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Items: 13

1.

Scn1b deletion in adult mice results in seizures and SUDEP.

O'Malley HA, Hull JM, Clawson BC, Chen C, Owens-Fiestan G, Jameson MB, Aton SJ, Parent JM, Isom LL.

Ann Clin Transl Neurol. 2019 May 8;6(6):1121-1126. doi: 10.1002/acn3.785. eCollection 2019 Jun.

2.

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Yuan Y, O'Malley HA, Smaldino MA, Bouza AA, Hull JM, Isom LL.

Sci Rep. 2019 Apr 17;9(1):6210. doi: 10.1038/s41598-019-42191-0.

3.

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy.

Lopez-Santiago LF, Yuan Y, Wagnon JL, Hull JM, Frasier CR, O'Malley HA, Meisler MH, Isom LL.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2383-2388. doi: 10.1073/pnas.1616821114. Epub 2017 Feb 13.

4.

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function.

Kruger LC, O'Malley HA, Hull JM, Kleeman A, Patino GA, Isom LL.

J Neurosci. 2016 Jun 8;36(23):6213-24. doi: 10.1523/JNEUROSCI.0405-16.2016.

5.

Sodium channel β subunits: emerging targets in channelopathies.

O'Malley HA, Isom LL.

Annu Rev Physiol. 2015;77:481-504. doi: 10.1146/annurev-physiol-021014-071846. Review.

6.

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism.

Liu Y, Lopez-Santiago LF, Yuan Y, Jones JM, Zhang H, O'Malley HA, Patino GA, O'Brien JE, Rusconi R, Gupta A, Thompson RC, Natowicz MR, Meisler MH, Isom LL, Parent JM.

Ann Neurol. 2013 Jul;74(1):128-39. doi: 10.1002/ana.23897. Epub 2013 Jul 2. Erratum in: Ann Neurol. 2015 Nov;78(5):838.

7.

Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.

Brackenbury WJ, Yuan Y, O'Malley HA, Parent JM, Isom LL.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1089-94. doi: 10.1073/pnas.1208767110. Epub 2012 Dec 31.

8.

Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.

Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafrenière RG, Cossette P, Rouleau GA, Isom LL.

J Neurosci. 2011 Oct 12;31(41):14577-91. doi: 10.1523/JNEUROSCI.0361-11.2011.

9.

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons.

O'Malley HA, Park Y, Isom LL, Gnegy ME.

Neurosci Lett. 2010 Aug 9;480(1):40-3.

10.

Conduction block in PMP22 deficiency.

Bai Y, Zhang X, Katona I, Saporta MA, Shy ME, O'Malley HA, Isom LL, Suter U, Li J.

J Neurosci. 2010 Jan 13;30(2):600-8. doi: 10.1523/JNEUROSCI.4264-09.2010.

11.

A functional null mutation of SCN1B in a patient with Dravet syndrome.

Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL.

J Neurosci. 2009 Aug 26;29(34):10764-78. doi: 10.1523/JNEUROSCI.2475-09.2009.

12.

Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL.

Mol Cell Neurosci. 2009 Feb;40(2):143-55. doi: 10.1016/j.mcn.2008.10.001. Epub 2008 Nov 1.

13.

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL.

J Neurosci. 2004 Apr 21;24(16):4030-42.

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