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Items: 19

1.

Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses.

O'Flanagan CH, Campbell KR, Zhang AW, Kabeer F, Lim JLP, Biele J, Eirew P, Lai D, McPherson A, Kong E, Bates C, Borkowski K, Wiens M, Hewitson B, Hopkins J, Pham J, Ceglia N, Moore R, Mungall AJ, McAlpine JN; CRUK IMAXT Grand Challenge Team, Shah SP, Aparicio S.

Genome Biol. 2019 Oct 17;20(1):210. doi: 10.1186/s13059-019-1830-0.

2.

A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.

Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, Légaré S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M.

Mol Cancer Res. 2019 Sep 19. doi: 10.1158/1541-7786.MCR-19-0264. [Epub ahead of print]

PMID:
31537618
3.

Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

Zhang AW, O'Flanagan C, Chavez EA, Lim JLP, Ceglia N, McPherson A, Wiens M, Walters P, Chan T, Hewitson B, Lai D, Mottok A, Sarkozy C, Chong L, Aoki T, Wang X, Weng AP, McAlpine JN, Aparicio S, Steidl C, Campbell KR, Shah SP.

Nat Methods. 2019 Oct;16(10):1007-1015. doi: 10.1038/s41592-019-0529-1. Epub 2019 Sep 9.

PMID:
31501550
4.

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer.

Cox OT, Edmunds SJ, Simon-Keller K, Li B, Moran B, Buckley NE, Bustamante-Garrido M, Healy N, O'Flanagan CH, Gallagher WM, Kennedy RD, Bernards R, Caldas C, Chin SF, Marx A, O'Connor R.

Cancer Res. 2019 May 15;79(10):2619-2633. doi: 10.1158/0008-5472.CAN-18-2787. Epub 2019 Mar 18.

PMID:
30885980
5.

clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers.

Campbell KR, Steif A, Laks E, Zahn H, Lai D, McPherson A, Farahani H, Kabeer F, O'Flanagan C, Biele J, Brimhall J, Wang B, Walters P, Consortium I, Bouchard-Côté A, Aparicio S, Shah SP.

Genome Biol. 2019 Mar 12;20(1):54. doi: 10.1186/s13059-019-1645-z.

6.

FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion.

Stanicka J, Rieger L, O'Shea S, Cox O, Coleman M, O'Flanagan C, Addario B, McCabe N, Kennedy R, O'Connor R.

Oncogene. 2018 Jun;37(23):3131-3150. doi: 10.1038/s41388-017-0113-z. Epub 2018 Mar 15.

PMID:
29540831
7.

Translating Mechanism-Based Strategies to Break the Obesity-Cancer Link: A Narrative Review.

Smith LA, O'Flanagan CH, Bowers LW, Allott EH, Hursting SD.

J Acad Nutr Diet. 2018 Apr;118(4):652-667. doi: 10.1016/j.jand.2017.08.112. Review.

8.

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.

Doerstling SS, O'Flanagan CH, Hursting SD.

Front Oncol. 2017 Sep 14;7:216. doi: 10.3389/fonc.2017.00216. eCollection 2017. Review.

9.

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

Lyons A, Coleman M, Riis S, Favre C, O'Flanagan CH, Zhdanov AV, Papkovsky DB, Hursting SD, O'Connor R.

J Biol Chem. 2017 Oct 13;292(41):16983-16998. doi: 10.1074/jbc.M117.792838. Epub 2017 Aug 18.

10.

Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer.

O'Flanagan CH, Rossi EL, McDonell SB, Chen X, Tsai YH, Parker JS, Usary J, Perou CM, Hursting SD.

NPJ Breast Cancer. 2017 Jul 17;3:26. doi: 10.1038/s41523-017-0027-5. eCollection 2017.

11.

When less may be more: calorie restriction and response to cancer therapy.

O'Flanagan CH, Smith LA, McDonell SB, Hursting SD.

BMC Med. 2017 May 24;15(1):106. doi: 10.1186/s12916-017-0873-x. Review.

12.

Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype.

Ashkavand Z, O'Flanagan C, Hennig M, Du X, Hursting SD, Krupenko SA.

Mol Cancer Res. 2017 Feb;15(2):189-200. doi: 10.1158/1541-7786.MCR-16-0317.

13.

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors.

Lashinger LM, O'Flanagan CH, Dunlap SM, Rasmussen AJ, Sweeney S, Guo JY, Lodi A, Tiziani S, White E, Hursting SD.

Cancer Metab. 2016 Sep 16;4:18. doi: 10.1186/s40170-016-0158-4. eCollection 2016.

14.

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin.

O'Flanagan CH, O'Shea S, Lyons A, Fogarty FM, McCabe N, Kennedy RD, O'Connor R.

Oncotarget. 2016 Aug 30;7(35):56826-56841. doi: 10.18632/oncotarget.10862.

15.

PINK1, cancer and neurodegeneration.

O'Flanagan CH, Morais VA, O'Neill C.

Oncoscience. 2016 Jan 12;3(1):1-2. eCollection 2016. No abstract available.

16.

A weighty problem: metabolic perturbations and the obesity-cancer link.

O'Flanagan CH, Bowers LW, Hursting SD.

Horm Mol Biol Clin Investig. 2015 Aug;23(2):47-57. doi: 10.1515/hmbci-2015-0022. Review.

17.

The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.

Bowers LW, Rossi EL, O'Flanagan CH, deGraffenried LA, Hursting SD.

Front Endocrinol (Lausanne). 2015 May 15;6:77. doi: 10.3389/fendo.2015.00077. eCollection 2015. Review.

18.

PINK1 signalling in cancer biology.

O'Flanagan CH, O'Neill C.

Biochim Biophys Acta. 2014 Dec;1846(2):590-8. doi: 10.1016/j.bbcan.2014.10.006. Epub 2014 Oct 23. Review.

PMID:
25450579
19.

The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes.

O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C.

Oncogene. 2015 Mar 12;34(11):1363-74. doi: 10.1038/onc.2014.81. Epub 2014 Mar 31.

PMID:
24681957

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