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Items: 1 to 50 of 131


A Genome-wide Screen Reveals that Reducing Mitochondrial DNA Polymerase Can Promote Elimination of Deleterious Mitochondrial Mutations.

Chiang AC, McCartney E, O'Farrell PH, Ma H.

Curr Biol. 2019 Dec 16;29(24):4330-4336.e3. doi: 10.1016/j.cub.2019.10.060. Epub 2019 Nov 27.


Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila.

Seller CA, Cho CY, O'Farrell PH.

Genes Dev. 2019 Apr 1;33(7-8):403-417. doi: 10.1101/gad.321646.118. Epub 2019 Feb 26.


Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition.

Seller CA, O'Farrell PH.

PLoS Biol. 2018 May 10;16(5):e2005687. doi: 10.1371/journal.pbio.2005687. eCollection 2018 May.


Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research.

Duronio RJ, O'Farrell PH, Sluder G, Su TT.

Dis Model Mech. 2017 Dec 19;10(12):1381-1389. doi: 10.1242/dmm.031203. Review.


The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes.

Yu Z, O'Farrell PH, Yakubovich N, DeLuca SZ.

Curr Biol. 2017 Apr 3;27(7):1033-1039. doi: 10.1016/j.cub.2017.02.014. Epub 2017 Mar 16.


Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.

Yuan K, Seller CA, Shermoen AW, O'Farrell PH.

Trends Genet. 2016 Aug;32(8):496-507. doi: 10.1016/j.tig.2016.05.006. Epub 2016 Jun 20. Review.


Selfish drive can trump function when animal mitochondrial genomes compete.

Ma H, O'Farrell PH.

Nat Genet. 2016 Jul;48(7):798-802. doi: 10.1038/ng.3587. Epub 2016 Jun 6.


TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.

Yuan K, O'Farrell PH.

Genes Dev. 2016 Mar 1;30(5):579-93. doi: 10.1101/gad.272237.115. Epub 2016 Feb 25.


Growing an Embryo from a Single Cell: A Hurdle in Animal Life.

O'Farrell PH.

Cold Spring Harb Perspect Biol. 2015 Aug 7;7(11). pii: a019042. doi: 10.1101/cshperspect.a019042. Review.


Selections that isolate recombinant mitochondrial genomes in animals.

Ma H, O'Farrell PH.

Elife. 2015 Aug 3;4. doi: 10.7554/eLife.07247.


Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.

Yuan K, O'Farrell PH.

Curr Biol. 2015 Mar 16;25(6):811-816. doi: 10.1016/j.cub.2015.01.053. Epub 2015 Mar 5.


From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition.

Farrell JA, O'Farrell PH.

Annu Rev Genet. 2014;48:269-94. doi: 10.1146/annurev-genet-111212-133531. Epub 2014 Sep 5. Review.


Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.

Ma H, Xu H, O'Farrell PH.

Nat Genet. 2014 Apr;46(4):393-7. doi: 10.1038/ng.2919. Epub 2014 Mar 9.


Two-dimensional gel electrophoresis and the beginning of proteomics.

O'Farrell PH.

Clin Chem. 2014 Jul;60(7):1012-3. doi: 10.1373/clinchem.2014.221630. Epub 2014 Feb 25. No abstract available.


Illuminating DNA replication during Drosophila development using TALE-lights.

Yuan K, Shermoen AW, O'Farrell PH.

Curr Biol. 2014 Feb 17;24(4):R144-5. doi: 10.1016/j.cub.2014.01.023. No abstract available.


Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.

Farrell JA, O'Farrell PH.

Curr Biol. 2013 Jan 21;23(2):118-26. doi: 10.1016/j.cub.2012.11.036. Epub 2013 Jan 3.


Different cyclin types collaborate to reverse the S-phase checkpoint and permit prompt mitosis.

Yuan K, Farrell JA, O'Farrell PH.

J Cell Biol. 2012 Sep 17;198(6):973-80. doi: 10.1083/jcb.201205007. Epub 2012 Sep 10.


Embryonic onset of late replication requires Cdc25 down-regulation.

Farrell JA, Shermoen AW, Yuan K, O'Farrell PH.

Genes Dev. 2012 Apr 1;26(7):714-25. doi: 10.1101/gad.186429.111. Epub 2012 Mar 19.


Barriers to male transmission of mitochondrial DNA in sperm development.

DeLuca SZ, O'Farrell PH.

Dev Cell. 2012 Mar 13;22(3):660-8. doi: 10.1016/j.devcel.2011.12.021.


Quiescence: early evolutionary origins and universality do not imply uniformity.

O'Farrell PH.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3498-507. doi: 10.1098/rstb.2011.0079. Review.


Developmental control of late replication and S phase length.

Shermoen AW, McCleland ML, O'Farrell PH.

Curr Biol. 2010 Dec 7;20(23):2067-77. doi: 10.1016/j.cub.2010.10.021. Epub 2010 Nov 11.


Patrick H. O'Farrell.

O'Farrell PH.

Curr Biol. 2010 Feb 23;20(4):R133-4. No abstract available.


Nitric oxide synthase is not essential for Drosophila development.

Yakubovich N, Silva EA, O'Farrell PH.

Curr Biol. 2010 Feb 23;20(4):R141-2. doi: 10.1016/j.cub.2009.12.011. No abstract available.


DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos.

McCleland ML, Shermoen AW, O'Farrell PH.

J Cell Biol. 2009 Oct 5;187(1):7-14. doi: 10.1083/jcb.200906191. Epub 2009 Sep 28.


Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade.

Dijkers PF, O'Farrell PH.

Mol Biol Cell. 2009 Sep;20(18):4083-90. doi: 10.1091/mbc.E09-05-0362. Epub 2009 Jul 22.


Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.

McCleland ML, Farrell JA, O'Farrell PH.

J Cell Biol. 2009 Mar 9;184(5):639-46. doi: 10.1083/jcb.200810012.


Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells.

Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD.

Methods Mol Biol. 2009;470:347-58. doi: 10.1007/978-1-59745-204-5_24.


The pre-omics era: the early days of two-dimensional gels.

O'Farrell PH.

Proteomics. 2008 Dec;8(23-24):4842-52. doi: 10.1002/pmic.200800719.


Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.

Xu H, DeLuca SZ, O'Farrell PH.

Science. 2008 Jul 25;321(5888):575-7. doi: 10.1126/science.1160226.


An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

Lee SJ, Feldman R, O'Farrell PH.

Mol Biol Cell. 2008 Oct;19(10):4051-61. doi: 10.1091/mbc.E08-03-0265. Epub 2008 Jul 23.


Anillin: a pivotal organizer of the cytokinetic machinery.

Hickson GR, O'Farrell PH.

Biochem Soc Trans. 2008 Jun;36(Pt 3):439-41. doi: 10.1042/BST0360439. Review.


RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle.

McCleland ML, O'Farrell PH.

Curr Biol. 2008 Feb 26;18(4):245-54. doi: 10.1016/j.cub.2008.01.041.


Rho-dependent control of anillin behavior during cytokinesis.

Hickson GR, O'Farrell PH.

J Cell Biol. 2008 Jan 28;180(2):285-94. doi: 10.1083/jcb.200709005. Epub 2008 Jan 21.


Drosophila calcineurin promotes induction of innate immune responses.

Dijkers PF, O'Farrell PH.

Curr Biol. 2007 Dec 4;17(23):2087-93.


The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.

Saleh MC, van Rij RP, Hekele A, Gillis A, Foley E, O'Farrell PH, Andino R.

Nat Cell Biol. 2006 Aug;8(8):793-802. Epub 2006 Jul 23.


Rho-kinase controls cell shape changes during cytokinesis.

Hickson GR, Echard A, O'Farrell PH.

Curr Biol. 2006 Feb 21;16(4):359-70.


Identification of Drosophila gene products required for phagocytosis of Candida albicans.

Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD.

PLoS Biol. 2006 Jan;4(1):e4. Epub 2005 Dec 20.


Terminal cytokinesis events uncovered after an RNAi screen.

Echard A, Hickson GR, Foley E, O'Farrell PH.

Curr Biol. 2004 Sep 21;14(18):1685-93.


Functional dissection of an innate immune response by a genome-wide RNAi screen.

Foley E, O'Farrell PH.

PLoS Biol. 2004 Aug;2(8):E203. Epub 2004 Jun 22.


Embryonic cleavage cycles: how is a mouse like a fly?

O'Farrell PH, Stumpff J, Su TT.

Curr Biol. 2004 Jan 6;14(1):R35-45. Review.


Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase.

Parry DH, Hickson GR, O'Farrell PH.

Curr Biol. 2003 Apr 15;13(8):647-53.


Nitric oxide-induced suspended animation promotes survival during hypoxia.

Teodoro RO, O'Farrell PH.

EMBO J. 2003 Feb 3;22(3):580-7.


Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation.

Vidwans SJ, Wong ML, O'Farrell PH.

J Cell Sci. 2003 Jan 1;116(Pt 1):137-43.


Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos.

Vidwans SJ, DiGregorio PJ, Shermoen AW, Foat B, Iwasa J, Yakubovich N, O'Farrell PH.

Curr Biol. 2002 May 14;12(10):829-33.


Triggering the all-or-nothing switch into mitosis.

O'Farrell PH.

Trends Cell Biol. 2001 Dec;11(12):512-9. Review.


Cell cycle roles for two 14-3-3 proteins during Drosophila development.

Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell PH, Purdy A.

J Cell Sci. 2001 Oct;114(Pt 19):3445-54.


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