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Items: 1 to 50 of 198

1.

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis.

Singhania A, Wilkinson RJ, Rodrigue M, Haldar P, O'Garra A.

Nat Immunol. 2018 Nov;19(11):1159-1168. doi: 10.1038/s41590-018-0225-9. Epub 2018 Oct 17. Review.

PMID:
30333612
2.

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.

Singhania A, Verma R, Graham CM, Lee J, Tran T, Richardson M, Lecine P, Leissner P, Berry MPR, Wilkinson RJ, Kaiser K, Rodrigue M, Woltmann G, Haldar P, O'Garra A.

Nat Commun. 2018 Jun 19;9(1):2308. doi: 10.1038/s41467-018-04579-w.

3.

Regulating the regulator: Bhlhe40 directly keeps IL-10 in check.

Gabryšová L, O'Garra A.

J Exp Med. 2018 Jul 2;215(7):1767-1769. doi: 10.1084/jem.20180824. Epub 2018 Jun 7.

PMID:
29880485
4.

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators, Moffatt MF, O'Garra A, Openshaw PJM.

Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18.

5.

Type I interferons in tuberculosis: Foe and occasionally friend.

Moreira-Teixeira L, Mayer-Barber K, Sher A, O'Garra A.

J Exp Med. 2018 May 7;215(5):1273-1285. doi: 10.1084/jem.20180325. Epub 2018 Apr 17. Review.

6.

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.

Gabryšová L, Alvarez-Martinez M, Luisier R, Cox LS, Sodenkamp J, Hosking C, Pérez-Mazliah D, Whicher C, Kannan Y, Potempa K, Wu X, Bhaw L, Wende H, Sieweke MH, Elgar G, Wilson M, Briscoe J, Metzis V, Langhorne J, Luscombe NM, O'Garra A.

Nat Immunol. 2018 May;19(5):497-507. doi: 10.1038/s41590-018-0083-5. Epub 2018 Apr 16.

7.

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Horswell S, Coussens AK, Barry CE 3rd, O'Garra A, Wilkinson RJ.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E964-E973. doi: 10.1073/pnas.1711853115. Epub 2018 Jan 16.

8.

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.

Bénard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L, Jouneau L, Boudinot P, Al-Saati T, Lang R, Rehwinkel J, Loxton AG, Kaufmann SHE, Anton-Leberre V, O'Garra A, Sasiain MDC, Gicquel B, Fillatreau S, Neyrolles O, Hudrisier D.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):801-813. doi: 10.1164/rccm.201707-1475OC.

9.

T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection.

Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT, Freitas do Rosário AP, Wu X, Langhorne J, O'Garra A.

J Immunol. 2017 Jul 15;199(2):613-623. doi: 10.4049/jimmunol.1601340. Epub 2017 Jun 5.

10.

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.

Lin JW, Sodenkamp J, Cunningham D, Deroost K, Tshitenge TC, McLaughlin S, Lamb TJ, Spencer-Dene B, Hosking C, Ramesar J, Janse CJ, Graham C, O'Garra A, Langhorne J.

Sci Rep. 2017 Feb 3;7:41722. doi: 10.1038/srep41722.

11.

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis.

Marais S, Lai RPJ, Wilkinson KA, Meintjes G, O'Garra A, Wilkinson RJ.

J Infect Dis. 2017 Mar 1;215(5):677-686. doi: 10.1093/infdis/jiw561.

12.

Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role.

O'Garra A, Gabryšová L.

J Immunol. 2016 Dec 1;197(11):4504. No abstract available.

13.

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling.

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M.

J Immunol. 2016 Dec 15;197(12):4714-4726. Epub 2016 Nov 14.

14.

The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis.

Blankley S, Graham CM, Turner J, Berry MP, Bloom CI, Xu Z, Pascual V, Banchereau J, Chaussabel D, Breen R, Santis G, Blankenship DM, Lipman M, O'Garra A.

PLoS One. 2016 Oct 5;11(10):e0162220. doi: 10.1371/journal.pone.0162220. eCollection 2016.

15.

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, Wilkinson RJ.

Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.

16.

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages.

Howes A, Taubert C, Blankley S, Spink N, Wu X, Graham CM, Zhao J, Saraiva M, Ricciardi-Castagnoli P, Bancroft GJ, O'Garra A.

J Immunol. 2016 Oct 1;197(7):2838-53. doi: 10.4049/jimmunol.1501923. Epub 2016 Aug 22.

17.

Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.

Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A.

J Immunol. 2016 Sep 1;197(5):1539-46. No abstract available.

18.

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.

Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A.

J Immunol. 2016 Sep 1;197(5):1531-8. No abstract available.

19.

Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role.

O'Garra A, Gabryšová L.

J Immunol. 2016 Jun 1;196(11):4423-5. doi: 10.4049/jimmunol.1600646. No abstract available. Erratum in: J Immunol. 2016 Dec 1;197(11):4504.

20.

A 380-gene meta-signature of active tuberculosis compared with healthy controls.

Blankley S, Graham CM, Levin J, Turner J, Berry MP, Bloom CI, Xu Z, Pascual V, Banchereau J, Chaussabel D, Breen R, Santis G, Blankenship DM, Lipman M, O'Garra A.

Eur Respir J. 2016 Jun;47(6):1873-6. doi: 10.1183/13993003.02121-2015. Epub 2016 Apr 13. No abstract available.

21.

Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling.

Pitt JM, Blankley S, Potempa K, Graham CM, Moreira-Teixeira L, McNab FW, Howes A, Stavropoulos E, Pascual V, Banchereau J, Chaussabel D, O'Garra A.

PLoS One. 2016 Feb 26;11(2):e0150251. doi: 10.1371/journal.pone.0150251. eCollection 2016.

22.

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.

Lai RP, Meintjes G, Wilkinson KA, Graham CM, Marais S, Van der Plas H, Deffur A, Schutz C, Bloom C, Munagala I, Anguiano E, Goliath R, Maartens G, Banchereau J, Chaussabel D, O'Garra A, Wilkinson RJ.

Nat Commun. 2015 Sep 24;6:8451. doi: 10.1038/ncomms9451.

23.

The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease.

Conejero L, Potempa K, Graham CM, Spink N, Blankley S, Salguero FJ, Pankla-Sranujit R, Khaenam P, Banchereau JF, Pascual V, Chaussabel D, Lertmemongkolchai G, O'Garra A, Bancroft GJ.

J Immunol. 2015 Oct 1;195(7):3248-3261. doi: 10.4049/jimmunol.1500641. Epub 2015 Aug 26.

24.

The human immune response to tuberculosis and its treatment: a view from the blood.

Cliff JM, Kaufmann SH, McShane H, van Helden P, O'Garra A.

Immunol Rev. 2015 Mar;264(1):88-102. doi: 10.1111/imr.12269. Review.

25.

Type I interferons in infectious disease.

McNab F, Mayer-Barber K, Sher A, Wack A, O'Garra A.

Nat Rev Immunol. 2015 Feb;15(2):87-103. doi: 10.1038/nri3787. Review.

PMID:
25614319
26.

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.

McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N, Saraiva M, O'Garra A.

J Immunol. 2014 Oct 1;193(7):3600-12. doi: 10.4049/jimmunol.1401088. Epub 2014 Sep 3.

27.

The regulation of IL-10 expression.

Gabryšová L, Howes A, Saraiva M, O'Garra A.

Curr Top Microbiol Immunol. 2014;380:157-90. doi: 10.1007/978-3-662-43492-5_8. Review.

PMID:
25004818
28.

Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro.

Blankley S, Graham CM, Howes A, Bloom CI, Berry MP, Chaussabel D, Pascual V, Banchereau J, Lipman M, O'Garra A.

PLoS One. 2014 May 19;9(5):e97702. doi: 10.1371/journal.pone.0097702. eCollection 2014.

29.

Preface. The science of infectious diseases.

Dye C, O'Garra A.

Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20140055. doi: 10.1098/rstb.2014.0055. Print 2014. No abstract available.

30.

The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.

Blankley S, Berry MP, Graham CM, Bloom CI, Lipman M, O'Garra A.

Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130427. doi: 10.1098/rstb.2013.0427. Print 2014. Review.

31.

Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.

Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley SC.

J Immunol. 2014 Apr 15;192(8):3518-3529. doi: 10.4049/jimmunol.1300172. Epub 2014 Mar 17.

32.

Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages.

Teixeira-Coelho M, Guedes J, Ferreirinha P, Howes A, Pedrosa J, Rodrigues F, Lai WS, Blackshear PJ, O'Garra A, Castro AG, Saraiva M.

Eur J Immunol. 2014 Mar;44(3):856-66. doi: 10.1002/eji.201343734. Epub 2013 Dec 16.

33.

Systems approach to understand the immune response in tuberculosis: an iterative process between mouse models and human disease.

O'Garra A.

Cold Spring Harb Symp Quant Biol. 2013;78:173-7. doi: 10.1101/sqb.2013.78.020172. Epub 2013 Oct 7.

PMID:
24100583
34.

Systems approaches to studying the immune response in tuberculosis.

Berry MP, Blankley S, Graham CM, Bloom CI, O'Garra A.

Curr Opin Immunol. 2013 Oct;25(5):579-87. doi: 10.1016/j.coi.2013.08.003. Epub 2013 Sep 7. Review.

PMID:
24021227
35.

Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.

Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y, Xu Z, Wilkinson KA, Wilkinson RJ, Kendrick Y, Devouassoux G, Ferry T, Miyara M, Bouvry D, Valeyre D, Gorochov G, Blankenship D, Saadatian M, Vanhems P, Beynon H, Vancheeswaran R, Wickremasinghe M, Chaussabel D, Banchereau J, Pascual V, Ho LP, Lipman M, O'Garra A.

PLoS One. 2013 Aug 5;8(8):e70630. doi: 10.1371/journal.pone.0070630. Print 2013. Erratum in: PLoS One. 2013;8(8).doi: 10.1371/annotation/7d9ec449-aee0-48fe-8111-0c110850c0c1. Dominique, Valeyre [corrected to Valeyre, Dominique].

36.

Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway.

Redford PS, Mayer-Barber KD, McNab FW, Stavropoulos E, Wack A, Sher A, O'Garra A.

J Infect Dis. 2014 Jan 15;209(2):270-4. doi: 10.1093/infdis/jit424. Epub 2013 Aug 9.

37.

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.

McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A.

J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10.

38.

The immune response in tuberculosis.

O'Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MP.

Annu Rev Immunol. 2013;31:475-527. doi: 10.1146/annurev-immunol-032712-095939. Review.

PMID:
23516984
39.

Brigitte Askonas (1923-2013).

O'Garra A.

Nature. 2013 Feb 7;494(7435):37. doi: 10.1038/494037a. No abstract available.

PMID:
23389536
40.

Driving change in tuberculosis research: an interview with Anne O'Garra.

O'Garra A.

Dis Model Mech. 2013 Jan;6(1):6-8. doi: 10.1242/dmm.011429. No abstract available.

41.

Vaccination against tuberculosis: how can we better BCG?

Pitt JM, Blankley S, McShane H, O'Garra A.

Microb Pathog. 2013 May;58:2-16. doi: 10.1016/j.micpath.2012.12.002. Epub 2012 Dec 17. Review.

PMID:
23257069
42.

Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.

Bloom CI, Graham CM, Berry MP, Wilkinson KA, Oni T, Rozakeas F, Xu Z, Rossello-Urgell J, Chaussabel D, Banchereau J, Pascual V, Lipman M, Wilkinson RJ, O'Garra A.

PLoS One. 2012;7(10):e46191. doi: 10.1371/journal.pone.0046191. Epub 2012 Oct 2.

43.

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.

Banchereau J, Pascual V, O'Garra A.

Nat Immunol. 2012 Oct;13(10):925-31. doi: 10.1038/ni.2406. Epub 2012 Sep 18. Review.

44.

Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.

Pitt JM, Stavropoulos E, Redford PS, Beebe AM, Bancroft GJ, Young DB, O'Garra A.

J Immunol. 2012 Oct 15;189(8):4079-87. doi: 10.4049/jimmunol.1201061. Epub 2012 Sep 12.

45.

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells.

Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z, Hawrylowicz CM.

Eur J Immunol. 2012 Oct;42(10):2697-708. doi: 10.1002/eji.201242370. Epub 2012 Aug 20.

46.

Editorial overview.

O'Garra A, Pamer E.

Curr Opin Immunol. 2012 Aug;24(4):361-3. doi: 10.1016/j.coi.2012.07.007. Epub 2012 Aug 4. No abstract available.

PMID:
22867964
47.

Contribution of cytokines to pathology and protection in virus infection.

Wack A, Openshaw P, O'Garra A.

Curr Opin Virol. 2011 Sep;1(3):184-95. doi: 10.1016/j.coviro.2011.05.015. Epub 2011 Jun 25. Review.

48.

IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.

Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney NP, Schuijs M, O'Garra A, Johansson C, Openshaw PJ.

PLoS One. 2012;7(2):e32371. doi: 10.1371/journal.pone.0032371. Epub 2012 Feb 29.

49.

Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.

Tattermusch S, Skinner JA, Chaussabel D, Banchereau J, Berry MP, McNab FW, O'Garra A, Taylor GP, Bangham CR.

PLoS Pathog. 2012 Jan;8(1):e1002480. doi: 10.1371/journal.ppat.1002480. Epub 2012 Jan 26.

50.

Remembering Ralph Steinman.

Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A.

J Exp Med. 2011 Nov 21;208(12):2343-7. No abstract available.

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