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Items: 1 to 50 of 140

1.

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia.

Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

Molecules. 2019 Nov 5;24(21). pii: E4005. doi: 10.3390/molecules24214005.

2.

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis.

Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2019 Oct 25;82(10):2852-2858. doi: 10.1021/acs.jnatprod.9b00596. Epub 2019 Sep 24.

PMID:
31550158
3.

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata.

Tsurumi F, Miura Y, Nakano M, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2019 Sep 27;82(9):2368-2378. doi: 10.1021/acs.jnatprod.8b00732. Epub 2019 Aug 23.

PMID:
31442048
4.

The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species.

He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR.

Fitoterapia. 2019 Sep;137:104285. doi: 10.1016/j.fitote.2019.104285. Epub 2019 Aug 3.

PMID:
31386897
5.

NMR characterization of rearranged staurosporine aglycone analogues from the marine sponge Damiria sp.

Tran TD, Cartner LK, Bokesch HR, Henrich CJ, Wang XW, Mahidol C, Ruchirawat S, Kittakoop P, O'Keefe BR, Gustafson KR.

Magn Reson Chem. 2019 Aug 4. doi: 10.1002/mrc.4932. [Epub ahead of print]

PMID:
31379005
6.

The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.

Matarlo JS, Krumpe LRH, Heinz WF, Oh D, Shenoy SR, Thomas CL, Goncharova EI, Lockett SJ, O'Keefe BR.

Cell Chem Biol. 2019 Aug 15;26(8):1133-1142.e4. doi: 10.1016/j.chembiol.2019.04.011. Epub 2019 May 30.

PMID:
31155509
7.

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.

Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH.

J Nat Prod. 2019 Apr 26;82(4):928-936. doi: 10.1021/acs.jnatprod.8b01015. Epub 2019 Mar 4.

PMID:
30830773
8.

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR.

J Nat Prod. 2019 Jan 25;82(1):154-162. doi: 10.1021/acs.jnatprod.8b00871. Epub 2019 Jan 2.

PMID:
30600998
9.

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10.

PMID:
30553734
10.

Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta.

Singh AJ, Gorka AP, Bokesch HR, Wamiru A, O'Keefe BR, Schnermann MJ, Gustafson KR.

J Nat Prod. 2018 Dec 28;81(12):2750-2755. doi: 10.1021/acs.jnatprod.8b00761. Epub 2018 Nov 29.

11.

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.

Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernández-Romero JA, Zydowsky TM.

Nat Commun. 2018 Sep 24;9(1):3881. doi: 10.1038/s41467-018-06349-0.

12.

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base.

White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL.

J Glob Oncol. 2018 Sep;4:1-10. doi: 10.1200/JGO.17.00099. Epub 2017 Nov 16. Review.

13.

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14.

14.

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7854-E7862. doi: 10.1073/pnas.1806022115. Epub 2018 Jul 30.

15.

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR.

ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13.

PMID:
29812901
16.

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6.

17.

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Org Chem. 2018 Jan 19;83(2):951-963. doi: 10.1021/acs.joc.7b02951. Epub 2018 Jan 10.

18.

US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer.

Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji T, White JD.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx007.

19.

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).

Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR.

SLAS Discov. 2017 Jul 1:2472555217717200. doi: 10.1177/2472555217717200. [Epub ahead of print]

PMID:
28697309
20.

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.

Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS Jr.

Org Lett. 2017 Apr 7;19(7):1726-1729. doi: 10.1021/acs.orglett.7b00496. Epub 2017 Mar 27.

21.

Antiviral lectins: Selective inhibitors of viral entry.

Mitchell CA, Ramessar K, O'Keefe BR.

Antiviral Res. 2017 Jun;142:37-54. doi: 10.1016/j.antiviral.2017.03.007. Epub 2017 Mar 18. Review.

22.

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa.

Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151. Epub 2017 Mar 14.

23.

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.

Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Jan 27;80(1):220-224. doi: 10.1021/acs.jnatprod.6b01153. Epub 2017 Jan 18.

24.

Acetophenone Monomers from Acronychia trifoliolata.

Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2016 Nov 23;79(11):2883-2889. Epub 2016 Oct 24.

25.

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.

Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G.

Viruses. 2016 Jun 6;8(6). pii: E158. doi: 10.3390/v8060158.

26.

Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro.

Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T.

Plant Cell Rep. 2016 Jun;35(6):1309-19. doi: 10.1007/s00299-016-1963-5. Epub 2016 Mar 23.

PMID:
27007716
27.

The canSAR data hub for drug discovery.

Chau CH, O'Keefe BR, Figg WD.

Lancet Oncol. 2016 Mar;17(3):286. doi: 10.1016/S1470-2045(16)00095-4. Epub 2016 Mar 2. No abstract available.

28.

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T.

Plant Biotechnol J. 2016 Jun;14(6):1427-37. doi: 10.1111/pbi.12507. Epub 2016 Jan 23.

29.

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR.

J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4.

PMID:
26538432
30.

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).

Jakób M, Lubkowski J, O'Keefe BR, Wlodawer A.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1429-36. doi: 10.1107/S2053230X15019858. Epub 2015 Oct 24.

31.

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus.

Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7290-8. doi: 10.1128/AAC.01816-15. Epub 2015 Sep 14.

32.

A Highly Convergent Total Synthesis of Leustroducsin B.

Trost BM, Biannic B, Brindle CS, O'Keefe BM, Hunter TJ, Ngai MY.

J Am Chem Soc. 2015 Sep 16;137(36):11594-7. doi: 10.1021/jacs.5b07438. Epub 2015 Sep 1.

33.

Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model.

Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, Samuelson J.

PLoS One. 2015 Aug 7;10(8):e0135340. doi: 10.1371/journal.pone.0135340. eCollection 2015.

34.

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus.

Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LR, Constantine B, Wilson J, Buckheit RW Jr, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR.

Retrovirology. 2015 Jan 23;12:6. doi: 10.1186/s12977-014-0127-3.

35.

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV.

O'Keefe BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araújo AC, Lacorte CC, Madeira L, McMahon JB, Rech EL.

Plant Biotechnol J. 2015 Sep;13(7):884-92. doi: 10.1111/pbi.12309. Epub 2015 Jan 9.

36.

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus.

Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG Jr, McMahon JB, Huggins J, O'Keefe BR.

Antiviral Res. 2014 Dec;112:1-7. doi: 10.1016/j.antiviral.2014.09.012. Epub 2014 Oct 5.

37.

Palladium-catalyzed dearomative trimethylenemethane cycloaddition reactions.

Trost BM, Ehmke V, O'Keefe BM, Bringley DA.

J Am Chem Soc. 2014 Jun 11;136(23):8213-6. doi: 10.1021/ja5044825. Epub 2014 May 29.

PMID:
24874093
38.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC.

J Biomol Screen. 2014 Sep;19(8):1201-11. doi: 10.1177/1087057114536227. Epub 2014 May 27.

39.

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.

Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SF, O'Keefe BR, Schneekloth JS Jr.

J Am Chem Soc. 2014 Jun 11;136(23):8402-10. doi: 10.1021/ja502754f. Epub 2014 May 28.

40.

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.

Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, Jones KS.

J Virol. 2014 Feb;88(4):2327-32. doi: 10.1128/JVI.02553-13. Epub 2013 Nov 27.

41.

Highly substituted enantioenriched cyclopentane derivatives by palladium-catalyzed [3 + 2] trimethylenemethane cycloadditions with disubstituted nitroalkenes.

Trost BM, Bringley DA, O'Keefe BM.

Org Lett. 2013 Nov 15;15(22):5630-3. doi: 10.1021/ol402487s. Epub 2013 Oct 25.

42.

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models.

Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE.

Antimicrob Agents Chemother. 2014;58(1):120-7. doi: 10.1128/AAC.01407-13. Epub 2013 Oct 21.

43.

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.

Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2013 Nov;446(1-2):66-76. doi: 10.1016/j.virol.2013.07.019. Epub 2013 Aug 15.

44.

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR.

PLoS One. 2013 May 21;8(5):e64449. doi: 10.1371/journal.pone.0064449. Print 2013.

45.

Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors.

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.

J Med Chem. 2012 Aug 23;55(16):7297. Epub 2012 Aug 14. No abstract available.

46.

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Bermingam A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.

J Med Chem. 2012 May 10;55(9):4457-78. doi: 10.1021/jm300335n. Epub 2012 Apr 26. Erratum in: J Med Chem. 2012 Aug 23;55(16):7297. Bermingam, Alun [corrected to Bermingham, Alun].

47.

International learning on increasing the value and effectiveness of primary care (I LIVE PC) New Zealand.

Goodyear-Smith F, Gauld R, Cumming J, O'Keefe B, Pert H, McCormack P.

J Am Board Fam Med. 2012 Mar;25 Suppl 1:S39-44. doi: 10.3122/jabfm.2012.02.110198.

48.

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.

Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2012 Feb 20;423(2):175-86. doi: 10.1016/j.virol.2011.12.001. Epub 2011 Dec 29.

49.

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.

Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O'Keefe BR, Palmer KE.

PLoS One. 2011;6(8):e22635. doi: 10.1371/journal.pone.0022635. Epub 2011 Aug 2.

50.

Studies Toward the Syntheses of Pluramycin Natural Products. The First Total Synthesis of Isokidamycin.

O'Keefe BM, Mans DM, Kaelin DE Jr, Martin SF.

Tetrahedron. 2011 Sep 2;67(35):6524-6538.

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