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Items: 1 to 50 of 104

1.

Intracellular GPCRs Play Key Roles in Synaptic Plasticity.

Jong YI, Harmon SK, O'Malley KL.

ACS Chem Neurosci. 2018 Feb 16. doi: 10.1021/acschemneuro.7b00516. [Epub ahead of print]

PMID:
29409317
2.

GPCR signalling from within the cell.

Jong YI, Harmon SK, O'Malley KL.

Br J Pharmacol. 2017 Sep 5. doi: 10.1111/bph.14023. [Epub ahead of print] Review.

PMID:
28872669
3.

Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization.

Sergin I, Jong YI, Harmon SK, Kumar V, O'Malley KL.

J Biol Chem. 2017 Mar 3;292(9):3637-3655. doi: 10.1074/jbc.M116.757724. Epub 2017 Jan 17.

4.

Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5.

Jong YI, O'Malley KL.

Neurochem Res. 2017 Jan;42(1):166-172. doi: 10.1007/s11064-016-2026-6. Epub 2016 Aug 11.

5.

Intracellular mGluR5 plays a critical role in neuropathic pain.

Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ.

Nat Commun. 2016 Feb 3;7:10604. doi: 10.1038/ncomms10604.

6.

Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers.

Dearborn JT, Harmon SK, Fowler SC, O'Malley KL, Taylor GT, Sands MS, Wozniak DF.

Sci Rep. 2015 Aug 4;5:12752. doi: 10.1038/srep12752.

7.

Reassessment of the role of aromatic amino acid hydroxylases and the effect of infection by Toxoplasma gondii on host dopamine.

Wang ZT, Harmon S, O'Malley KL, Sibley LD.

Infect Immun. 2015 Mar;83(3):1039-47. doi: 10.1128/IAI.02465-14. Epub 2014 Dec 29.

8.

Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.

Jong YJ, Sergin I, Purgert CA, O'Malley KL.

Mol Pharmacol. 2014 Dec;86(6):774-85. doi: 10.1124/mol.114.094763. Epub 2014 Oct 17. Review.

9.

Functional G protein-coupled receptors on nuclei from brain and primary cultured neurons.

Jong YJ, O'Malley KL.

Methods Mol Biol. 2015;1234:113-21. doi: 10.1007/978-1-4939-1755-6_10.

10.

The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons.

Lu X, Kim-Han JS, Harmon S, Sakiyama-Elbert SE, O'Malley KL.

Mol Neurodegener. 2014 May 3;9:17. doi: 10.1186/1750-1326-9-17.

11.

Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus.

Purgert CA, Izumi Y, Jong YJ, Kumar V, Zorumski CF, O'Malley KL.

J Neurosci. 2014 Mar 26;34(13):4589-98. doi: 10.1523/JNEUROSCI.3451-13.2014.

12.

MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death.

Bernstein AI, O'Malley KL.

Toxicol Lett. 2013 May 23;219(2):93-8. doi: 10.1016/j.toxlet.2013.03.003. Epub 2013 Mar 14.

13.

Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.

Pandey N, Fahey MT, Jong YJ, O'Malley KL.

PLoS One. 2012;7(9):e45149. doi: 10.1371/journal.pone.0045149. Epub 2012 Sep 13.

14.

A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons.

Lu X, Kim-Han JS, O'Malley KL, Sakiyama-Elbert SE.

J Neurosci Methods. 2012 Jul 30;209(1):35-9. doi: 10.1016/j.jneumeth.2012.05.021. Epub 2012 May 28.

15.

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.

Antenor-Dorsey JA, O'Malley KL.

Mol Neurodegener. 2012 Feb 8;7:5. doi: 10.1186/1750-1326-7-5.

16.

Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.

Kumar V, Fahey PG, Jong YJ, Ramanan N, O'Malley KL.

J Biol Chem. 2012 Feb 17;287(8):5412-25. doi: 10.1074/jbc.M111.301366. Epub 2011 Dec 16.

17.

The role of axonopathy in Parkinson's disease.

O'Malley KL.

Exp Neurobiol. 2010 Dec;19(3):115-9. doi: 10.5607/en.2010.19.3.115. Epub 2010 Dec 31.

18.

The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons.

Kim-Han JS, Antenor-Dorsey JA, O'Malley KL.

J Neurosci. 2011 May 11;31(19):7212-21. doi: 10.1523/JNEUROSCI.0711-11.2011.

19.

6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death.

Bernstein AI, Garrison SP, Zambetti GP, O'Malley KL.

Mol Neurodegener. 2011 Jan 6;6(1):2. doi: 10.1186/1750-1326-6-2.

20.

Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice.

Brown JA, Emnett RJ, White CR, Yuede CM, Conyers SB, O'Malley KL, Wozniak DF, Gutmann DH.

Hum Mol Genet. 2010 Nov 15;19(22):4515-28. doi: 10.1093/hmg/ddq382. Epub 2010 Sep 7.

21.

Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts.

Jong YJ, Kumar V, O'Malley KL.

J Biol Chem. 2009 Dec 18;284(51):35827-38. doi: 10.1074/jbc.M109.046276.

22.

Activated nuclear metabotropic glutamate receptor mGlu5 couples to nuclear Gq/11 proteins to generate inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ release.

Kumar V, Jong YJ, O'Malley KL.

J Biol Chem. 2008 May 16;283(20):14072-83. doi: 10.1074/jbc.M708551200. Epub 2008 Mar 12.

23.
25.
26.

Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

Hasbani DM, O'Malley KL.

Exp Neurol. 2006 Nov;202(1):93-9. Epub 2006 Jun 27.

PMID:
16806180
27.

Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo.

Hasbani DM, Perez FA, Palmiter RD, O'Malley KL.

J Neurosci. 2005 Oct 12;25(41):9428-33.

28.

Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand.

Jong YJ, Kumar V, Kingston AE, Romano C, O'Malley KL.

J Biol Chem. 2005 Aug 26;280(34):30469-80. Epub 2005 Jun 15.

29.

Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death.

Holtz WA, Turetzky JM, O'Malley KL.

Antioxid Redox Signal. 2005 May-Jun;7(5-6):639-48.

PMID:
15890008
30.

Rat tyrosine hydroxylase promoter directs tetracycline-inducible foreign gene expression in dopaminergic cell types.

Gardaneh M, O'Malley KL.

Brain Res Mol Brain Res. 2004 Jul 26;126(2):173-80.

PMID:
15249141
31.

Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons.

O'Malley KL, Liu J, Lotharius J, Holtz W.

Neurobiol Dis. 2003 Oct;14(1):43-51.

PMID:
13678665
32.
33.

Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons.

O'Malley KL, Jong YJ, Gonchar Y, Burkhalter A, Romano C.

J Biol Chem. 2003 Jul 25;278(30):28210-9. Epub 2003 May 7.

34.

Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons.

Holtz WA, O'Malley KL.

J Biol Chem. 2003 May 23;278(21):19367-77. Epub 2003 Feb 21.

35.

Developmental regulation of metabotropic glutamate receptor 5b protein in rodent brain.

Romano C, Smout S, Miller JK, O'Malley KL.

Neuroscience. 2002;111(3):693-8.

PMID:
12031354
36.

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.

Kilts JD, Connery HS, Arrington EG, Lewis MM, Lawler CP, Oxford GS, O'Malley KL, Todd RD, Blake BL, Nichols DE, Mailman RB.

J Pharmacol Exp Ther. 2002 Jun;301(3):1179-89.

37.

Fullerene-based antioxidants and neurodegenerative disorders.

Dugan LL, Lovett EG, Quick KL, Lotharius J, Lin TT, O'Malley KL.

Parkinsonism Relat Disord. 2001 Jul;7(3):243-246.

PMID:
11331193
38.
39.

The dopamine receptor DRD4 gene: are duplications distracting?

Todd RD, O'Malley KL.

Trends Pharmacol Sci. 2001 Feb;22(2):55-6. No abstract available.

PMID:
11166839
40.

Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization.

Romano C, Miller JK, Hyrc K, Dikranian S, Mennerick S, Takeuchi Y, Goldberg MP, O'Malley KL.

Mol Pharmacol. 2001 Jan;59(1):46-53.

42.

Developmental cell death in dopaminergic neurons of the substantia nigra of mice.

Jackson-Lewis V, Vila M, Djaldetti R, Guegan C, Liberatore G, Liu J, O'Malley KL, Burke RE, Przedborski S.

J Comp Neurol. 2000 Aug 28;424(3):476-88.

PMID:
10906714
43.

A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter.

Cazorla P, Smidt MP, O'Malley KL, Burbach JP.

J Neurochem. 2000 May;74(5):1829-37.

44.

Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins.

Choi WS, Canzoniero LM, Sensi SL, O'Malley KL, Gwag BJ, Sohn S, Kim JE, Oh TH, Lee EB, Oh YJ.

Exp Neurol. 1999 Sep;159(1):274-82.

PMID:
10486196
45.

kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons.

Dalman FC, O'Malley KL.

J Neurosci. 1999 Jul 15;19(14):5750-7.

46.

Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK.

Choi WS, Yoon SY, Oh TH, Choi EJ, O'Malley KL, Oh YJ.

J Neurosci Res. 1999 Jul 1;57(1):86-94.

PMID:
10397638
48.

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

Lotharius J, Dugan LL, O'Malley KL.

J Neurosci. 1999 Feb 15;19(4):1284-93.

49.

Overexpression of HA-Bax but not Bcl-2 or Bcl-XL attenuates 6-hydroxydopamine-induced neuronal apoptosis.

Oh JH, Choi WS, Kim JE, Seo JW, O'Malley KL, Oh YJ.

Exp Neurol. 1998 Nov;154(1):193-8.

PMID:
9875280
50.

In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector.

During MJ, Samulski RJ, Elsworth JD, Kaplitt MG, Leone P, Xiao X, Li J, Freese A, Taylor JR, Roth RH, Sladek JR Jr, O'Malley KL, Redmond DE Jr.

Gene Ther. 1998 Jun;5(6):820-7.

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