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Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S, Elliott N, Rice S, Buck G, Fordham N, Garnett C, Godfrey L, Crump NT, Wright G, Inglott S, Hua P, Psaila B, Povinelli B, Knapp DJHF, Agraz-Doblas A, Bueno C, Varela I, Bennett P, Koohy H, Watt SM, Karadimitris A, Mead AJ, Ancliff P, Vyas P, Menendez P, Milne TA, Roberts I, Roy A.

Blood. 2019 Sep 26;134(13):1059-1071. doi: 10.1182/blood.2019001289. Epub 2019 Aug 5.


Sustained Clinical Remission With Vedolizumab in Patients With Moderate-to-Severe Ulcerative Colitis.

Feagan BG, Schreiber S, Wolf DC, Axler JL, Kaviya A, James A, Curtis RI, Geransar P, Stallmach A, Ehehalt R, Bokemeyer B, Khalid JM, O'Byrne S.

Inflamm Bowel Dis. 2019 May 4;25(6):1028-1035. doi: 10.1093/ibd/izy323.


Effect of noise-induced wavelength fluctuation in tunable diode lasers on narrow-linewidth absorption measurements.

Krishna Y, O'Byrne S, Munuswamy K, Jagadeesh G.

Appl Opt. 2018 Jun 10;57(17):4943-4949. doi: 10.1364/AO.57.004943.


1.6  MHz scanning rate direct absorption temperature measurements using a single vertical-cavity surface-emitting laser diode.

Kaebe BD, Robins NP, Boyson TK, Kleine H, O'Byrne S.

Appl Opt. 2018 Jul 10;57(20):5680-5687. doi: 10.1364/AO.57.005680.


Use of online promotion to encourage patient awareness of aspirin use to prevent heart attack and stroke.

Southwell BG, Eder M, Finnegan J, Hirsch AT, Luepker RV, Duval S, Russell C, O'Byrne S.

J Epidemiol Community Health. 2018 Nov;72(11):1059-1063. doi: 10.1136/jech-2018-210676. Epub 2018 Aug 6. Review.


Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease.

Lamb CA, O'Byrne S, Keir ME, Butcher EC.

J Crohns Colitis. 2018 Aug 22;12(suppl_2):S653-S668. doi: 10.1093/ecco-jcc/jjy060. Review.


A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

Sng CCT, O'Byrne S, Prigozhin DM, Bauer MR, Harvey JC, Ruhle M, Challis BG, Lear S, Roberts LD, Workman S, Janowitz T, Magiera L, Doffinger R, Buckland MS, Jodrell DJ, Semple RK, Wilson TJ, Modis Y, Thaventhiran JED.

J Allergy Clin Immunol. 2018 Jul;142(1):311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Epub 2018 Mar 6. No abstract available.


Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis.

Wei X, Gibiansky L, Wang Y, Fuh F, Erickson R, O'Byrne S, Tang MT.

J Clin Pharmacol. 2018 Mar;58(3):386-398. doi: 10.1002/jcph.1031. Epub 2017 Nov 26.


Identification of a Human Airway Epithelial Cell Subpopulation with Altered Biophysical, Molecular, and Metastatic Properties.

Pagano PC, Tran LM, Bendris N, O'Byrne S, Tse HT, Sharma S, Hoech JW, Park SJ, Liclican EL, Jing Z, Li R, Krysan K, Paul MK, Fontebasso Y, Larsen JE, Hakimi S, Seki A, Fishbein MC, Gimzewski JK, Carlo DD, Minna JD, Walser TC, Dubinett SM.

Cancer Prev Res (Phila). 2017 Sep;10(9):514-524. doi: 10.1158/1940-6207.CAPR-16-0335. Epub 2017 Jul 28.


High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans.

Roy A, Bystry V, Bohn G, Goudevenou K, Reigl T, Papaioannou M, Krejci A, O'Byrne S, Chaidos A, Grioni A, Darzentas N, Roberts IAG, Karadimitris A.

Clin Immunol. 2017 Oct;183:8-16. doi: 10.1016/j.clim.2017.06.005. Epub 2017 Jun 20.


αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis.

Lamb CA, Mansfield JC, Tew GW, Gibbons D, Long AK, Irving P, Diehl L, Eastham-Anderson J, Price MB, O'Boyle G, Jones DEJ, O'Byrne S, Hayday A, Keir ME, Egen JG, Kirby JA.

J Crohns Colitis. 2017 May 1;11(5):610-620. doi: 10.1093/ecco-jcc/jjw189.


Toll-like receptor-induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma.

Tworek D, Heroux D, O'Byrne SN, Mitchell P, O'Byrne PM, Denburg JA.

Clin Exp Allergy. 2017 Jul;47(7):900-908. doi: 10.1111/cea.12913. Epub 2017 Mar 31.


MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA.

Cell Rep. 2017 Jan 10;18(2):482-495. doi: 10.1016/j.celrep.2016.12.054.


Multiparameter mechanical and morphometric screening of cells.

Masaeli M, Gupta D, O'Byrne S, Tse HT, Gossett DR, Tseng P, Utada AS, Jung HJ, Young S, Clark AT, Di Carlo D.

Sci Rep. 2016 Dec 2;6:37863. doi: 10.1038/srep37863.


Multiple receivers in a high-resolution near-infrared heterodyne spectrometer.

Kurtz J, O'Byrne S.

Opt Express. 2016 Oct 17;24(21):23838-23848. doi: 10.1364/OE.24.023838.


Discovery of Biomarkers of Response in Early Drug Development.

O'Byrne S, Kaser A, Parik A, Chowers Y.

J Crohns Colitis. 2016 Sep;10 Suppl 2:S560-6. doi: 10.1093/ecco-jcc/jjw115. Epub 2016 Jun 14.


Lipocalin 2, a Regulator of Retinoid Homeostasis and Retinoid-mediated Thermogenic Activation in Adipose Tissue.

Guo H, Foncea R, O'Byrne SM, Jiang H, Zhang Y, Deis JA, Blaner WS, Bernlohr DA, Chen X.

J Biol Chem. 2016 May 20;291(21):11216-29. doi: 10.1074/jbc.M115.711556. Epub 2016 Mar 22.


Piezoresistive nanocomposite as an embedded stress sensor in instrumented knee prosthesis.

Quyen Do, O'Byrne S, Perriman D, Smith P.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:2677-80. doi: 10.1109/EMBC.2015.7318943.


Magnetic resonance enterography is feasible and reliable in multicenter clinical trials in patients with Crohn's disease, and may help select subjects with active inflammation.

Coimbra AJ, Rimola J, O'Byrne S, Lu TT, Bengtsson T, de Crespigny A, Luca D, Rutgeerts P, Bruining DH, Fidler JL, Sandborn WJ, Santillan CS, Higgins PD, Al-Hawary MM, Vermeire S, Vanbeckevoort D, Vanslembrouck R, Peyrin-Biroulet L, Laurent V, Herrmann KA, Panes J.

Aliment Pharmacol Ther. 2016 Jan;43(1):61-72. doi: 10.1111/apt.13453. Epub 2015 Nov 9.


Agreement Between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients With Ulcerative Colitis.

Colombel JF, Ordás I, Ullman T, Rutgeerts P, Chai A, O'Byrne S, Lu TT, Panés J.

Gastroenterology. 2016 Feb;150(2):389-95.e3. doi: 10.1053/j.gastro.2015.10.016. Epub 2015 Oct 23.


Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.

Tew GW, Hackney JA, Gibbons D, Lamb CA, Luca D, Egen JG, Diehl L, Eastham Anderson J, Vermeire S, Mansfield JC, Feagan BG, Panes J, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Kirby JA, Irving PM, De Hertogh G, Van Assche GA, Rutgeerts P, O'Byrne S, Hayday A, Keir ME.

Gastroenterology. 2016 Feb;150(2):477-87.e9. doi: 10.1053/j.gastro.2015.10.041. Epub 2015 Oct 30.


Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein.

O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW.

Hepatology. 2015 Aug;62(2):615-26. doi: 10.1002/hep.27645. Epub 2015 Mar 23.


Baseline correction for stray light in log-ratio diode laser absorption measurements.

Krishna Y, O'Byrne S, Kurtz JJ.

Appl Opt. 2014 Jul 1;53(19):4128-35. doi: 10.1364/AO.53.004128.


Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial.

Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, Kirby JA, van Assche G, Rutgeerts P.

Lancet. 2014 Jul 26;384(9940):309-18. doi: 10.1016/S0140-6736(14)60661-9. Epub 2014 May 9.


T cell-mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells.

Hui CC, Murphy DM, Neighbour H, Al-Sayegh M, O'Byrne S, Thong B, Denburg JA, Larché M.

Clin Exp Allergy. 2014 Jul;44(7):953-64. doi: 10.1111/cea.12330.


EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) study identifies fecal calprotectin, serum MMP9, and serum IL-22 as a novel combination of biomarkers for Crohn's disease activity: role of cross-sectional imaging.

Faubion WA Jr, Fletcher JG, O'Byrne S, Feagan BG, de Villiers WJ, Salzberg B, Plevy S, Proctor DD, Valentine JF, Higgins PD, Harris JM, Diehl L, Wright L, Tew GW, Luca D, Basu K, Keir ME.

Am J Gastroenterol. 2013 Dec;108(12):1891-900. doi: 10.1038/ajg.2013.354. Epub 2013 Oct 15. Erratum in: Am J Gastroenterol. 2014 May;109(5):780.


Size-selective collection of circulating tumor cells using Vortex technology.

Sollier E, Go DE, Che J, Gossett DR, O'Byrne S, Weaver WM, Kummer N, Rettig M, Goldman J, Nickols N, McCloskey S, Kulkarni RP, Di Carlo D.

Lab Chip. 2014 Jan 7;14(1):63-77. doi: 10.1039/c3lc50689d. Epub 2013 Sep 23.


The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.

J Biol Chem. 2013 Aug 23;288(34):24528-39. doi: 10.1074/jbc.M113.484014. Epub 2013 Jul 9.


Retinol and retinyl esters: biochemistry and physiology.

O'Byrne SM, Blaner WS.

J Lipid Res. 2013 Jul;54(7):1731-43. doi: 10.1194/jlr.R037648. Epub 2013 Apr 26. Review.


Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology.

Garcia-Arcos I, Hiyama Y, Drosatos K, Bharadwaj KG, Hu Y, Son NH, O'Byrne SM, Chang CL, Deckelbaum RJ, Takahashi M, Westerterp M, Obunike JC, Jiang H, Yagyu H, Blaner WS, Goldberg IJ.

J Biol Chem. 2013 May 17;288(20):14046-58. doi: 10.1074/jbc.M113.469270. Epub 2013 Mar 31.


Visualization of jet development in laser-induced plasmas.

Brieschenk S, O'Byrne S, Kleine H.

Opt Lett. 2013 Mar 1;38(5):664-6. doi: 10.1364/OL.38.000664.


A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.

Rutgeerts PJ, Fedorak RN, Hommes DW, Sturm A, Baumgart DC, Bressler B, Schreiber S, Mansfield JC, Williams M, Tang M, Visich J, Wei X, Keir M, Luca D, Danilenko D, Egen J, O'Byrne S.

Gut. 2013 Aug;62(8):1122-30. doi: 10.1136/gutjnl-2011-301769. Epub 2012 Jun 20.


Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6.

Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N.

Mol Cell Biol. 2012 Aug;32(15):3164-75. doi: 10.1128/MCB.00505-12. Epub 2012 Jun 4.


Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.

Flowers MT, Paton CM, O'Byrne SM, Schiesser K, Dawson JA, Blaner WS, Kendziorski C, Ntambi JM.

PLoS One. 2011 May 9;6(5):e19734. doi: 10.1371/journal.pone.0019734.


Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.

Drager LF, Li J, Shin MK, Reinke C, Aggarwal NR, Jun JC, Bevans-Fonti S, Sztalryd C, O'Byrne SM, Kroupa O, Olivecrona G, Blaner WS, Polotsky VY.

Eur Heart J. 2012 Mar;33(6):783-90. doi: 10.1093/eurheartj/ehr097. Epub 2011 Apr 9.


Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.

Kluwe J, Wongsiriroj N, Troeger JS, Gwak GY, Dapito DH, Pradere JP, Jiang H, Siddiqi M, Piantedosi R, O'Byrne SM, Blaner WS, Schwabe RF.

Gut. 2011 Sep;60(9):1260-8. doi: 10.1136/gut.2010.209551. Epub 2011 Jan 27.


A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes.

Stefanich EG, Danilenko DM, Wang H, O'Byrne S, Erickson R, Gelzleichter T, Hiraragi H, Chiu H, Ivelja S, Jeet S, Gadkari S, Hwang O, Fuh F, Looney C, Howell K, Albert V, Balazs M, Refino C, Fong S, Iyer S, Williams M.

Br J Pharmacol. 2011 Apr;162(8):1855-70. doi: 10.1111/j.1476-5381.2011.01205.x.


Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice.

O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS.

Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E862-70. doi: 10.1152/ajpendo.00491.2009. Epub 2009 Dec 29.


Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage.

Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, Jiang H, Schwabe RF, Hillman EM, Piantedosi R, Libien J.

Biochim Biophys Acta. 2009 Jun;1791(6):467-73. doi: 10.1016/j.bbalip.2008.11.001. Epub 2008 Nov 24. Review.


Serum retinol-binding protein concentration and its association with components of the uremic metabolic syndrome in nondiabetic patients with chronic kidney disease stage 5.

Axelsson J, O'Byrne SM, Blaner WS, Carrero JJ, Bruchfeld A, Heimbürger O, Bárány P, Lindholm B, Stenvinkel P.

Am J Nephrol. 2009;29(5):447-53. doi: 10.1159/000176534. Epub 2008 Nov 21.


Retinoids and the metabolic syndrome.

O'Byrne SM, Blaner WS.

Expert Rev Endocrinol Metab. 2008 Sep;3(5):539-541. doi: 10.1586/17446651.3.5.539. No abstract available.


Diode-laser-based near-resonantly enhanced flow visualization in shock tunnels.

Hruschka R, O'Byrne S, Kleine H.

Appl Opt. 2008 Aug 20;47(24):4352-60.


Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT).

O'Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS.

J Biol Chem. 2005 Oct 21;280(42):35647-57. Epub 2005 Aug 22.


Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.

Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ.

Gut. 2005 Jan;54(1):142-51.


The effects and metabolic fate of nitroflurbiprofen in healthy volunteers.

Zacharowski P, Zacharowski K, Donnellan C, Johnston A, Vojnovic I, Forte P, Del Soldato P, Benjamin N, O'Byrne S.

Clin Pharmacol Ther. 2004 Oct;76(4):350-8.


Retinol-binding protein-deficient mice: biochemical basis for impaired vision.

Vogel S, Piantedosi R, O'Byrne SM, Kako Y, Quadro L, Gottesman ME, Goldberg IJ, Blaner WS.

Biochemistry. 2002 Dec 24;41(51):15360-8.


The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans.

Richardson G, Hicks SL, O'Byrne S, Frost MT, Moore K, Benjamin N, McKnight GM.

Nitric Oxide. 2002 Aug;7(1):24-9.


Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

O'Byrne S, Forte P, Roberts LJ 2nd, Morrow JD, Johnston A, Anggård E, Leslie RD, Benjamin N.

Diabetes. 2000 May;49(5):857-62.


Inhibition of platelet aggregation with glyceryl trinitrate and xanthine oxidoreductase.

O'Byrne S, Shirodaria C, Millar T, Stevens C, Blake D, Benjamin N.

J Pharmacol Exp Ther. 2000 Jan;292(1):326-30.


The genetic basis of hypertension: progress and opportunities.

Caulfield M, Collier D, O'Byrne S.

Hosp Med. 1998 Jan;59(1):37-40. Review.


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