG, Gonzalez RG, O'Neil SP.

PLoS One. 2010 Dec 23;5(12):e14429. doi: 10.1371/journal.pone.0014429.


Neurometabolite abnormalities in simian immunodeficiency virus-infected macaques with chronic morphine administration.

Cloak CC, Chang L, O'Neil SP, Ernst TM, Anderson DC, Donahoe RM.

J Neuroimmune Pharmacol. 2011 Sep;6(3):371-80. doi: 10.1007/s11481-010-9246-3. Epub 2010 Oct 12.


Cloning and characterization of rhesus IL-18 binding protein, a natural antagonist to IL-18.

Yellayi S, Braun S, Domingues HG, Kityatana N, Murali R, Johnson RP, Mansfield K, Westmoreland SV, O'Neil SP.

Cytokine. 2010 Sep;51(3):232-9. doi: 10.1016/j.cyto.2010.05.010.


Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques.

Annamalai L, Bhaskar V, Pauley DR, Knight H, Williams K, Lentz M, Ratai E, Westmoreland SV, González RG, O'Neil SP.

Am J Pathol. 2010 Aug;177(2):777-91. doi: 10.2353/ajpath.2010.091248. Epub 2010 Jul 1.


Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

Morris DL, O'Neil SP, Devraj RV, Portanova JP, Gilles RW, Gross CJ, Curtiss SW, Komocsar WJ, Garner DS, Happa FA, Kraus LJ, Nikula KJ, Monahan JB, Selness SR, Galluppi GR, Shevlin KM, Kramer JA, Walker JK, Messing DM, Anderson DR, Mourey RJ, Whiteley LO, Daniels JS, Yang JZ, Rowlands PC, Alden CL, Davis JW 2nd, Sagartz JE.

Toxicol Pathol. 2010 Jun;38(4):606-18. doi: 10.1177/0192623310367807. Epub 2010 May 6.


Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.

Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM.

J Infect Dis. 2010 Apr 15;201(8):1155-63. doi: 10.1086/651274.


Reduced genetic diversity in lymphoid and central nervous system tissues and selection-induced tissue-specific compartmentalization of neuropathogenic SIVsmmFGb during acute infection.

Reeve AB, Patel K, Pearce NC, Augustus KV, Domingues HG, O'Neil SP, Novembre FJ.

AIDS Res Hum Retroviruses. 2009 Jun;25(6):583-601. doi: 10.1089/aid.2008.0240.


Probable deceleration of progression of Simian AIDS affected by opiate dependency: studies with a rhesus macaque/SIVsmm9 model.

Donahoe RM, O'neil SP, Marsteller FA, Novembre FJ, Anderson DC, Lankford-Turner P, McClure HH.

J Acquir Immune Defic Syndr. 2009 Mar 1;50(3):241-9. doi: 10.1097/QAI.0b013e3181967354.


Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature.

Yearley JH, King N, Liu X, Curran EH, O'Neil SP.

Vet Pathol. 2008 Nov;45(6):922-7. doi: 10.1354/vp.45-6-922. Review.


Rhesus lymphocryptovirus type 1-associated B-cell nasal lymphoma in SIV-infected rhesus macaques.

Marr-Belvin AK, Carville AK, Fahey MA, Boisvert K, Klumpp SA, Ohashi M, Wang F, O'Neil SP, Westmoreland SV.

Vet Pathol. 2008 Nov;45(6):914-21. doi: 10.1354/vp.45-6-914.


SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys.

Humbert M, Rasmussen RA, Song R, Ong H, Sharma P, Chenine AL, Kramer VG, Siddappa NB, Xu W, Else JG, Novembre FJ, Strobert E, O'Neil SP, Ruprecht RM.

Retrovirology. 2008 Oct 17;5:94. doi: 10.1186/1742-4690-5-94.


Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection.

Yearley JH, Kanagy S, Anderson DC, Dalecki K, Pauley DR, Suwyn C, Donahoe RM, McClure HM, O'Neil SP.

Dev Comp Immunol. 2008;32(12):1510-21. doi: 10.1016/j.dci.2008.06.006. Epub 2008 Jul 9.


Evolution of a TRIM5-CypA splice isoform in old world monkeys.

Newman RM, Hall L, Kirmaier A, Pozzi LA, Pery E, Farzan M, O'Neil SP, Johnson W.

PLoS Pathog. 2008 Feb 29;4(2):e1000003. doi: 10.1371/journal.ppat.1000003.


Trichomonad gastritis in rhesus macaques (Macaca mulatta) infected with simian immunodeficiency virus.

Kondova I, Simon MA, Klumpp SA, MacKey J, Widmer G, Domingues HG, Persengiev SP, O'Neil SP.

Vet Pathol. 2005 Jan;42(1):19-29.


Correlation of acute humoral response with brain virus burden and survival time in pig-tailed macaques infected with the neurovirulent simian immunodeficiency virus SIVsmmFGb.

O'Neil SP, Suwyn C, Anderson DC, Niedziela G, Bradley J, Novembre FJ, Herndon JG, McClure HM.

Am J Pathol. 2004 Apr;164(4):1157-72.


Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge.

Buge SL, Ma HL, Amara RR, Wyatt LS, Earl PL, Villinger F, Montefiori DC, Staprans SI, Xu Y, Carter E, O'Neil SP, Herndon JG, Hill E, Moss B, Robinson HL, McNicholl JM.

AIDS Res Hum Retroviruses. 2003 Oct;19(10):891-900.


CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice.

Foell J, Strahotin S, O'Neil SP, McCausland MM, Suwyn C, Haber M, Chander PN, Bapat AS, Yan XJ, Chiorazzi N, Hoffmann MK, Mittler RS.

J Clin Invest. 2003 May;111(10):1505-18.


CD137-mediated T cell co-stimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice.

Foell J, McCausland M, Burch J, Corriazzi N, Yan XJ, Suwyn C, O'Neil SP, Hoffmann MK, Mittler RS.

Ann N Y Acad Sci. 2003 Apr;987:230-5.


Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, Staprans SI, Feinberg MB.

Immunity. 2003 Mar;18(3):441-52.


Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine.

Amara RR, Smith JM, Staprans SI, Montefiori DC, Villinger F, Altman JD, O'Neil SP, Kozyr NL, Xu Y, Wyatt LS, Earl PL, Herndon JG, McNicholl JM, McClure HM, Moss B, Robinson HL.

J Virol. 2002 Jun;76(12):6138-46.


Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, McClure HM, McNicholl JM, Moss B, Robinson HL.

Vaccine. 2002 May 6;20(15):1949-55. Review.


Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, Miller J, McClure HM, McNicholl JM, Moss B, Robinson HL.

Science. 2001 Apr 6;292(5514):69-74.


Rapid CD4(+) T-cell loss induced by human immunodeficiency virus type 1(NC) in uninfected and previously infected chimpanzees.

Novembre FJ, de Rosayro J, Nidtha S, O'Neil SP, Gibson TR, Evans-Strickfaden T, Hart CE, McClure HM.

J Virol. 2001 Feb;75(3):1533-9. Erratum in: J Virol 2001 Jun;75(11):5441.


Progressive infection in a subset of HIV-1-positive chimpanzees.

O'Neil SP, Novembre FJ, Hill AB, Suwyn C, Hart CE, Evans-Strickfaden T, Anderson DC, deRosayro J, Herndon JG, Saucier M, McClure HM.

J Infect Dis. 2000 Oct;182(4):1051-62. Epub 2000 Sep 8.


In vivo cell and tissue tropism of SIVsmmPBj14-bcl.3.

O'Neil SP, Mossman SP, Maul DH, Hoover EA.

AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):203-15.


Virus threshold determines disease in SIVsmmPBj14-infected macaques.

O'Neil SP, Mossman SP, Maul DH, Hoover EA.

AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):183-94.


Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey.

Novembre FJ, De Rosayro J, O'Neil SP, Anderson DC, Klumpp SA, McClure HM.

J Virol. 1998 Nov;72(11):8841-51.


Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1.

Novembre FJ, Saucier M, Anderson DC, Klumpp SA, O'Neil SP, Brown CR 2nd, Hart CE, Guenthner PC, Swenson RB, McClure HM.

J Virol. 1997 May;71(5):4086-91.


Protection against lethal simian immunodeficiency virus SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by a gp120 subunit vaccine.

Mossman SP, Bex F, Berglund P, Arthos J, O'Neil SP, Riley D, Maul DH, Bruck C, Momin P, Burny A, Fultz PN, Mullins JI, Liljeström P, Hoover EA.

J Virol. 1996 Mar;70(3):1953-60.


Monoclonal gammopathy in a dog with chronic pyoderma.

Burkhard MJ, Meyer DJ, Rosychuk RA, O'Neil SP, Schultheiss PC.

J Vet Intern Med. 1995 Sep-Oct;9(5):357-60.


Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines.

Israel ZR, Edmonson PF, Maul DH, O'Neil SP, Mossman SP, Thiriart C, Fabry L, Van Opstal O, Bruck C, Bex F, et al.

J Virol. 1994 Mar;68(3):1843-53.


Early pathogenesis of disease caused by SIVsmmPBj14 molecular clone 1.9 in macaques.

Israel ZR, Dean GA, Maul DH, O'Neil SP, Dreitz MJ, Mullins JI, Fultz PN, Hoover EA.

AIDS Res Hum Retroviruses. 1993 Mar;9(3):277-86.


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