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Puma genomes from North and South America provide insights into the genomic consequences of inbreeding.

Saremi NF, Supple MA, Byrne A, Cahill JA, Coutinho LL, Dalén L, Figueiró HV, Johnson WE, Milne HJ, O'Brien SJ, O'Connell B, Onorato DP, Riley SPD, Sikich JA, Stahler DR, Villela PMS, Vollmers C, Wayne RK, Eizirik E, Corbett-Detig RB, Green RE, Wilmers CC, Shapiro B.

Nat Commun. 2019 Oct 18;10(1):4769. doi: 10.1038/s41467-019-12741-1.


Higher rates of bleeding and use of treatment products among young boys compared to girls with von Willebrand Disease.

Abe K, Dupervil B, O'Brien SH, Oakley M, Kulkarni R, Gill JC, Byams V, Soucie MJ; US Hemophilia Treatment Center Network.

Am J Hematol. 2019 Oct 15. doi: 10.1002/ajh.25656. [Epub ahead of print]


The use and misuse of indirectly standardized, risk-adjusted outcomes and star ratings.

Shahian DM, Kozower BD, Fernandez FG, Badhwar V, O'Brien SM.

Ann Thorac Surg. 2019 Oct 8. pii: S0003-4975(19)31558-9. doi: 10.1016/j.athoracsur.2019.09.010. [Epub ahead of print] No abstract available.


Evaluating the intactness of persistent viral genomes in SIV-infected rhesus macaques initiating antiretroviral therapy within one year of infection.

Long S, Fennessey CM, Newman L, Reid C, O'Brien SP, Li Y, Del Prete GQ, Lifson JD, Gorelick RJ, Keele BF.

J Virol. 2019 Oct 9. pii: JVI.01308-19. doi: 10.1128/JVI.01308-19. [Epub ahead of print]


In vivo validation of the viral barcoding of SIVmac239 and the development of new barcoded SIV and subtype B and C SHIVs.

Khanal S, Fennessey CM, O'Brien SP, Thorpe A, Reid C, Immonen TT, Smith R, Bess JW Jr, Swanstrom AE, Del Prete GQ, Davenport MP, Okoye AA, Picker LJ, Lifson JD, Keele BF.

J Virol. 2019 Oct 9. pii: JVI.01420-19. doi: 10.1128/JVI.01420-19. [Epub ahead of print]


Finally, a More Balanced View of Venous Thromboembolism Prophylaxis.

Polk HC Jr, O'Brien S, Qadan M.

Dis Colon Rectum. 2019 Nov;62(11):1269-1270. doi: 10.1097/DCR.0000000000001491. No abstract available.


Philadelphia chromosome-positive acute lymphoblastic leukemia at first relapse in the era of tyrosine kinase inhibitors.

Dalle IA, Kantarjian HM, Short NJ, Konopleva M, Jain N, Garcia-Manero G, Garris R, Qiao W, Cortes JE, O'Brien S, Kebriaei P, Kadia T, Jabbour E, Ravandi F.

Am J Hematol. 2019 Oct 8. doi: 10.1002/ajh.25648. [Epub ahead of print]


Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations.

O'Brien S, Kümmerli R, Paterson S, Winstanley C, Brockhurst MA.

Proc Biol Sci. 2019 Oct 9;286(1912):20191794. doi: 10.1098/rspb.2019.1794. Epub 2019 Oct 9.


A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System.

McIntyre KM, Bolton FJ, Christley RM, Cleary P, Deja E, Durie AE, Diggle PJ, Hughes DA, de Lusignan S, Orton L, Radford AD, Elliot AJ, Smith GE, Snape DA, Stanistreet D, Vivancos R, Winstanley C, O'Brien SJ.

JMIR Res Protoc. 2019 Sep 26;8(9):e13941. doi: 10.2196/13941.


The microRNA-200 family acts as an oncogene in colorectal cancer by inhibiting the tumor suppressor RASSF2.

Carter JV, O'Brien SJ, Burton JF, Oxford BG, Stephen V, Hallion J, Bishop C, Galbraith NJ, Eichenberger MR, Sarojini H, Hattab E, Galandiuk S.

Oncol Lett. 2019 Oct;18(4):3994-4007. doi: 10.3892/ol.2019.10753. Epub 2019 Aug 16.


Ublituximab and Umbralisib in Relapsed/ Refractory B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia.

Lunning M, Vose J, Nastoupil L, Fowler N, Burger JA, Wierda WG, Schreeder M, Siddiqi T, Flowers CR, Cohen JB, Sportelli P, Miskin HP, Weiss MS, O'Brien S.

Blood. 2019 Sep 26. pii: blood.2019002118. doi: 10.1182/blood.2019002118. [Epub ahead of print]


Highlights in chronic lymphocytic leukemia from the 60th American Society of Hematology Annual Meeting: commentary.

O'Brien SM.

Clin Adv Hematol Oncol. 2019 Jan;17 Suppl 1(1):20-23. No abstract available.


Undetectable MRD Using Next Generation Sequencing is Associated With Improved PFS After Treatment with FCR for CLL.

Thompson PA, Srivastava J, Peterson C, Strati P, Jorgensen JL, Hether T, Keating M, O'Brien S, Ferrajoli A, Burger JA, Estrov Z, Jain N, Wierda WG.

Blood. 2019 Sep 19. pii: blood.2019001077. doi: 10.1182/blood.2019001077. [Epub ahead of print]


Chronic Pancreatitis and Nutrition Therapy.

O'Brien SJ, Omer E.

Nutr Clin Pract. 2019 Oct;34 Suppl 1:S13-S26. doi: 10.1002/ncp.10379. Review.


Regularization of the Ostwald supersaturation model for Liesegang bands.

Duley JM, Fowler AC, Moyles IR, O'Brien SBG.

Proc Math Phys Eng Sci. 2019 Aug;475(2228):20190154. doi: 10.1098/rspa.2019.0154. Epub 2019 Aug 14.


Final analysis from RESONATE: Up to six years of follow-up on ibrutinib in patients with previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma.

Munir T, Brown JR, O'Brien S, Barrientos JC, Barr PM, Reddy NM, Coutre S, Tam CS, Mulligan SP, Jaeger U, Kipps TJ, Moreno C, Montillo M, Burger JA, Byrd JC, Hillmen P, Dai S, Szoke A, Dean JP, Woyach JA.

Am J Hematol. 2019 Sep 11. doi: 10.1002/ajh.25638. [Epub ahead of print]


Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.

Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS.

Elife. 2019 Aug 27;8. pii: e46134. doi: 10.7554/eLife.46134.


Trial re-investment to build better research for better impact.

Fox TA, Horne GA, Craddock C, Cook G, O'Brien S, Fox S, Hockaday A, Silk G, Hillmen P.

Lancet. 2019 Aug 24;394(10199):635-636. doi: 10.1016/S0140-6736(19)31363-7. No abstract available.


Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia.

Kipps TJ, Fraser G, Coutre SE, Brown JR, Barrientos JC, Barr PM, Byrd JC, O'Brien SM, Dilhuydy MS, Hillmen P, Jaeger U, Moreno C, Cramer P, Stilgenbauer S, Chanan-Khan AA, Mahler M, Salman M, Eckert K, Solman IG, Balasubramanian S, Cheng M, Londhe A, Ninomoto J, Howes A, James DF, Hallek M.

Clin Lymphoma Myeloma Leuk. 2019 Jul 15. pii: S2152-2650(19)30398-2. doi: 10.1016/j.clml.2019.07.004. [Epub ahead of print]


Family income and exposure to norovirus in childhood: Findings from the UK Millennium Cohort Study.

Violato M, Taylor-Robinson D, Hungerford D, Gray A, O'Brien S, Iturriza-Gomara M.

SSM Popul Health. 2019 Jul 3;8:100445. doi: 10.1016/j.ssmph.2019.100445. eCollection 2019 Aug.


Precision nomenclature for the new genomics.

Lewin HA, Graves JAM, Ryder OA, Graphodatsky AS, O'Brien SJ.

Gigascience. 2019 Aug 1;8(8). pii: giz086. doi: 10.1093/gigascience/giz086.


Every person is an individual: physical therapist clinical reasoning used in inpatient rehabilitation for walking assistive device prescription in patients with stroke and brain injury.

O'Brien SR, Durr K, Laubisch E, Losi L, Parrillo V, Pericozzi S, Poirier B, Poirier L, Ray K, Sackett A, Simoneau D.

Disabil Rehabil Assist Technol. 2019 Aug 20:1-8. doi: 10.1080/17483107.2019.1647568. [Epub ahead of print]


Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes.

Klampatsa A, O'Brien SM, Thompson JC, Rao AS, Stadanlick JE, Martinez MC, Liousia M, Cantu E, Cengel K, Moon EK, Singhal S, Eruslanov EB, Albelda SM.

Oncoimmunology. 2019 Jul 13;8(9):e1638211. doi: 10.1080/2162402X.2019.1638211. eCollection 2019.


The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab.

Kreuzer KA, Furman RR, Stilgenbauer S, Dubowy RL, Kim Y, Munugalavadla V, Lilienweiss E, Reinhardt HC, Cramer P, Eichhorst B, Hillmen P, O'Brien SM, Pettitt AR, Hallek M.

Leukemia. 2019 Aug 19. doi: 10.1038/s41375-019-0533-6. [Epub ahead of print] No abstract available.


Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation.

O'Brien SG, Carton EG, Fealy GM.

ASAIO J. 2019 Aug 6. doi: 10.1097/MAT.0000000000001042. [Epub ahead of print]


Physical activity counselling in Ireland: a survey of doctors' knowledge, attitudes and self-reported practice.

O'Brien S, Prihodova L, Heffron M, Wright P.

BMJ Open Sport Exerc Med. 2019 Jul 22;5(1):e000572. doi: 10.1136/bmjsem-2019-000572. eCollection 2019.


Perceptions of participating in family-centered fertility research among adolescent and young adult males newly diagnosed with cancer: A qualitative study.

Nahata L, Morgan TL, Lipak KG, Clark OE, Yeager ND, O'Brien SH, Whiteside S, Audino A, Quinn GP, Gerhardt CA.

Pediatr Blood Cancer. 2019 Nov;66(11):e27966. doi: 10.1002/pbc.27966. Epub 2019 Aug 12.


Allocation of Treatment Responsibility and Adherence to Hydroxyurea Among Adolescents With Sickle Cell Disease.

Creary SE, Modi AC, Stanek JR, Chisolm DJ, O'Brien SH, Nwankwo C, Crosby LE.

J Pediatr Psychol. 2019 Aug 12. pii: jsz061. doi: 10.1093/jpepsy/jsz061. [Epub ahead of print]


A Multidimensional Electronic Hydroxyurea Adherence Intervention for Children With Sickle Cell Disease: Single-Arm Before-After Study.

Creary S, Chisolm D, Stanek J, Hankins J, O'Brien SH.

JMIR Mhealth Uhealth. 2019 Aug 8;7(8):e13452. doi: 10.2196/13452.


Three wound-dressing strategies to reduce surgical site infection after abdominal surgery: the Bluebelle feasibility study and pilot RCT.

Reeves BC, Rooshenas L, Macefield RC, Woodward M, Welton NJ, Waterhouse BR, Torrance AD, Strong S, Siassakos D, Seligman W, Rogers CA, Rickard L, Pullyblank A, Pope C, Pinkney TD, Pathak S, Owais A, O'Callaghan J, O'Brien S, Nepogodiev D, Nadi K, Murkin CE, Munder T, Milne T, Messenger D, McMullan CM, Mathers JM, Mason M, Marshall M, Lovegrove R, Longman RJ, Lloyd J, Lim J, Lee K, Korwar V, Hughes D, Hill G, Harris R, Hamdan M, Brown HG, Gooberman-Hill R, Glasbey J, Fryer C, Ellis L, Elliott D, Dumville JC, Draycott T, Donovan JL, Cotton D, Coast J, Clout M, Calvert MJ, Byrne BE, Brown OD, Blencowe NS, Bera KD, Bennett J, Bamford R, Bakhbakhi D, Atif M, Ashton K, Armstrong E, Andronis L, Ananthavarathan P, Blazeby JM.

Health Technol Assess. 2019 Aug;23(39):1-166. doi: 10.3310/hta23390.


STXBP1-associated neurodevelopmental disorder: a comparative study of behavioural characteristics.

O'Brien S, Ng-Cordell E; DDD Study, Astle DE, Scerif G, Baker K.

J Neurodev Disord. 2019 Aug 6;11(1):17. doi: 10.1186/s11689-019-9278-9.


Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype.

Borges R, Fonseca J, Gomes C, Johnson WE, O'Brien SJ, Zhang G, Gilbert MTP, Jarvis ED, Antunes A.

Genome Biol Evol. 2019 Aug 1;11(8):2244-2255. doi: 10.1093/gbe/evz111.


Prevalence of Babesia in Canadian blood donors: June-October 2018.

Tonnetti L, O'Brien SF, Grégoire Y, Proctor MC, Drews SJ, Delage G, Fearon MA, Brès V, Linnen JM, Stramer SL.

Transfusion. 2019 Oct;59(10):3171-3176. doi: 10.1111/trf.15470. Epub 2019 Aug 5.


Changing the deferral for men who have sex with men - an improved model to estimate HIV residual risk.

Davison KL, Gregoire Y, Germain M, Custer B, O'Brien SF, Steele WR, Pillonel J, Seed CR; the Surveillance, Risk Assessment, Policy Sub-Group of the ISBT Transfusion Transmitted Diseases Working Party.

Vox Sang. 2019 Oct;114(7):666-674. doi: 10.1111/vox.12826. Epub 2019 Aug 1.


Conducting reproductive research during a new childhood cancer diagnosis: ethical considerations and impact on participants.

Nahata L, Morgan TL, Lipak KG, Clark OE, Yeager ND, O'Brien SH, Whiteside S, Audino AN, Gerhardt CA, Quinn GP.

J Assist Reprod Genet. 2019 Sep;36(9):1787-1791. doi: 10.1007/s10815-019-01546-2. Epub 2019 Aug 1.


Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia.

Shanafelt TD, Wang XV, Kay NE, Hanson CA, O'Brien S, Barrientos J, Jelinek DF, Braggio E, Leis JF, Zhang CC, Coutre SE, Barr PM, Cashen AF, Mato AR, Singh AK, Mullane MP, Little RF, Erba H, Stone RM, Litzow M, Tallman M.

N Engl J Med. 2019 Aug 1;381(5):432-443. doi: 10.1056/NEJMoa1817073.


Analysing extraction uniformity from porous coffee beds using mathematical modelling and computational fluid dynamics approaches.

Moroney KM, O'Connell K, Meikle-Janney P, O'Brien SBG, Walker GM, Lee WT.

PLoS One. 2019 Jul 31;14(7):e0219906. doi: 10.1371/journal.pone.0219906. eCollection 2019.


Symptom profiling for infectious intestinal disease (IID): a secondary data analysis of the IID2 study.

Donaldson AL, Clough HE, O'Brien SJ, Harris JP.

Epidemiol Infect. 2019 Jan;147:e229. doi: 10.1017/S0950268819001201.


Influence of socio-economic status on Shiga toxin-producing Escherichia coli (STEC) infection incidence, risk factors and clinical features.

Adams NL, Byrne L, Rose TC, Adak GK, Jenkins C, Charlett A, Violato M, O'Brien SJ, Whitehead MM, Barr B, Taylor-Robinson DC, Hawker JI.

Epidemiol Infect. 2019 Jan;147:e215. doi: 10.1017/S0950268819000864.


The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2019 Update on Research.

Jacobs ML, Jacobs JP, Hill KD, O'Brien SM, Pasquali SK, Vener D, Kumar SR, Chiswell K, St Louis JD, Mayer JE, Habib RH, Shahian DM, Fernandez FG.

Ann Thorac Surg. 2019 Sep;108(3):671-679. doi: 10.1016/j.athoracsur.2019.07.002. Epub 2019 Jul 20.


Reply to: Atomic bomb and CRISPR gene editing technology.

O'Brien SJ, Galandiuk S.

Surgery. 2019 Jul 19. pii: S0039-6060(19)30339-3. doi: 10.1016/j.surg.2019.05.052. [Epub ahead of print] No abstract available.


Key Worker-Mediated Enhancement of Physical Health in First Episode Psychosis: Protocol For a Feasibility Study in Primary Care.

McCombe G, Harrold A, Brown K, Hennessy L, Clarke M, Hanlon D, O'Brien S, Lyne J, Corcoran C, McGorry P, Cullen W.

JMIR Res Protoc. 2019 Jul 10;8(7):e13115. doi: 10.2196/13115.


Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma.

Liao X, Wang X, Huang K, Han C, Deng J, Yu T, Yang C, Huang R, Liu X, Yu L, Zhu G, Su H, Qin W, Zeng X, Han B, Han Q, Liu Z, Zhou X, Gong Y, Liu Z, Huang J, Winkler CA, O'Brien SJ, Ye X, Peng T.

J Cancer. 2019 Jun 2;10(14):3267-3283. doi: 10.7150/jca.29986. eCollection 2019.


Effect of a proficiency-based progression simulation programme on clinical communication for the deteriorating patient: a randomised controlled trial.

Breen D, O'Brien S, McCarthy N, Gallagher A, Walshe N.

BMJ Open. 2019 Jul 9;9(7):e025992. doi: 10.1136/bmjopen-2018-025992.


Adverse outcomes and short-term cost implications of bile duct injury during cholecystectomy.

O'Brien S, Wei D, Bhutiani N, Rao MK, Johnston SS, Patkar A, Vitale GC, Martin RCG 2nd.

Surg Endosc. 2019 Jul 8. doi: 10.1007/s00464-019-06809-8. [Epub ahead of print]


'Rational use of high-flow therapy in infants with bronchiolitis. What do the latest trials tell us?' A Paediatric Research in Emergency Departments International Collaborative perspective.

O'Brien S, Craig S, Babl FE, Borland ML, Oakley E, Dalziel SR; Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network, Australasia.

J Paediatr Child Health. 2019 Jul;55(7):746-752. doi: 10.1111/jpc.14496.


Self-Inflicted Stab Wounds: A Single-Center Experience from 2010 to 2016.

O'Brien S, Nicolas MD, Bhutiani N, Schucht JE, Stollo B, Miller KR, Benns MV, Nash NA, Franklin GA, Smith JW, Harbrecht BG, Bozeman MC.

Am Surg. 2019 Jun 1;85(6):572-578.


Twenty-year survivorship of a cemented mobile bearing Total Knee Arthroplasty.

Milligan DJ, O'Brien S, Doran E, Gallagher NE, Beverland DE.

Knee. 2019 Aug;26(4):933-940. doi: 10.1016/j.knee.2019.06.004. Epub 2019 Jun 29.


Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP.

Cancer Cell. 2019 Jul 8;36(1):100-114.e25. doi: 10.1016/j.ccell.2019.05.014. Epub 2019 Jun 27.


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