Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 98

1.

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H; ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC.

Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28.

PMID:
31253980
2.

A retrospective analysis of outcomes in low- and intermediate-high-risk pulmonary embolism patients managed on an ambulatory medical unit in the UK.

Reschen ME, Raby J, Bowen J, Singh S, Lasserson D, O'Callaghan CA.

ERJ Open Res. 2019 Apr 8;5(2). pii: 00184-2018. doi: 10.1183/23120541.00184-2018. eCollection 2019 Apr.

3.

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Nov 13;9(1):4833. doi: 10.1038/s41467-018-07304-9.

4.

[Spanish adaptation of the free OxMaR software for minimization and randomization of clinical studies].

Guillaumes S, O'Callaghan CA.

Gac Sanit. 2019 Jul - Aug;33(4):395-397. doi: 10.1016/j.gaceta.2018.07.013. Epub 2018 Nov 1. Spanish.

5.

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Früh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM.

Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z. Erratum in: Nat Commun. 2018 Nov 13;9(1):4833.

6.

MetClo: methylase-assisted hierarchical DNA assembly using a single type IIS restriction enzyme.

Lin D, O'Callaghan CA.

Nucleic Acids Res. 2018 Nov 2;46(19):e113. doi: 10.1093/nar/gky596.

7.

Intragenic transcriptional interference regulates the human immune ligand MICA.

Lin D, Hiron TK, O'Callaghan CA.

EMBO J. 2018 May 15;37(10). pii: e97138. doi: 10.15252/embj.201797138. Epub 2018 Apr 11.

8.

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.

McCarthy MT, Moncayo G, Hiron TK, Jakobsen NA, Valli A, Soga T, Adam J, O'Callaghan CA.

J Biol Chem. 2018 Mar 16;293(11):3913-3924. doi: 10.1074/jbc.M117.809459. Epub 2017 Dec 26.

9.

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.

Lombard SE, Pollitt AY, Hughes CE, Di Y, Mckinnon T, O'callaghan CA, Watson SP.

Platelets. 2018 Nov;29(7):716-722. doi: 10.1080/09537104.2017.1356919. Epub 2017 Nov 1.

PMID:
29090616
10.

Systematic Review and Metaanalysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.

McFadden EC, Hirst JA, Verbakel JY, McLellan JH, Hobbs FDR, Stevens RJ, O'Callaghan CA, Lasserson DS.

Clin Chem. 2018 Mar;64(3):475-485. doi: 10.1373/clinchem.2017.276683. Epub 2017 Oct 18.

11.

Requirement for cystatin C testing in chronic kidney disease: a retrospective population-based study.

Lasserson DS, Shine B, O'Callaghan CA, James T.

Br J Gen Pract. 2017 Oct;67(663):e732-e735. doi: 10.3399/bjgp17X692585. Epub 2017 Sep 11.

12.

The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus.

Davison LJ, Holder A, Catchpole B, O'Callaghan CA.

J Vet Intern Med. 2017 Mar;31(2):343-348. doi: 10.1111/jvim.14636. Epub 2017 Feb 8. Erratum in: J Vet Intern Med. 2017 Jul;31(4):1362.

13.

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner.

Moncayo G, Lin D, McCarthy MT, Watson AA, O'Callaghan CA.

Front Immunol. 2017 Jan 19;7:687. doi: 10.3389/fimmu.2016.00687. eCollection 2016.

14.

Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis.

Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, Hobbs FD.

PLoS One. 2016 Jul 6;11(7):e0158765. doi: 10.1371/journal.pone.0158765. eCollection 2016. Review.

15.

What is the relationship between renal function and visit-to-visit blood pressure variability in primary care? Retrospective cohort study from routinely collected healthcare data.

Lasserson DS, Scherpbier de Haan N, de Grauw W, van der Wel M, Wetzels JF, O'Callaghan CA.

BMJ Open. 2016 Jun 10;6(6):e010702. doi: 10.1136/bmjopen-2015-010702.

16.

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.

Reschen ME, Lin D, Chalisey A, Soilleux EJ, O'Callaghan CA.

Atherosclerosis. 2016 Jul;250:95-105. doi: 10.1016/j.atherosclerosis.2016.04.025. Epub 2016 May 2.

17.

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney AS, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WH, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JR, Platou CG, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJ, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CN, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.

Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. Epub 2015 Nov 9.

18.

Analysis of Ebola Virus Entry Into Macrophages.

Dahlmann F, Biedenkopf N, Babler A, Jahnen-Dechent W, Karsten CB, Gnirß K, Schneider H, Wrensch F, O'Callaghan CA, Bertram S, Herrler G, Becker S, Pöhlmann S, Hofmann-Winkler H.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S247-57. doi: 10.1093/infdis/jiv140. Epub 2015 Apr 14.

19.

Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP.

Biochem J. 2015 Jun 15;468(3):459-73. doi: 10.1042/BJ20150192. Epub 2015 Apr 7.

PMID:
25849538
20.

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.

Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA.

PLoS Genet. 2015 Apr 2;11(4):e1005061. doi: 10.1371/journal.pgen.1005061. eCollection 2015 Apr.

21.

OxMaR: open source free software for online minimization and randomization for clinical trials.

O'Callaghan CA.

PLoS One. 2014 Oct 29;9(10):e110761. doi: 10.1371/journal.pone.0110761. eCollection 2014.

22.

PeaKDEck: a kernel density estimator-based peak calling program for DNaseI-seq data.

McCarthy MT, O'Callaghan CA.

Bioinformatics. 2014 May 1;30(9):1302-4. doi: 10.1093/bioinformatics/btt774. Epub 2014 Jan 8.

23.

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK.

Hill NR, Lasserson D, Fatoba S, O'Callaghan CA, Pugh C, Perera-Salazar R, Shine B, Thompson B, Wolstenholme J, McManus R, Hobbs FD.

BMJ Open. 2013 Dec 17;3(12):e004265. doi: 10.1136/bmjopen-2013-004265.

24.

Solid-phase plate-reader quantification of specific PCR products by measurement of band-specific ethidium bromide fluorescence.

McCarthy MT, O'Callaghan CA.

Anal Biochem. 2014 Feb 15;447:30-2. doi: 10.1016/j.ab.2013.11.003. Epub 2013 Nov 13.

PMID:
24239570
25.

Impact on cardiovascular risk follow-up from a shift to the CKD-EPI formula for eGFR reporting: a cross-sectional population-based primary care study.

van Gelder VA, Scherpbier-de Haan ND, de Grauw WJ, O'Callaghan CA, Wetzels JF, Lasserson DS.

BMJ Open. 2013 Sep 25;3(9):e003631. doi: 10.1136/bmjopen-2013-003631.

26.

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP.

J Biol Chem. 2013 Feb 15;288(7):5127-35. doi: 10.1074/jbc.M112.411462. Epub 2012 Dec 21.

27.

Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.

Reschen M, Kini U, Hood RL, Boycott KM, Hurst J, O'Callaghan CA.

Am J Med Genet A. 2012 Dec;158A(12):3196-200. doi: 10.1002/ajmg.a.35635. Epub 2012 Nov 19.

PMID:
23165645
28.

Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting.

O'Callaghan CA, Shine B, Lasserson DS.

BMJ Open. 2011 Dec 19;1(2):e000308. doi: 10.1136/bmjopen-2011-000308. Print 2011.

29.

NF-κB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site.

Lin D, Lavender H, Soilleux EJ, O'Callaghan CA.

J Biol Chem. 2012 Feb 3;287(6):4299-310. doi: 10.1074/jbc.M111.282152. Epub 2011 Dec 14.

30.

Molecular analysis of the interaction of the snake venom rhodocytin with the platelet receptor CLEC-2.

Watson AA, O'Callaghan CA.

Toxins (Basel). 2011 Aug;3(8):991-1003. doi: 10.3390/toxins3080991. Epub 2011 Aug 10.

31.

Antigen-specific T cell responses to BK polyomavirus antigens identify functional anti-viral immunity and may help to guide immunosuppression following renal transplantation.

Chakera A, Bennett S, Lawrence S, Morteau O, Mason PD, O'Callaghan CA, Cornall RJ.

Clin Exp Immunol. 2011 Sep;165(3):401-9. doi: 10.1111/j.1365-2249.2011.04429.x. Epub 2011 Jun 14.

32.

Expression, purification and crystallization of the human UL16-binding protein ULBP1.

Watson AA, Christou CM, O'Callaghan CA.

Protein Expr Purif. 2011 Sep;79(1):44-8. doi: 10.1016/j.pep.2011.04.019. Epub 2011 May 7.

PMID:
21575723
33.

Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.

Watson AA, Lebedev AA, Hall BA, Fenton-May AE, Vagin AA, Dejnirattisai W, Felce J, Mongkolsapaya J, Palma AS, Liu Y, Feizi T, Screaton GR, Murshudov GN, O'Callaghan CA.

J Biol Chem. 2011 Jul 8;286(27):24208-18. doi: 10.1074/jbc.M111.226142. Epub 2011 May 12.

34.

Recognition and blocking of innate immunity cells by Candida albicans chitin.

Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, Brown AJ, Munro CA, Gow NA.

Infect Immun. 2011 May;79(5):1961-70. doi: 10.1128/IAI.01282-10. Epub 2011 Feb 28.

35.

Biology-The Path Ahead.

O'Callaghan CA.

Biology (Basel). 2011 Sep 1;1(1):1-4. doi: 10.3390/biology1010001.

36.

A lucky fall? Case report.

Chakera A, Leslie T, Roberts I, O'Callaghan CA, Cranston D.

Transplant Proc. 2010 Nov;42(9):3883-6. doi: 10.1016/j.transproceed.2010.08.031.

PMID:
21094877
37.

Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.

Morteau O, Blundell S, Chakera A, Bennett S, Christou CM, Mason PD, Cornall RJ, O'Callaghan CA.

PLoS One. 2010 Oct 12;5(10):e13294. doi: 10.1371/journal.pone.0013294.

38.

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC.

Hum Immunol. 2010 Jun;71(6):610-20. doi: 10.1016/j.humimm.2010.02.018. Epub 2010 Mar 15.

PMID:
20219610
39.

Reversible renal impairment caused by thyroid disease.

Chakera A, Paul HJ, O'Callaghan CA.

Scand J Urol Nephrol. 2010 Apr;44(3):190-2. doi: 10.3109/00365591003636604.

PMID:
20199343
40.

CLEC-2 activates Syk through dimerization.

Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.

Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.

41.

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.

Watson AA, O'Callaghan CA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):29-31. doi: 10.1107/S1744309109047915. Epub 2009 Dec 25.

42.

The hyponatraemic hairdresser: highlighting the differentials.

Herrington WG, Al-Mossawi MH, Roberts IS, O'Callaghan CA.

Lancet. 2009 Oct 17;374(9698):1392. doi: 10.1016/S0140-6736(09)61198-3. No abstract available.

PMID:
19837256
43.

The platelet receptor CLEC-2 is active as a dimer.

Watson AA, Christou CM, James JR, Fenton-May AE, Moncayo GE, Mistry AR, Davis SJ, Gilbert RJ, Chakera A, O'Callaghan CA.

Biochemistry. 2009 Nov 24;48(46):10988-96. doi: 10.1021/bi901427d.

PMID:
19824697
44.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C.

Nat Struct Mol Biol. 2009 Jul;16(7):698-703. doi: 10.1038/nsmb.1607. Epub 2009 Jun 28.

45.

Chronic kidney disease--assessing the impact.

O'Callaghan CA.

QJM. 2009 Jun;102(6):431-3. doi: 10.1093/qjmed/hcp043. Epub 2009 Apr 17. No abstract available.

PMID:
19376794
46.

Thrombomodulation via CLEC-2 targeting.

O'Callaghan CA.

Curr Opin Pharmacol. 2009 Apr;9(2):90-5. doi: 10.1016/j.coph.2008.11.001. Epub 2008 Dec 16. Review.

PMID:
19091630
47.

Kidney transplantation--the long term view.

O'Callaghan CA.

QJM. 2008 Dec;101(12):985-6. doi: 10.1093/qjmed/hcn144. Epub 2008 Oct 24. No abstract available.

PMID:
18952631
48.

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2.

Watson AA, Eble JA, O'Callaghan CA.

Protein Sci. 2008 Sep;17(9):1611-6. doi: 10.1110/ps.035568.108. Epub 2008 Jun 26.

49.

Renal cells activate the platelet receptor CLEC-2 through podoplanin.

Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA.

Biochem J. 2008 Apr 1;411(1):133-40. doi: 10.1042/BJ20071216.

50.

Regulation of ligands for the activating receptor NKG2D.

Mistry AR, O'Callaghan CA.

Immunology. 2007 Aug;121(4):439-47. Review.

Supplemental Content

Loading ...
Support Center