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Items: 17

1.

Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.

Schnute ME, Benoit SE, Buchler IP, Caspers N, Grapperhaus ML, Han S, Hotchandani R, Huang N, Hughes RO, Juba BM, Kim KH, Liu E, McCarthy E, Messing D, Miyashiro JS, Mohan S, O'Connell TN, Ohren JF, Parikh MD, Schmidt M, Selness SR, Springer JR, Thanabal V, Trujillo JI, Walker DP, Wan ZK, Withka JM, Wittwer AJ, Wood NL, Xing L, Zapf CW, Douhan J 3rd.

ACS Med Chem Lett. 2018 Dec 3;10(1):80-85. doi: 10.1021/acsmedchemlett.8b00461. eCollection 2019 Jan 10.

PMID:
30655951
2.

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.

Petersen DN, Hawkins J, Ruangsiriluk W, Stevens KA, Maguire BA, O'Connell TN, Rocke BN, Boehm M, Ruggeri RB, Rolph T, Hepworth D, Loria PM, Carpino PA.

Cell Chem Biol. 2016 Nov 17;23(11):1362-1371. doi: 10.1016/j.chembiol.2016.08.016. Epub 2016 Oct 13.

3.

Solution-based indirect affinity selection mass spectrometry--a general tool for high-throughput screening of pharmaceutical compound libraries.

O'Connell TN, Ramsay J, Rieth SF, Shapiro MJ, Stroh JG.

Anal Chem. 2014 Aug 5;86(15):7413-20. doi: 10.1021/ac500938y. Epub 2014 Jul 23.

PMID:
25033415
4.

Integrating intramolecular hydrogen bonding (IMHB) considerations in drug discovery using ΔlogP as a tool.

Shalaeva M, Caron G, Abramov YA, O'Connell TN, Plummer MS, Yalamanchi G, Farley KA, Goetz GH, Philippe L, Shapiro MJ.

J Med Chem. 2013 Jun 27;56(12):4870-9. doi: 10.1021/jm301850m. Epub 2013 Jun 12.

PMID:
23710574
5.

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.

Efremov IV, Vajdos FF, Borzilleri KA, Capetta S, Chen H, Dorff PH, Dutra JK, Goldstein SW, Mansour M, McColl A, Noell S, Oborski CE, O'Connell TN, O'Sullivan TJ, Pandit J, Wang H, Wei B, Withka JM.

J Med Chem. 2012 Nov 8;55(21):9069-88. doi: 10.1021/jm201715d. Epub 2012 May 9.

PMID:
22468999
6.

Metabolism, pharmacokinetics, and excretion of the 5-hydroxytryptamine1b receptor antagonist elzasonan in humans.

Kamel A, Obach RS, Colizza K, Wang W, O'Connell TN, Coelho RV Jr, Kelley RM, Schildknegt K.

Drug Metab Dispos. 2010 Nov;38(11):1984-99. doi: 10.1124/dmd.110.034595. Epub 2010 Jul 28.

PMID:
20668248
7.

Species differences in the biotransformation of an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist: the effects of distinct glucuronide metabolites on overall compound disposition.

Shaffer CL, Gunduz M, Ryder TF, O'Connell TN.

Drug Metab Dispos. 2010 Feb;38(2):292-301. doi: 10.1124/dmd.109.030171. Epub 2009 Nov 12.

PMID:
19910512
8.

Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite.

Shaffer CL, Ryder TF, Venkatakrishnan K, Henne IK, O'Connell TN.

Drug Metab Dispos. 2009 Jul;37(7):1480-9. doi: 10.1124/dmd.109.027037. Epub 2009 Apr 1.

PMID:
19339375
9.

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies.

Walker GS, O'Connell TN.

Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1295-305. doi: 10.1517/17425255.4.10.1295 . Review.

PMID:
18798699
10.

Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro.

Obach RS, Reed-Hagen AE, Krueger SS, Obach BJ, O'Connell TN, Zandi KS, Miller S, Coe JW.

Drug Metab Dispos. 2006 Jan;34(1):121-30. Epub 2005 Oct 12.

PMID:
16221753
11.

Biotransformation of a GABAA receptor partial agonist in sprague-dawley rats and cynomolgus monkeys: identification of two unique N-carbamoyl metabolites.

Shaffer CL, Gunduz M, O'Connell TN, Obach RS, Yee S.

Drug Metab Dispos. 2005 Nov;33(11):1688-99. Epub 2005 Aug 4.

PMID:
16081672
12.

Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.

Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.

Drug Metab Dispos. 2005 Apr;33(4):484-8. Epub 2005 Jan 7.

PMID:
15640374
14.

Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin.

Sakya SM, Suarez-Contreras M, Dirlam JP, O'Connell TN, Hayashi SF, Santoro SL, Kamicker BJ, George DM, Ziegler CB.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2751-4.

PMID:
11591516
15.

Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.

Brown MS, Dirlam JP, McArthur HA, McCormick EL, Morse BK, Murphy PA, O'Connell TN, Pacey M, Rescek DM, Ruddock J, Wax RG.

J Antibiot (Tokyo). 1999 Aug;52(8):742-7.

16.

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.

Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ.

J Antibiot (Tokyo). 1998 Nov;51(11):1029-34.

17.

S.B. 340: Disclosure of social and medical history of the biological parents of an adopted child.

O'Connell TN.

Univ Dayton Law Rev. 1979 Summer;4(2):533-7. No abstract available.

PMID:
11661822

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