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Items: 1 to 50 of 378

1.

Disease modelling of core pre-mRNA splicing factor haploinsufficiency.

Wood KA, Rowlands CF, Qureshi WMS, Thomas HB, Buczek WA, Briggs TA, Hubbard SJ, Hentges K, Newman WG, O'Keefe RT.

Hum Mol Genet. 2019 Jul 13. pii: ddz169. doi: 10.1093/hmg/ddz169. [Epub ahead of print]

PMID:
31304552
2.

What is the Impact of Social Deprivation on Physical and Mental Health in Orthopaedic Patients?

Wright MA, Adelani M, Dy C, OʼKeefe R, Calfee RP.

Clin Orthop Relat Res. 2019 Apr 27. doi: 10.1097/CORR.0000000000000698. [Epub ahead of print]

PMID:
31107333
3.
4.

Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.

Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ.

Ann Biomed Eng. 2019 Apr 12. doi: 10.1007/s10439-019-02264-7. [Epub ahead of print]

PMID:
30980293
5.

Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.

Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ.

Am J Transl Res. 2019 Mar 15;11(3):1736-1747. eCollection 2019.

6.

Treatment of intra-articular hip malignancy with extra-articular resection, preservation of the acetabular columns, and total hip arthroplasty.

Wells JE, Clohisy JC, O'Keefe RJ.

Arthroplast Today. 2018 Sep 7;4(4):431-435. doi: 10.1016/j.artd.2018.07.007. eCollection 2018 Dec.

7.

Safety of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study.

Dy CJ, Osei DA, Maak TG, Gottschalk MB, Zhang AL, Maloney MD, Presson AP, O'Keefe RJ.

J Bone Joint Surg Am. 2018 Nov 21;100(22):1902-1911. doi: 10.2106/JBJS.17.01625.

PMID:
30480594
8.

Scholarly Success of Orthopaedic Surgeons Participating in the Clinician Scholar Career Development Program.

Bernstein DN, Lawson M, Menga EN, O'Keefe RJ, Rubery PT, Mesfin A.

J Bone Joint Surg Am. 2018 Sep 5;100(17):e115. doi: 10.2106/JBJS.17.01605.

PMID:
30180065
9.

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.

Lee DS, O'Keefe RA, Ha PK, Grandis JR, Johnson DE.

Int J Mol Sci. 2018 May 30;19(6). pii: E1608. doi: 10.3390/ijms19061608.

10.

BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC.

Leonard B, Brand TM, O'Keefe RA, Lee ED, Zeng Y, Kemmer JD, Li H, Grandis JR, Bhola NE.

Cancer Res. 2018 Aug 1;78(15):4331-4343. doi: 10.1158/0008-5472.CAN-18-0459. Epub 2018 May 23.

PMID:
29792310
11.

A known pathogenic variant in the essential mitochondrial translation gene RMND1 causes a Perrault-like syndrome with renal defects.

Demain LAM, Antunes D, O'Sullivan J, Bhaskhar SS, O'Keefe RT, Newman WG.

Clin Genet. 2018 Aug;94(2):276-277. doi: 10.1111/cge.13255. Epub 2018 Apr 19. No abstract available.

PMID:
29671881
12.

Clinical translation and application in orthopaedics.

Chen CH, O'Keefe R.

J Orthop Translat. 2017 Dec 16;12:A3-A4. doi: 10.1016/j.jot.2017.12.001. eCollection 2018 Jan. No abstract available.

13.

The impact of translational orthopaedic research: Journal of Orthopaedic Translation indexed in Science Citation Index Expanded.

Qin L, Chen CH, Genant HK, Guo XD, Li G, O'Keefe R, Richards RG, Tang TT, Chan KM.

J Orthop Translat. 2018 Feb 3;12:A1-A2. doi: 10.1016/j.jot.2018.01.004. eCollection 2018 Jan. No abstract available.

14.

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis.

Wang C, Silverman RM, Shen J, O'Keefe RJ.

J Orthop Translat. 2018 Jan 2;12:66-73. doi: 10.1016/j.jot.2017.12.004. eCollection 2018 Jan.

15.

Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development.

Xu T, Wang C, Shen J, Tong P, O'Keefe R.

J Cell Biochem. 2018 Jul;119(7):5852-5863. doi: 10.1002/jcb.26775. Epub 2018 Apr 10.

16.

Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates.

Ding Q, Ren Y, Che H, Ma C, Li H, Yu S, Zhang Y, An H, O'Keefe RJ, Chen D, Block JA, Yin G, Li T.

Am J Transl Res. 2018 Mar 15;10(3):718-730. eCollection 2018.

17.

Large-scale profiling of noncoding RNA function in yeast.

Parker S, Fraczek MG, Wu J, Shamsah S, Manousaki A, Dungrattanalert K, de Almeida RA, Invernizzi E, Burgis T, Omara W, Griffiths-Jones S, Delneri D, O'Keefe RT.

PLoS Genet. 2018 Mar 12;14(3):e1007253. doi: 10.1371/journal.pgen.1007253. eCollection 2018 Mar.

18.

AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran S.

Mol Cancer Res. 2018 Apr;16(4):720-727. doi: 10.1158/1541-7786.MCR-17-0480. Epub 2018 Feb 16.

19.

Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.

Brand TM, Hartmann S, Bhola NE, Li H, Zeng Y, O'Keefe RA, Ranall MV, Bandyopadhyay S, Soucheray M, Krogan NJ, Kemp C, Duvvuri U, LaVallee T, Johnson DE, Ozbun MA, Bauman JE, Grandis JR.

Cancer Res. 2018 May 1;78(9):2383-2395. doi: 10.1158/0008-5472.CAN-17-1672. Epub 2018 Feb 12.

20.

Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ.

Bone. 2018 May;110:150-159. doi: 10.1016/j.bone.2018.02.001. Epub 2018 Feb 3.

21.

Targeting the IL-6/JAK/STAT3 signalling axis in cancer.

Johnson DE, O'Keefe RA, Grandis JR.

Nat Rev Clin Oncol. 2018 Apr;15(4):234-248. doi: 10.1038/nrclinonc.2018.8. Epub 2018 Feb 6. Review.

22.

Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.

Wang C, Abu-Amer Y, O'Keefe RJ, Shen J.

J Bone Miner Res. 2018 Feb;33(2):283-297. doi: 10.1002/jbmr.3305. Epub 2017 Nov 2.

23.

Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.

Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE.

Sci Rep. 2017 Aug 17;7(1):8658. doi: 10.1038/s41598-017-09407-7.

24.

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ.

JCI Insight. 2017 Jun 15;2(12). pii: 93612. doi: 10.1172/jci.insight.93612. eCollection 2017 Jun 15.

25.

A resource for functional profiling of noncoding RNA in the yeast Saccharomyces cerevisiae.

Parker S, Fraczek MG, Wu J, Shamsah S, Manousaki A, Dungrattanalert K, de Almeida RA, Estrada-Rivadeneyra D, Omara W, Delneri D, O'Keefe RT.

RNA. 2017 Aug;23(8):1166-1171. doi: 10.1261/rna.061564.117. Epub 2017 May 3.

26.

PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.

Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ.

J Cell Biochem. 2017 Dec;118(12):4383-4393. doi: 10.1002/jcb.26092. Epub 2017 May 31.

27.

Corrigendum: Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O'Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Barañano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenço CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Õunap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, van der Knaap MS, Livingston JH, O'Keefe RT, Crow YJ.

Nat Genet. 2017 Jan 31;49(2):317. doi: 10.1038/ng0217-317b. No abstract available.

PMID:
28138155
28.

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.

Bartley CM, O'Keefe RA, Blice-Baum A, Mihailescu MR, Gong X, Miyares L, Karaca E, Bordey A.

eNeuro. 2016 Nov 21;3(6). pii: ENEURO.0092-16.2016. eCollection 2016 Nov-Dec.

29.

Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice.

Albadawi H, Oklu R, Raacke Malley RE, O'Keefe RM, Uong TP, Cormier NR, Watkins MT.

J Vasc Surg. 2016 Aug;64(2):484-493. doi: 10.1016/j.jvs.2015.01.031. Epub 2015 Dec 15.

30.

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Jenkinson EM, Rodero MP, Kasher PR, Uggenti C, Oojageer A, Goosey LC, Rose Y, Kershaw CJ, Urquhart JE, Williams SG, Bhaskar SS, O'Sullivan J, Baerlocher GM, Haubitz M, Aubert G, Barañano KW, Barnicoat AJ, Battini R, Berger A, Blair EM, Brunstrom-Hernandez JE, Buckard JA, Cassiman DM, Caumes R, Cordelli DM, De Waele LM, Fay AJ, Ferreira P, Fletcher NA, Fryer AE, Goel H, Hemingway CA, Henneke M, Hughes I, Jefferson RJ, Kumar R, Lagae L, Landrieu PG, Lourenço CM, Malpas TJ, Mehta SG, Metz I, Naidu S, Õunap K, Panzer A, Prabhakar P, Quaghebeur G, Schiffmann R, Sherr EH, Sinnathuray KR, Soh C, Stewart HS, Stone J, Van Esch H, Van Mol CE, Vanderver A, Wakeling EL, Whitney A, Pavitt GD, Griffiths-Jones S, Rice GI, Revy P, van der Knaap MS, Livingston JH, O'Keefe RT, Crow YJ.

Nat Genet. 2016 Oct;48(10):1185-92. doi: 10.1038/ng.3661. Epub 2016 Aug 29. Erratum in: Nat Genet. 2017 Jan 31;49(2):317.

31.

HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Jordan NV, Bardia A, Wittner BS, Benes C, Ligorio M, Zheng Y, Yu M, Sundaresan TK, Licausi JA, Desai R, O'Keefe RM, Ebright RY, Boukhali M, Sil S, Onozato ML, Iafrate AJ, Kapur R, Sgroi D, Ting DT, Toner M, Ramaswamy S, Haas W, Maheswaran S, Haber DA.

Nature. 2016 Sep 1;537(7618):102-106. doi: 10.1038/nature19328. Epub 2016 Aug 24.

32.

Non-coding RNAs and disease: the classical ncRNAs make a comeback.

de Almeida RA, Fraczek MG, Parker S, Delneri D, O'Keefe RT.

Biochem Soc Trans. 2016 Aug 15;44(4):1073-8. doi: 10.1042/BST20160089. Review.

33.

Inflammation and epigenetic regulation in osteoarthritis.

Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A.

Connect Tissue Res. 2017 Jan;58(1):49-63. doi: 10.1080/03008207.2016.1208655. Epub 2016 Jul 7. Review.

34.

BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling.

Zhang Y, O'Keefe RJ, Jonason JH.

J Cell Biochem. 2017 Jan;118(1):204-210. doi: 10.1002/jcb.25626. Epub 2016 Jun 27.

35.

Clusters of circulating tumor cells traverse capillary-sized vessels.

Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52. doi: 10.1073/pnas.1524448113. Epub 2016 Apr 18.

36.

NOTCH signaling in skeletal progenitors is critical for fracture repair.

Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ.

J Clin Invest. 2016 Apr 1;126(4):1471-81. doi: 10.1172/JCI80672. Epub 2016 Mar 7.

37.

Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing.

Orner CA, Geary MB, Hammert WC, O'Keefe RJ, Loiselle AE.

Plast Reconstr Surg. 2016 Mar;137(3):545e-553e. doi: 10.1097/01.prs.0000475823.01907.53.

38.

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Bone Res. 2015 Aug 11;3:15021. doi: 10.1038/boneres.2015.21. eCollection 2015.

39.

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Osteoarthritis Cartilage. 2016 Apr;24(4):740-51. doi: 10.1016/j.joca.2015.10.015. Epub 2015 Oct 30.

40.

Fibrinolysis as a Target to Enhance Fracture Healing.

O'Keefe RJ.

N Engl J Med. 2015 Oct 29;373(18):1776-8. doi: 10.1056/NEJMcibr1510090. Review. No abstract available.

41.

Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis.

Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W.

J Bone Oncol. 2015 Sep;4(3):69-76. Epub 2015 Sep 12.

42.

CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ.

J Bone Miner Res. 2016 Mar;31(3):549-59. doi: 10.1002/jbmr.2712.

43.

Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.

Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE.

PLoS One. 2015 Aug 27;10(8):e0136351. doi: 10.1371/journal.pone.0136351. eCollection 2015.

44.

Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses.

Chimenti PC, Drinkwater CJ, Li W, Lemay CA, Franklin PD, O'Keefe RJ.

J Arthroplasty. 2016 Jan;31(1):176-9. doi: 10.1016/j.arth.2015.07.028. Epub 2015 Jul 17.

PMID:
26276572
45.

A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792.

46.

Pseudoepitheliomatous hyperplasia secondary to allergic contact dermatitis to Grevillea Robyn Gordon.

Meani RE, Nixon RL, O'Keefe R, Chong AH.

Australas J Dermatol. 2017 Feb;58(1):e8-e10. doi: 10.1111/ajd.12358. Epub 2015 Jun 14.

PMID:
26074320
47.

Prevalence and Predictors of Complementary and Alternative Medicine (CAM) Use Among Ivy League College Students: Implications for Student Health Services.

Versnik Nowak AL, DeGise J, Daugherty A, O'Keefe R, Seward S Jr, Setty S, Tang F.

J Am Coll Health. 2015;63(6):362-72. doi: 10.1080/07448481.2015.1042878.

PMID:
26010373
48.

Demonstrating the value of orthopaedic surgery through multicenter trials: AOA critical issues.

Hilibrand AS, Spindler K, O'Keefe RJ.

J Bone Joint Surg Am. 2015 Apr 1;97(7):e35. doi: 10.2106/JBJS.N.00159. Review.

PMID:
25834087
49.

Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair.

Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ.

J Orthop Res. 2015 Jun;33(6):859-66. doi: 10.1002/jor.22890.

50.

The NineTeen Complex (NTC) and NTC-associated proteins as targets for spliceosomal ATPase action during pre-mRNA splicing.

de Almeida RA, O'Keefe RT.

RNA Biol. 2015;12(2):109-14. doi: 10.1080/15476286.2015.1008926.

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