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Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role.

Venanzi Rullo E, Cannon L, Pinzone MR, Ceccarelli M, Nunnari G, O'Doherty U.

Clin Infect Dis. 2019 Nov 27;69(12):2236-2237. doi: 10.1093/cid/ciz378. No abstract available.


Heavy metal protease takes a tiki torch to HIV assembly.

O'Doherty U, Freed EO.

Nat Immunol. 2019 Jun;20(6):668-669. doi: 10.1038/s41590-019-0387-0. No abstract available.


Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.

Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U.

Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7.


More efficient exchange of sickle red blood cells can be achieved by exchanging the densest red blood cells: An ex vivo proof of concept study.

Thibodeaux SR, Tanhehco YC, Irwin L, Jamensky L, Schell K, O'Doherty U.

Transfus Apher Sci. 2019 Feb;58(1):100-106. doi: 10.1016/j.transci.2018.12.005. Epub 2019 Jan 2.


Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR.

Lada SM, Huang K, VanBelzen DJ, Montaner LJ, O'Doherty U, Richman DD.

J Clin Microbiol. 2018 Nov 27;56(12). pii: e01158-18. doi: 10.1128/JCM.01158-18. Print 2018 Dec.


HLA-C downregulation by HIV-1 adapts to host HLA genotype.

Bachtel ND, Umviligihozo G, Pickering S, Mota TM, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini CS, Cerqueira NB, O'Doherty UT, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R.

PLoS Pathog. 2018 Sep 4;14(9):e1007257. doi: 10.1371/journal.ppat.1007257. eCollection 2018 Sep.


Clinical use of lentiviral vectors.

Milone MC, O'Doherty U.

Leukemia. 2018 Jul;32(7):1529-1541. doi: 10.1038/s41375-018-0106-0. Epub 2018 Mar 22. Review.


HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome.

Natesampillai S, Cummins NW, Nie Z, Sampath R, Baker JV, Henry K, Pinzone M, O'Doherty U, Polley EC, Bren GD, Katzmann DJ, Badley AD.

J Virol. 2018 Jun 13;92(13). pii: e00037-18. doi: 10.1128/JVI.00037-18. Print 2018 Jul 1.


Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA.

Strongin Z, Sharaf R, VanBelzen DJ, Jacobson JM, Connick E, Volberding P, Skiest DJ, Gandhi RT, Kuritzkes DR, O'Doherty U, Li JZ.

J Virol. 2018 May 29;92(12). pii: e00285-18. doi: 10.1128/JVI.00285-18. Print 2018 Jun 15.


Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained.

Pinzone MR, O'Doherty U.

Retrovirology. 2018 Feb 17;15(1):22. doi: 10.1186/s12977-018-0396-3. Review.


Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs.

Baxter AE, O'Doherty U, Kaufmann DE.

Retrovirology. 2018 Feb 2;15(1):18. doi: 10.1186/s12977-018-0392-7. Review.


Rapid prediction of stem cell mobilization using volume and conductivity data from automated hematology analyzers.

Villa CH, Porturas T, Sell M, Wall M, DeLeo G, Fetters J, Mignono S, Irwin L, Hwang WT, O'Doherty U.

Transfusion. 2018 Feb;58(2):330-338. doi: 10.1111/trf.14449. Epub 2017 Dec 11.


Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs.

Tapia G, Højen JF, Ökvist M, Olesen R, Leth S, Nissen SK, VanBelzen DJ, O'Doherty U, Mørk A, Krogsgaard K, Søgaard OS, Østergaard L, Tolstrup M, Pantaleo G, Sommerfelt MA.

J Infect. 2017 Dec;75(6):555-571. doi: 10.1016/j.jinf.2017.09.004. Epub 2017 Sep 14.


Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.

Mavigner M, Lee ST, Habib J, Robinson C, Silvestri G, O'Doherty U, Chahroudi A.

J Virus Erad. 2016 Oct 5;2(4):219-226.


Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.

Pinzone MR, Graf E, Lynch L, McLaughlin B, Hecht FM, Connors M, Migueles SA, Hwang WT, Nunnari G, O'Doherty U.

J Virol. 2016 Nov 14;90(23):10436-10445. doi: 10.1128/JVI.00242-16. Print 2016 Dec 1.


Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.

Lee SA, Bacchetti P, Chomont N, Fromentin R, Lewin SR, O'Doherty U, Palmer S, Richman DD, Siliciano JD, Yukl SA, Deeks SG, Burbelo PD.

PLoS One. 2016 Aug 2;11(8):e0160192. doi: 10.1371/journal.pone.0160192. eCollection 2016.


Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy.

Imamichi H, Dewar RL, Adelsberger JW, Rehm CA, O'Doherty U, Paxinos EE, Fauci AS, Lane HC.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8783-8. doi: 10.1073/pnas.1609057113. Epub 2016 Jul 18.


Minor Contribution of Chimeric Host-HIV Readthrough Transcripts to the Level of HIV Cell-Associated gag RNA.

Pasternak AO, DeMaster LK, Kootstra NA, Reiss P, O'Doherty U, Berkhout B.

J Virol. 2015 Nov 11;90(2):1148-51. doi: 10.1128/JVI.02597-15. Print 2016 Jan 15.


A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy.

DeMaster LK, Liu X, VanBelzen DJ, Trinité B, Zheng L, Agosto LM, Migueles SA, Connors M, Sambucetti L, Levy DN, Pasternak AO, O'Doherty U.

J Virol. 2015 Nov 4;90(5):2165-79. doi: 10.1128/JVI.01913-15.


A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

Procopio FA, Fromentin R, Kulpa DA, Brehm JH, Bebin AG, Strain MC, Richman DD, O'Doherty U, Palmer S, Hecht FM, Hoh R, Barnard RJ, Miller MD, Hazuda DJ, Deeks SG, Sékaly RP, Chomont N.

EBioMedicine. 2015 Jun 27;2(8):874-83. doi: 10.1016/j.ebiom.2015.06.019. eCollection 2015 Aug.


Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.

Aqui N, O'Doherty U.

Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):457-60. doi: 10.1182/asheducation-2014.1.457. Epub 2014 Nov 18. Review.


CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.

Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG.

PLoS One. 2014 Oct 23;9(10):e110731. doi: 10.1371/journal.pone.0110731. eCollection 2014.


Association between mobilization regimen and PFS after auto-SCT for multiple myeloma.

Garfall AL, Dougherty AL, Vogl DT, Weiss BM, Cohen AD, Mick R, O'Doherty U, Stadtmauer EA.

Bone Marrow Transplant. 2014 Nov;49(11):1439-41. doi: 10.1038/bmt.2014.153. Epub 2014 Jul 21. No abstract available.


Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of poisson statistics.

De Spiegelaere W, Malatinkova E, Lynch L, Van Nieuwerburgh F, Messiaen P, O'Doherty U, Vandekerckhove L.

Clin Chem. 2014 Jun;60(6):886-95. doi: 10.1373/clinchem.2013.219378. Epub 2014 Mar 24.


Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG.

PLoS Pathog. 2013;9(10):e1003691. doi: 10.1371/journal.ppat.1003691. Epub 2013 Oct 10.


HIV latency and integration site placement in five cell-based models.

Sherrill-Mix S, Lewinski MK, Famiglietti M, Bosque A, Malani N, Ocwieja KE, Berry CC, Looney D, Shan L, Agosto LM, Pace MJ, Siliciano RF, O'Doherty U, Guatelli J, Planelles V, Bushman FD.

Retrovirology. 2013 Aug 16;10:90. doi: 10.1186/1742-4690-10-90.


Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected].

Graf EH, Pace MJ, Peterson BA, Lynch LJ, Chukwulebe SB, Mexas AM, Shaheen F, Martin JN, Deeks SG, Connors M, Migueles SA, O'Doherty U.

PLoS One. 2013 Aug 7;8(8):e71879. doi: 10.1371/journal.pone.0071879. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/3aa92c3d-b6dd-4c6e-8cee-9587ce80a9c9.


Improved treatment for primary HIV infection by interferon-alfa therapy? Does HCV treatment in HIV/HCV coinfected patients help us to test this hypothesis? Reply to zur Wiesch and van Lunzen.

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, O'Doherty U, Kostman J, Montaner LJ.

J Infect Dis. 2013 Jul 15;208(2):363. doi: 10.1093/infdis/jit160. Epub 2013 Apr 9. No abstract available.


Hematopoietic stem cells and HIV infection.

Pace M, O'Doherty U.

J Infect Dis. 2013 Jun 15;207(12):1790-2. doi: 10.1093/infdis/jit120. Epub 2013 Apr 3. No abstract available.


HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.

Pace MJ, Graf EH, O'Doherty U.

Virology. 2013 Jun 20;441(1):18-21. doi: 10.1016/j.virol.2013.02.028. Epub 2013 Mar 26.


Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD.

PLoS Pathog. 2013 Feb;9(2):e1003174. doi: 10.1371/journal.ppat.1003174. Epub 2013 Feb 14.


The evolving role of plerixafor in hematopoietic progenitor cell mobilization.

Tanhehco YC, Vogl DT, Stadtmauer EA, O'Doherty U.

Transfusion. 2013 Oct;53(10):2314-26. doi: 10.1111/trf.12102. Epub 2013 Jan 30. Review.


Quantitation of HIV DNA integration: effects of differential integration site distributions on Alu-PCR assays.

Brady T, Kelly BJ, Male F, Roth S, Bailey A, Malani N, Gijsbers R, O'Doherty U, Bushman FD.

J Virol Methods. 2013 Apr;189(1):53-7. doi: 10.1016/j.jviromet.2013.01.004. Epub 2013 Jan 21.


Quantitation of integrated proviral DNA in viral reservoirs.

Graf EH, O'Doherty U.

Curr Opin HIV AIDS. 2013 Mar;8(2):100-5. doi: 10.1097/COH.0b013e32835d8132. Review.


American Society for Apheresis white paper: considerations for medical staff apheresis medicine physician credentialing and privileging.

Andrzejewski C Jr, Linz W, Hofmann J, O'Doherty U, Robinson RS, Arepally GM, Golden P.

J Clin Apher. 2012;27(6):330-5. doi: 10.1002/jca.21250. Epub 2012 Nov 2.


Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration.

Azzoni L, Foulkes AS, Papasavvas E, Mexas AM, Lynn KM, Mounzer K, Tebas P, Jacobson JM, Frank I, Busch MP, Deeks SG, Carrington M, O'Doherty U, Kostman J, Montaner LJ.

J Infect Dis. 2013 Jan 15;207(2):213-22. doi: 10.1093/infdis/jis663. Epub 2012 Oct 26.


Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials.

Mexas AM, Graf EH, Pace MJ, Yu JJ, Papasavvas E, Azzoni L, Busch MP, Di Mascio M, Foulkes AS, Migueles SA, Montaner LJ, O'Doherty U.

AIDS. 2012 Nov 28;26(18):2295-306. doi: 10.1097/QAD.0b013e32835a5c2f.


Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency.

Pace MJ, Graf EH, Agosto LM, Mexas AM, Male F, Brady T, Bushman FD, O'Doherty U.

PLoS Pathog. 2012;8(7):e1002818. doi: 10.1371/journal.ppat.1002818. Epub 2012 Jul 26.


Towards an HIV cure: a global scientific strategy.

International AIDS Society Scientific Working Group on HIV Cure, Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barré-Sinoussi F.

Nat Rev Immunol. 2012 Jul 20;12(8):607-14. doi: 10.1038/nri3262. Review.


Comprehensive analysis of unique cases with extraordinary control over HIV replication.

Mendoza D, Johnson SA, Peterson BA, Natarajan V, Salgado M, Dewar RL, Burbelo PD, Doria-Rose NA, Graf EH, Greenwald JH, Hodge JN, Thompson WL, Cogliano NA, Chairez CL, Rehm CA, Jones S, Hallahan CW, Kovacs JA, Sereti I, Sued O, Peel SA, O'Connell RJ, O'Doherty U, Chun TW, Connors M, Migueles SA.

Blood. 2012 May 17;119(20):4645-55. doi: 10.1182/blood-2011-10-381996. Epub 2012 Apr 5.


Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.

Graf EH, Mexas AM, Yu JJ, Shaheen F, Liszewski MK, Di Mascio M, Migueles SA, Connors M, O'Doherty U.

PLoS Pathog. 2011 Feb;7(2):e1001300. doi: 10.1371/journal.ppat.1001300. Epub 2011 Feb 24. Erratum in: PLoS Pathog. 2011 Mar;7(3). doi: 10.1371/annotation/0d21de23-d44c-49c0-9a9f-53d421648cbf.


HIV reservoirs and latency models.

Pace MJ, Agosto L, Graf EH, O'Doherty U.

Virology. 2011 Mar 15;411(2):344-54. doi: 10.1016/j.virol.2010.12.041. Epub 2011 Feb 1. Review.


R5 HIV env and vesicular stomatitis virus G protein cooperate to mediate fusion to naive CD4+ T Cells.

Pace MJ, Agosto L, O'Doherty U.

J Virol. 2011 Jan;85(1):644-8. doi: 10.1128/JVI.01851-10. Epub 2010 Oct 27.


Patients on HAART often have an excess of unintegrated HIV DNA: implications for monitoring reservoirs.

Agosto LM, Liszewski MK, Mexas A, Graf E, Pace M, Yu JJ, Bhandoola A, O'Doherty U.

Virology. 2011 Jan 5;409(1):46-53. doi: 10.1016/j.virol.2010.08.024.


Plerixafor mobilization leads to a lower ratio of CD34+ cells to total nucleated cells which results in greater storage costs.

Tanhehco YC, Adamski J, Sell M, Cunningham K, Eisenmann C, Magee D, Stadtmauer EA, O'Doherty U.

J Clin Apher. 2010;25(4):202-8. doi: 10.1002/jca.20239.


Stem cell collection in patients with multiple myeloma: impact of induction therapy and mobilization regimen.

Nazha A, Cook R, Vogl DT, Mangan PA, Gardler M, Hummel K, Cunningham K, Luger SM, Porter DL, Schuster S, O'Doherty U, Siegel D, Stadtmauer EA.

Bone Marrow Transplant. 2011 Jan;46(1):59-63. doi: 10.1038/bmt.2010.63. Epub 2010 May 3.


HIV integration site distributions in resting and activated CD4+ T cells infected in culture.

Brady T, Agosto LM, Malani N, Berry CC, O'Doherty U, Bushman F.

AIDS. 2009 Jul 31;23(12):1461-71. doi: 10.1097/QAD.0b013e32832caf28.


The CXCR4-tropic human immunodeficiency virus envelope promotes more-efficient gene delivery to resting CD4+ T cells than the vesicular stomatitis virus glycoprotein G envelope.

Agosto LM, Yu JJ, Liszewski MK, Baytop C, Korokhov N, Humeau LM, O'Doherty U.

J Virol. 2009 Aug;83(16):8153-62. doi: 10.1128/JVI.00220-09. Epub 2009 Jun 3.


Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells.

Dai J, Agosto LM, Baytop C, Yu JJ, Pace MJ, Liszewski MK, O'Doherty U.

J Virol. 2009 May;83(9):4528-37. doi: 10.1128/JVI.01910-08. Epub 2009 Feb 11.


Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR.

Liszewski MK, Yu JJ, O'Doherty U.

Methods. 2009 Apr;47(4):254-60. doi: 10.1016/j.ymeth.2009.01.002. Epub 2009 Feb 3. Review.

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