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Items: 1 to 50 of 125

1.

Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects.

Rodvold KA, Gotfried MH, Isaacs RD, O'Donnell JP, Stone E.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01089-18. doi: 10.1128/AAC.01089-18. Print 2018 Nov.

PMID:
30126953
2.

Neurophysiological Response to Olfactory Stimuli in Combat Veterans With Posttraumatic Stress Disorder.

Bedwell JS, Bohil CJ, Neider MB, Gramlich MA, Neer SM, OʼDonnell JP, Beidel DC.

J Nerv Ment Dis. 2018 Jun;206(6):423-428. doi: 10.1097/NMD.0000000000000818.

PMID:
29781888
3.

Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.

O'Donnell JP, Marsh HM, Sondermann H, Sevier CS.

Biochemistry. 2018 Feb 20;57(7):1073-1086. doi: 10.1021/acs.biochem.7b01005. Epub 2018 Feb 1.

PMID:
29300467
4.

A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.

O'Donnell JP, Byrnes LJ, Cooley RB, Sondermann H.

J Biol Chem. 2018 Jan 12;293(2):687-700. doi: 10.1074/jbc.RA117.000380. Epub 2017 Nov 27.

5.

Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.

O'Donnell JP, Cooley RB, Kelly CM, Miller K, Andersen OS, Rusinova R, Sondermann H.

Structure. 2017 Jul 5;25(7):997-1010.e4. doi: 10.1016/j.str.2017.05.007. Epub 2017 Jun 9.

6.

Chloroplastic iron-sulfur scaffold protein NFU3 is essential to overall plant fitness.

Nath K, O'Donnell JP, Lu Y.

Plant Signal Behav. 2017 Feb;12(2):e1282023. doi: 10.1080/15592324.2017.1282023.

7.

Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor.

Cooley RB, O'Donnell JP, Sondermann H.

Elife. 2016 Dec 21;5. pii: e21848. doi: 10.7554/eLife.21848.

8.

Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.

Singh R, Kim A, Tanudra MA, Harris JJ, McLaughlin RE, Patey S, O'Donnell JP, Bradford PA, Eakin AE.

J Antimicrob Chemother. 2015 Sep;70(9):2618-26. doi: 10.1093/jac/dkv132. Epub 2015 May 29.

PMID:
26024868
9.

LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens.

Tomaras AP, McPherson CJ, Kuhn M, Carifa A, Mullins L, George D, Desbonnet C, Eidem TM, Montgomery JI, Brown MF, Reilly U, Miller AA, O'Donnell JP.

MBio. 2014 Sep 30;5(5):e01551-14. doi: 10.1128/mBio.01551-14.

10.

The selective Aurora-A kinase inhibitor MLN8237 (alisertib) potently inhibits proliferation of glioblastoma neurosphere tumor stem-like cells and potentiates the effects of temozolomide and ionizing radiation.

Hong X, O'Donnell JP, Salazar CR, Van Brocklyn JR, Barnett KD, Pearl DK, deCarvalho AC, Ecsedy JA, Brown SL, Mikkelsen T, Lehman NL.

Cancer Chemother Pharmacol. 2014 May;73(5):983-90. doi: 10.1007/s00280-014-2430-z. Epub 2014 Mar 14.

11.

Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa.

Tomaras AP, Crandon JL, McPherson CJ, Banevicius MA, Finegan SM, Irvine RL, Brown MF, O'Donnell JP, Nicolau DP.

Antimicrob Agents Chemother. 2013 Sep;57(9):4197-207. doi: 10.1128/AAC.00629-13. Epub 2013 Jun 17.

12.

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.

Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM.

J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18.

PMID:
23735048
13.

Differential expression of aurora-A kinase in T-cell lymphomas.

Kanagal-Shamanna R, Lehman NL, O'Donnell JP, Lim MS, Schultz DS, Chitale DA, Bueso-Ramos CE, Medeiros LJ, Inamdar KV.

Mod Pathol. 2013 May;26(5):640-7. doi: 10.1038/modpathol.2012.211. Epub 2013 Feb 15.

14.

Structural basis for conformational switching and GTP loading of the large G protein atlastin.

Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H.

EMBO J. 2013 Feb 6;32(3):369-84. doi: 10.1038/emboj.2012.353. Epub 2013 Jan 18.

15.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

McAllister LA, Montgomery JI, Abramite JA, Reilly U, Brown MF, Chen JM, Barham RA, Che Y, Chung SW, Menard CA, Mitton-Fry M, Mullins LM, Noe MC, O'Donnell JP, Oliver RM 3rd, Penzien JB, Plummer M, Price LM, Shanmugasundaram V, Tomaras AP, Uccello DP.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6832-8. doi: 10.1016/j.bmcl.2012.09.058. Epub 2012 Sep 24.

PMID:
23046961
16.

Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

McPherson CJ, Aschenbrenner LM, Lacey BM, Fahnoe KC, Lemmon MM, Finegan SM, Tadakamalla B, O'Donnell JP, Mueller JP, Tomaras AP.

Antimicrob Agents Chemother. 2012 Dec;56(12):6334-42. doi: 10.1128/AAC.01345-12. Epub 2012 Oct 1.

17.

Effect of linezolid on the 50% lethal dose and 50% protective dose in treatment of infections by Gram-negative pathogens in naive and immunosuppressed mice and on the efficacy of ciprofloxacin in an acute murine model of septicemia.

Marra A, Lamb L, Medina I, George D, Gibson G, Hardink J, Rugg J, Van Deusen J, O'Donnell JP.

Antimicrob Agents Chemother. 2012 Sep;56(9):4671-5. doi: 10.1128/AAC.00276-12. Epub 2012 Jun 18.

18.

Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.

Lehman NL, O'Donnell JP, Whiteley LJ, Stapp RT, Lehman TD, Roszka KM, Schultz LR, Williams CJ, Mikkelsen T, Brown SL, Ecsedy JA, Poisson LM.

Cell Cycle. 2012 Feb 1;11(3):489-502. doi: 10.4161/cc.11.3.18996. Epub 2012 Feb 1.

19.

Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

Flanagan ME, Brickner SJ, Lall M, Casavant J, Deschenes L, Finegan SM, George DM, Granskog K, Hardink JR, Huband MD, Hoang T, Lamb L, Marra A, Mitton-Fry M, Mueller JP, Mullins LM, Noe MC, O'Donnell JP, Pattavina D, Penzien JB, Schuff BP, Sun J, Whipple DA, Young J, Gootz TD.

ACS Med Chem Lett. 2011 Mar 2;2(5):385-90. doi: 10.1021/ml200012f. eCollection 2011 May 12.

20.

Regulators of ribonucleotide reductase inhibit Ty1 mobility in saccharomyces cerevisiae.

O'Donnell JP, Gehman M, Keeney JB.

Mob DNA. 2010 Nov 22;1(1):23. doi: 10.1186/1759-8753-1-23.

21.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME.

J Med Chem. 2009 Dec 10;52(23):7446-57. doi: 10.1021/jm900729s.

PMID:
19775168
22.

Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.

Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.

Chem Res Toxicol. 2007 Oct;20(10):1488-97. Epub 2007 Sep 25.

PMID:
17892269
23.

Health-related quality of life measured by the UW-QoL--reference values from a general dental practice.

Rogers SN, O'donnell JP, Williams-Hewitt S, Christensen JC, Lowe D.

Oral Oncol. 2006 Mar;42(3):281-7. Epub 2005 Nov 2.

PMID:
16263326
24.

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP.

Curr Drug Metab. 2005 Jun;6(3):161-225. Review.

PMID:
15975040
25.

Metabolism, pharmacokinetics, tissue distribution, and excretion of [14C]CP-424391 in rats.

Khojasteh-Bakht SC, O'donnell JP, Fouda HG, Potchoiba MJ.

Drug Metab Dispos. 2005 Jan;33(1):190-9. Epub 2004 Oct 14.

PMID:
15486077
26.

The protean face of renal sarcoid.

Carmichael P, O'Donnell JP.

J Nephrol. 2003 Sep-Oct;16(5):721-7.

PMID:
14733420
27.

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.

O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS.

Drug Metab Dispos. 2003 Nov;31(11):1369-77.

PMID:
14570769
28.

Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats.

Rowe WB, O'Donnell JP, Pearson D, Rose GM, Meaney MJ, Quirion R.

Behav Brain Res. 2003 Oct 17;145(1-2):171-8.

PMID:
14529815
29.

An unusual presentation of sarcoidosis.

Carmichael P, O'Donnell JP.

Clin Nephrol. 2003 Jul;60(1):58-9. No abstract available.

PMID:
12872860
30.

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.

Kalgutkar AS, Dalvie DK, O'Donnell JP, Taylor TJ, Sahakian DC.

Curr Drug Metab. 2002 Aug;3(4):379-424. Review.

PMID:
12093357
31.

Biotransformation reactions of five-membered aromatic heterocyclic rings.

Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP.

Chem Res Toxicol. 2002 Mar;15(3):269-99. Review. No abstract available.

PMID:
11896674
32.

Assessing adult ADHD using a self-report symptom checklist.

O'Donnell JP, McCann KK, Pluth S.

Psychol Rep. 2001 Jun;88(3 Pt 1):871-81.

PMID:
11508038
33.

(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes.

Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS.

Drug Metab Dispos. 2000 Oct;28(10):1187-91.

PMID:
10997938
34.

Managed care organizations' arrangements with nurse practitioners: a Connecticut perspective.

O'Donnell JP, Cohen SS, Mason DJ, Baxter K, Chase AB.

Conn Nurs News. 1998 Mar-May;71(1):19-20.

PMID:
10614235
35.
36.

Characterization of polar urinary metabolites by ionspray tandem mass spectrometry following dansylation.

Dalvie DK, O'Donnell JP.

Rapid Commun Mass Spectrom. 1998;12(8):419-22.

PMID:
9586229
37.

Metabolism of droloxifene in the CD-1 mouse, Fischer-344 rat and cynomolgus monkey.

O'Donnell JP, Khosla NB, Dalvie DK.

Xenobiotica. 1998 Feb;28(2):153-66.

PMID:
9522440
38.

Managed care organizations' arrangements with nurse practitioners.

Mason DJ, Cohen SS, O'Donnell JP, Baxter K, Chase AB.

Nurs Econ. 1997 Nov-Dec;15(6):306-14.

PMID:
9416097
39.

Health plans and state tort liability.

Saccoccio L, O'Donnell JP.

Manag Care Interface. 1998 Jan;11(1):67-70.

PMID:
10178974
40.

11-Ketotigogenin cellobioside (pamaqueside): a potent cholesterol absorption inhibitor in the hamster.

McCarthy PA, DeNinno MP, Morehouse LA, Chandler CE, Bangerter FW, Wilson TC, Urban FJ, Walinsky SW, Cosgrove PG, Duplantier K, Etienne JB, Fowler MA, Lambert JF, O'Donnell JP, Pezzullo SL, Watson HA Jr, Wilkins RW, Zaccaro LM, Zawistoski MP.

J Med Chem. 1996 May 10;39(10):1935-7. No abstract available.

PMID:
8642548
41.
42.

Clinical management of traumatized anterior permanent teeth.

O'Donnell JP.

J Mass Dent Soc. 1994 Fall;43(4):30, 33-8, 43 passim. Review. No abstract available.

PMID:
9509011
43.

Dental care for special needs individuals: a new barrier to access.

O'Donnell JP.

Spec Care Dentist. 1994 Sep-Oct;14(5):178-9. No abstract available.

PMID:
7754451
44.

Construct validity of neuropsychological tests of conceptual and attentional abilities.

O'Donnell JP, Macgregor LA, Dabrowski JJ, Oestreicher JM, Romero JJ.

J Clin Psychol. 1994 Jul;50(4):596-600.

PMID:
7983209
45.

Bioequivalence of two methotrexate formulations in psoriatic and cancer patients.

Teresi ME, Riggs CE, Webster PM, Adams MJ, Noonan PK, O'Donnell JP.

Ann Pharmacother. 1993 Dec;27(12):1434-8.

PMID:
8305770
46.

Characterization of two forms of cationic peroxidase from cultured peanut cells.

O'Donnell JP, Wan L, van Huystee RB.

Biochem Cell Biol. 1992 Feb;70(2):166-9.

PMID:
1510827
47.

Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.

Colby HD, O'Donnell JP, Flowers NL, Kossor DC, Johnson PB, Levitt M.

Toxicology. 1991 Apr 8;67(2):143-54.

PMID:
2031249
48.

Cosolvency of dimethyl isosorbide for steroid solubility.

Zia H, Ma JK, O'Donnell JP, Luzzi LA.

Pharm Res. 1991 Apr;8(4):502-4.

PMID:
1871047
50.

Standards for temporomandibular evaluation in the pediatric patient.

Okeson JP, O'Donnell JP.

Pediatr Dent. 1989 Dec;11(4):329-30. No abstract available.

PMID:
2639330

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