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Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4.

Garwin SA, Kelley MS, Sue AC, Que EL, Schatz GC, Woodruff TK, O'Halloran TV.

J Am Chem Soc. 2019 Oct 23;141(42):16696-16705. doi: 10.1021/jacs.9b06442. Epub 2019 Oct 15.


Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.

Miodragović Đ, Merlino A, Swindell EP, Bogachkov A, Ahn RW, Abuhadba S, Ferraro G, Marzo T, Mazar AP, Messori L, O'Halloran TV.

J Am Chem Soc. 2019 Apr 24;141(16):6453-6457. doi: 10.1021/jacs.8b13681. Epub 2019 Apr 15.


Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation.

Que EL, Duncan FE, Lee HC, Hornick JE, Vogt S, Fissore RA, O'Halloran TV, Woodruff TK.

Theriogenology. 2019 Mar 15;127:41-48. doi: 10.1016/j.theriogenology.2018.12.031. Epub 2018 Dec 24.


Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity.

Johnson SE, Ugolkov A, Haney CR, Bondarenko G, Li L, Waters EA, Bergan R, Tran A, O'Halloran TV, Mazar A, Zhao M.

Clin Cancer Res. 2019 Feb 15;25(4):1331-1342. doi: 10.1158/1078-0432.CCR-18-1846. Epub 2018 Nov 12.


Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer.

Ugolkov AV, Matsangou M, Taxter TJ, O'Halloran TV, Cryns VL, Giles FJ, Mazar AP.

Oncol Lett. 2018 Nov;16(5):6437-6444. doi: 10.3892/ol.2018.9483. Epub 2018 Sep 21.


9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma.

Ugolkov AV, Bondarenko GI, Dubrovskyi O, Berbegall AP, Navarro S, Noguera R, O'Halloran TV, Hendrix MJ, Giles FJ, Mazar AP.

Anticancer Drugs. 2018 Sep;29(8):717-724. doi: 10.1097/CAD.0000000000000652.


A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli.

Velasco E, Wang S, Sanet M, Fernández-Vázquez J, Jové D, Glaría E, Valledor AF, O'Halloran TV, Balsalobre C.

Sci Rep. 2018 Apr 25;8(1):6535. doi: 10.1038/s41598-018-24964-1.


Macrogenomic engineering via modulation of the scaling of chromatin packing density.

Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V.

Nat Biomed Eng. 2017 Nov;1(11):902-913. doi: 10.1038/s41551-017-0153-2. Epub 2017 Nov 6.


Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy.

Que EL, Duncan FE, Bayer AR, Philips SJ, Roth EW, Bleher R, Gleber SC, Vogt S, Woodruff TK, O'Halloran TV.

Integr Biol (Camb). 2017 Feb 20;9(2):135-144. doi: 10.1039/c6ib00212a.


Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer.

Walz A, Ugolkov A, Chandra S, Kozikowski A, Carneiro BA, O'Halloran TV, Giles FJ, Billadeau DD, Mazar AP.

Clin Cancer Res. 2017 Apr 15;23(8):1891-1897. doi: 10.1158/1078-0432.CCR-15-2240. Epub 2017 Jan 4. Review.


Zinc availability during germline development impacts embryo viability in Caenorhabditis elegans.

Mendoza AD, Woodruff TK, Wignall SM, O'Halloran TV.

Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:194-202. doi: 10.1016/j.cbpc.2016.09.007. Epub 2016 Sep 21.


Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer.

Upreti M, Jyoti A, Johnson SE, Swindell EP, Napier D, Sethi P, Chan R, Feddock JM, Weiss HL, O'Halloran TV, Evers BM.

Oncotarget. 2016 Jul 5;7(27):41559-41574. doi: 10.18632/oncotarget.9490.


The zinc spark is an inorganic signature of human egg activation.

Duncan FE, Que EL, Zhang N, Feinberg EC, O'Halloran TV, Woodruff TK.

Sci Rep. 2016 Apr 26;6:24737. doi: 10.1038/srep24737.


The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development.

Zhang N, Duncan FE, Que EL, O'Halloran TV, Woodruff TK.

Sci Rep. 2016 Mar 18;6:22772. doi: 10.1038/srep22772.


Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria.

Staehlin BM, Gibbons JG, Rokas A, O'Halloran TV, Slot JC.

Genome Biol Evol. 2016 Feb 17;8(3):811-26. doi: 10.1093/gbe/evw031.


Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors.

Bondarenko G, Ugolkov A, Rohan S, Kulesza P, Dubrovskyi O, Gursel D, Mathews J, O'Halloran TV, Wei JJ, Mazar AP.

Neoplasia. 2015 Sep;17(9):735-741. doi: 10.1016/j.neo.2015.09.004.


TRANSCRIPTION. Allosteric transcriptional regulation via changes in the overall topology of the core promoter.

Philips SJ, Canalizo-Hernandez M, Yildirim I, Schatz GC, Mondragón A, O'Halloran TV.

Science. 2015 Aug 21;349(6250):877-81. doi: 10.1126/science.aaa9809.


3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.

Sethi P, Jyoti A, Swindell EP, Chan R, Langner UW, Feddock JM, Nagarajan R, O'Halloran TV, Upreti M.

Nanomedicine. 2015 Nov;11(8):2013-23. doi: 10.1016/j.nano.2015.07.013. Epub 2015 Aug 15.


The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions.

Kong BY, Duncan FE, Que EL, Xu Y, Vogt S, O'Halloran TV, Woodruff TK.

Dev Dyn. 2015 Aug;244(8):935-47. doi: 10.1002/dvdy.24285. Epub 2015 Jul 16.


Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks.

Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O'Halloran TV.

Nat Chem. 2015 Feb;7(2):130-9. doi: 10.1038/nchem.2133. Epub 2014 Dec 15.


Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon.

Gilston BA, Wang S, Marcus MD, Canalizo-Hernández MA, Swindell EP, Xue Y, Mondragón A, O'Halloran TV.

PLoS Biol. 2014 Nov 4;12(11):e1001987. doi: 10.1371/journal.pbio.1001987. eCollection 2014 Nov.


Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors.

Beauchamp EM, Kosciuczuk EM, Serrano R, Nanavati D, Swindell EP, Viollet B, O'Halloran TV, Altman JK, Platanias LC.

Mol Cancer Ther. 2015 Jan;14(1):202-12. doi: 10.1158/1535-7163.MCT-14-0665-T. Epub 2014 Oct 24.


Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.

Kong BY, Duncan FE, Que EL, Kim AM, O'Halloran TV, Woodruff TK.

Mol Hum Reprod. 2014 Nov;20(11):1077-89. doi: 10.1093/molehr/gau066. Epub 2014 Aug 20.


pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.

Hong BJ, Swindell EP, Macrenaris KW, Hankins PL, Chipre AJ, Mastarone DJ, Ahn RW, Meade TJ, O'Halloran TV, Nguyen ST.

Part Part Syst Charact. 2013 Sep;30(9):770-774.


Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM).

Xu X, Cai Y, Wei Y, Donate F, Juarez J, Parry G, Chen L, Meehan EJ, Ahn RW, Ugolkov A, Dubrovskyi O, O'Halloran TV, Huang M, Mazar AP.

PLoS One. 2014 Jan 21;9(1):e85349. doi: 10.1371/journal.pone.0085349. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99911.


Alignment of low-dose X-ray fluorescence tomography images using differential phase contrast.

Hong YP, Gleber SC, O'Halloran TV, Que EL, Bleher R, Vogt S, Woodruff TK, Jacobsen C.

J Synchrotron Radiat. 2014 Jan;21(Pt 1):229-34. doi: 10.1107/S1600577513029512. Epub 2013 Dec 12.


Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes.

Swindell EP, Hankins PL, Chen H, Miodragović DU, O'Halloran TV.

Inorg Chem. 2013 Nov 4;52(21):12292-304. doi: 10.1021/ic401211u. Epub 2013 Oct 22. Review.


Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.

Zhang Y, Kenny HA, Swindell EP, Mitra AK, Hankins PL, Ahn RW, Gwin K, Mazar AP, O'Halloran TV, Lengyel E.

Mol Cancer Ther. 2013 Dec;12(12):2628-39. doi: 10.1158/1535-7163.MCT-13-0204. Epub 2013 Sep 23.


Zinc, insulin, and the liver: a ménage à trois.

O'Halloran TV, Kebede M, Philips SJ, Attie AD.

J Clin Invest. 2013 Oct;123(10):4136-9. doi: 10.1172/JCI72325. Epub 2013 Sep 24.


Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes.

Miodragović ĐU, Quentzel JA, Kurutz JW, Stern CL, Ahn RW, Kandela I, Mazar A, O'Halloran TV.

Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10749-52. doi: 10.1002/anie.201303251. Epub 2013 Aug 22. No abstract available.


The many spaces of uPAR: delivery of theranostic agents and nanobins to multiple tumor compartments through a single target.

O'Halloran TV, Ahn R, Hankins P, Swindell E, Mazar AP.

Theranostics. 2013 Jun 25;3(7):496-506. doi: 10.7150/thno.4953. Print 2013. Review.


A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.


Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo.

Ahn RW, Barrett SL, Raja MR, Jozefik JK, Spaho L, Chen H, Bally MB, Mazar AP, Avram MJ, Winter JN, Gordon LI, Shea LD, O'Halloran TV, Woodruff TK.

PLoS One. 2013;8(3):e58491. doi: 10.1371/journal.pone.0058491. Epub 2013 Mar 20.


A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.

Raja MR, Waterman SR, Qiu J, Bleher R, Williamson PR, O'Halloran TV.

Metallomics. 2013 Apr;5(4):363-71. doi: 10.1039/c3mt20220h.


Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.

Krovi SA, Swindell EP, O'Halloran TV, Nguyen ST.

J Mater Chem. 2012 Dec 28;22(48):25463-25470.


Imaging and elemental mapping of biological specimens with a dual-EDS dedicated scanning transmission electron microscope.

Wu JS, Kim AM, Bleher R, Myers BD, Marvin RG, Inada H, Nakamura K, Zhang XF, Roth E, Li SY, Woodruff TK, O'Halloran TV, Dravid VP.

Ultramicroscopy. 2013 May;128:24-31. doi: 10.1016/j.ultramic.2013.01.004. Epub 2013 Feb 4.


Accumulation of cadmium in insulin-producing β cells.

El Muayed M, Raja MR, Zhang X, MacRenaris KW, Bhatt S, Chen X, Urbanek M, O'Halloran TV, Lowe WL Jr.

Islets. 2012 Nov-Dec;4(6):405-16. doi: 10.4161/isl.23101. Epub 2012 Nov 1.


Role of CTR4 in the Virulence of Cryptococcus neoformans.

Waterman SR, Park YD, Raja M, Qiu J, Hammoud DA, O'Halloran TV, Williamson PR.

mBio. 2012 Oct 2;3(5). pii: e00285-12. doi: 10.1128/mBio.00285-12. Print 2012.


Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum.

Marvin RG, Wolford JL, Kidd MJ, Murphy S, Ward J, Que EL, Mayer ML, Penner-Hahn JE, Haldar K, O'Halloran TV.

Chem Biol. 2012 Jun 22;19(6):731-41. doi: 10.1016/j.chembiol.2012.04.013.


Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.

Kong BY, Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK.

Biol Reprod. 2012 Jul 1;87(1):11, 1-12. doi: 10.1095/biolreprod.112.099390. Print 2012 Jul.


A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes.

Bernhardt ML, Kong BY, Kim AM, O'Halloran TV, Woodruff TK.

Biol Reprod. 2012 Apr 19;86(4):114. doi: 10.1095/biolreprod.111.097253. Print 2012 Apr.


Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples.

Schmidt B, Mahmud G, Soh S, Kim SH, Page T, O'Halloran TV, Grzybowski BA, Hoffman BM.

Appl Magn Reson. 2011 Feb 11;40(4):415-425.


Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.

Kim AM, Bernhardt ML, Kong BY, Ahn RW, Vogt S, Woodruff TK, O'Halloran TV.

ACS Chem Biol. 2011 Jul 15;6(7):716-23. doi: 10.1021/cb200084y. Epub 2011 Apr 28.


Triggered release of pharmacophores from [Ni(HAsO₃)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combined experimental and theoretical study.

Lee SM, Lee OS, O'Halloran TV, Schatz GC, Nguyen ST.

ACS Nano. 2011 May 24;5(5):3961-9. doi: 10.1021/nn200478m. Epub 2011 May 9.


Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release.

Lee SM, Song Y, Hong BJ, MacRenaris KW, Mastarone DJ, O'Halloran TV, Meade TJ, Nguyen ST.

Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9960-4. doi: 10.1002/anie.201004867. No abstract available.


Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.

Lee SM, O'Halloran TV, Nguyen ST.

J Am Chem Soc. 2010 Dec 8;132(48):17130-8. doi: 10.1021/ja107333g. Epub 2010 Nov 15.


Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.

Bernhardt ML, Kim AM, O'Halloran TV, Woodruff TK.

Biol Reprod. 2011 Mar;84(3):526-36. doi: 10.1095/biolreprod.110.086488. Epub 2010 Nov 10.


Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy.

Lee SM, Ahn RW, Chen F, Fought AJ, O'Halloran TV, Cryns VL, Nguyen ST.

ACS Nano. 2010 Sep 28;4(9):4971-8. doi: 10.1021/nn100560p.


Zinc availability regulates exit from meiosis in maturing mammalian oocytes.

Kim AM, Vogt S, O'Halloran TV, Woodruff TK.

Nat Chem Biol. 2010 Sep;6(9):674-81. doi: 10.1038/nchembio.419. Epub 2010 Aug 8.

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