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Resting VE/VCO2 adds to inspiratory capacity to predict the burden of exertional dyspnea in COPD.

Neder JA, Berton DC, Marillier M, Bernard AC, de Torres JP, O'Donnell DE.

Eur Respir J. 2020 Mar 17. pii: 1902434. doi: 10.1183/13993003.02434-2019. [Epub ahead of print] No abstract available.


Integrating measurements of pulmonary gas exchange to answer clinically relevant questions.

Neder JA, Berton DC, O'Donnell DE.

J Bras Pneumol. 2020 Mar 2;46(1):e20200019. doi: 10.1590/1806-3713/e20200019. English, Portuguese. No abstract available.


Identification and definition of asthma-COPD overlap: The CanCOLD study.

Barrecheguren M, Pinto L, Mostafavi-Pour-Manshadi SM, Tan WC, Li PZ, Aaron SD, Benedetti A, Chapman KR, Walker B, Fitzgerald JM, Hernandez P, Maltais F, Marciniuk DD, O'Donnell DE, Sin DD, Bourbeau J; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network.

Respirology. 2020 Feb 16. doi: 10.1111/resp.13780. [Epub ahead of print]


Practical challenges of diagnosing obstruction in the presence of restriction.

Neder JA, O'Donnell DE, Berton DC.

J Bras Pneumol. 2019 Dec 13;45(5):e20190318. doi: 10.1590/1806-3713/e20190318. English, Portuguese. No abstract available.


The enigma of dyspnoea in COPD: A physiological perspective.

O'Donnell DE, Neder JA.

Respirology. 2020 Feb;25(2):134-136. doi: 10.1111/resp.13736. Epub 2019 Nov 26. No abstract available.


Exertional dyspnoea-ventilation relationship to discriminate respiratory from cardiac impairment.

Plachi F, Balzan FM, Fröhlich LF, Gass R, Mendes NB, Schroeder E, Berton DC, O'Donnell DE, Neder JA.

Eur Respir J. 2020 Mar 12;55(3). pii: 1901518. doi: 10.1183/13993003.01518-2019. Print 2020 Mar. No abstract available.


Impact of a Specialized Ambulatory Clinic on Refractory Breathlessness in Subjects With Advanced COPD.

Elbehairy AF, McIsaac H, Hill E, Norman PA, Day AG, Neder JA, O'Donnell DE, Harle IA.

Respir Care. 2020 Apr;65(4):444-454. doi: 10.4187/respcare.06950. Epub 2019 Nov 12.


On the complexities of measuring exercise "ventilatory efficiency" in obstructive lung diseases.

Neder JA, Di Paolo M, O'Donnell DE, Palange P.

Pediatr Pulmonol. 2020 Feb;55(2):280-282. doi: 10.1002/ppul.24556. Epub 2019 Nov 4. No abstract available.


Dyspnea in COPD: New Mechanistic Insights and Management Implications.

O'Donnell DE, Milne KM, James MD, de Torres JP, Neder JA.

Adv Ther. 2020 Jan;37(1):41-60. doi: 10.1007/s12325-019-01128-9. Epub 2019 Oct 30. Review.


Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema.

Costa CM, Neder JA, Verrastro CG, Paula-Ribeiro M, Ramos R, Ferreira EM, Nery LE, O'Donnell DE, Pereira CAC, Ota-Arakaki J.

Eur Respir J. 2020 Jan 30;55(1). pii: 1901319. doi: 10.1183/13993003.01319-2019. Print 2020 Jan.


Physiological and perceptual responses to exercise according to locus of symptom limitation in COPD.

Tracey L, Lewthwaite H, Abdallah SJ, Murray S, Wilkinson-Maitland CA, Donovan A, Maltais F, O'Donnell DE, Bourbeau J, Smith BM, Jensen D; Canadian Respiratory Research Network (CRRN).

Respir Physiol Neurobiol. 2020 Feb;273:103322. doi: 10.1016/j.resp.2019.103322. Epub 2019 Oct 17.


Prescription Synthetic Oral Cannabinoid use Among Older Adults with Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study.

Vozoris NT, Yao Z, Li P, Austin PC, Stephenson AL, Gill SS, O'Donnell DE, Gershon AS, Rochon PA.

Drugs Aging. 2019 Nov;36(11):1035-1045. doi: 10.1007/s40266-019-00707-3.


Effects of lung deflation induced by tiotropium/olodaterol on the cardiocirculatory responses to exertion in COPD.

Berton DC, Marques RD, Palmer B, O'Donnell DE, Neder JA.

Respir Med. 2019 Oct;157:59-68. doi: 10.1016/j.rmed.2019.09.006. Epub 2019 Sep 10.


Why we should never ignore an "isolated" low lung diffusing capacity.

Neder JA, Berton DC, O'Donnell DE.

J Bras Pneumol. 2019 Sep 5;45(4):e20190241. doi: 10.1590/1806-3713/e20190241. English, Portuguese. No abstract available.


Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.

Elbehairy AF, O'Donnell CD, Abd Elhameed A, Vincent SG, Milne KM, James MD, Webb KA, Neder JA, O'Donnell DE; Canadian Respiratory Research Network.

J Appl Physiol (1985). 2019 Oct 1;127(4):1107-1116. doi: 10.1152/japplphysiol.00341.2019. Epub 2019 Aug 1.


Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.

Muller PT, Barbosa GW, O'Donnell DE, Neder JA.

Front Physiol. 2019 Jul 10;10:859. doi: 10.3389/fphys.2019.00859. eCollection 2019. Review.


Inspiratory Constraints and Ventilatory Inefficiency Are Superior to Breathing Reserve in the Assessment of Exertional Dyspnea in COPD.

Neder JA, Berton DC, Marillier M, Bernard AC, O'Donnell DE; Canadian Respiratory Research Network.

COPD. 2019 Apr;16(2):174-181. doi: 10.1080/15412555.2019.1631776. Epub 2019 Jul 5. Erratum in: COPD. 2019 Dec;16(5-6):429.


Uncovering the beneficial effects of inhaled bronchodilator in COPD: beyond forced spirometry.

Neder JA, Berton DC, O'Donnell DE.

J Bras Pneumol. 2019 Jun 27;45(3):e20190168. doi: 10.1590/1806-3713/e20190168. English, Portuguese. No abstract available.


Chronic respiratory diseases: The dawn of precision rehabilitation.

O'Donnell DE, Neder JA.

Respirology. 2019 Sep;24(9):826-827. doi: 10.1111/resp.13640. Epub 2019 Jul 4. No abstract available.


Activity-related dyspnea in chronic obstructive pulmonary disease: physical and psychological consequences, unmet needs, and future directions.

Hanania NA, O'Donnell DE.

Int J Chron Obstruct Pulmon Dis. 2019 May 24;14:1127-1138. doi: 10.2147/COPD.S188141. eCollection 2019. Review.


Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.

Shorofsky M, Bourbeau J, Kimoff J, Jen R, Malhotra A, Ayas N, Tan WC, Aaron SD, Sin DD, Road J, Chapman KR, O'Donnell DE, Maltais F, Hernandez P, Walker BL, Marciniuk D, Kaminska M; Canadian Respiratory Research Network; CanCOLD Collaborative Research group.

Chest. 2019 Nov;156(5):852-863. doi: 10.1016/j.chest.2019.04.132. Epub 2019 May 28.


The Integrative Physiology of Exercise Training in Patients with COPD.

Neder JA, Marillier M, Bernard AC, James MD, Milne KM, O'Donnell DE.

COPD. 2019 Apr;16(2):182-195. doi: 10.1080/15412555.2019.1606189. Epub 2019 May 16.


Why Clinical Physiology Remains Vital in the Modern Era.

O'Donnell DE, Neder JA.

Clin Chest Med. 2019 Jun;40(2):xiii-xiv. doi: 10.1016/j.ccm.2019.03.001. No abstract available.


Unraveling the Causes of Unexplained Dyspnea: The Value of Exercise Testing.

O'Donnell DE, Milne KM, Vincent SG, Neder JA.

Clin Chest Med. 2019 Jun;40(2):471-499. doi: 10.1016/j.ccm.2019.02.014. Review.


Clinical and Physiologic Implications of Negative Cardiopulmonary Interactions in Coexisting Chronic Obstructive Pulmonary Disease-Heart Failure.

Neder JA, Rocha A, Berton DC, O'Donnell DE.

Clin Chest Med. 2019 Jun;40(2):421-438. doi: 10.1016/j.ccm.2019.02.006. Review.


The Pathophysiology of Dyspnea and Exercise Intolerance in Chronic Obstructive Pulmonary Disease.

O'Donnell DE, James MD, Milne KM, Neder JA.

Clin Chest Med. 2019 Jun;40(2):343-366. doi: 10.1016/j.ccm.2019.02.007. Review.


Incorporating Lung Diffusing Capacity for Carbon Monoxide in Clinical Decision Making in Chest Medicine.

Neder JA, Berton DC, Muller PT, O'Donnell DE.

Clin Chest Med. 2019 Jun;40(2):285-305. doi: 10.1016/j.ccm.2019.02.005. Review.


Transfer coefficient of the lung for carbon monoxide and the accessible alveolar volume: clinically useful if used wisely.

Neder JA, Marillier M, Bernard AC, O'Donnell DE.

Breathe (Sheff). 2019 Mar;15(1):69-76. doi: 10.1183/20734735.0345-2018.


Is the Slow Vital Capacity Clinically Useful to Uncover Airflow Limitation in Subjects With Preserved FEV1/FVC Ratio?

Saint-Pierre M, Ladha J, Berton DC, Reimao G, Castelli G, Marillier M, Bernard AC, O'Donnell DE, Neder JA.

Chest. 2019 Sep;156(3):497-506. doi: 10.1016/j.chest.2019.02.001. Epub 2019 Feb 12.


Exercise intolerance in comorbid COPD and heart failure: the role of impaired aerobic function.

Rocha A, Arbex FF, Sperandio PA, Mancuso F, Marillier M, Bernard AC, Alencar MCN, O'Donnell DE, Neder JA.

Eur Respir J. 2019 Apr 18;53(4). pii: 1802386. doi: 10.1183/13993003.02386-2018. Print 2019 Apr.


Ventilatory Demand During Stepping and Running: Implications for Exercise-Induced Bronchoconstriction in Children.

Selman JP, Lanza FC, Wandalsen GF, Solé D, O'Donnell DE, Neder JA, Dal Corso S.

Respir Care. 2019 Apr;64(4):445-452. doi: 10.4187/respcare.06363. Epub 2019 Feb 5.


Psychological distress is related to poor health behaviours in COPD and non-COPD patients: Evidence from the CanCOLD study.

Paine NJ, Bacon SL, Bourbeau J, Tan WC, Lavoie KL; CanCOLD Study Investigators, Aaron SD, Chapman KR, FitzGerald JM, Hernandez P, Marciniuk DD, Maltais F, O'Donnell DE, Sin D, Walker BL; Canadian Respiratory Research Network and teh CanCOLD Collaborative Research Group.

Respir Med. 2019 Jan;146:1-9. doi: 10.1016/j.rmed.2018.11.006. Epub 2018 Nov 15.


Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD.

Maltais F, Aumann JL, Kirsten AM, Nadreau É, Macesic H, Jin X, Hamilton A, O'Donnell DE.

Eur Respir J. 2019 Mar 28;53(3). pii: 1802049. doi: 10.1183/13993003.02049-2018. Print 2019 Mar.


Severe Exertional Dyspnea in an Ex-Smoker with a Large Apical Bulla.

Elbehairy AF, Faisal A, Ciavaglia CE, Kwok C, Reid K, Vincent SG, Domnik NJ, Neder JA, O'Donnell DE.

Ann Am Thorac Soc. 2018 Oct;15(10):1221-1228. doi: 10.1513/AnnalsATS.201804-288CC. No abstract available.


Heart or Lungs? Uncovering the Causes of Exercise Intolerance in a Patient with Chronic Cardiopulmonary Disease.

Rocha A, Arbex FF, Sperandio PA, Mancuso F, Alencar MCN, Souza A, Biazzim L, O'Donnell DE, Neder JA.

Ann Am Thorac Soc. 2018 Sep;15(9):1096-1104. doi: 10.1513/AnnalsATS.201802-073CC. No abstract available.


Current challenges in managing comorbid heart failure and COPD.

Neder JA, Rocha A, Alencar MCN, Arbex F, Berton DC, Oliveira MF, Sperandio PA, Nery LE, O'Donnell DE.

Expert Rev Cardiovasc Ther. 2018 Sep;16(9):653-673. doi: 10.1080/14779072.2018.1510319. Epub 2018 Sep 3. Review.


The diagnostic performance of patient symptoms in screening for COPD.

Johnson KM, Tan WC, Bourbeau J, Sin DD, Sadatsafavi M; Canadian Cohort of Obstructive Lung Disease (CanCOLD) study and the Canadian Respiratory Research Network.

Respir Res. 2018 Aug 3;19(1):147. doi: 10.1186/s12931-018-0853-5.


Serotonergic antidepressant use and morbidity and mortality among older adults with COPD.

Vozoris NT, Wang X, Austin PC, Stephenson AL, O'Donnell DE, Gershon AS, Gill SS, Rochon PA.

Eur Respir J. 2018 Jul 27;52(1). pii: 1800475. doi: 10.1183/13993003.00475-2018. Print 2018 Jul.


Increasing Physical Activity in Chronic Obstructive Pulmonary Disease One Step at a Time.

O'Donnell DE.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):977-978. doi: 10.1164/rccm.201804-0755ED. No abstract available.


Correction to: Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis.

Di Marco F, Sotgiu G, Santus P, O'Donnell DE, Beeh KM, Dore S, Roggi MA, Giuliani L, Blasi F, Centanni S.

Respir Res. 2018 Apr 24;19(1):70. doi: 10.1186/s12931-018-0764-5.


Acute bronchodilator therapy does not reduce wasted ventilation during exercise in COPD.

Elbehairy AF, Webb KA, Laveneziana P, Domnik NJ, Neder JA, O'Donnell DE; Canadian Respiratory Research Network (CRRN).

Respir Physiol Neurobiol. 2018 Jun;252-253:64-71. doi: 10.1016/j.resp.2018.03.012. Epub 2018 Mar 22.


Inspiratory muscle training reduces diaphragm activation and dyspnea during exercise in COPD.

Langer D, Ciavaglia C, Faisal A, Webb KA, Neder JA, Gosselink R, Dacha S, Topalovic M, Ivanova A, O'Donnell DE.

J Appl Physiol (1985). 2018 Aug 1;125(2):381-392. doi: 10.1152/japplphysiol.01078.2017. Epub 2018 Mar 15.


Systemic vascular dysfunction is associated with emphysema burden in mild COPD.

Zelt JT, Jones JH, Hirai DM, King TJ, Berton DC, Pyke KE, O'Donnell DE, Neder JA.

Respir Med. 2018 Mar;136:29-36. doi: 10.1016/j.rmed.2018.01.007. Epub 2018 Jan 12.


A Simplified Approach to Select Exercise Endurance Intensity for Interventional Studies in COPD.

Degani-Costa LH, O'Donnell DE, Webb K, Aranda LC, Carlstron JP, Cesar TDS, Plachi F, Berton DC, Neder JA, Nery LE.

COPD. 2018 Apr;15(2):139-147. doi: 10.1080/15412555.2018.1428944. Epub 2018 Feb 27.


Effect of tiotropium on spontaneous expiratory flow-volume curves during exercise in GOLD 1-2 COPD.

Porszasz J, Carraro N, Cao R, Gore A, Ma S, Jiang T, Maltais F, Ferguson GT, O'Donnell DE, Shaikh A, Rossiter HB, Casaburi R.

Respir Physiol Neurobiol. 2018 May;251:8-15. doi: 10.1016/j.resp.2018.02.006. Epub 2018 Feb 10.


Excess ventilation in COPD: Implications for dyspnoea and tolerance to interval exercise.

Bravo DM, Gimenes AC, Amorim BC, Alencar MC, Berton DC, O'Donnell DE, Nery LE, Neder JA.

Respir Physiol Neurobiol. 2018 Apr;250:7-13. doi: 10.1016/j.resp.2018.01.013. Epub 2018 Jan 31.


Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis.

Di Marco F, Sotgiu G, Santus P, O'Donnell DE, Beeh KM, Dore S, Roggi MA, Giuliani L, Blasi F, Centanni S.

Respir Res. 2018 Jan 24;19(1):18. doi: 10.1186/s12931-018-0721-3. Review. Erratum in: Respir Res. 2018 Apr 24;19(1):70.


Unraveling the Cause of Severe Exertional Dyspnea in a Heavy Smoker.

Elbehairy AF, Hockmann K, Ciavaglia CE, Faisal A, Hill E, Webb KA, Neder JA, O'Donnell DE.

Ann Am Thorac Soc. 2017 Dec;14(12):1849-1855. doi: 10.1513/AnnalsATS.201705-382CC. No abstract available.


Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Dürr S, Fernandez-Villar A, Groenen MTJ, Guimarães M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003. Review.


Activity-Related Dyspnoea in Chronic Pulmonary Diseases: New Mechanistic Insights.

O'Donnell DE.

Tanaffos. 2017;16(Suppl 1):S5-S6. No abstract available.

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