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Comment on "Degradation of the Polymeric Brominated Flame Retardant "Polymeric FR" by Heat and UV Exposure".

Buffey K, Davis JW, Kram S, Lukas C, O'Connor JC, Hunter SE.

Environ Sci Technol. 2019 Sep 17;53(18):11056-11057. doi: 10.1021/acs.est.9b02088. Epub 2019 Sep 5. No abstract available.


Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points.

Kucheryavenko O, Lurman G, Lehmann A, Braz J, Niemann L, Chahoud I, Mantovani A, Håkansson H, Schneider S, Strauss V, Coder PS, Freyberger A, O'Connor JC, Rauch M, Renko K, Solano MLM, Andersson N, Blanck O, Ritz V, Solecki R.

Arch Toxicol. 2019 Apr;93(4):1157-1167. doi: 10.1007/s00204-019-02436-3. Epub 2019 Mar 30.


Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory.

Lu Y, Sareddy GR, Wang J, Wang R, Li Y, Dong Y, Zhang Q, Liu J, O'Connor JC, Xu J, Vadlamudi RK, Brann DW.

J Neurosci. 2019 Apr 10;39(15):2792-2809. doi: 10.1523/JNEUROSCI.1970-18.2019. Epub 2019 Feb 6.


Author response to: Modulating kynurenine monooxygenase in microglia: The need for further characterization.

Garrison AM, Parrott JM, Tunon A, Delgado J, Redus L, O'Connor JC.

Psychoneuroendocrinology. 2018 Dec;98:231-232. doi: 10.1016/j.psyneuen.2018.08.019. Epub 2018 Aug 24. No abstract available.


Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia.

Bhattacharya A, Lord B, Grigoleit JS, He Y, Fraser I, Campbell SN, Taylor N, Aluisio L, O'Connor JC, Papp M, Chrovian C, Carruthers N, Lovenberg TW, Letavic MA.

Neuropsychopharmacology. 2018 Dec;43(13):2586-2596. doi: 10.1038/s41386-018-0141-6. Epub 2018 Jul 9.


Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms.

Rodriguez-Zas SL, Wu C, Southey BR, O'Connor JC, Nixon SE, Garcia R, Zavala C, Lawson M, McCusker RH, Romanova EV, Sweedler JV, Kelley KW, Dantzer R.

Psychoneuroendocrinology. 2018 Nov;97:47-58. doi: 10.1016/j.psyneuen.2018.06.024. Epub 2018 Jun 30.


Management Practices to Build Evidence-Based Decision-Making Capacity for Chronic Disease Prevention in Georgia: A Case Study.

Allen P, O'Connor JC, Best LA, Lakshman M, Jacob RR, Brownson RC.

Prev Chronic Dis. 2018 Jul 12;15:E92. doi: 10.5888/pcd15.170482.


Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.

Garrison AM, Parrott JM, Tuñon A, Delgado J, Redus L, O'Connor JC.

Psychoneuroendocrinology. 2018 Aug;94:1-10. doi: 10.1016/j.psyneuen.2018.04.019. Epub 2018 Apr 22.


GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.

Chen C, Li X, Ge G, Liu J, Biju KC, Laing SD, Qian Y, Ballard C, He Z, Masliah E, Clark RA, O'Connor JC, Li S.

Sci Rep. 2018 Apr 3;8(1):5460. doi: 10.1038/s41598-018-23795-4.


Leading the Way in Preventing Childhood Obesity in Georgia.

Vall EA, Kibbe DL, Greene C, Smith KS, O'Connor JC.

Public Health Rep. 2017 Nov/Dec;132(2_suppl):3S-6S. doi: 10.1177/0033354917722993. No abstract available. Erratum in: Public Health Rep. 2018 Jan/Feb;133(1):NP1.


DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway.

Bai J, Cervantes C, Liu J, He S, Zhou H, Zhang B, Cai H, Yin D, Hu D, Li Z, Chen H, Gao X, Wang F, O'Connor JC, Xu Y, Liu M, Dong LQ, Liu F.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12196-12201. doi: 10.1073/pnas.1708744114. Epub 2017 Oct 30.


Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A.

Brain Behav Immun. 2017 Nov;66:94-102. doi: 10.1016/j.bbi.2017.07.008. Epub 2017 Jul 11.


Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers.

Debnath S, Velagapudi C, Redus L, Thameem F, Kasinath B, Hura CE, Lorenzo C, Abboud HE, O'Connor JC.

Int J Tryptophan Res. 2017 Mar 10;10:1178646917694600. doi: 10.1177/1178646917694600. eCollection 2017.


Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation.

Parrott JM, Redus L, Santana-Coelho D, Morales J, Gao X, O'Connor JC.

Transl Psychiatry. 2016 Oct 18;6(10):e918. doi: 10.1038/tp.2016.200.


Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge.

Parrott JM, Redus L, O'Connor JC.

J Neuroinflammation. 2016 May 27;13(1):124. doi: 10.1186/s12974-016-0590-y.


Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge.

Gonzalez-Pena D, Nixon SE, O'Connor JC, Southey BR, Lawson MA, McCusker RH, Borras T, Machuca D, Hernandez AG, Dantzer R, Kelley KW, Rodriguez-Zas SL.

PLoS One. 2016 Mar 9;11(3):e0150858. doi: 10.1371/journal.pone.0150858. eCollection 2016.


Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain.

Sareddy GR, Zhang Q, Wang R, Scott E, Zou Y, O'Connor JC, Chen Y, Dong Y, Vadlamudi RK, Brann D.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6673-82. doi: 10.1073/pnas.1516729112. Epub 2015 Nov 16.


Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology.

Parrott JM, O'Connor JC.

Front Psychiatry. 2015 Aug 20;6:116. doi: 10.3389/fpsyt.2015.00116. eCollection 2015. Review.


Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+/- Mice: Interleukin-10 and Kynurenic Acid.

Dugan AM, Parrott JM, Redus L, Hensler JG, O'Connor JC.

Int J Neuropsychopharmacol. 2015 Aug 1;19(3):pyv089. doi: 10.1093/ijnp/pyv089.


Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory.

Heisler JM, O'Connor JC.

Brain Behav Immun. 2015 Nov;50:115-124. doi: 10.1016/j.bbi.2015.06.022. Epub 2015 Jun 27.


The attentional set shifting task: a measure of cognitive flexibility in mice.

Heisler JM, Morales J, Donegan JJ, Jett JD, Redus L, O'Connor JC.

J Vis Exp. 2015 Feb 4;(96). doi: 10.3791/51944.


Analytical workflow profiling gene expression in murine macrophages.

Nixon SE, González-Peña D, Lawson MA, McCusker RH, Hernandez AG, O'Connor JC, Dantzer R, Kelley KW, Rodriguez-Zas SL.

J Bioinform Comput Biol. 2015 Apr;13(2):1550010. doi: 10.1142/S0219720015500109. Epub 2015 Jan 14.


Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice.

Mukerji P, Rae JC, Buck RC, O'Connor JC.

Toxicol Rep. 2014 Dec 15;2:130-143. doi: 10.1016/j.toxrep.2014.12.002. eCollection 2015.


Advancing the understanding of behaviors associated with Bacille Calmette Guérin infection using multivariate analysis.

Rodriguez-Zas SL, Nixon SE, Lawson MA, Mccusker RH, Southey BR, O'Connor JC, Dantzer R, Kelley KW.

Brain Behav Immun. 2015 Feb;44:176-86. doi: 10.1016/j.bbi.2014.09.018. Epub 2014 Oct 7.


Key learnings from the Endocrine Disruptor Screening Program (EDSP) Tier 1 rodent uterotrophic and Hershberger assays.

Marty MS, O'Connor JC.

Birth Defects Res B Dev Reprod Toxicol. 2014 Feb;101(1):63-79. doi: 10.1002/bdrb.21098. Epub 2014 Feb 10.


Key learnings from performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 in vitro assays.

LeBaron MJ, Coady KK, O'Connor JC, Nabb DL, Markell LK, Snajdr S, Sue Marty M.

Birth Defects Res B Dev Reprod Toxicol. 2014 Feb;101(1):23-42. doi: 10.1002/bdrb.21094. Epub 2014 Feb 10.


Key lessons from performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 male and female pubertal assays.

Stump DG, O'Connor JC, Lewis JM, Marty MS.

Birth Defects Res B Dev Reprod Toxicol. 2014 Feb;101(1):43-62. doi: 10.1002/bdrb.21097. Epub 2014 Feb 7.


Evaluation of the reproductive and developmental toxicity of 6:2 fluorotelomer alcohol in rats.

O'Connor JC, Munley SM, Serex TL, Buck RC.

Toxicology. 2014 Mar 20;317:6-16. doi: 10.1016/j.tox.2014.01.002. Epub 2014 Jan 18.


Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease.

Li X, Redus L, Chen C, Martinez PA, Strong R, Li S, O'Connor JC.

PLoS One. 2013 Aug 15;8(8):e71341. doi: 10.1371/journal.pone.0071341. eCollection 2013.


Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors.

Lawson MA, Parrott JM, McCusker RH, Dantzer R, Kelley KW, O'Connor JC.

J Neuroinflammation. 2013 Jul 18;10:87. doi: 10.1186/1742-2094-10-87.


Paying for prevention: a critical opportunity for public health.

O'Connor JC, Gutelius BJ, Girard KE, Drum Hastings D, Longoria L, Kohn MA.

J Law Med Ethics. 2013 Mar;41 Suppl 1:69-72. doi: 10.1111/jlme.12043.


Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.

Kelley KW, O'Connor JC, Lawson MA, Dantzer R, Rodriguez-Zas SL, McCusker RH.

Brain Behav Immun. 2013 Aug;32:63-9. doi: 10.1016/j.bbi.2013.02.003. Epub 2013 Feb 26.


Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.

Corona AW, Norden DM, Skendelas JP, Huang Y, O'Connor JC, Lawson M, Dantzer R, Kelley KW, Godbout JP.

Brain Behav Immun. 2013 Jul;31:134-42. doi: 10.1016/j.bbi.2012.08.008. Epub 2012 Aug 19.


Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice.

Gould GG, Seillier A, Weiss G, Giuffrida A, Burke TF, Hensler JG, Rock C, Tristan A, McMahon LR, Salazar A, O'Connor JC, Satsangi N, Satsangi RK, Gu TT, Treat K, Smolik C, Schultz ST.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):260-9. doi: 10.1016/j.pnpbp.2012.04.011. Epub 2012 Apr 21.


Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge.

Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC.

Horm Behav. 2012 Aug;62(3):202-9. doi: 10.1016/j.yhbeh.2012.03.010. Epub 2012 Mar 31. Review.


Interlaboratory study comparison of the 15-day intact adult male rat screening assay: evaluation of an antithyroid chemical and a negative control chemical.

Becker RA, Bergfelt DR, Borghoff S, Davis JP, Hamby BT, O'Connor JC, Kaplan AM, Sloan CS, Tyl RW, Wade M, Marty MS.

Birth Defects Res B Dev Reprod Toxicol. 2012 Feb;95(1):63-78. doi: 10.1002/bdrb.20343. Epub 2011 Nov 29.


What gets measured, gets changed: evaluating law and policy for maximum impact.

Chriqui JF, O'Connor JC, Chaloupka FJ.

J Law Med Ethics. 2011 Mar;39 Suppl 1:21-6. doi: 10.1111/j.1748-720X.2011.00559.x. No abstract available.


Prism therapy and visual rehabilitation in homonymous visual field loss.

O'Neill EC, Connell PP, O'Connor JC, Brady J, Reid I, Logan P.

Optom Vis Sci. 2011 Feb;88(2):263-8. doi: 10.1097/OPX.0b013e318205a3b8.


Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide.

Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, Godbout JP.

J Neuroinflammation. 2010 Dec 17;7:93. doi: 10.1186/1742-2094-7-93.


Inflammation-associated depression: from serotonin to kynurenine.

Dantzer R, O'Connor JC, Lawson MA, Kelley KW.

Psychoneuroendocrinology. 2011 Apr;36(3):426-36. doi: 10.1016/j.psyneuen.2010.09.012. Epub 2010 Oct 30. Review.


Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures.

Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW.

J Neuroinflammation. 2010 Aug 2;7:43. doi: 10.1186/1742-2094-7-43.


Toxicological evaluation of sodium perfluorohexanoate.

Loveless SE, Slezak B, Serex T, Lewis J, Mukerji P, O'Connor JC, Donner EM, Frame SR, Korzeniowski SH, Buck RC.

Toxicology. 2009 Oct 1;264(1-2):32-44. doi: 10.1016/j.tox.2009.07.011. Epub 2009 Jul 24.


Two-day inhalation toxicity study of methyl iodide in the rat.

Himmelstein MW, Kegelman TA, DeLorme MP, Everds NE, O'Connor JC, Kemper RA, Nabb DL, Mileson BE, Bevan C.

Inhal Toxicol. 2009 May;21(6):480-7. doi: 10.1080/08958370802596892.


Psychoneuroimmune implications of type 2 diabetes: redux.

O'Connor JC, Johnson DR, Freund GG.

Immunol Allergy Clin North Am. 2009 May;29(2):339-58. doi: 10.1016/j.iac.2009.02.004.


Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin.

O'Connor JC, André C, Wang Y, Lawson MA, Szegedi SS, Lestage J, Castanon N, Kelley KW, Dantzer R.

J Neurosci. 2009 Apr 1;29(13):4200-9. doi: 10.1523/JNEUROSCI.5032-08.2009.


Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior.

O'Connor JC, Lawson MA, André C, Briley EM, Szegedi SS, Lestage J, Castanon N, Herkenham M, Dantzer R, Kelley KW.

J Immunol. 2009 Mar 1;182(5):3202-12. doi: 10.4049/jimmunol.0802722.


The laparotomy incision: a technique to facilitate capsulorhexis in microincision cataract surgery.

O'Connor JC, O'Connell ED, Sciscio A, Mulhern MG.

Ophthalmic Surg Lasers Imaging. 2008 Nov-Dec;39(6):519-21.


Non-coplanar 2,2',3,3',4,4',5,5',6,6'-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities.

Han X, O'Connor JC, Donner EM, Nabb DL, Mingoia RT, Snajdr SI, Clarke JJ, Kaplan AM.

Toxicology. 2009 Jan 31;255(3):177-86. doi: 10.1016/j.tox.2008.10.013. Epub 2008 Oct 31.


Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration.

André C, O'Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N.

J Neuroimmunol. 2008 Aug 30;200(1-2):90-9. doi: 10.1016/j.jneuroim.2008.06.011. Epub 2008 Jul 23.


Preemption of local smoke-free air ordinances: the implications of judicial opinions for meeting national health objectives.

O'Connor JC, MacNeil A, Chriqui JF, Tynan M, Bates H, Eidson SK.

J Law Med Ethics. 2008 Summer;36(2):403-12, 214. doi: 10.1111/j.1748-720X.2008.00284.x. Review.


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