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Items: 35

1.

Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.

Mahalingam SM, Dudkin VY, Goldberg S, Klein D, Yi F, Singhal S, O'Neil KT, Low PS.

Bioconjug Chem. 2017 Nov 15;28(11):2865-2873. doi: 10.1021/acs.bioconjchem.7b00566. Epub 2017 Oct 17.

PMID:
28945346
2.

Conformational flexibility of an anti-IL-13 DARPin†.

Teplyakov A, Malia TJ, Obmolova G, Jacobs SA, O'Neil KT, Gilliland GL.

Protein Eng Des Sel. 2017 Jan;30(1):31-37. Epub 2016 Nov 23.

PMID:
27881684
3.

Engineering a targeted delivery platform using Centyrins.

Goldberg SD, Cardoso RM, Lin T, Spinka-Doms T, Klein D, Jacobs SA, Dudkin V, Gilliland G, O'Neil KT.

Protein Eng Des Sel. 2016 Dec;29(12):563-572. Epub 2016 Oct 13.

PMID:
27737926
4.

Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics.

Jacobs SA, Gibbs AC, Conk M, Yi F, Maguire D, Kane C, O'Neil KT.

Protein Eng Des Sel. 2015 Oct;28(10):385-93. doi: 10.1093/protein/gzv040. Epub 2015 Aug 13.

PMID:
26275855
5.

Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.

Obmolova G, Teplyakov A, Malia TJ, Keough E, Luo J, Sweet R, Jacobs SA, Yi F, Hippensteel R, O'Neil KT, Gilliland GL.

Proteins. 2015 Jun;83(6):1191-7. doi: 10.1002/prot.24815. Epub 2015 May 8.

6.

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.

Diem MD, Hyun L, Yi F, Hippensteel R, Kuhar E, Lowenstein C, Swift EJ, O'Neil KT, Jacobs SA.

Protein Eng Des Sel. 2014 Oct;27(10):419-29. doi: 10.1093/protein/gzu016. Epub 2014 Apr 30.

PMID:
24786107
7.

N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions.

Luo J, Teplyakov A, Obmolova G, Malia TJ, Chan W, Jacobs SA, O'Neil KT, Gilliland GL.

Proteins. 2014 Jul;82(7):1527-33. doi: 10.1002/prot.24517. Epub 2014 Feb 18.

PMID:
24464739
8.

C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold.

Teplyakov A, Obmolova G, Malia TJ, Luo J, Jacobs SA, Chan W, Domingo D, Baker A, O'Neil KT, Gilliland GL.

Proteins. 2014 Jul;82(7):1359-69. doi: 10.1002/prot.24502. Epub 2014 Feb 12.

PMID:
24375666
9.

Mechanisms of self-association of a human monoclonal antibody CNTO607.

Bethea D, Wu SJ, Luo J, Hyun L, Lacy ER, Teplyakov A, Jacobs SA, O'Neil KT, Gilliland GL, Feng Y.

Protein Eng Des Sel. 2012 Oct;25(10):531-7. Epub 2012 Aug 22.

PMID:
22915597
10.

Design of novel FN3 domains with high stability by a consensus sequence approach.

Jacobs SA, Diem MD, Luo J, Teplyakov A, Obmolova G, Malia T, Gilliland GL, O'Neil KT.

Protein Eng Des Sel. 2012 Mar;25(3):107-17. doi: 10.1093/protein/gzr064. Epub 2012 Jan 12.

PMID:
22240293
11.

Structure-based engineering of a monoclonal antibody for improved solubility.

Wu SJ, Luo J, O'Neil KT, Kang J, Lacy ER, Canziani G, Baker A, Huang M, Tang QM, Raju TS, Jacobs SA, Teplyakov A, Gilliland GL, Feng Y.

Protein Eng Des Sel. 2010 Aug;23(8):643-51. doi: 10.1093/protein/gzq037. Epub 2010 Jun 11.

PMID:
20543007
12.

Cross-interaction chromatography: a rapid method to identify highly soluble monoclonal antibody candidates.

Jacobs SA, Wu SJ, Feng Y, Bethea D, O'Neil KT.

Pharm Res. 2010 Jan;27(1):65-71. doi: 10.1007/s11095-009-0007-z. Epub 2009 Nov 13.

PMID:
19911257
13.

Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis.

Picha KM, Cunningham MR, Drucker DJ, Mathur A, Ort T, Scully M, Soderman A, Spinka-Doms T, Stojanovic-Susulic V, Thomas BA, O'Neil KT.

Diabetes. 2008 Jul;57(7):1926-34. doi: 10.2337/db07-1775. Epub 2008 Apr 21.

14.

Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II).

Xiang H, Wynn R, Nguyen LH, Ross OH, Ahrens DP, O'Neil KT, Hollis GF, Patrick DR.

J Chromatogr A. 2002 Nov 29;978(1-2):153-64.

PMID:
12458952
15.

A comprehensive system for protein purification and biochemical analysis based on antibodies to c-myc peptide.

Hillman MC, Yang LS, Sun S, Duke JL, O'Neil KT, Kochie JE, Karjoo A, Nath P, Breth LA, Murphy K, Ross OH, Burn TC, Hollis GF, Wynn R.

Protein Expr Purif. 2001 Nov;23(2):359-68.

PMID:
11676612
16.

Structural consequences of an amino acid deletion in the B1 domain of protein G.

O'Neil KT, Bach AC 2nd, DeGrado WF.

Proteins. 2000 Nov 15;41(3):323-33.

PMID:
11025544
17.

Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin.

Dinchuk JE, Henderson NL, Burn TC, Huber R, Ho SP, Link J, O'Neil KT, Focht RJ, Scully MS, Hollis JM, Hollis GF, Friedman PA.

J Biol Chem. 2000 Dec 15;275(50):39543-54.

18.

An early intermediate in the folding reaction of the B1 domain of protein G contains a native-like core.

Park SH, O'Neil KT, Roder H.

Biochemistry. 1997 Nov 25;36(47):14277-83.

PMID:
9400366
19.

Expression of de novo designed alpha-helical bundles.

Betz SF, Bryson JW, Passador MC, Brown RJ, O'Neil KT, DeGrado WF.

Acta Chem Scand. 1996 Aug;50(8):688-96.

PMID:
8756357
20.

Protein design: a hierarchic approach.

Bryson JW, Betz SF, Lu HS, Suich DJ, Zhou HX, O'Neil KT, DeGrado WF.

Science. 1995 Nov 10;270(5238):935-41. Review.

PMID:
7481798
21.

Phage display: protein engineering by directed evolution.

O'Neil KT, Hoess RH.

Curr Opin Struct Biol. 1995 Aug;5(4):443-9. Review.

PMID:
8528759
22.

Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G.

O'Neil KT, Hoess RH, Raleigh DP, DeGrado WF.

Proteins. 1995 Jan;21(1):11-21.

PMID:
7716165
23.

Identification of recognition sequences of adhesion molecules using phage display technology.

O'Neil KT, DeGrado WF, Mousa SA, Ramachandran N, Hoess RH.

Methods Enzymol. 1994;245:370-86. No abstract available.

PMID:
7539093
24.

Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library.

O'Neil KT, Hoess RH, Jackson SA, Ramachandran NS, Mousa SA, DeGrado WF.

Proteins. 1992 Dec;14(4):509-15.

PMID:
1438188
25.

X-ray grade crystals of a designed alpha-helical coiled coil.

Lovejoy B, Le TC, Lüthy R, Cascio D, O'Neil KT, DeGrado WF, Eisenberg D.

Protein Sci. 1992 Jul;1(7):956-7. No abstract available.

26.

DNA-induced increase in the alpha-helical content of C/EBP and GCN4.

O'Neil KT, Shuman JD, Ampe C, DeGrado WF.

Biochemistry. 1991 Sep 17;30(37):9030-4.

PMID:
1892816
27.

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids.

O'Neil KT, DeGrado WF.

Science. 1990 Nov 2;250(4981):646-51. Erratum in: Science 1991 Aug 30;253(5023):952.

PMID:
2237415
28.

Design of DNA-binding peptides based on the leucine zipper motif.

O'Neil KT, Hoess RH, DeGrado WF.

Science. 1990 Aug 17;249(4970):774-8.

PMID:
2389143
29.

How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices.

O'Neil KT, DeGrado WF.

Trends Biochem Sci. 1990 Feb;15(2):59-64. Review.

PMID:
2186516
30.

Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine.

O'Neil KT, Erickson-Viitanen S, DeGrado WF.

J Biol Chem. 1989 Aug 25;264(24):14571-8.

32.

Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity.

O'Neil KT, Wolfe HR Jr, Erickson-Viitanen S, DeGrado WF.

Science. 1987 Jun 12;236(4807):1454-6.

PMID:
3589665
33.

Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase.

DeGrado WF, Erickson-Viitanen S, Wolfe HR Jr, O'Neil KT.

Proteins. 1987;2(1):20-33. Erratum in: Proteins 1987;2(3):260-1.

PMID:
3447166
34.

A predicted structure of calmodulin suggests an electrostatic basis for its function.

O'Neil KT, DeGrado WF.

Proc Natl Acad Sci U S A. 1985 Aug;82(15):4954-8.

35.

Palmitic acid and lecithin measurements in amniotic fluid.

Moore RA, O'Neil KT, Cooke RJ, MacLennan AH.

Br J Obstet Gynaecol. 1975 Mar;82(3):194-8.

PMID:
1173549

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