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A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces.

Hogan S, Kasotakis E, Maher S, Cavanagh B, O'Gara JP, Pandit A, Keyes TE, Devocelle M, O'Neill E.

FEMS Microbiol Lett. 2019 May 1;366(9). pii: fnz107. doi: 10.1093/femsle/fnz107.


Complete Genome Sequence of Staphylococcus epidermidis CSF41498.

Galac MR, Hoang TM, Ong AC, Hinkle M, O'Gara JP, Fey PD.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01138-18. doi: 10.1128/MRA.01138-18. eCollection 2019 Jan.


Novel Treatment of Staphylococcus aureus Device-Related Infections Using Fibrinolytic Agents.

Hogan S, O'Gara JP, O'Neill E.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02008-17. doi: 10.1128/AAC.02008-17. Print 2018 Feb.


Tandem Amplification of the Staphylococcal Cassette Chromosome mec Element Can Drive High-Level Methicillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Gallagher LA, Coughlan S, Black NS, Lalor P, Waters EM, Wee B, Watson M, Downing T, Fitzgerald JR, Fleming GTA, O'Gara JP.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00869-17. doi: 10.1128/AAC.00869-17. Print 2017 Sep.


Into the storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life-threatening infections.

O'Gara JP.

Environ Microbiol. 2017 Oct;19(10):3823-3833. doi: 10.1111/1462-2920.13833. Epub 2017 Jul 24. Review.


Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides.

Zapotoczna M, Forde É, Hogan S, Humphreys H, O'Gara JP, Fitzgerald-Hughes D, Devocelle M, O'Neill E.

J Infect Dis. 2017 Mar 15;215(6):975-983. doi: 10.1093/infdis/jix062.


Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm-related infections.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E.

J Hosp Infect. 2017 Jun;96(2):177-182. doi: 10.1016/j.jhin.2017.02.008. Epub 2017 Feb 16.


Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds: MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea} and MMV665807 {5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide}.

Zapotoczna M, Boksmati N, Donohue S, Bahtiar B, Boland A, Somali HA, Cox A, Humphreys H, O'Gara JP, Brennan M, O'Neill E.

J Med Microbiol. 2017 Mar;66(3):377-387. doi: 10.1099/jmm.0.000446. Epub 2017 Mar 23.


Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections.

Waters EM, Rudkin JK, Coughlan S, Clair GC, Adkins JN, Gore S, Xia G, Black NS, Downing T, O'Neill E, Kadioglu A, O'Gara JP.

J Infect Dis. 2017 Jan 1;215(1):80-87. doi: 10.1093/infdis/jiw461. Epub 2016 Nov 14.


Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?

Waters EM, Rowe SE, O'Gara JP, Conlon BP.

PLoS Pathog. 2016 Dec 29;12(12):e1006012. doi: 10.1371/journal.ppat.1006012. eCollection 2016 Dec. Review. No abstract available.


5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

Zapotoczna M, Murray EJ, Hogan S, O'Gara JP, Chhabra SR, Chan WC, O'Neill E, Williams P.

J Antimicrob Chemother. 2017 Mar 1;72(3):744-753. doi: 10.1093/jac/dkw482.


AraC-Type Regulator Rbf Controls the Staphylococcus epidermidis Biofilm Phenotype by Negatively Regulating the icaADBC Repressor SarR.

Rowe SE, Campbell C, Lowry C, O'Donnell ST, Olson ME, Lindgren JK, Waters EM, Fey PD, O'Gara JP.

J Bacteriol. 2016 Oct 7;198(21):2914-2924. Print 2016 Nov 1.


Eradication of Staphylococcus aureus Catheter-Related Biofilm Infections Using ML:8 and Citrox.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5968-75. doi: 10.1128/AAC.00910-16. Print 2016 Oct.


Untangling the Diverse and Redundant Mechanisms of Staphylococcus aureus Biofilm Formation.

Zapotoczna M, O'Neill E, O'Gara JP.

PLoS Pathog. 2016 Jul 21;12(7):e1005671. doi: 10.1371/journal.ppat.1005671. eCollection 2016 Jul. Review. No abstract available.


The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model.

McCarthy H, Waters EM, Bose JL, Foster S, Bayles KW, O'Neill E, Fey PD, O'Gara JP.

FEMS Microbiol Lett. 2016 May;363(9). pii: fnw087. doi: 10.1093/femsle/fnw087. Epub 2016 Apr 3.


In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2923-31. doi: 10.1128/AAC.02885-15. Print 2016 May.


The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation.

Khodaparast L, Khodaparast L, Shahrooei M, Stijlemans B, Merckx R, Baatsen P, O'Gara JP, Waters E, Van Mellaert L, Van Eldere J.

PLoS One. 2016 Jan 22;11(1):e0146704. doi: 10.1371/journal.pone.0146704. eCollection 2016.


Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation.

Spoor LE, Richardson E, Richards AC, Wilson GJ, Mendonca C, Gupta RK, McAdam PR, Nutbeam-Tuffs S, Black NS, O'Gara JP, Lee CY, Corander J, Fitzgerald JR.

Microb Genom. 2015 Oct 30;1(4):e000036. doi: 10.1099/mgen.0.000036. eCollection 2015 Oct.


Electrophoretic Mobility Shift Assays.

Rowe SE, O'Gara JP.

Methods Mol Biol. 2016;1373:155-67. doi: 10.1007/7651_2015_277.


An Essential Role for Coagulase in Staphylococcus aureus Biofilm Development Reveals New Therapeutic Possibilities for Device-Related Infections.

Zapotoczna M, McCarthy H, Rudkin JK, O'Gara JP, O'Neill E.

J Infect Dis. 2015 Dec 15;212(12):1883-93. doi: 10.1093/infdis/jiv319. Epub 2015 Jun 4.


Methicillin resistance and the biofilm phenotype in Staphylococcus aureus.

McCarthy H, Rudkin JK, Black NS, Gallagher L, O'Neill E, O'Gara JP.

Front Cell Infect Microbiol. 2015 Jan 28;5:1. doi: 10.3389/fcimb.2015.00001. eCollection 2015. Review.


Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype.

Conlon BP, Geoghegan JA, Waters EM, McCarthy H, Rowe SE, Davies JR, Schaeffer CR, Foster TJ, Fey PD, O'Gara JP.

J Bacteriol. 2014 Dec;196(24):4268-75. doi: 10.1128/JB.01946-14. Epub 2014 Sep 29.


Current and future approaches to the prevention and treatment of staphylococcal medical device-related infections.

Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E.

Curr Pharm Des. 2015;21(1):100-13. Review.


Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistant Staphylococcus aureus strain LAC.

McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA.

FEMS Microbiol Lett. 2014 Apr;353(2):157-64. doi: 10.1111/1574-6968.12424. Epub 2014 Apr 10.


Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus.

Rudkin JK, Laabei M, Edwards AM, Joo HS, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RC.

Antimicrob Agents Chemother. 2014;58(2):1100-7. doi: 10.1128/AAC.01618-13. Epub 2013 Dec 2.


Rapid quantitative and qualitative analysis of biofilm production by Staphylococcus epidermidis under static growth conditions.

Waters EM, McCarthy H, Hogan S, Zapotoczna M, O'Neill E, O'Gara JP.

Methods Mol Biol. 2014;1106:157-66. doi: 10.1007/978-1-62703-736-5_14.


Subdomains N2N3 of fibronectin binding protein A mediate Staphylococcus aureus biofilm formation and adherence to fibrinogen using distinct mechanisms.

Geoghegan JA, Monk IR, O'Gara JP, Foster TJ.

J Bacteriol. 2013 Jun;195(11):2675-83. doi: 10.1128/JB.02128-12. Epub 2013 Apr 5.


Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties.

Stallard CP, McDonnell KA, Onayemi OD, O'Gara JP, Dowling DP.

Biointerphases. 2012 Dec;7(1-4):31. doi: 10.1007/s13758-012-0031-0. Epub 2012 May 3.


Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections.

Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB, Fey PD, Massey RC, O'Gara JP.

PLoS Pathog. 2012;8(4):e1002626. doi: 10.1371/journal.ppat.1002626. Epub 2012 Apr 5.


Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.

Stevens NT, Greene CM, O'Gara JP, Bayston R, Sattar MT, Farrell M, Humphreys H.

Br J Neurosurg. 2012 Dec;26(6):792-7. doi: 10.3109/02688697.2011.651514. Epub 2012 Feb 3. Review.


Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system.

Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O'Gara JP, Massey RC.

J Infect Dis. 2012 Mar 1;205(5):798-806. doi: 10.1093/infdis/jir845. Epub 2012 Feb 1.


Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study.

Galvin S, Boyle M, Russell RJ, Coleman DC, Creamer E, O'Gara JP, Fitzgerald-Hughes D, Humphreys H.

J Hosp Infect. 2012 Jan;80(1):67-70. doi: 10.1016/j.jhin.2011.10.013. Epub 2011 Nov 29.


Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma.

Cotter JJ, Maguire P, Soberon F, Daniels S, O'Gara JP, Casey E.

J Hosp Infect. 2011 Jul;78(3):204-7. doi: 10.1016/j.jhin.2011.03.019. Epub 2011 May 23.


Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity.

Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ.

J Med Microbiol. 2011 Jul;60(Pt 7):968-76. doi: 10.1099/jmm.0.025619-0. Epub 2011 Mar 10.


A novel role for SarX in Staphylococcus epidermidis biofilm regulation.

Rowe SE, Mahon V, Smith SG, O'Gara JP.

Microbiology. 2011 Apr;157(Pt 4):1042-9. doi: 10.1099/mic.0.046581-0. Epub 2011 Feb 3.


Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype.

Houston P, Rowe SE, Pozzi C, Waters EM, O'Gara JP.

Infect Immun. 2011 Mar;79(3):1153-65. doi: 10.1128/IAI.00364-10. Epub 2010 Dec 28.


Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development.

Holland LM, Conlon B, O'Gara JP.

Microbiology. 2011 Feb;157(Pt 2):408-18. doi: 10.1099/mic.0.042234-0. Epub 2010 Nov 4.


Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm.

Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E.

J Appl Microbiol. 2010 Dec;109(6):2105-17. doi: 10.1111/j.1365-2672.2010.04842.x. Epub 2010 Sep 16.


Role of surface protein SasG in biofilm formation by Staphylococcus aureus.

Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ.

J Bacteriol. 2010 Nov;192(21):5663-73. doi: 10.1128/JB.00628-10. Epub 2010 Sep 3.


Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus.

Oduwole KO, Glynn AA, Molony DC, Murray D, Rowe S, Holland LM, McCormack DJ, O'Gara JP.

J Orthop Res. 2010 Sep;28(9):1252-6. doi: 10.1002/jor.21110.


Offsetting virulence and antibiotic resistance costs by MRSA.

Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC.

ISME J. 2010 Apr;4(4):577-84. doi: 10.1038/ismej.2009.151. Epub 2010 Jan 14.


Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC.

Cue D, Lei MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY.

J Bacteriol. 2009 Oct;191(20):6363-73. doi: 10.1128/JB.00913-09. Epub 2009 Aug 14.


Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis.

Stevens NT, Greene CM, O'Gara JP, Humphreys H.

J Med Microbiol. 2009 Jul;58(Pt 7):855-62. doi: 10.1099/jmm.0.009209-0. Epub 2009 Jun 5.


Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.

Stevens NT, Sadovskaya I, Jabbouri S, Sattar T, O'Gara JP, Humphreys H, Greene CM.

Cell Microbiol. 2009 Mar;11(3):421-32. doi: 10.1111/j.1462-5822.2008.01264.x. Epub 2008 Nov 7.


Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis.

Cotter JJ, O'Gara JP, Mack D, Casey E.

Appl Environ Microbiol. 2009 Jan;75(1):261-4. doi: 10.1128/AEM.00261-08. Epub 2008 Nov 14.


Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis.

Glynn AA, O'Donnell ST, Molony DC, Sheehan E, McCormack DJ, O'Gara JP.

J Orthop Res. 2009 May;27(5):627-30. doi: 10.1002/jor.20758.


Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis.

Stevens NT, Tharmabala M, Dillane T, Greene CM, O'Gara JP, Humphreys H.

Clin Microbiol Infect. 2008 Jul;14(7):719-22. doi: 10.1111/j.1469-0691.2008.02012.x.


A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP.

Holland LM, O'Donnell ST, Ryjenkov DA, Gomelsky L, Slater SR, Fey PD, Gomelsky M, O'Gara JP.

J Bacteriol. 2008 Aug;190(15):5178-89. doi: 10.1128/JB.00375-08. Epub 2008 May 23.

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