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Items: 29

1.

Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta.

Lofthouse EM, Torrens C, Manousopoulou A, Nahar M, Cleal JK, O'Kelly IM, Sengers BG, Garbis SD, Lewis RM.

FASEB J. 2019 Mar 28:fj201900015RR. doi: 10.1096/fj.201900015RR. [Epub ahead of print]

2.

Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux.

Lofthouse EM, Cleal JK, O'Kelly IM, Sengers BG, Lewis RM.

Biochem Biophys Res Commun. 2018 Nov 17;506(1):237-242. doi: 10.1016/j.bbrc.2018.10.074. Epub 2018 Oct 19.

3.

AMMECR1: a single point mutation causes developmental delay, midface hypoplasia and elliptocytosis.

Andreoletti G, Seaby EG, Dewing JM, O'Kelly I, Lachlan K, Gilbert RD, Ennis S.

J Med Genet. 2017 Apr;54(4):269-277. doi: 10.1136/jmedgenet-2016-104100. Epub 2016 Nov 3.

4.

Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans.

Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, FitzPatrick DR; UK10K Consortium, Wilson DI, Mital S, Hurles ME.

Am J Hum Genet. 2016 Mar 3;98(3):592. doi: 10.1016/j.ajhg.2016.02.016. Epub 2016 Mar 3. No abstract available.

5.

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

Crisford A, Ebbinghaus-Kintscher U, Schoenhense E, Harder A, Raming K, O'Kelly I, Ndukwe K, O'Connor V, Walker RJ, Holden-Dye L.

PLoS Negl Trop Dis. 2015 Oct 5;9(10):e0004062. doi: 10.1371/journal.pntd.0004062. eCollection 2015.

6.

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast.

Lofthouse EM, Brooks S, Cleal JK, Hanson MA, Poore KR, O'Kelly IM, Lewis RM.

J Physiol. 2015 Oct 15;593(20):4549-59. doi: 10.1113/JP270743. Epub 2015 Sep 9.

7.

Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K₂p) channels.

O'Kelly I.

Pflugers Arch. 2015 May;467(5):1133-42. doi: 10.1007/s00424-014-1641-9. Epub 2014 Nov 22. Review.

8.

Rare variants in NR2F2 cause congenital heart defects in humans.

Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LC, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Low J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, Fitzpatrick DF; UK10K Consortium, Wilson DI, Mital S, Hurles ME.

Am J Hum Genet. 2014 Apr 3;94(4):574-85. doi: 10.1016/j.ajhg.2014.03.007. Erratum in: Am J Hum Genet. 2014 Jul 3;95(1):126. Am J Hum Genet. 2016 Mar 3;98(3):592. Low, Jacoba [corrected to Louw, Jacoba].

9.

Altered expression of two-pore domain potassium (K2P) channels in cancer.

Williams S, Bateman A, O'Kelly I.

PLoS One. 2013 Oct 7;8(10):e74589. doi: 10.1371/journal.pone.0074589. eCollection 2013.

10.

Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosis.

Mant A, Williams S, O'Kelly I.

Channels (Austin). 2013 Jul-Aug;7(4):288-302. Epub 2013 Jun 10.

11.

N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1.

Mant A, Williams S, Roncoroni L, Lowry E, Johnson D, O'Kelly I.

J Biol Chem. 2013 Feb 1;288(5):3251-64. doi: 10.1074/jbc.M112.405167. Epub 2012 Dec 18.

12.

Protein kinase A is central for forward transport of two-pore domain potassium channels K2P3.1 and K2P9.1.

Mant A, Elliott D, Eyers PA, O'Kelly IM.

J Biol Chem. 2011 Apr 22;286(16):14110-9. doi: 10.1074/jbc.M110.190702. Epub 2011 Feb 28.

13.

Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.

O'Kelly I, Goldstein SA.

Traffic. 2008 Jan;9(1):72-8. Epub 2007 Oct 24.

14.

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose.

Burdakov D, Jensen LT, Alexopoulos H, Williams RH, Fearon IM, O'Kelly I, Gerasimenko O, Fugger L, Verkhratsky A.

Neuron. 2006 Jun 1;50(5):711-22.

15.

Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells.

Fearon IM, Campanucci VA, Brown ST, Hudasek K, O'Kelly IM, Nurse CA.

Adv Exp Med Biol. 2006;580:203-8; discussion 351-9. No abstract available.

PMID:
16683720
16.

O2 sensing by recombinant TWIK-related halothane-inhibitable K+ channel-1 background K+ channels heterologously expressed in human embryonic kidney cells.

Campanucci VA, Brown ST, Hudasek K, O'kelly IM, Nurse CA, Fearon IM.

Neuroscience. 2005;135(4):1087-94. Epub 2005 Sep 8.

PMID:
16154284
17.

The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin.

Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM.

Exp Cell Res. 2005 May 1;305(2):253-65.

PMID:
15817151
18.

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of Pharmacology.

Pharmacol Rev. 2003 Dec;55(4):583-6.

PMID:
14657415
19.

System-specific O2 sensitivity of the tandem pore domain K+ channel TASK-1.

Johnson RP, O'Kelly IM, Fearon IM.

Am J Physiol Cell Physiol. 2004 Feb;286(2):C391-7. Epub 2003 Oct 22.

20.

Airway chemotransduction: from oxygen sensor to cellular effector.

Kemp PJ, Lewis A, Hartness ME, Searle GJ, Miller P, O'Kelly I, Peers C.

Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S17-24. Review.

PMID:
12471084
21.

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.

O'Kelly I, Butler MH, Zilberberg N, Goldstein SA.

Cell. 2002 Nov 15;111(4):577-88.

22.

NADPH oxidase does not account fully for O2-sensing in model airway chemoreceptor cells.

O'Kelly I, Peers C, Kemp PJ.

Biochem Biophys Res Commun. 2001 May 25;283(5):1131-4.

PMID:
11355890
23.

Combined antisense and pharmacological approaches implicate hTASK as an airway O(2) sensing K(+) channel.

Hartness ME, Lewis A, Searle GJ, O'Kelly I, Peers C, Kemp PJ.

J Biol Chem. 2001 Jul 13;276(28):26499-508. Epub 2001 May 8.

24.

Potassium leak channels and the KCNK family of two-P-domain subunits.

Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N.

Nat Rev Neurosci. 2001 Mar;2(3):175-84. Review.

PMID:
11256078
25.

O2-sensing by model airway chemoreceptors. Hypoxic inhibition of K+ channels in H146 cells.

O'Kelly I, Peers C, Kemp PJ.

Adv Exp Med Biol. 2000;475:611-22. No abstract available.

PMID:
10849701
26.
27.

Mechanosensitive calcium entry and mobilization in renal A6 cells.

Urbach V, Leguen I, O'Kelly I, Harvey BJ.

J Membr Biol. 1999 Mar 1;168(1):29-37.

PMID:
10051687
28.

Potential identification of the O2-sensitive K+ current in a human neuroepithelial body-derived cell line.

O'Kelly I, Stephens RH, Peers C, Kemp PJ.

Am J Physiol. 1999 Jan;276(1):L96-L104. doi: 10.1152/ajplung.1999.276.1.L96.

PMID:
9887061
29.

O2-sensitive K+ channels in neuroepithelial body-derived small cell carcinoma cells of the human lung.

O'Kelly I, Peers C, Kemp PJ.

Am J Physiol. 1998 Oct;275(4):L709-16. doi: 10.1152/ajplung.1998.275.4.L709.

PMID:
9755103

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