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Items: 36

1.

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.

Witty DR, Bateson J, Hervieu GJ, Al-Barazanji K, Jeffrey P, Hamprecht D, Haynes A, Johnson CN, Muir AI, O'Hanlon PJ, Stemp G, Stevens AJ, Thewlis K, Winborn KY.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4872-8. Epub 2006 Jul 12.

PMID:
16839763
2.

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.

Witty DR, Bateson JH, Hervieu GJ, Jeffrey P, Johnson CN, Muir AI, O'Hanlon PJ, Stemp G, Stevens AJ, Thewlis KM, Wilson S, Winborn KY.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4865-71. Epub 2006 Jul 12.

PMID:
16839761
3.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A.

Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9.

PMID:
15837314
4.

S-alkyl dithioformates as 1,3-dipolarophiles. Generation of C(2)-unsubstituted penems.

Sanchez S, Bateson JH, O'Hanlon PJ, Gallagher T.

Org Lett. 2004 Aug 5;6(16):2781-3.

PMID:
15281768
5.

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41.

PMID:
15225702
6.

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.

Crasto CF, Forrest AK, Karoli T, March DR, Mensah L, O'Hanlon PJ, Nairn MR, Oldham MD, Yue W, Banwell MG, Easton CJ.

Bioorg Med Chem. 2003 Jul 3;11(13):2687-94.

PMID:
12788342
7.

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ.

Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9.

8.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8.

PMID:
12657260
9.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8.

PMID:
12639554
10.

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4.

PMID:
12372526
11.

Multi-component assembly of the bicyclic core associated with the tRNA synthetase inhibitors SB-203207 and SB-203208. Application to the synthesis of biologically active analogues.

Banwell MG, Crasto CF, Easton CJ, Karoli T, March DR, Nairn MR, O'Hanlon PJ, Oldham MD, Willis AC, Yue W.

Chem Commun (Camb). 2001 Nov 7;(21):2210-1.

PMID:
12240115
12.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A.

J Med Chem. 2002 May 9;45(10):1959-62.

PMID:
11985462
13.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

Jarvest RL, Berge JM, Houge-Frydrych CS, Mensah LM, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2499-502.

PMID:
11549455
14.

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

Jarvest RL, Berge JM, Brown P, Hamprecht DW, McNair DJ, Mensah L, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):715-8.

PMID:
11266176
15.

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

Brown P, Eggleston DS, Haltiwanger RC, Jarvest RL, Mensah L, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):711-4.

PMID:
11266175
16.

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

Berge JM, Broom NJ, Houge-Frydrych CS, Jarvest RL, Mensah L, McNair DJ, O'Hanlon PJ, Pope AJ, Rittenhouse S.

J Antibiot (Tokyo). 2000 Nov;53(11):1282-92.

17.

Antimicrobial properties and mode of action of the pyrrothine holomycin.

Oliva B, O'Neill A, Wilson JM, O'Hanlon PJ, Chopra I.

Antimicrob Agents Chemother. 2001 Feb;45(2):532-9.

18.

Analogues of SB-203207 as inhibitors of tRNA synthetases.

Banwell MG, Crasto CF, Easton CJ, Forrest AK, Karoli T, March DR, Mensah L, Nairn MR, O'Hanlon PJ, Oldham MD, Yue W.

Bioorg Med Chem Lett. 2000 Oct 16;10(20):2263-6.

PMID:
11055334
19.

Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

Forrest AK, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ, Sheppard RJ.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1871-4.

PMID:
10969988
20.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

Berge JM, Copley RC, Eggleston DS, Hamprecht DW, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1811-4.

PMID:
10969974
21.

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

Brown MJ, Mensah LM, Doyle ML, Broom NJ, Osbourne N, Forrest AK, Richardson CM, O'Hanlon PJ, Pope AJ.

Biochemistry. 2000 May 23;39(20):6003-11.

PMID:
10821672
22.

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.

Brown P, Richardson CM, Mensah LM, O'Hanlon PJ, Osborne NF, Pope AJ, Walker G.

Bioorg Med Chem. 1999 Nov;7(11):2473-85.

PMID:
10632057
23.

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Jarvest RL, Berge JM, Houge-Frydrych CS, Janson C, Mensah LM, O'Hanlon PJ, Pope A, Saldanha A, Qiu X.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62.

PMID:
10522706
24.

Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A.

Bennett I, Broom NJ, Cassels R, Elder JS, Masson ND, O'Hanlon PJ.

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1847-52.

PMID:
10406653
25.

The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity.

Brown P, Best DJ, Broom NJ, Cassels R, O'Hanlon PJ, Mitchell TJ, Osborne NF, Wilson JM.

J Med Chem. 1997 Aug 1;40(16):2563-70.

PMID:
9258363
26.

The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity.

Broom NJ, Cassels R, Cheng HY, Elder JS, Hannan PC, Masson N, O'Hanlon PJ, Pope A, Wilson JM.

J Med Chem. 1996 Aug 30;39(18):3596-600.

PMID:
8784459
27.

Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.

Abson A, Broom NJ, Coates PA, Elder JS, Forrest AK, Hannan PC, Hicks AJ, O'Hanlon PJ, Masson ND, Pearson ND, Pons JE, Wilson JM.

J Antibiot (Tokyo). 1996 Apr;49(4):390-4.

28.
29.

The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.

Broom NJ, Elder JS, Hannan PC, Pons JE, O'Hanlon PJ, Walker G, Wilson J, Woodall P.

J Antibiot (Tokyo). 1995 Nov;48(11):1336-44.

30.

SB 205952, a novel semisynthetic monic acid analog with at least two modes of action.

Wilson JM, Oliva B, Cassels R, O'Hanlon PJ, Chopra I.

Antimicrob Agents Chemother. 1995 Sep;39(9):1925-33.

32.
33.

Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives.

Banks RM, Donald AC, Hannan PC, O'Hanlon PJ, Rogers NH.

J Antibiot (Tokyo). 1988 May;41(5):609-13.

34.

beta-lactam antibiotics. II. Structure-activity relationships of 6-[alpha-(alpha'-ureido-acylamino) acylamino] penicillanic acids.

Ferres H, Basker MJ, Best DJ, Harrington FP, O'Hanlon PJ.

J Antibiot (Tokyo). 1978 Oct;31(10):1013-22.

35.

Synthetic and biosynthetic studies of porphyrins. Part 2. Synthesis of isopempto- and isochlorocruoro-porphyrins.

Games DE, Jackson AH, O'Hanlon PJ.

J Chem Soc Perkin 1. 1976;(23):2501-5. No abstract available.

PMID:
1034644

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