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Knob protein enhances epithelial barrier integrity and attenuates airway inflammation.

Ha SG, Dileepan M, Ge XN, Kang BN, Greenberg YG, Rao A, Muralidhar G, Medina-Kauwe L, Thompson MA, Pabelick CM, O'Grady SM, Rao SP, Sriramarao P.

J Allergy Clin Immunol. 2018 Mar 6. pii: S0091-6749(18)30328-2. doi: 10.1016/j.jaci.2018.01.049. [Epub ahead of print]


P2Y receptor regulation of K2P channels that facilitate K+ secretion by human mammary epithelial cells.

Srisomboon Y, Zaidman NA, Maniak PJ, Deachapunya C, O'Grady SM.

Am J Physiol Cell Physiol. 2018 May 1;314(5):C627-C639. doi: 10.1152/ajpcell.00342.2016. Epub 2018 Jan 24.


Taking intestinal anion secretion to TASK: a role for K2P channels in cyclic AMP-regulated anion secretion.

O'Grady SM.

J Physiol. 2018 Feb 1;596(3):359-360. doi: 10.1113/JP275567. Epub 2017 Dec 27. No abstract available.


Large-conductance Ca2+ -activated K+ channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium.

Zaidman NA, Panoskaltsis-Mortari A, O'Grady SM.

J Physiol. 2017 Jul 15;595(14):4631-4645. doi: 10.1113/JP274200. Epub 2017 Jun 11.


Airway epithelial anion secretion and barrier function following exposure to fungal aeroallergens: role of oxidative stress.

Zaidman NA, O'Grady KE, Patil N, Milavetz F, Maniak PJ, Kita H, O'Grady SM.

Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C68-C79. doi: 10.1152/ajpcell.00043.2017. Epub 2017 Apr 26.


Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium.

Uchida M, Anderson EL, Squillace DL, Patil N, Maniak PJ, Iijima K, Kita H, O'Grady SM.

Allergy. 2017 Oct;72(10):1521-1531. doi: 10.1111/all.13158. Epub 2017 Mar 31.


The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis.

Cero C, Razzoli M, Han R, Sahu BS, Patricelli J, Guo Z, Zaidman NA, Miles JM, O'Grady SM, Bartolomucci A.

Mol Metab. 2016 Oct 31;6(1):148-158. doi: 10.1016/j.molmet.2016.10.005. eCollection 2017 Jan.


Desensitization of idiopathic pulmonary fibrosis fibroblasts to Alternaria alternata extract-mediated necrotic cell death.

Im J, Kim K, Yhee JY, O'Grady SM, Nho RS.

Physiol Rep. 2016 Nov;4(21). pii: e13020. Epub 2016 Nov 15.


Differentiation of human bronchial epithelial cells: role of hydrocortisone in development of ion transport pathways involved in mucociliary clearance.

Zaidman NA, Panoskaltsis-Mortari A, O'Grady SM.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C225-36. doi: 10.1152/ajpcell.00073.2016. Epub 2016 Jun 15.


Carvedilol binding to β2-adrenergic receptors inhibits CFTR-dependent anion secretion in airway epithelial cells.

Peitzman ER, Zaidman NA, Maniak PJ, O'Grady SM.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L50-8. doi: 10.1152/ajplung.00296.2015. Epub 2015 Nov 13.


Agonist binding to β-adrenergic receptors on human airway epithelial cells inhibits migration and wound repair.

Peitzman ER, Zaidman NA, Maniak PJ, O'Grady SM.

Am J Physiol Cell Physiol. 2015 Dec 15;309(12):C847-55. doi: 10.1152/ajpcell.00159.2015. Epub 2015 Oct 21.


Differential Induction of Type I and Type III Interferons by Swine and Human Origin H1N1 Influenza A Viruses in Porcine Airway Epithelial Cells.

Krishna VD, Roach E, Zaidman NA, Panoskaltsis-Mortari A, Rotschafer JH, O'Grady SM, Cheeran MC.

PLoS One. 2015 Sep 18;10(9):e0138704. doi: 10.1371/journal.pone.0138704. eCollection 2015.


Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3.

Jang SH, Byun JK, Jeon WI, Choi SY, Park J, Lee BH, Yang JE, Park JB, O'Grady SM, Kim DY, Ryu PD, Joo SW, Lee SY.

J Biol Chem. 2015 May 15;290(20):12547-57. doi: 10.1074/jbc.M114.561324. Epub 2015 Mar 31.


Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair.

Itokazu Y, Pagano RE, Schroeder AS, O'Grady SM, Limper AH, Marks DL.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C819-30. doi: 10.1152/ajpcell.00168.2013. Epub 2014 Feb 5.


ATP release and Ca2+ signalling by human bronchial epithelial cells following Alternaria aeroallergen exposure.

O'Grady SM, Patil N, Melkamu T, Maniak PJ, Lancto C, Kita H.

J Physiol. 2013 Sep 15;591(18):4595-609. doi: 10.1113/jphysiol.2013.254649. Epub 2013 Jul 15.


Cystic fibrosis transmembrane conductance regulator is expressed in mucin granules from Calu-3 and primary human airway epithelial cells.

LeSimple P, Goepp J, Palmer ML, Fahrenkrug SC, O'Grady SM, Ferraro P, Robert R, Hanrahan JW.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):511-6. doi: 10.1165/rcmb.2012-0419RC.


TLR3 activation evokes IL-6 secretion, autocrine regulation of Stat3 signaling and TLR2 expression in human bronchial epithelial cells.

Melkamu T, Kita H, O'Grady SM.

J Cell Commun Signal. 2013 Jun;7(2):109-18. doi: 10.1007/s12079-012-0185-z. Epub 2012 Dec 13.


Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1β release and macrophage transepithelial migration.

Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S.

Infect Immun. 2012 Sep;80(9):3225-35. doi: 10.1128/IAI.06322-11. Epub 2012 Jul 9.


Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3.

Shan J, Liao J, Huang J, Robert R, Palmer ML, Fahrenkrug SC, O'Grady SM, Hanrahan JW.

J Physiol. 2012 Nov 1;590(21):5273-97. doi: 10.1113/jphysiol.2012.236893. Epub 2012 Jul 9.


Purinergic signaling and immune cell chemotaxis. Focus on "the UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils".

O'Grady SM.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C486-7. doi: 10.1152/ajpcell.00184.2012. Epub 2012 Jun 6. No abstract available.


K(Ca)3.1 channels facilitate K+ secretion or Na+ absorption depending on apical or basolateral P2Y receptor stimulation.

Palmer ML, Peitzman ER, Maniak PJ, Sieck GC, Prakash YS, O'Grady SM.

J Physiol. 2011 Jul 15;589(Pt 14):3483-94. doi: 10.1113/jphysiol.2011.207548. Epub 2011 May 23.


The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.

Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H.

J Immunol. 2011 Apr 1;186(7):4375-87. doi: 10.4049/jimmunol.1003020. Epub 2011 Feb 25.


Cystic fibrosis transmembrane conductance regulator is involved in airway epithelial wound repair.

Schiller KR, Maniak PJ, O'Grady SM.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C912-21. doi: 10.1152/ajpcell.00215.2010. Epub 2010 Aug 4.


Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition.

Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC.

Transgenic Res. 2011 Feb;20(1):29-45. doi: 10.1007/s11248-010-9386-5. Epub 2010 Mar 30.


Mechanisms of alveolar epithelial chloride absorption.

Ingbar DH, Bhargava M, O'Grady SM.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L813-5. doi: 10.1152/ajplung.00324.2009. Epub 2009 Sep 25. No abstract available.


Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2.

Kouzaki H, O'Grady SM, Lawrence CB, Kita H.

J Immunol. 2009 Jul 15;183(2):1427-34. doi: 10.4049/jimmunol.0900904. Epub 2009 Jun 26.


Regulation of TLR2 expression and function in human airway epithelial cells.

Melkamu T, Squillace D, Kita H, O'Grady SM.

J Membr Biol. 2009 May;229(2):101-13. doi: 10.1007/s00232-009-9175-3. Epub 2009 Jun 10.


Silencing of Kv4.1 potassium channels inhibits cell proliferation of tumorigenic human mammary epithelial cells.

Jang SH, Choi C, Hong SG, Yarishkin OV, Bae YM, Kim JG, O'Grady SM, Yoon KA, Kang KS, Ryu PD, Lee SY.

Biochem Biophys Res Commun. 2009 Jun 26;384(2):180-6. doi: 10.1016/j.bbrc.2009.04.108. Epub 2009 May 3.


Beta2-integrin-mediated adhesion and intracellular Ca2+ release in human eosinophils.

Bankers-Fulbright JL, Bartemes KR, Kephart GM, Kita H, O'Grady SM.

J Membr Biol. 2009 Mar;228(2):99-109. doi: 10.1007/s00232-009-9163-7. Epub 2009 Mar 17.


The Ussing chamber and measurement of drug actions on mucosal ion transport.

Brown DR, O'Grady SM.

Curr Protoc Pharmacol. 2008 Jun;Chapter 7:Unit 7.12. doi: 10.1002/0471141755.ph0712s41.


P2Y(1) receptor modulation of endogenous ion channel function in Xenopus oocytes: Involvement of transmembrane domains.

Lee SY, Nicholas RA, O'Grady SM.

Purinergic Signal. 2004 Dec;1(1):75-81. doi: 10.1007/s11302-004-4744-5.


Apical SK potassium channels and Ca2+-dependent anion secretion in endometrial epithelial cells.

Palmer ML, Schiller KR, O'Grady SM.

J Physiol. 2008 Feb 1;586(3):717-26. Epub 2007 Nov 29.


P2Y receptor regulation of sodium transport in human mammary epithelial cells.

Lee SY, Palmer ML, Maniak PJ, Jang SH, Ryu PD, O'Grady SM.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1472-80. Epub 2007 Aug 22.


Interactions of connexins with other membrane channels and transporters.

Chanson M, Kotsias BA, Peracchia C, O'Grady SM.

Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):233-44. Epub 2007 Mar 14. Review.


RNA interference and ion channel physiology.

Palmer ML, Fahrenkrug SC, O'Grady SM.

Cell Biochem Biophys. 2006;46(2):175-91. Review.


Protease-activated receptor regulation of Cl- secretion in Calu-3 cells requires prostaglandin release and CFTR activation.

Palmer ML, Lee SY, Maniak PJ, Carlson D, Fahrenkrug SC, O'Grady SM.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1189-98.


Stable knockdown of CFTR establishes a role for the channel in P2Y receptor-stimulated anion secretion.

Palmer ML, Lee SY, Carlson D, Fahrenkrug S, O'Grady SM.

J Cell Physiol. 2006 Mar;206(3):759-70.


Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells.

O'Grady SM, Lee SY.

Int J Biochem Cell Biol. 2005 Aug;37(8):1578-94. Epub 2005 Apr 26. Review.


Sodium and anion transport across the avian uterine (shell gland) epithelium.

Vetter AE, O'Grady SM.

J Exp Biol. 2005 Feb;208(Pt 3):479-86.


Platelet-activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils.

Bankers-Fulbright JL, Kephart GM, Bartemes KR, Kita H, O'Grady SM.

J Cell Sci. 2004 Nov 15;117(Pt 24):5749-57. Epub 2004 Oct 26.


Modulation of ion channel function by P2Y receptors.

Lee SY, O'Grady SM.

Cell Biochem Biophys. 2003;39(1):75-88. Review.


Regulation of eosinophil membrane depolarization during NADPH oxidase activation.

Bankers-Fulbright JL, Gleich GJ, Kephart GM, Kita H, O'Grady SM.

J Cell Sci. 2003 Aug 1;116(Pt 15):3221-6.


Chloride and potassium channel function in alveolar epithelial cells.

O'Grady SM, Lee SY.

Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L689-700. Review.


Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels.

Boland LM, Jiang M, Lee SY, Fahrenkrug SC, Harnett MT, O'Grady SM.

Am J Physiol Cell Physiol. 2003 Jul;285(1):C161-70. Epub 2003 Mar 19.


P2Y receptors modulate ion channel function through interactions involving the C-terminal domain.

Lee SY, Wolff SC, Nicholas RA, O'Grady SM.

Mol Pharmacol. 2003 Apr;63(4):878-85.


Adult alveolar epithelial cells express multiple subtypes of voltage-gated K+ channels that are located in apical membrane.

Lee SY, Maniak PJ, Ingbar DH, O'Grady SM.

Am J Physiol Cell Physiol. 2003 Jun;284(6):C1614-24. Epub 2003 Feb 26.


Basolateral Cl- transport is stimulated by terbutaline in adult rat alveolar epithelial cells.

Lee SY, Maniak PJ, Rhodes R, Ingbar DH, O'Grady SM.

J Membr Biol. 2003 Jan 15;191(2):133-9.


UTP-dependent inhibition of Na+ absorption requires activation of PKC in endometrial epithelial cells.

Palmer-Densmore M, Deachapunya C, Kannan M, O'Grady SM.

J Gen Physiol. 2002 Dec;120(6):897-906.


Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase.

Kim H, Farris J, Christman SA, Kong BW, Foster LK, O'Grady SM, Foster DN.

Biochem J. 2002 Aug 1;365(Pt 3):765-72.

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