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Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial.

Patel PB, Brett SJ, O'Callaghan D, Anjum A, Cross M, Warwick J, Gordon AC.

Intensive Care Med. 2020 Feb 3. doi: 10.1007/s00134-019-05913-6. [Epub ahead of print]


Age-Friendly Environments, Active Lives? Associations Between the Local Physical and Social Environment and Physical Activity Among Adults Aged 55 and Older in Ireland.

Ward M, Gibney S, O'Callaghan D, Shannon S.

J Aging Phys Act. 2019 Oct 17:1-9. doi: 10.1123/japa.2019-0012. [Epub ahead of print]


Intranasal treatment with CpG-B oligodeoxynucleotides protects CBA mice from lethal equine herpesvirus 1 challenge by an innate immune response.

Kim SK, Shakya AK, O'Callaghan DJ.

Antiviral Res. 2019 Sep;169:104546. doi: 10.1016/j.antiviral.2019.104546. Epub 2019 Jun 25.


Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner.

Shakya AK, O'Callaghan DJ, Kim SK.

J Virol. 2019 May 29;93(12). pii: e00257-19. doi: 10.1128/JVI.00257-19. Print 2019 Jun 15.


Infection by Brucella melitensis or Brucella papionis modifies essential physiological functions of human trophoblasts.

García-Méndez KB, Hielpos SM, Soler-Llorens PF, Arce-Gorvel V, Hale C, Gorvel JP, O'Callaghan D, Keriel A.

Cell Microbiol. 2019 Jul;21(7):e13019. doi: 10.1111/cmi.13019. Epub 2019 Mar 14.


The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection.

Gomes MC, Tasrini Y, Subramoni S, Agnoli K, Feliciano JR, Eberl L, Sokol P, O'Callaghan D, Vergunst AC.

PLoS Pathog. 2018 Dec 4;14(12):e1007473. doi: 10.1371/journal.ppat.1007473. eCollection 2018 Dec.


Comparative Genomics and in vitro Infection of Field Clonal Isolates of Brucella melitensis Biovar 3 Did Not Identify Signature of Host Adaptation.

Holzapfel M, Girault G, Keriel A, Ponsart C, O'Callaghan D, Mick V.

Front Microbiol. 2018 Oct 22;9:2505. doi: 10.3389/fmicb.2018.02505. eCollection 2018.


A MALDI-TOF MS database with broad genus coverage for species-level identification of Brucella.

Mesureur J, Arend S, Cellière B, Courault P, Cotte-Pattat PJ, Totty H, Deol P, Mick V, Girard V, Touchberry J, Burrowes V, Lavigne JP, O'Callaghan D, Monnin V, Keriel A.

PLoS Negl Trop Dis. 2018 Oct 18;12(10):e0006874. doi: 10.1371/journal.pntd.0006874. eCollection 2018 Oct.


Evaluation of Models for Temperature-Dependent Viscosity Changes in Dairy Protein Beverage Formulations During Thermal Processing.

Kelleher CM, O'Mahony JA, Kelly AL, O'Callaghan DJ, McCarthy NA.

J Food Sci. 2018 Apr;83(4):937-945. doi: 10.1111/1750-3841.14097. Epub 2018 Mar 25.


Assessment of infant formula quality and composition using Vis-NIR, MIR and Raman process analytical technologies.

Wang X, Esquerre C, Downey G, Henihan L, O'Callaghan D, O'Donnell C.

Talanta. 2018 Jun 1;183:320-328. doi: 10.1016/j.talanta.2018.02.080. Epub 2018 Mar 19.


New Delhi Metallo-β-Lactamase-Producing Carbapenem-Resistant Enterobacteriacae Isolated From Bronchial Washings.

Cullivan S, Brady DM, O'Callaghan DS.

Ir Med J. 2017 Dec 18;110(10):663. No abstract available.


Comparative Genomic Sequencing and Pathogenic Properties of Equine Herpesvirus 1 KyA and RacL11.

Shakya AK, O'Callaghan DJ, Kim SK.

Front Vet Sci. 2017 Dec 11;4:211. doi: 10.3389/fvets.2017.00211. eCollection 2017.


Correction: Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.

Mesureur J, Feliciano JR, Wagner N, Gomes MC, Zhang L, Blanco-Gonzalez M, van der Vaart M, O'Callaghan D, Meijer AH, Vergunst AC.

PLoS Pathog. 2017 Dec 20;13(12):e1006795. doi: 10.1371/journal.ppat.1006795. eCollection 2017 Dec.


Macrophages as drivers of an opportunistic infection.

Vergunst AC, Carranza NL, Zhang L, Gomes MC, Tasrini Y, Meijer AH, O'Callaghan D.

Microb Cell. 2017 Sep 13;4(10):362-364. doi: 10.15698/mic2017.10.595.


Brucella suis biovar 2 infection in humans in France: emerging infection or better recognition?

Mailles A, Ogielska M, Kemiche F, Garin-Bastuji B, Brieu N, Burnusus Z, Creuwels A, Danjean MP, Guiet P, Nasser V, Tourrand B, Valour F, Maurin M, O'Callaghan D, Mick V, Vaillant V, Jay M, Lavigne JP, DE Valk H.

Epidemiol Infect. 2017 Oct;145(13):2711-2716. doi: 10.1017/S0950268817001704. Epub 2017 Aug 8.


Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.

Mesureur J, Feliciano JR, Wagner N, Gomes MC, Zhang L, Blanco-Gonzalez M, van der Vaart M, O'Callaghan D, Meijer AH, Vergunst AC.

PLoS Pathog. 2017 Jun 26;13(6):e1006437. doi: 10.1371/journal.ppat.1006437. eCollection 2017 Jun. Erratum in: PLoS Pathog. 2017 Dec 20;13(12 ):e1006795.


Data-as-a-Service Platform for Delivering Healthy Lifestyle and Preventive Medicine: Concept and Structure of the DAPHNE Project.

Gibbons C, Bailador Del Pozo G, Andrés J, Lobstein T, Manco M, Lewy H, Bergman E, O'Callaghan D, Doherty G, Kudrautseva O, Palomares A, Ram R, Olmo A.

JMIR Res Protoc. 2016 Dec 9;5(4):e222.


A Brucella spp. Isolate from a Pac-Man Frog (Ceratophrys ornata) Reveals Characteristics Departing from Classical Brucellae.

Soler-Lloréns PF, Quance CR, Lawhon SD, Stuber TP, Edwards JF, Ficht TA, Robbe-Austerman S, O'Callaghan D, Keriel A.

Front Cell Infect Microbiol. 2016 Sep 28;6:116. eCollection 2016.


Human brucellosis in France in the 21st century: Results from national surveillance 2004-2013.

Mailles A, Garin-Bastuji B, Lavigne JP, Jay M, Sotto A, Maurin M, Pelloux I, O'Callaghan D, Mick V, Vaillant V, De Valk H.

Med Mal Infect. 2016 Dec;46(8):411-418. doi: 10.1016/j.medmal.2016.08.007. Epub 2016 Oct 4.


Protocol for a randomised control trial of methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients (MOTION).

Patel PB, Brett SJ, O'Callaghan D, Anjum A, Cross M, Warwick J, Gordon AC.

BMJ Open. 2016 Jul 13;6(7):e011750. doi: 10.1136/bmjopen-2016-011750.


Immunization with Attenuated Equine Herpesvirus 1 Strain KyA Induces Innate Immune Responses That Protect Mice from Lethal Challenge.

Kim SK, Shakya AK, O'Callaghan DJ.

J Virol. 2016 Aug 26;90(18):8090-104. doi: 10.1128/JVI.00986-16. Print 2016 Sep 15.


Effect of hydrolyzed whey protein on surface morphology, water sorption, and glass transition temperature of a model infant formula.

Kelly GM, O'Mahony JA, Kelly AL, O'Callaghan DJ.

J Dairy Sci. 2016 Sep;99(9):6961-6972. doi: 10.3168/jds.2015-10447. Epub 2016 Jun 16.


A high-throughput assay for the measurement of uropathogenic Escherichia coli attachment to urinary bladder cells.

García Méndez KB, Bragagnolo G, O'Callaghan D, Lavigne JP, Keriel A.

Int J Exp Pathol. 2016 Apr;97(2):194-201. doi: 10.1111/iep.12181. Epub 2016 Jun 8.


A Functional oriT in the Ptw Plasmid of Burkholderia cenocepacia Can Be Recognized by the R388 Relaxase TrwC.

Fernández-González E, Bakioui S, Gomes MC, O'Callaghan D, Vergunst AC, Sangari FJ, Llosa M.

Front Mol Biosci. 2016 May 3;3:16. doi: 10.3389/fmolb.2016.00016. eCollection 2016.


A Simple and Safe Protocol for Preparing Brucella Samples for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Analysis.

Mesureur J, Ranaldi S, Monnin V, Girard V, Arend S, Welker M, O'Callaghan D, Lavigne JP, Keriel A.

J Clin Microbiol. 2016 Feb;54(2):449-52. doi: 10.1128/JCM.02730-15. Epub 2015 Nov 18.


Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing.

Saadeh B, Caswell CC, Chao Y, Berta P, Wattam AR, Roop RM 2nd, O'Callaghan D.

J Bacteriol. 2015 Nov 9;198(3):427-35. doi: 10.1128/JB.00711-15. Print 2016 Feb 1.


[Tunnelled central venous line-associated infections in patients with pulmonary arterial hypertension treated with intravenous prostacyclin].

Boucly A, O'Connell C, Savale L, O'Callaghan DS, Jaïs X, Montani D, Humbert M, Simonneau G, Sitbon O.

Presse Med. 2016 Jan;45(1):20-8. doi: 10.1016/j.lpm.2015.10.001. Epub 2015 Nov 4. French.


Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer.

O'Callaghan DS, Rexhepaj E, Gately K, Coate L, Delaney D, O'Donnell DM, Kay E, O'Connell F, Gallagher WM, O'Byrne KJ.

Eur Respir J. 2015 Dec;46(6):1762-72. doi: 10.1183/13993003.00176-2014. Epub 2015 Nov 5.


Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence.

Kim SK, Shakya AK, O'Callaghan DJ.

Virus Res. 2016 Jan 4;211:222-32. doi: 10.1016/j.virusres.2015.10.026. Epub 2015 Nov 2.


Functional Characterization of the Serine-Rich Tract of Varicella-Zoster Virus IE62.

Kim SK, Shakya AK, Kim S, O'Callaghan DJ.

J Virol. 2015 Nov 4;90(2):959-71. doi: 10.1128/JVI.02096-15. Print 2016 Jan 15.


Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation.

Herrmann IK, Bertazzo S, O'Callaghan DJ, Schlegel AA, Kallepitis C, Antcliffe DB, Gordon AC, Stevens MM.

Nanoscale. 2015 Aug 28;7(32):13511-20. doi: 10.1039/c5nr01851j. Epub 2015 Jul 23.


The Space From Heart Disease Intervention for People With Cardiovascular Disease and Distress: A Mixed-Methods Study.

Barley EA, Clifton A, Lee G, Norman IJ, O'Callaghan D, Tierney K, Richards D.

JMIR Res Protoc. 2015 Jul 1;4(3):e81. doi: 10.2196/resprot.4280.


What's new in vasopressin?

O'Callaghan DJ, Gordon AC.

Intensive Care Med. 2015 Dec;41(12):2177-9. doi: 10.1007/s00134-015-3849-3. Epub 2015 May 7. Review. No abstract available.


Existence of a Colonizing Staphylococcus aureus Strain Isolated in Diabetic Foot Ulcers.

Messad N, Prajsnar TK, Lina G, O'Callaghan D, Foster SJ, Renshaw SA, Skaar EP, Bes M, Dunyach-Remy C, Vandenesch F, Sotto A, Lavigne JP.

Diabetes. 2015 Aug;64(8):2991-5. doi: 10.2337/db15-0031. Epub 2015 Apr 21.


Paraneoplastic limbic encephalitis and small-cell lung carcinoma.

Bolster F, Crosbie I, O'Callaghan DS, Murray B, Kavanagh EC.

J Thorac Oncol. 2015 May;10(5):852-3. doi: 10.1097/JTO.0000000000000386. No abstract available.


Monocyte Tumor Necrosis Factor-α-Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation.

O'Callaghan DJ, O'Dea KP, Scott AJ, Takata M, Gordon AC.

Crit Care Med. 2015 Jul;43(7):1375-85. doi: 10.1097/CCM.0000000000000992.


The quest for a true One Health perspective of brucellosis.

Godfroid J, DeBolle X, Roop RM, O'Callaghan D, Tsolis RM, Baldwin C, Santos RL, McGiven J, Olsen S, Nymo IH, Larsen A, Al Dahouk S, Letesson JJ.

Rev Sci Tech. 2014 Aug;33(2):521-38. Review.


From the intensive care bed: we need to hear and listen.

O'Callaghan D, Holley A, Lipman J.

Intensive Care Med. 2015 May;41(5):921-2. doi: 10.1007/s00134-014-3614-z. Epub 2015 Jan 23. No abstract available.


Brucella Intracellular Life Relies on the Transmembrane Protein CD98 Heavy Chain.

Keriel A, Botella E, Estrach S, Bragagnolo G, Vergunst AC, Feral CC, O'Callaghan D.

J Infect Dis. 2015 Jun 1;211(11):1769-78. doi: 10.1093/infdis/jiu673. Epub 2014 Dec 11.


The Brucella TIR domain containing proteins BtpA and BtpB have a structural WxxxE motif important for protection against microtubule depolymerisation.

Felix C, Kaplan Türköz B, Ranaldi S, Koelblen T, Terradot L, O'Callaghan D, Vergunst AC.

Cell Commun Signal. 2014 Oct 12;12:53. doi: 10.1186/s12964-014-0053-y.


The development of counselling psychology in Ireland.

Connolly A, O'Callaghan D, O'Brien O, Broderick J, Long C, O'Grady I.

Ir J Psychol. 2014 Mar;35(1):16-24. Epub 2014 Apr 14.


The Brucella suis IbpA heat-shock chaperone is not required for virulence or for expression of the VirB type IV secretion system VirB8 protein.

Berta P, Bourg G, Hanna N, Saadeh B, Armengaud J, Patey G, O'Callaghan D.

Lett Appl Microbiol. 2014 Jun;58(6):564-8. doi: 10.1111/lam.12231. Epub 2014 Mar 8.


The EHV-1 UL4 protein that tempers viral gene expression interacts with cellular transcription factors.

Zhang Y, Charvat RA, Kim SK, O'Callaghan DJ.

Virology. 2014 Jan 20;449:25-34. doi: 10.1016/j.virol.2013.11.005. Epub 2013 Nov 21.


Comparative phylogenomics and evolution of the Brucellae reveal a path to virulence.

Wattam AR, Foster JT, Mane SP, Beckstrom-Sternberg SM, Beckstrom-Sternberg JM, Dickerman AW, Keim P, Pearson T, Shukla M, Ward DV, Williams KP, Sobral BW, Tsolis RM, Whatmore AM, O'Callaghan D.

J Bacteriol. 2014 Mar;196(5):920-30. doi: 10.1128/JB.01091-13. Epub 2013 Dec 13.


Novel medical therapies for pulmonary arterial hypertension.

O'Connell C, O'Callaghan DS, Humbert M.

Clin Chest Med. 2013 Dec;34(4):867-80. doi: 10.1016/j.ccm.2013.08.002. Review.


An update on medical therapy for pulmonary arterial hypertension.

Wu Y, O'Callaghan DS, Humbert M.

Curr Hypertens Rep. 2013 Dec;15(6):614-22. Review.


Structure of the Toll/interleukin 1 receptor (TIR) domain of the immunosuppressive Brucella effector BtpA/Btp1/TcpB.

Kaplan-Türköz B, Koelblen T, Felix C, Candusso MP, O'Callaghan D, Vergunst AC, Terradot L.

FEBS Lett. 2013 Nov 1;587(21):3412-6. doi: 10.1016/j.febslet.2013.09.007. Epub 2013 Sep 25.


Effect of increasing the protein-to-fat ratio and reducing fat content on the chemical and physical properties of processed cheese product.

Guinee TP, O'Callaghan DJ.

J Dairy Sci. 2013;96(11):6830-6839. doi: 10.3168/jds.2013-6685. Epub 2013 Aug 29.


Differentiating pulmonary cavities.

O'Connell C, Abdul Aziz M, O'Keane JC, Healy D, O'Callaghan DS.

Eur Respir Rev. 2013 Jun 1;22(128):191-2. doi: 10.1183/09059180.00005012. No abstract available.


Volatile release from whey protein isolate-pectin multilayer stabilized emulsions: effect of pH, salt, and artificial salivas.

Mao L, Roos YH, O'Callaghan DJ, Miao S.

J Agric Food Chem. 2013 Jul 3;61(26):6231-9. doi: 10.1021/jf4011615. Epub 2013 Jun 19.


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