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Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS.

Lancet Respir Med. 2020 Jan 13. pii: S2213-2600(19)30369-8. doi: 10.1016/S2213-2600(19)30369-8. [Epub ahead of print]


Consequences Matter: Compassion in Conservation Means Caring for Individuals, Populations and Species.

Johnson PJ, Adams VM, Armstrong DP, Baker SE, Biggs D, Boitani L, Cotterill A, Dale E, O'Donnell H, Douglas DJT, Droge E, Ewen JG, Feber RE, Genovesi P, Hambler C, Harmsen BJ, Harrington LA, Hinks A, Hughes J, Katsis L, Loveridge A, Moehrenschlager A, O'Kane C, Pierre M, Redpath S, Sibanda L, Soorae P, Stanley Price M, Tyrrell P, Zimmermann A, Dickman A.

Animals (Basel). 2019 Dec 11;9(12). pii: E1115. doi: 10.3390/ani9121115.


Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.

Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S, Dark P, Roy AI, Perkins GD, McMullan R, Emerson LM, Blackwood B, Wright SE, Kefala K, O'Kane CM, Baudouin SV, Paterson RL, Rostron AJ, Agus A, Bannard-Smith J, Robin NM, Welters ID, Bassford C, Yates B, Spencer C, Laha SK, Hulme J, Bonner S, Linnett V, Sonksen J, Van Den Broeck T, Boschman G, Keenan DJ, Scott J, Allen AJ, Phair G, Parker J, Bowett SA, Simpson AJ.

Lancet Respir Med. 2019 Dec 3. pii: S2213-2600(19)30367-4. doi: 10.1016/S2213-2600(19)30367-4. [Epub ahead of print]


A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis.

Dumigan A, Fitzgerald M, Santos JSG, Hamid U, O'Kane CM, McAuley DF, Bengoechea JA.

mBio. 2019 Dec 3;10(6). pii: e02802-19. doi: 10.1128/mBio.02802-19.


Motivational interviewing with families in the home environment.

O'Kane C, Irwin JD, Morrow D, Tang L, Wong S, Buchholz AC, Ma DWL, Haines J; Guelph Family Health Study.

Patient Educ Couns. 2019 Nov;102(11):2073-2080. doi: 10.1016/j.pec.2019.06.002. Epub 2019 Jun 8.


Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.

Santhakumaran S, Gordon A, Prevost AT, O'Kane C, McAuley DF, Shankar-Hari M.

Crit Care. 2019 May 3;23(1):156. doi: 10.1186/s13054-019-2446-1.


Yeast epigenetics: the inheritance of histone modification states.

O'Kane CJ, Hyland EM.

Biosci Rep. 2019 May 7;39(5). pii: BSR20182006. doi: 10.1042/BSR20182006. Print 2019 May 31. Review.


IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

Harris AJ, Mirchandani AS, Lynch RW, Murphy F, Delaney L, Small D, Coelho P, Watts ER, Sadiku P, Griffith D, Dickinson RS, Clark E, Willson JA, Morrison T, Mazzone M, Carmeliet P, Ghesquiere B, O'Kane C, McAuley D, Jenkins SJ, Whyte MKB, Walmsley SR.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):235-246. doi: 10.1164/rccm.201808-1599OC.


Emerging drugs for treating the acute respiratory distress syndrome.

Shaw TD, McAuley DF, O'Kane CM.

Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41. doi: 10.1080/14728214.2019.1591369. Epub 2019 Mar 18. Review.


Resting Energy Expenditure and Metabolic Adaptation in Adolescents at 12 Months After Bariatric Surgery.

Chu L, Steinberg A, Mehta M, O'Kane C, Toulany A, Langer JC, Hamilton JK.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2648-2656. doi: 10.1210/jc.2018-02244.


Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair.

Fergie N, Todd N, McClements L, McAuley D, O'Kane C, Krasnodembskaya A.

FASEB J. 2019 Apr;33(4):5585-5598. doi: 10.1096/fj.201802056R. Epub 2019 Jan 16.


Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial.

Shyamsundar M, O'Kane C, Perkins GD, Kennedy G, Campbell C, Agus A, Phair G, McAuley D.

Trials. 2018 Dec 18;19(1):690. doi: 10.1186/s13063-018-3078-5.


GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila.

Pérez-Moreno JJ, O'Kane CJ.

G3 (Bethesda). 2019 Feb 7;9(2):453-462. doi: 10.1534/g3.118.200809.


Where next for cell-based therapy in ARDS.

Boyle AJ, O'Kane CM, McAuley DF.

Thorax. 2019 Jan;74(1):13-15. doi: 10.1136/thoraxjnl-2018-212272. Epub 2018 Nov 12. No abstract available.


Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.


Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group.

Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.


Guelph Family Health Study: pilot study of a home-based obesity prevention intervention.

Haines J, Douglas S, Mirotta JA, O'Kane C, Breau R, Walton K, Krystia O, Chamoun E, Annis A, Darlington GA, Buchholz AC, Duncan AM, Vallis LA, Spriet LL, Mutch DM, Brauer P, Allen-Vercoe E, Taveras EM, Ma DWL; Guelph Family Health Study.

Can J Public Health. 2018 Aug;109(4):549-560. doi: 10.17269/s41997-018-0072-3. Epub 2018 Apr 25.


NaCl-saturated brines are thermodynamically moderate, rather than extreme, microbial habitats.

Lee CJD, McMullan PE, O'Kane CJ, Stevenson A, Santos IC, Roy C, Ghosh W, Mancinelli RL, Mormile MR, McMullan G, Banciu HL, Fares MA, Benison KC, Oren A, Dyall-Smith ML, Hallsworth JE.

FEMS Microbiol Rev. 2018 Sep 1;42(5):672-693. doi: 10.1093/femsre/fuy026.


Synthesis and characterization of an iron complex bearing a hemilabile NNN-pincer for catalytic hydrosilylation of organic carbonyl compounds.

Lin HJ, Lutz S, O'Kane C, Zeller M, Chen CH, Al Assil T, Lee WT.

Dalton Trans. 2018 Mar 6;47(10):3243-3247. doi: 10.1039/c7dt04928e.


Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT.

McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, Murphy L, McNally C, Agus AM, McDowell C, Jackson C.

Southampton (UK): NIHR Journals Library; 2018 Jan.


Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF.

Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29.


Living with an indwelling urethral catheter in a community setting: Exploring triggers for unscheduled community nurse "out-of-hours" visits.

Mackay WG, MacIntosh T, Kydd A, Fleming A, O'Kane C, Shepherd A, Hagen S, Williams C, Mundie J, Russell C, Rodgers F, MacLachlan M, Galbraith R, Rankin J, McIver V.

J Clin Nurs. 2018 Feb;27(3-4):866-875. doi: 10.1111/jocn.14117. Epub 2017 Dec 27.


Family-Based Obesity Prevention: Perceptions of Canadian Parents of Preschool-Age Children.

O'Kane C, Wallace A, Wilson L, Annis A, Ma DWL, Haines J; Guelph Family Health Study.

Can J Diet Pract Res. 2018 Mar 1;79(1):13-17. doi: 10.3148/cjdpr-2017-027. Epub 2017 Oct 3.


Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancer.

Sheng Y, Beguin E, Nesbitt H, Kamila S, Owen J, Barnsley LC, Callan B, O'Kane C, Nomikou N, Hamoudi R, Taylor MA, Love M, Kelly P, O'Rourke D, Stride E, McHale AP, Callan JF.

J Control Release. 2017 Sep 28;262:192-200. doi: 10.1016/j.jconrel.2017.07.040. Epub 2017 Jul 29.


Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins.

Yalçın B, Zhao L, Stofanko M, O'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O'Kane CJ.

Elife. 2017 Jul 25;6. pii: e23882. doi: 10.7554/eLife.23882.


Oxytocin reduces alcohol consumption in prairie voles.

Stevenson JR, Wenner SM, Freestone DM, Romaine CC, Parian MC, Christian SM, Bohidar AE, Ndem JR, Vogel IR, O'Kane CM.

Physiol Behav. 2017 Oct 1;179:411-421. doi: 10.1016/j.physbeh.2017.07.021. Epub 2017 Jul 14.


Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.


Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, O'Kane CM, Krasnodembskaya AD.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286. doi: 10.1164/rccm.201701-0170OC.


Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM.

Lancet Respir Med. 2017 Jun;5(6):484-491. doi: 10.1016/S2213-2600(17)30171-6. Epub 2017 May 16.


Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial.

Agus A, Hulme C, Verghis RM, McDowell C, Jackson C, O'Kane CM, Laffey JG, McAuley DF.

Crit Care. 2017 May 17;21(1):108. doi: 10.1186/s13054-017-1695-0.


Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol.

Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF.

Trials. 2017 May 11;18(1):214. doi: 10.1186/s13063-017-1930-7. No abstract available.


Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM.

Thorax. 2017 Nov;72(11):971-980. doi: 10.1136/thoraxjnl-2016-208571. Epub 2017 Jan 12.


Safety of sedation for gastrointestinal endoscopy in a group of university-affiliated hospitals: a prospective cohort study.

Leslie K, Allen ML, Hessian EC, Peyton PJ, Kasza J, Courtney A, Dhar PA, Briedis J, Lee S, Beeton AR, Sayakkarage D, Palanivel S, Taylor JK, Haughton AJ, O'Kane CX.

Br J Anaesth. 2017 Jan;118(1):90-99. doi: 10.1093/bja/aew393.


CCT complex restricts neuropathogenic protein aggregation via autophagy.

Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC.

Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821.


Aspergillus penicillioides differentiation and cell division at 0.585 water activity.

Stevenson A, Hamill PG, O'Kane CJ, Kminek G, Rummel JD, Voytek MA, Dijksterhuis J, Hallsworth JE.

Environ Microbiol. 2017 Feb;19(2):687-697. doi: 10.1111/1462-2920.13597. Epub 2017 Jan 30.


Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.

Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.


Evidence for chemokine synergy during neutrophil migration in ARDS.

Williams AE, José RJ, Mercer PF, Brealey D, Parekh D, Thickett DR, O'Kane C, McAuley DF, Chambers RC.

Thorax. 2017 Jan;72(1):66-73. doi: 10.1136/thoraxjnl-2016-208597. Epub 2016 Aug 5.


Phenothiazinium photosensitisers XI. Improved toluidine blue photoantimicrobials.

Wainwright M, O'Kane C, Rawthore S.

J Photochem Photobiol B. 2016 Jul;160:68-71. doi: 10.1016/j.jphotobiol.2016.03.035. Epub 2016 Apr 8.


Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD.

Stem Cells. 2016 Aug;34(8):2210-23. doi: 10.1002/stem.2372. Epub 2016 Apr 29.


Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS.

Thorax. 2016 Dec;71(12):1130-1136. doi: 10.1136/thoraxjnl-2015-207886. Epub 2016 Feb 2.


Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome.

Muir R, Osbourn M, Dubois AV, Doran E, Small DM, Monahan A, O'Kane CM, McAllister K, Fitzgerald DC, Kissenpfennig A, McAuley DF, Ingram RJ.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):407-16. doi: 10.1164/rccm.201410-1782OC.


Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ.

Sci Transl Med. 2015 Sep 2;7(303):303ra140. doi: 10.1126/scitranslmed.aab3459.


A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair.

Duffy MJ, O'Kane CM, Stevenson M, Young IS, Harkin DW, Mullan BA, McAuley DF.

Intensive Care Med Exp. 2015 Dec;3(1):50. doi: 10.1186/s40635-015-0050-5. Epub 2015 Jul 1.


Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D.

J Immunol. 2015 Jul 1;195(1):87-95. doi: 10.4049/jimmunol.1500054. Epub 2015 May 22.


Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis.

Boyle AJ, Di Gangi S, Hamid UI, Mottram LJ, McNamee L, White G, Cross LJ, McNamee JJ, O'Kane CM, McAuley DF.

Crit Care. 2015 Mar 23;19:109. doi: 10.1186/s13054-015-0846-4.


siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC.

Nat Chem Biol. 2015 May;11(5):347-354. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6.


A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung.

Glasgow AM, Small DM, Scott A, McLean DT, Camper N, Hamid U, Hegarty S, Parekh D, O'Kane C, Lundy FT, McNally P, Elborn JS, McAuley DF, Weldon S, Taggart CC.

Thorax. 2015 May;70(5):426-32. doi: 10.1136/thoraxjnl-2014-206488. Epub 2015 Mar 13.


Impact of a structured intern education programme on clinical documentation in the emergency department.

McLean A, Lawlor J, Mitchell R, Kault D, O'Kane C, Lees M.

Emerg Med Australas. 2015 Feb;27(1):29-34. doi: 10.1111/1742-6723.12341. Epub 2015 Jan 13.


Applying community-based participatory research to better understand and improve kinship care practices: insights from the Democratic Republic of Congo, Nigeria, and Sierra Leone.

Chukwudozie O, Feinstein C, Jensen C, OʼKane C, Pina S, Skovdal M, Smith R.

Fam Community Health. 2015 Jan-Mar;38(1):108-19. doi: 10.1097/FCH.0000000000000052.


Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

Hellyer TP, Morris AC, McAuley DF, Walsh TS, Anderson NH, Singh S, Dark P, Roy AI, Baudouin SV, Wright SE, Perkins GD, Kefala K, Jeffels M, McMullan R, O'Kane CM, Spencer C, Laha S, Robin N, Gossain S, Gould K, Ruchaud-Sparagano MH, Scott J, Browne EM, MacFarlane JG, Wiscombe S, Widdrington JD, Dimmick I, Laurenson IF, Nauwelaers F, Simpson AJ.

Thorax. 2015 Jan;70(1):41-7. doi: 10.1136/thoraxjnl-2014-205766. Epub 2014 Oct 8.

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