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Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species.

Bosma KJ, Syring KE, Oeser JK, Lee JD, Benninger RKP, Pamenter ME, O'Brien RM.

J Mol Evol. 2019 Jul 4. doi: 10.1007/s00239-019-09898-0. [Epub ahead of print]


The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.

Syring KE, Bosma KJ, Oeser JK, Shiota M, O'Brien RM.

J Mol Evol. 2018 Dec;86(9):613-617. doi: 10.1007/s00239-018-9873-5. Epub 2018 Nov 3.


A consistent and general modified Venn diagram approach that provides insights into regression analysis.

O'Brien RM.

PLoS One. 2018 May 17;13(5):e0196740. doi: 10.1371/journal.pone.0196740. eCollection 2018.


Mixed models, linear dependency, and identification in age-period-cohort models.

O'Brien RM.

Stat Med. 2017 Jul 20;36(16):2590-2600. doi: 10.1002/sim.7305. Epub 2017 Apr 4.


Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion.

Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, Printz RL, O'Brien RM, Cherrington AD.

JCI Insight. 2017 Mar 23;2(6):e91863. doi: 10.1172/jci.insight.91863.


Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.

Singh P, Han EH, Endrizzi JA, O'Brien RM, Chi YI.

J Struct Biol. 2017 Apr;198(1):54-64. doi: 10.1016/j.jsb.2017.02.006. Epub 2017 Feb 20.


Effects of G6pc2 deletion on body weight and cholesterol in mice.

Boortz KA, Syring KE, Pound LD, Mo H, Bastarache L, Oeser JK, McGuinness OP, Denny JC, O'Brien RM.

J Mol Endocrinol. 2017 Apr;58(3):127-139. doi: 10.1530/JME-16-0202. Epub 2017 Jan 25.


G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.

Boortz KA, Syring KE, Lee RA, Dai C, Oeser JK, McGuinness OP, Wang JC, O'Brien RM.

Endocrinology. 2016 Nov;157(11):4133-4145. Epub 2016 Sep 21.


Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Syring KE, Boortz KA, Oeser JK, Ustione A, Platt KA, Shadoan MK, McGuinness OP, Piston DW, Powell DR, O'Brien RM.

Endocrinology. 2016 Dec;157(12):4534-4541. Epub 2016 Oct 18.


Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.

Boortz KA, Syring KE, Pound LD, Wang Y, Oeser JK, O'Brien RM.

PLoS One. 2016 Sep 9;11(9):e0162439. doi: 10.1371/journal.pone.0162439. eCollection 2016.


G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM.

Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.


Bariatric surgery results: reporting clinical characteristics and adverse outcomes from an integrated healthcare delivery system.

Li RA, Fisher DP, Dutta S, O'Brien RM, Ackerson LM, Sorel ME, Sidney S.

Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1119-25. doi: 10.1016/j.soard.2015.03.002. Epub 2015 Mar 9.


Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets.

Wall ML, Pound LD, Trenary I, O'Brien RM, Young JD.

Diabetes. 2015 Jun;64(6):2129-37. doi: 10.2337/db14-0745. Epub 2014 Dec 31.


Zinc transporter 8 (ZnT8) and β cell function.

Davidson HW, Wenzlau JM, O'Brien RM.

Trends Endocrinol Metab. 2014 Aug;25(8):415-24. doi: 10.1016/j.tem.2014.03.008. Epub 2014 Apr 18. Review.


Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.

O'Brien RM.

Curr Diab Rep. 2013 Dec;13(6):768-77. doi: 10.1007/s11892-013-0422-8.


Comment of Liying Luo's article, "assessing validity and application scope of the intrinsic estimator approach to the age-period-cohort problem".

O'Brien RM.

Demography. 2013 Dec;50(6):1973-5; discussion 1985-8. doi: 10.1007/s13524-013-0250-0. No abstract available.


Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.

Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O; MAGIC Investigators, Dadi PK, Jacobson DA, Froguel P, O'Brien RM.

Diabetologia. 2013 Jun;56(6):1306-16. doi: 10.1007/s00125-013-2875-3. Epub 2013 Mar 19.


G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM.

Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28.


The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.


Visualizing rank deficient models: a row equation geometry of rank deficient matrices and constrained-regression.

O'Brien RM.

PLoS One. 2012;7(6):e38923. doi: 10.1371/journal.pone.0038923. Epub 2012 Jun 19.


Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.

Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM.

Diabetes. 2011 Nov;60(11):2922-7. doi: 10.2337/db11-0220. Epub 2011 Sep 6.


Characterization of the human SLC30A8 promoter and intronic enhancer.

Pound LD, Sarkar SA, Cauchi S, Wang Y, Oeser JK, Lee CE, Froguel P, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2011 Sep 30;47(3):251-9. doi: 10.1530/JME-11-0055. Print 2011 Dec.


The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer.

Pound LD, Hang Y, Sarkar SA, Wang Y, Milam LA, Oeser JK, Printz RL, Lee CE, Stein R, Hutton JC, O'Brien RM.

Biochem J. 2011 Jan 1;433(1):95-105. doi: 10.1042/BJ20101488.


Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

Bouatia-Naji N, Bonnefond A, Baerenwald DA, Marchand M, Bugliani M, Marchetti P, Pattou F, Printz RL, Flemming BP, Umunakwe OC, Conley NL, Vaxillaire M, Lantieri O, Balkau B, Marre M, Lévy-Marchal C, Elliott P, Jarvelin MR, Meyre D, Dina C, Oeser JK, Froguel P, O'Brien RM.

Diabetes. 2010 Oct;59(10):2662-71. doi: 10.2337/db10-0389. Epub 2010 Jul 9.


Glucose-6-phosphatase catalytic subunit gene family.

Hutton JC, O'Brien RM.

J Biol Chem. 2009 Oct 23;284(43):29241-5. doi: 10.1074/jbc.R109.025544. Epub 2009 Aug 20. Review.


Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6. doi: 10.1042/BJ20090530.


Familial hyperaldosteronism type 1 in pregnancy.

Hamilton E, O'Callaghan C, O'Brien RM, Stowasser M, Gordon R, Zajac J, Grossmann M.

Intern Med J. 2009 Feb;39(2):135-6. doi: 10.1111/j.1445-5994.2008.01869.x. No abstract available.


Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.

Onuma H, Oeser JK, Nelson BA, Wang Y, Flemming BP, Scheving LA, Russell WE, O'Brien RM.

Biochem J. 2009 Jan 15;417(2):611-20. doi: 10.1042/BJ20080999.


Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.

Martin CC, Flemming BP, Wang Y, Oeser JK, O'Brien RM.

J Mol Endocrinol. 2008 Nov;41(5):315-28. doi: 10.1677/JME-08-0062. Epub 2008 Aug 27.


Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha.

Schilling MM, Oeser JK, Chandy JK, Flemming BP, Allen SR, O'Brien RM.

Diabetologia. 2008 Aug;51(8):1505-14. doi: 10.1007/s00125-008-1050-8. Epub 2008 Jun 19.


Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.

Wang Y, Flemming BP, Martin CC, Allen SR, Walters J, Oeser JK, Hutton JC, O'Brien RM.

Diabetes. 2008 Jan;57(1):133-41. Epub 2007 Oct 17.


Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype.

Wang Y, Martin CC, Oeser JK, Sarkar S, McGuinness OP, Hutton JC, O'Brien RM.

Diabetologia. 2007 Apr;50(4):774-8. Epub 2007 Jan 31.


Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.

Schilling MM, Oeser JK, Boustead JN, Flemming BP, O'Brien RM.

Nature. 2006 Oct 5;443(7111):E10-1.


Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM.

J Biol Chem. 2006 Dec 29;281(52):39982-9. Epub 2006 Oct 5.


Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin.

Onuma H, Vander Kooi BT, Boustead JN, Oeser JK, O'Brien RM.

Mol Endocrinol. 2006 Nov;20(11):2831-47. Epub 2006 Jul 13.


Characterizing the phospholipid profiles in mammalian tissues by MALDI FTMS.

Jones JJ, Borgmann S, Wilkins CL, O'Brien RM.

Anal Chem. 2006 May 1;78(9):3062-71.


Competence imagery: a case study treating emetophobia.

Moran DJ, O'Brien RM.

Psychol Rep. 2005 Jun;96(3 Pt 1):635-6.


The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.

Vander Kooi BT, Onuma H, Oeser JK, Svitek CA, Allen SR, Vander Kooi CW, Chazin WJ, O'Brien RM.

Mol Endocrinol. 2005 Dec;19(12):3001-22. Epub 2005 Jul 21.


Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line.

Ayala JE, Boustead JN, Chapman SC, Svitek CA, Oeser JK, Robey RB, O'Brien RM.

J Mol Endocrinol. 2004 Aug;33(1):263-80.


Diverse presentation and clinical features of Churg-Strauss syndrome: two cases from a Melbourne teaching hospital.

Jayasuriya I, Nikpour M, Hunt JM, Holmes MC, O'Brien RM.

Intern Med J. 2004 Jun;34(6):367-8. No abstract available.


Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.

Boustead JN, Martin CC, Oeser JK, Svitek CA, Hunter SI, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2004 Feb;32(1):33-53.


Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ.

Hornbuckle LA, Everett CA, Martin CC, Gustavson SS, Svitek CA, Oeser JK, Neal DW, Cherrington AD, O'Brien RM.

Am J Physiol Endocrinol Metab. 2004 May;286(5):E795-808. Epub 2004 Jan 13.


The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct.

Vander Kooi BT, Streeper RS, Svitek CA, Oeser JK, Powell DR, O'Brien RM.

J Biol Chem. 2003 Apr 4;278(14):11782-93. Epub 2003 Jan 28.


Contextual Variation, Familiarity, Academic Literacy, and Rural Adolescents' Idiom Knowledge.

Qualls CD, O'Brien RM, Blood GW, Hammer CS.

Lang Speech Hear Serv Sch. 2003 Jan 1;34(1):69-79. doi: 10.1044/0161-1461(2003/007).


Characterization and immunobiology of house dust mite allergens.

Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM.

Int Arch Allergy Immunol. 2002 Sep;129(1):1-18. Review.


Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein.

Martin CC, Oeser JK, Svitek CA, Hunter SI, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2002 Oct;29(2):205-22.


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