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Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity.

Therajaran P, Hamilton JA, O'Brien TJ, Jones NC, Ali I.

Epilepsia. 2020 Jan 13. doi: 10.1111/epi.16424. [Epub ahead of print]


The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Sun M, McDonald SJ, Brady RD, Collins-Praino L, Yamakawa GR, Monif M, O'Brien TJ, Cloud GC, Sobey CG, Mychasiuk R, Loane DJ, Shultz SR.

Neurosci Biobehav Rev. 2019 Dec 23;109:114-128. doi: 10.1016/j.neubiorev.2019.12.027. [Epub ahead of print] Review.


A Continuous-Flow Model for in vitro Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections.

O'Brien TJ, Welch M.

Front Microbiol. 2019 Nov 22;10:2713. doi: 10.3389/fmicb.2019.02713. eCollection 2019.


Genomic and clinical predictors of lacosamide response in refractory epilepsies.

Heavin SB, McCormack M, Wolking S, Slattery L, Walley N, Avbersek A, Novy J, Sinha SR, Radtke R, Doherty C, Auce P, Craig J, Johnson MR, Koeleman BPC, Krause R, Kunz WS, Marson AG, O'Brien TJ, Sander JW, Sills GJ, Stefansson H, Striano P, Zara F; EPIGEN Consortium; EpiPGX Consortium, Depondt C, Sisodiya S, Goldstein D, Lerche H, Cavalleri GL, Delanty N.

Epilepsia Open. 2019 Sep 25;4(4):563-571. doi: 10.1002/epi4.12360. eCollection 2019 Dec.


Role of cerebral glutamate in post-stroke epileptogenesis.

Nicolo JP, O'Brien TJ, Kwan P.

Neuroimage Clin. 2019;24:102069. doi: 10.1016/j.nicl.2019.102069. Epub 2019 Nov 5. Review.


NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour.

Hudson MR, Sokolenko E, O'Brien TJ, Jones NC.

Neurobiol Dis. 2019 Nov 28;134:104625. doi: 10.1016/j.nbd.2019.104625. [Epub ahead of print]


Comparisons of direct and indirect utilities in adult epilepsy populations: A systematic review.

Foster E, Chen Z, Ofori-Asenso R, Norman R, Carney P, O'Brien TJ, Kwan P, Liew D, Ademi Z.

Epilepsia. 2019 Dec;60(12):2466-2476. doi: 10.1111/epi.16396. Epub 2019 Nov 30.


Recapitulation of polymicrobial communities associated with cystic fibrosis airway infections: a perspective.

O'Brien TJ, Welch M.

Future Microbiol. 2019 Nov;14:1437-1450. doi: 10.2217/fmb-2019-0200. Epub 2019 Nov 28.


Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs.

Brady RD, Wong KR, Robinson DL, Mychasiuk R, McDonald SJ, D'Cunha RA, Yamakawa GR, Sun M, Wark JD, Lee PVS, O'Brien TJ, Casillas-Espinosa PM, Shultz SR.

Front Pharmacol. 2019 Oct 29;10:1278. doi: 10.3389/fphar.2019.01278. eCollection 2019.


Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets.

Sharma R, Leung WL, Zamani A, O'Brien TJ, Casillas Espinosa PM, Semple BD.

Brain Sci. 2019 Nov 9;9(11). pii: E318. doi: 10.3390/brainsci9110318. Review.


Preexisting illness, fetal malformation, and seizure control rates in pregnant women with epilepsy.

Vajda FJE, O'Brien TJ, Graham JE, Hitchcock AA, Lander CM, Eadie MJ.

Epilepsy Behav. 2019 Nov 8:106481. doi: 10.1016/j.yebeh.2019.106481. [Epub ahead of print]


Distinct psychopathology profiles in patients with epileptic seizures compared to non-epileptic psychogenic seizures.

Wang AD, Leong M, Johnstone B, Rayner G, Kalincik T, Roos I, Kwan P, O'Brien TJ, Velakoulis D, Malpas CB.

Epilepsy Res. 2019 Dec;158:106234. doi: 10.1016/j.eplepsyres.2019.106234. Epub 2019 Nov 1.


Author response: Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring.

Sivathamboo S, O'Brien TJ, Goldin J, Perucca P, Kwan P, Velakoulis D.

Neurology. 2019 Nov 5;93(19):864-865. doi: 10.1212/WNL.0000000000008454. No abstract available.


The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies.

Dvir N, Javaid MS, Jones NC, Powell KL, Kwan P, O'Brien TJ, Antonic-Baker A.

Syst Rev. 2019 Nov 1;8(1):255. doi: 10.1186/s13643-019-1169-3.


Abbreviated assessment of psychopathology in patients with suspected seizure disorders.

Malpas CB, Wang AD, Leong M, Johnstone B, Rayner G, Kalincik T, Kwan P, O'Brien TJ, Velakoulis D.

Epilepsy Behav. 2019 Nov;100(Pt A):106530. doi: 10.1016/j.yebeh.2019.106530. Epub 2019 Oct 25.


Personality profiles differ between patients with epileptic seizures and patients with psychogenic non-epileptic seizures.

Leong M, Wang AD, Trainor D, Johnstone B, Rayner G, Kalincik T, Roos I, Kwan P, O'Brien TJ, Velakoulis D, Malpas CB.

Seizure. 2019 Dec;73:1-8. doi: 10.1016/j.seizure.2019.10.011. Epub 2019 Oct 17.


Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

Wright DK, Brady RD, Kamnaksh A, Trezise J, Sun M, McDonald SJ, Mychasiuk R, Kolbe SC, Law M, Johnston LA, O'Brien TJ, Agoston DV, Shultz SR.

Sci Rep. 2019 Oct 10;9(1):14626. doi: 10.1038/s41598-019-51267-w.


Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?

Wesselingh R, Butzkueven H, Buzzard K, Tarlinton D, O'Brien TJ, Monif M.

Front Immunol. 2019 Sep 10;10:2066. doi: 10.3389/fimmu.2019.02066. eCollection 2019. Review.


Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy.

O'Brien TJ, Lorenzo MF, Zhao Y, Neal Ii RE, Robertson JL, Goldberg SN, Davalos RV.

Int J Hyperthermia. 2019;36(1):953-963. doi: 10.1080/02656736.2019.1657187.


Seizures in infancy in the offspring of women with epilepsy.

Vajda FJE, O'Brien TJ, Graham JE, Hitchcock AA, Lander CM, Eadie MJ.

Acta Neurol Scand. 2020 Jan;141(1):33-37. doi: 10.1111/ane.13170. Epub 2019 Oct 22.


Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer's Disease.

Paudel YN, Angelopoulou E, Jones NC, O'Brien TJ, Kwan P, Piperi C, Othman I, Shaikh MF.

ACS Chem Neurosci. 2019 Oct 16;10(10):4199-4212. doi: 10.1021/acschemneuro.9b00460. Epub 2019 Sep 30.


The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice.

Tan XL, Zheng P, Wright DK, Sun M, Brady RD, Liu S, McDonald SJ, Mychasiuk R, Cenap S, Jones NC, O'Brien TJ, Shultz SR.

Brain Inj. 2020;34(1):131-139. doi: 10.1080/02699052.2019.1667539. Epub 2019 Sep 16.


An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats.

Leung WL, Casillas-Espinosa P, Sharma P, Perucca P, Powell K, O'Brien TJ, Semple BD.

Epilepsia. 2019 Oct;60(10):2023-2036. doi: 10.1111/epi.16329. Epub 2019 Aug 29. Review.


Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy.

Silvennoinen K, de Lange N, Zagaglia S, Balestrini S, Androsova G, Wassenaar M, Auce P, Avbersek A, Becker F, Berghuis B, Campbell E, Coppola A, Francis B, Wolking S, Cavalleri GL, Craig J, Delanty N, Johnson MR, Koeleman BPC, Kunz WS, Lerche H, Marson AG, O'Brien TJ, Sander JW, Sills GJ, Striano P, Zara F, van der Palen J, Krause R, Depondt C, Sisodiya SM; EpiPGX Consortium.

Epilepsia Open. 2019 Jul 4;4(3):420-430. doi: 10.1002/epi4.12349. eCollection 2019 Sep.


Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy.

Casillas-Espinosa PM, Shultz SR, Braine EL, Jones NC, Snutch TP, Powell KL, O'Brien TJ.

Prog Neurobiol. 2019 Nov;182:101677. doi: 10.1016/j.pneurobio.2019.101677. Epub 2019 Aug 13.


Epilepsy and seizure-related deaths: Mortality statistics do not tell the complete story.

Panelli RJ, O'Brien TJ.

Epilepsy Behav. 2019 Sep;98(Pt A):266-272. doi: 10.1016/j.yebeh.2019.07.003. Epub 2019 Aug 10.


Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance.

Li MCH, O'Brien TJ, Todaro M, Powell KL.

Epilepsia. 2019 Sep;60(9):1753-1767. doi: 10.1111/epi.16301. Epub 2019 Jul 29. Review.


Pharmaceutical Benefits Scheme restrictions on anti-epileptic drug prescribing promote unsafe and outdated practice.

Gericke CA, O'Brien TJ.

Med J Aust. 2019 Jul;211(2):55-57.e1. doi: 10.5694/mja2.50246. Epub 2019 Jun 30. No abstract available.


Multiunit cluster firing patterns of piriform cortex and mediodorsal thalamus in absence epilepsy.

Young JC, Nasser HM, Casillas-Espinosa PM, O'Brien TJ, Jackson GD, Paolini AG.

Epilepsy Behav. 2019 Aug;97:229-243. doi: 10.1016/j.yebeh.2019.05.032. Epub 2019 Jun 26.


Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences.

Webster KM, Shultz SR, Ozturk E, Dill LK, Sun M, Casillas-Espinosa P, Jones NC, Crack PJ, O'Brien TJ, Semple BD.

Exp Neurol. 2019 Oct;320:112979. doi: 10.1016/j.expneurol.2019.112979. Epub 2019 Jun 21.


Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences.

Scheltema MJ, O'Brien TJ, van den Bos W, de Bruin DM, Davalos RV, van den Geld CWM, Laguna MP, Neal RE 2nd, Varkarakis IM, Skolarikos A, Stricker PD, de Reijke TM, Arena CB, de la Rosette J.

Ther Adv Urol. 2019 Jun 7;11:1756287219852305. doi: 10.1177/1756287219852305. eCollection 2019 Jan-Dec.


Cav 3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg.

Çarçak N, Ali I, Powell K, Zheng T, Onat F, O'Brien TJ.

Epilepsia. 2019 Jul;60(7):1378-1386. doi: 10.1111/epi.16076. Epub 2019 Jun 17.


The utility of an automated and ambulatory device for detecting and differentiating epileptic and psychogenic non-epileptic seizures.

Naganur VD, Kusmakar S, Chen Z, Palaniswami MS, Kwan P, O'Brien TJ.

Epilepsia Open. 2019 May 13;4(2):309-317. doi: 10.1002/epi4.12327. eCollection 2019 Jun.


Experimental High-Frequency Irreversible Electroporation Using a Single-Needle Delivery Approach for Nonthermal Pancreatic Ablation In Vivo.

O'Brien TJ, Passeri M, Lorenzo MF, Sulzer JK, Lyman WB, Swet JH, Vrochides D, Baker EH, Iannitti DA, Davalos RV, McKillop IH.

J Vasc Interv Radiol. 2019 Jun;30(6):854-862.e7. doi: 10.1016/j.jvir.2019.01.032.


Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis.

Casillas-Espinosa PM, Andrade P, Santana-Gomez C, Paananen T, Smith G, Ali I, Ciszek R, Ndode-Ekane XE, Brady RD, Tohka J, Hudson MR, Perucca P, Braine EL, Immonen R, Puhakka N, Shultz SR, Jones NC, Staba RJ, Pitkänen A, O'Brien TJ.

Epilepsy Res. 2019 Oct;156:106131. doi: 10.1016/j.eplepsyres.2019.04.011. Epub 2019 Apr 27.


Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Sun M, Brady RD, Casillas-Espinosa PM, Wright DK, Semple BD, Kim HA, Mychasiuk R, Sobey CG, O'Brien TJ, Vinh A, McDonald SJ, Shultz SR.

Brain Behav Immun. 2019 Aug;80:536-550. doi: 10.1016/j.bbi.2019.04.038. Epub 2019 Apr 27.


Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems.

Sharma R, Shultz SR, Robinson MJ, Belli A, Hibbs ML, O'Brien TJ, Semple BD.

Brain Behav Immun. 2019 Jul;79:63-74. doi: 10.1016/j.bbi.2019.04.034. Epub 2019 Apr 25. Review.


Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent.

Opie NL, John SE, Rind GS, Ronayne SM, Wong YT, Gerboni G, Yoo PE, Lovell TJH, Scordas TCM, Wilson SL, Dornom A, Vale T, O'Brien TJ, Grayden DB, May CN, Oxley TJ.

Nat Biomed Eng. 2018 Dec;2(12):907-914. doi: 10.1038/s41551-018-0321-z. Epub 2018 Dec 3.


Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis.

Santana-Gomez C, Andrade P, Hudson MR, Paananen T, Ciszek R, Smith G, Ali I, Rundle BK, Ndode-Ekane XE, Casillas-Espinosa PM, Immonen R, Puhakka N, Jones N, Brady RD, Perucca P, Shultz SR, Pitkänen A, O'Brien TJ, Staba R.

Epilepsy Res. 2019 Oct;156:106110. doi: 10.1016/j.eplepsyres.2019.03.008. Epub 2019 Mar 15.


Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.

Luwor R, Morokoff AP, Amiridis S, D'Abaco G, Paradiso L, Stylli SS, Nguyen HPT, Tarleton M, Young KA, O'Brien TJ, Robinson PJ, Chircop M, McCluskey A, Jones NC.

Cancer Invest. 2019;37(3):144-155. doi: 10.1080/07357907.2019.1582060. Epub 2019 Mar 25.


Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy.

Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ.

Epilepsia Open. 2019 Feb 22;4(1):153-163. doi: 10.1002/epi4.12308. eCollection 2019 Mar.


A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

Berghuis B, Stapleton C, Sonsma ACM, Hulst J, de Haan GJ, Lindhout D, Demurtas R; EpiPGX Consortium, Krause R, Depondt C, Kunz WS, Zara F, Striano P, Craig J, Auce P, Marson AG, Stefansson H, O'Brien TJ, Johnson MR, Sills GJ, Wolking S, Lerche H, Sisodiya SM, Sander JW, Cavalleri GL, Koeleman BPC, McCormack M.

Epilepsia Open. 2019 Jan 17;4(1):102-109. doi: 10.1002/epi4.12297. eCollection 2019 Mar.


A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy.

Casillas-Espinosa PM, Sargsyan A, Melkonian D, O'Brien TJ.

Epilepsia. 2019 Apr;60(4):783-791. doi: 10.1111/epi.14691. Epub 2019 Mar 13.


Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging.

Neal A, Moffat BA, Stein JM, Nanga RPR, Desmond P, Shinohara RT, Hariharan H, Glarin R, Drummond K, Morokoff A, Kwan P, Reddy R, O'Brien TJ, Davis KA.

Neuroimage Clin. 2019;22:101694. doi: 10.1016/j.nicl.2019.101694. Epub 2019 Jan 29.


Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.

Ndode-Ekane XE, Santana-Gomez C, Casillas-Espinosa PM, Ali I, Brady RD, Smith G, Andrade P, Immonen R, Puhakka N, Hudson MR, Braine EL, Shultz SR, Staba RJ, O'Brien TJ, Pitkänen A.

Epilepsy Res. 2019 Mar;151:7-16. doi: 10.1016/j.eplepsyres.2019.01.006. Epub 2019 Jan 18.


Epilepsy in adults.

Thijs RD, Surges R, O'Brien TJ, Sander JW.

Lancet. 2019 Feb 16;393(10172):689-701. doi: 10.1016/S0140-6736(18)32596-0. Epub 2019 Jan 24. Review.


Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis.

Immonen R, Smith G, Brady RD, Wright D, Johnston L, Harris NG, Manninen E, Salo R, Branch C, Duncan D, Cabeen R, Ndode-Ekane XE, Gomez CS, Casillas-Espinosa PM, Ali I, Shultz SR, Andrade P, Puhakka N, Staba RJ, O'Brien TJ, Toga AW, Pitkänen A, Gröhn O.

Epilepsy Res. 2019 Feb;150:46-57. doi: 10.1016/j.eplepsyres.2019.01.001. Epub 2019 Jan 7.


A recurrent nova super-remnant in the Andromeda galaxy.

Darnley MJ, Hounsell R, O'Brien TJ, Henze M, Rodríguez-Gil P, Shafter AW, Shara MM, Vaytet NMH, Bode MF, Ciardullo R, Davis BD, Galera-Rosillo R, Harman DJ, Harvey EJ, Healy MW, Ness JU, Ribeiro VARM, Williams SC.

Nature. 2019 Jan;565(7740):460-463. doi: 10.1038/s41586-018-0825-4. Epub 2019 Jan 9.


A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice.

Sun M, Brady RD, van der Poel C, Apted D, Semple BD, Church JE, O'Brien TJ, McDonald SJ, Shultz SR.

Front Neurol. 2018 Dec 11;9:1089. doi: 10.3389/fneur.2018.01089. eCollection 2018.

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