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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.

Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, Shen X, Aubert-Nicol S, Chen YC, Cheong J, Crawford JJ, Hafner M, Haghshenas P, Jakalian A, Leclerc JP, Lim NK, O'Brien T, Plise EG, Shalan H, Sturino C, Wai J, Xiao Y, Yin J, Zhao L, Gould S, Olivero A, Heffron TP.

Bioorg Med Chem Lett. 2019 Jun 26. pii: S0960-894X(19)30401-9. doi: 10.1016/j.bmcl.2019.06.021. [Epub ahead of print]


Effects of land-use change on community diversity and composition are highly variable among functional groups.

Graham SI, Kinnaird MF, O'Brien TG, Vågen TG, Winowiecki LA, Young TP, Young HS.

Ecol Appl. 2019 Jul 15. doi: 10.1002/eap.1973. [Epub ahead of print]


TCR α+ β+ /CD19+ cell-depleted hematopoietic stem cell transplantation for pediatric patients.

Mitchell R, Cole T, Shaw PJ, Mechinaud F, O'Brien T, Fraser C.

Pediatr Transplant. 2019 Jul 4:e13517. doi: 10.1111/petr.13517. [Epub ahead of print]


A novel multivariate approach for biomechanical profiling of stair negotiation.

Ackermans TMA, Francksen NC, Casana-Eslava RV, Lees C, Baltzopoulos V, Lisboa PJG, Hollands MA, O'Brien TD, Maganaris CN.

Exp Gerontol. 2019 Jun 30;124:110646. doi: 10.1016/j.exger.2019.110646. [Epub ahead of print]


Pharmaceutical Benefits Scheme restrictions on anti-epileptic drug prescribing promote unsafe and outdated practice.

Gericke CA, O'Brien TJ.

Med J Aust. 2019 Jul;211(2):55-57.e1. doi: 10.5694/mja2.50246. Epub 2019 Jun 30. No abstract available.


Multiunit cluster firing patterns of piriform cortex and mediodorsal thalamus in absence epilepsy.

Young JC, Nasser HM, Casilla-Espinosa P, O'Brien TJ, Jackson GD, Paolini AG.

Epilepsy Behav. 2019 Jun 26;97:229-243. doi: 10.1016/j.yebeh.2019.05.032. [Epub ahead of print]


Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences.

Webster KM, Shultz SR, Ozturk E, Dill LK, Sun M, Casillas-Espinosa P, Jones NC, Crack PJ, O'Brien TJ, Semple BD.

Exp Neurol. 2019 Jun 21;320:112979. doi: 10.1016/j.expneurol.2019.112979. [Epub ahead of print]


Healthcare professionals' attitudes toward cancer precision medicine: A systematic review.

Vetsch J, Wakefield CE, Techakesari P, Warby M, Ziegler DS, O'Brien TA, Drinkwater C, Neeman N, Tucker K.

Semin Oncol. 2019 Jun 10. pii: S0093-7754(19)30050-8. doi: 10.1053/j.seminoncol.2019.05.001. [Epub ahead of print] Review.


Numerical simulation modeling of the irreversible electroporation treatment zone for focal therapy of prostate cancer, correlation with whole-mount pathology and T2-weighted MRI sequences.

Scheltema MJ, O'Brien TJ, van den Bos W, de Bruin DM, Davalos RV, van den Geld CWM, Laguna MP, Neal RE 2nd, Varkarakis IM, Skolarikos A, Stricker PD, de Reijke TM, Arena CB, de la Rosette J.

Ther Adv Urol. 2019 Jun 7;11:1756287219852305. doi: 10.1177/1756287219852305. eCollection 2019 Jan-Dec.


Cav 3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg.

Çarçak N, Ali I, Powell K, Zheng T, Onat F, O'Brien TJ.

Epilepsia. 2019 Jul;60(7):1378-1386. doi: 10.1111/epi.16076. Epub 2019 Jun 17.


Impact of Centralizing Care for Genitourinary Malignancies to High-volume Providers: A Systematic Review.

Williams SB, Ray-Zack MD, Hudgins HK, Oldenburg J, Trinh QD, Nguyen PL, Shore ND, Wirth MP, O'Brien T, Catto JWF.

Eur Urol Oncol. 2019 May;2(3):265-273. doi: 10.1016/j.euo.2018.10.006. Epub 2018 Nov 5. Review.


The utility of an automated and ambulatory device for detecting and differentiating epileptic and psychogenic non-epileptic seizures.

Naganur VD, Kusmakar S, Chen Z, Palaniswami MS, Kwan P, O'Brien TJ.

Epilepsia Open. 2019 May 13;4(2):309-317. doi: 10.1002/epi4.12327. eCollection 2019 Jun.


Letter to the editor regarding: Effects of cerebral palsy on Achilles tendon moment arm length - Do children with CP have larger or smaller moment arms than typically developing children? Commentary on: Alexander et al.

Kalkman BM, Maganaris CN, Bar-On L, O'Brien TD.

J Biomech. 2019 Jul 19;92:175-177. doi: 10.1016/j.jbiomech.2019.03.039. Epub 2019 May 9. No abstract available.


What Have We Learned from Studies of IFN-λ Variants and HCV Infection?

O'Brien TR, Jackson SS.

J Interferon Cytokine Res. 2019 Jun 4. doi: 10.1089/jir.2019.0048. [Epub ahead of print]


Experimental High-Frequency Irreversible Electroporation Using a Single-Needle Delivery Approach for Nonthermal Pancreatic Ablation In Vivo.

O'Brien TJ, Passeri M, Lorenzo MF, Sulzer JK, Lyman WB, Swet JH, Vrochides D, Baker EH, Iannitti DA, Davalos RV, McKillop IH.

J Vasc Interv Radiol. 2019 Jun;30(6):854-862.e7. doi: 10.1016/j.jvir.2019.01.032.


Hematopoietic stem cell transplantation for children with acute myeloid leukemia in second remission: A report from the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group.

Selim A, Alvaro F, Cole CH, Fraser CJ, Mechinaud F, O'Brien TA, Shaw PJ, Tapp H, Teague L, Nivison-Smith I, Moore AS.

Pediatr Blood Cancer. 2019 Aug;66(8):e27812. doi: 10.1002/pbc.27812. Epub 2019 May 20.


Piloting a parent and patient decision aid to support clinical trial decision making in childhood cancer.

Robertson EG, Wakefield CE, Cohn RJ, Battisti RA, Donoghoe MW, Ziegler DS, Fardell JE, Mitchell R, O'Brien TA.

Psychooncology. 2019 Jul;28(7):1520-1529. doi: 10.1002/pon.5109. Epub 2019 Jun 11.


Management and prevention of cytomegalovirus infection in paediatric hematopoietic stem cell transplant (HSCT) recipients: A binational survey.

Al Yazidi LS, Mitchell R, Palasanthiran P, O'Brien TA, McMullan B.

Pediatr Transplant. 2019 May 12:e13458. doi: 10.1111/petr.13458. [Epub ahead of print]


Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis.

Casillas-Espinosa PM, Andrade P, Santana-Gomez C, Paananen T, Smith G, Ali I, Ciszek R, Ndode-Ekane XE, Brady RD, Tohka J, Hudson MR, Perucca P, Braine EL, Immonen R, Puhakka N, Shultz SR, Jones NC, Staba RJ, Pitkänen A, O'Brien TJ.

Epilepsy Res. 2019 Apr 27. pii: S0920-1211(18)30489-3. doi: 10.1016/j.eplepsyres.2019.04.011. [Epub ahead of print]


The Past, Present and Future of Cardiac Resynchronization Therapy.

O'Brien T, Park MS, Youn JC, Chung ES.

Korean Circ J. 2019 May;49(5):384-399. doi: 10.4070/kcj.2019.0114. Review.


Ictal cerebral blood flow in psychogenic non-epileptic seizures: a preliminary SPECT study.

Olver J, Castro-de-Araujo LF, Mullen SA, O'Brien T, Berlangieri SU, Vivash L, Velakoulis D, Lichtenstein M, Kanaan R.

J Neurol Neurosurg Psychiatry. 2019 Apr 30. pii: jnnp-2018-320173. doi: 10.1136/jnnp-2018-320173. [Epub ahead of print] No abstract available.


Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Sun M, Brady RD, Casillas-Espinosa PM, Wright DK, Semple BD, Kim HA, Mychasiuk R, Sobey CG, O'Brien TJ, Vinh A, McDonald SJ, Shultz SR.

Brain Behav Immun. 2019 Apr 27. pii: S0889-1591(18)30850-X. doi: 10.1016/j.bbi.2019.04.038. [Epub ahead of print]


The role of microglia and P2X7 receptors in gliomas.

Kan LK, Williams D, Drummond K, O'Brien T, Monif M.

J Neuroimmunol. 2019 Jul 15;332:138-146. doi: 10.1016/j.jneuroim.2019.04.010. Epub 2019 Apr 20. Review.


Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems.

Sharma R, Shultz SR, Robinson MJ, Belli A, Hibbs ML, O'Brien TJ, Semple BD.

Brain Behav Immun. 2019 Jul;79:63-74. doi: 10.1016/j.bbi.2019.04.034. Epub 2019 Apr 25. Review.


Unpredictable shoe midsole perturbations provide an instability stimulus to train ankle posture and motion during forward and lateral gym lunges.

Apps C, Lake M, O'Brien TD, Sterzing T.

J Sports Sci. 2019 Sep;37(17):1951-1961. doi: 10.1080/02640414.2019.1609161. Epub 2019 Apr 26.


Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent.

Opie NL, John SE, Rind GS, Ronayne SM, Wong YT, Gerboni G, Yoo PE, Lovell TJH, Scordas TCM, Wilson SL, Dornom A, Vale T, O'Brien TJ, Grayden DB, May CN, Oxley TJ.

Nat Biomed Eng. 2018 Dec;2(12):907-914. doi: 10.1038/s41551-018-0321-z. Epub 2018 Dec 3.


A Revised Look at Relativistic Electrons in the Earth's Inner Radiation Zone and Slot Region.

Claudepierre SG, O'Brien TP, Looper MD, Blake JB, Fennell JF, Roeder JL, Clemmons JH, Mazur JE, Turner DL, Reeves GD, Spence HE.

J Geophys Res Space Phys. 2019 Feb;124(2):934-951. doi: 10.1029/2018JA026349. Epub 2019 Feb 4.


Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

O'Brien TR, Young HA, Donnelly RP, Prokunina-Olsson L.

J Interferon Cytokine Res. 2019 Apr 17. doi: 10.1089/jir.2019.0018. [Epub ahead of print]


Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis.

Santana-Gomez C, Andrade P, Hudson MR, Paananen T, Ciszek R, Smith G, Ali I, Rundle BK, Ndode-Ekane XE, Casillas-Espinosa PM, Immonen R, Puhakka N, Jones N, Brady RD, Perucca P, Shultz SR, Pitkänen A, O'Brien TJ, Staba R.

Epilepsy Res. 2019 Mar 15. pii: S0920-1211(18)30612-0. doi: 10.1016/j.eplepsyres.2019.03.008. [Epub ahead of print]


Incidence of hepatocellular carcinoma among older Americans attributable to hepatitis C and hepatitis B: 2001 through 2013.

Shiels MS, Engels EA, Yanik EL, McGlynn KA, Pfeiffer RM, O'Brien TR.

Cancer. 2019 Aug 1;125(15):2621-2630. doi: 10.1002/cncr.32129. Epub 2019 Apr 12.


Engaging primary care physicians in care coordination for patients with complex medical conditions.

Lockhart E, Hawker GA, Ivers NM, O'Brien T, Mukerji G, Pariser P, Stanaitis I, Pus L, Baker GR.

Can Fam Physician. 2019 Apr;65(4):e155-e162.


Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats.

Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A.

Toxicol Appl Pharmacol. 2019 Jun 1;372:19-32. doi: 10.1016/j.taap.2019.04.001. Epub 2019 Apr 8.


The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia.

Keating AK, Langenhorst J, Wagner JE, Page KM, Veys P, Wynn RF, Stefanski H, Elfeky R, Giller R, Mitchell R, Milano F, O'Brien TA, Dahlberg A, Delaney C, Kurtzberg J, Verneris MR, Boelens JJ.

Blood Adv. 2019 Apr 9;3(7):1118-1128. doi: 10.1182/bloodadvances.2018025908.


First seizure presentations in adults: beyond assessment and treatment.

Foster E, Carney P, Liew D, Ademi Z, O'Brien T, Kwan P.

J Neurol Neurosurg Psychiatry. 2019 Apr 4. pii: jnnp-2018-320215. doi: 10.1136/jnnp-2018-320215. [Epub ahead of print] Review.


PAK2 links cell survival to mechanotransduction and metabolism.

Campbell HK, Salvi AM, O'Brien T, Superfine R, DeMali KA.

J Cell Biol. 2019 Jun 3;218(6):1958-1971. doi: 10.1083/jcb.201807152. Epub 2019 Apr 2.


Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129.

Gomes CPC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M, Hoydal MA, Jankovic A, Jusic A, Kardassis D, Kerkelä R, Kuster GM, Lakkisto P, Leszek P, Lustrek M, Maegdefessel L, Martelli F, Novella S, O'Brien T, Papaneophytou C, Pedrazzini T, Pinet F, Popescu O, Potočnjak I, Robinson E, Sasson S, Scholz M, Simionescu M, Stoll M, Varga ZV, Vinciguerra M, Xuereb A, Yilmaz MB, Emanueli C, Devaux Y, on behalf of the EU-CardioRNA COST Action (CA17129).

Noncoding RNA. 2019 Mar 29;5(2). pii: E31. doi: 10.3390/ncrna5020031.


Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis.

Deng X, Mettelman RC, O'Brien A, Thompson JA, O'Brien TE, Baker SC.

J Virol. 2019 May 29;93(12). pii: e02140-18. doi: 10.1128/JVI.02140-18. Print 2019 Jun 15.


The role of vitamin D and P2X7R in multiple sclerosis.

Voo VTF, O'Brien T, Butzkueven H, Monif M.

J Neuroimmunol. 2019 May 15;330:159-169. doi: 10.1016/j.jneuroim.2019.03.004. Epub 2019 Mar 14. Review.


Surgery for high-risk locally advanced (pT3c) renal tumours: oncological outcomes and prognostic significance of a modified International Metastatic Renal Cell Cancer Database Consortium (IMDC) score.

Warren H, Fernando A, Thomas K, Austin C, Chowdhury S, O'Brien T.

BJU Int. 2019 Mar 25. doi: 10.1111/bju.14755. [Epub ahead of print]


Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.

Luwor R, Morokoff AP, Amiridis S, D'Abaco G, Paradiso L, Stylli SS, Nguyen HPT, Tarleton M, Young KA, O'Brien TJ, Robinson PJ, Chircop M, McCluskey A, Jones NC.

Cancer Invest. 2019;37(3):144-155. doi: 10.1080/07357907.2019.1582060. Epub 2019 Mar 25.


Exploring patients' interest in complementary therapies in a specialist palliative care unit.

Harte J, Leahy H, McCarthy J, O'Brien T.

Int J Palliat Nurs. 2019 Mar 2;25(3):108-110. doi: 10.12968/ijpn.2019.25.3.108.


Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.

Vinnakota KC, Pannala VR, Wall ML, Rahim M, Estes SK, Trenary I, O'Brien TP, Printz RL, Reifman J, Shiota M, Young JD, Wallqvist A.

Front Physiol. 2019 Mar 1;10:161. doi: 10.3389/fphys.2019.00161. eCollection 2019.


Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient.

Ma J, Guo R, Song Y, Zhang J, Feng B, Amponsah AE, Kong D, He J, Zhang W, Liu A, Wei L, Shen S, O'Brien T, Cui H.

Stem Cell Res. 2019 Apr;36:101417. doi: 10.1016/j.scr.2019.101417. Epub 2019 Mar 7.


Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy.

Borges K, Kaul N, Germaine J, Kwan P, O'Brien TJ.

Epilepsia Open. 2019 Feb 22;4(1):153-163. doi: 10.1002/epi4.12308. eCollection 2019 Mar.


A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.

Berghuis B, Stapleton C, Sonsma ACM, Hulst J, de Haan GJ, Lindhout D, Demurtas R; EpiPGX Consortium, Krause R, Depondt C, Kunz WS, Zara F, Striano P, Craig J, Auce P, Marson AG, Stefansson H, O'Brien TJ, Johnson MR, Sills GJ, Wolking S, Lerche H, Sisodiya SM, Sander JW, Cavalleri GL, Koeleman BPC, McCormack M.

Epilepsia Open. 2019 Jan 17;4(1):102-109. doi: 10.1002/epi4.12297. eCollection 2019 Mar.


A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy.

Casillas-Espinosa PM, Sargsyan A, Melkonian D, O'Brien TJ.

Epilepsia. 2019 Apr;60(4):783-791. doi: 10.1111/epi.14691. Epub 2019 Mar 13.


Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging.

Neal A, Moffat BA, Stein JM, Nanga RPR, Desmond P, Shinohara RT, Hariharan H, Glarin R, Drummond K, Morokoff A, Kwan P, Reddy R, O'Brien TJ, Davis KA.

Neuroimage Clin. 2019;22:101694. doi: 10.1016/j.nicl.2019.101694. Epub 2019 Jan 29.


Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy.

Allebone J, Kanaan R, Maller J, O'Brien T, Mullen SA, Cook M, Adams SJ, Vogrin S, Vaughan DN, Connelly A, Kwan P, Berkovic SF, D'Souza WJ, Jackson G, Velakoulis D, Wilson SJ.

J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):688-694. doi: 10.1136/jnnp-2018-319396. Epub 2019 Feb 22.


Pathophysiology and management of opioid-induced constipation: European expert consensus statement.

Farmer AD, Drewes AM, Chiarioni G, De Giorgio R, O'Brien T, Morlion B, Tack J.

United European Gastroenterol J. 2019 Feb;7(1):7-20. doi: 10.1177/2050640618818305. Epub 2018 Dec 14. Review. Erratum in: United European Gastroenterol J. 2019 Mar;7(2):178.


Prognosis in autoimmune encephalitis: Database.

Broadley J, Seneviratne U, Beech P, Buzzard K, Butzkueven H, O'Brien T, Monif M.

Data Brief. 2018 Nov 13;21:2694-2703. doi: 10.1016/j.dib.2018.11.020. eCollection 2018 Dec.

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