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Items: 21


The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer.

Savant SS, Sriramkumar S, O'Hagan HM.

Cancers (Basel). 2018 Jul 30;10(8). pii: E251. doi: 10.3390/cancers10080251. Review.


Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors.

Maiuri AR, Li H, Stein BD, Tennessen JM, O'Hagan HM.

Cancer Metab. 2018 Jul 10;6:9. doi: 10.1186/s40170-018-0182-7. eCollection 2018.


Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion.

Tang J, Pulliam N, Özeş A, Buechlein A, Ding N, Keer H, Rusch D, O'Hagan H, Stack MS, Nephew KP.

Mol Cancer Res. 2018 Aug;16(8):1226-1240. doi: 10.1158/1541-7786.MCR-17-0406. Epub 2018 May 14.


Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.

Vaz M, Hwang SY, Kagiampakis I, Phallen J, Patil A, O'Hagan HM, Murphy L, Zahnow CA, Gabrielson E, Velculescu VE, Easwaran HP, Baylin SB.

Cancer Cell. 2017 Sep 11;32(3):360-376.e6. doi: 10.1016/j.ccell.2017.08.006.


Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

Maiuri AR, Peng M, Podicheti R, Sriramkumar S, Kamplain CM, Rusch DB, DeStefano Shields CE, Sears CL, O'Hagan HM.

Cancer Res. 2017 Jul 1;77(13):3467-3478. doi: 10.1158/0008-5472.CAN-17-0056. Epub 2017 May 18. Erratum in: Cancer Res. 2018 Jan 15;78(2):584.


Interplay Between Inflammation and Epigenetic Changes in Cancer.

Maiuri AR, O'Hagan HM.

Prog Mol Biol Transl Sci. 2016;144:69-117. doi: 10.1016/bs.pmbts.2016.09.002. Epub 2016 Oct 7. Review.


Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.

DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL.

J Infect Dis. 2016 Jul 1;214(1):122-9. doi: 10.1093/infdis/jiw069. Epub 2016 Feb 21.


Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.

Ding N, Bonham EM, Hannon BE, Amick TR, Baylin SB, O'Hagan HM.

J Mol Cell Biol. 2016 Jun;8(3):244-54. doi: 10.1093/jmcb/mjv050. Epub 2015 Jul 17.


Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer.

Calmon MF, Jeschke J, Zhang W, Dhir M, Siebenkäs C, Herrera A, Tsai HC, O'Hagan HM, Pappou EP, Hooker CM, Fu T, Schuebel KE, Gabrielson E, Rahal P, Herman JG, Baylin SB, Ahuja N.

Epigenetics. 2015;10(7):622-32. doi: 10.1080/15592294.2015.1050173.


Increased understanding of the impact of environmental exposures on the epigenome.

O'Hagan HM, Tang WY.

Environ Mol Mutagen. 2014 Apr;55(3):151-4. doi: 10.1002/em.21843. Epub 2013 Dec 14. No abstract available.


Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.

O'Hagan HM.

Environ Mol Mutagen. 2014 Apr;55(3):278-91. doi: 10.1002/em.21830. Epub 2013 Nov 20. Review.


Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines.

Jeschke J, O'Hagan HM, Zhang W, Vatapalli R, Calmon MF, Danilova L, Nelkenbrecher C, Van Neste L, Bijsmans IT, Van Engeland M, Gabrielson E, Schuebel KE, Winterpacht A, Baylin SB, Herman JG, Ahuja N.

Clin Cancer Res. 2013 Jun 15;19(12):3201-11. doi: 10.1158/1078-0432.CCR-12-3751. Epub 2013 Apr 29.


Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

O'Hagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB.

Cancer Cell. 2011 Nov 15;20(5):606-19. doi: 10.1016/j.ccr.2011.09.012.


Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Mohammad HP, Cai Y, McGarvey KM, Easwaran H, Van Neste L, Ohm JE, O'Hagan HM, Baylin SB.

Cancer Res. 2009 Aug 1;69(15):6322-30. doi: 10.1158/0008-5472.CAN-09-0065. Epub 2009 Jul 14.


Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.

O'Hagan HM, Mohammad HP, Baylin SB.

PLoS Genet. 2008 Aug 15;4(8):e1000155. doi: 10.1371/journal.pgen.1000155.


RPA and ATR link transcriptional stress to p53.

Derheimer FA, O'Hagan HM, Krueger HM, Hanasoge S, Paulsen MT, Ljungman M.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12778-83. Epub 2007 Jul 6.


Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs.

O'Hagan HM, Ljungman M.

Exp Cell Res. 2004 Jul 15;297(2):548-59.


Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.

Ljungman M, O'Hagan HM, Paulsen MT.

Oncogene. 2001 Sep 20;20(42):5964-71.


Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

Klibanov SA, O'Hagan HM, Ljungman M.

J Cell Sci. 2001 May;114(Pt 10):1867-73.

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