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Caveolae facilitate TRPV4-mediated Ca2+ signaling and the hierarchical activation of Ca2+-activated K+ channels in K+-secreting renal collecting duct cells.

Li Y, Hu H, O'Neil RG.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1626-F1636. doi: 10.1152/ajprenal.00076.2018. Epub 2018 Sep 12.


Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.

Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H.

J Allergy Clin Immunol. 2018 Feb;141(2):608-619.e7. doi: 10.1016/j.jaci.2017.05.051. Epub 2017 Aug 11.


Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells.

Li Y, Hu H, Tian JB, Zhu MX, O'Neil RG.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1081-F1089. doi: 10.1152/ajprenal.00037.2017. Epub 2017 Mar 8.


The renal TRPV4 channel is essential for adaptation to increased dietary potassium.

Mamenko MV, Boukelmoune N, Tomilin VN, Zaika OL, Jensen VB, O'Neil RG, Pochynyuk OM.

Kidney Int. 2017 Jun;91(6):1398-1409. doi: 10.1016/j.kint.2016.12.010. Epub 2017 Feb 7.


Correction: Emerging Role of the Calcium-Activated, Small Conductance, SK3 K+ Channel in Distal Tubule Function: Regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2016 May 19;11(5):e0156368. doi: 10.1371/journal.pone.0156368. eCollection 2016.


Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney.

Li Y, Hu H, Butterworth MB, Tian JB, Zhu MX, O'Neil RG.

PLoS One. 2016 May 9;11(5):e0155006. doi: 10.1371/journal.pone.0155006. eCollection 2016.


Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.

Mamenko M, Zaika O, Boukelmoune N, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F275-86. doi: 10.1152/ajprenal.00485.2014. Epub 2014 Dec 10. Review.


Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2014 Apr 24;9(4):e95149. doi: 10.1371/journal.pone.0095149. eCollection 2014. Erratum in: PLoS One. 2016;11(5):e0156368.


Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.

Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE.

Nat Struct Mol Biol. 2014 Feb;21(2):180-8. doi: 10.1038/nsmb.2752. Epub 2014 Jan 19.


TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury.

Wu Z, Yang Q, Crook RJ, O'Neil RG, Walters ET.

Pain. 2013 Oct;154(10):2130-41. doi: 10.1016/j.pain.2013.06.040. Epub 2013 Jun 27.


Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.

Mamenko M, Zaika OL, Boukelmoune N, Berrout J, O'Neil RG, Pochynyuk O.

J Biol Chem. 2013 Jul 12;288(28):20306-14. doi: 10.1074/jbc.M113.466797. Epub 2013 May 24.


Ca2+ Imaging as a tool to assess TRP channel function in murine distal nephrons.

Mamenko M, Zaika O, O'Neil RG, Pochynyuk O.

Methods Mol Biol. 2013;998:371-84. doi: 10.1007/978-1-62703-351-0_29.


TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease.

Zaika O, Mamenko M, Berrout J, Boukelmoune N, O'Neil RG, Pochynyuk O.

J Am Soc Nephrol. 2013 Mar;24(4):604-16. doi: 10.1681/ASN.2012050442. Epub 2013 Feb 14.


Novel insights into TRPV4 function in the kidney.

Pochynyuk O, Zaika O, O'Neil RG, Mamenko M.

Pflugers Arch. 2013 Feb;465(2):177-86. doi: 10.1007/s00424-012-1190-z. Epub 2012 Dec 4. Review.


Regulation of TRP Channels by Osmomechanical Stress.

Jin M, Berrout J, O’Neil RG.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 16.


Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine.

Lichtenberger LM, Zhou Y, Jayaraman V, Doyen JR, O'Neil RG, Dial EJ, Volk DE, Gorenstein DG, Boggara MB, Krishnamoorti R.

Biochim Biophys Acta. 2012 Jul;1821(7):994-1002. doi: 10.1016/j.bbalip.2012.04.002. Epub 2012 Apr 14.


Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system.

Berrout J, Jin M, Mamenko M, Zaika O, Pochynyuk O, O'Neil RG.

J Biol Chem. 2012 Mar 16;287(12):8782-91. doi: 10.1074/jbc.M111.308411. Epub 2012 Feb 1.


Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by progressive cross-talk with Ca2+-activated K+ channels.

Jin M, Berrout J, Chen L, O'Neil RG.

Cell Calcium. 2012 Feb;51(2):131-9. doi: 10.1016/j.ceca.2011.11.011. Epub 2011 Dec 26.


Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells.

Berrout J, Jin M, O'Neil RG.

Brain Res. 2012 Feb 3;1436:1-12. doi: 10.1016/j.brainres.2011.11.044. Epub 2011 Dec 1.


Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells.

Ma X, Cheng KT, Wong CO, O'Neil RG, Birnbaumer L, Ambudkar IS, Yao X.

Cell Calcium. 2011 Dec;50(6):502-9. doi: 10.1016/j.ceca.2011.08.006. Epub 2011 Sep 18.


Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron.

Mamenko M, Zaika O, Jin M, O'Neil RG, Pochynyuk O.

PLoS One. 2011;6(8):e22824. doi: 10.1371/journal.pone.0022824. Epub 2011 Aug 5.


Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.

Jin M, Wu Z, Chen L, Jaimes J, Collins D, Walters ET, O'Neil RG.

PLoS One. 2011 Feb 14;6(2):e16713. doi: 10.1371/journal.pone.0016713.


Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Zaika O, Mamenko M, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2011 May;300(5):F1105-15. doi: 10.1152/ajprenal.00606.2010. Epub 2011 Feb 16.


Molecular Mechanisms of TRPV4 Gating.

Heller S, O’Neil RG.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 8.


TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress.

Hicks K, O'Neil RG, Dubinsky WS, Brown RC.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1583-93. doi: 10.1152/ajpcell.00458.2009. Epub 2010 Feb 17.


Long-lasting hyperexcitability induced by depolarization in the absence of detectable Ca2+ signals.

Kunjilwar KK, Fishman HM, Englot DJ, O'Neil RG, Walters ET.

J Neurophysiol. 2009 Mar;101(3):1351-60. doi: 10.1152/jn.91012.2008. Epub 2009 Jan 14.


Optical imaging: skin cancer imaging.

Mullani NA, O'Neil RG.

J Nucl Med. 2008 Jun;49(6):1031. doi: 10.2967/jnumed.108.051185. Epub 2008 May 15. No abstract available.


Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels.

Brown RC, Wu L, Hicks K, O'neil RG.

Microcirculation. 2008 May;15(4):359-71. doi: 10.1080/10739680701762656.


Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flow.

Mullani NA, Herbst RS, O'Neil RG, Gould KL, Barron BJ, Abbruzzese JL.

J Nucl Med. 2008 Apr;49(4):517-23. doi: 10.2967/jnumed.107.048504. Epub 2008 Mar 14.


VASP: a TRPC4-associated phosphoprotein that mediates PKG-induced inhibition of store-operated calcium influx.

O'Neil RG.

Am J Physiol Renal Physiol. 2007 Dec;293(6):F1766-7. Epub 2007 Oct 17. No abstract available.


Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells.

Wu L, Gao X, Brown RC, Heller S, O'Neil RG.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1699-713. Epub 2007 Aug 15.


Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells.

Brown RC, Morris AP, O'Neil RG.

Brain Res. 2007 Jan 26;1130(1):17-30. Epub 2006 Dec 12.


PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries.

Marrelli SP, O'neil RG, Brown RC, Bryan RM Jr.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1390-7. Epub 2006 Oct 27.


Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells.

O'Neil RG, Wu L, Mullani N.

Mol Imaging Biol. 2005 Nov-Dec;7(6):388-92.


The mechanosensitive nature of TRPV channels.

O'Neil RG, Heller S.

Pflugers Arch. 2005 Oct;451(1):193-203. Epub 2005 May 21. Review.


Osmomechanical stress selectively regulates translocation of protein kinase C isoforms.

Liu X, Zhang MI, Peterson LB, O'Neil RG.

FEBS Lett. 2003 Mar 13;538(1-3):101-6.


Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis.

Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ.

J Biol Chem. 2002 Jun 7;277(23):20301-8. Epub 2002 Mar 21.


Kinetics of activation of a PKC-regulated epithelial calcium channel.

Zhang MI, O'Neil RG.

Cell Calcium. 2001 Apr;29(4):263-75.


Molecular characterization of rabbit renal epithelial calcium channel.

Zhang MI, O'Neil RG.

Biochem Biophys Res Commun. 2001 Jan 19;280(2):435-9.


Osmomechanical regulation of membrane trafficking in polarized cells.

Reid JM, O'Neil RG.

Biochem Biophys Res Commun. 2000 May 10;271(2):429-34.


The diversity of calcium channels and their regulation in epithelial cells.

Zhang MI, O'Neil RG.

Adv Pharmacol. 1999;46:43-83. Review. No abstract available.


Expression of dihydropyridine binding sites in renal epithelial cells.

O'Neil RG, Reid JM, Williams RL, Karin NJ.

Biochem Biophys Res Commun. 1997 Aug 8;237(1):41-5.


Modulating Ca2+ in radiation-induced apoptosis suppresses DNA fragmentation but does not enhance clonogenic survival.

Voehringer DW, Story MD, O'Neil RG, Meyn RE.

Int J Radiat Biol. 1997 Mar;71(3):237-43.


An L-type calcium channel in renal epithelial cells.

Zhang MI, O'Neil RG.

J Membr Biol. 1996 Dec;154(3):259-66.


Regulated calcium channel in apical membranes renal proximal tubule cells.

Zhang MI, O'Neil RG.

Am J Physiol. 1996 Nov;271(5 Pt 1):C1757-64.


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