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Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age.

Roberts G, Lloyd JJ, Kane JPM, Durcan R, Lawley S, Howe K, Petrides GS, O'Brien JT, Thomas AJ.

J Nucl Cardiol. 2019 Sep 16. doi: 10.1007/s12350-019-01887-6. [Epub ahead of print]


New evidence on the management of Lewy body dementia.

Taylor JP, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT.

Lancet Neurol. 2019 Sep 10. pii: S1474-4422(19)30153-X. doi: 10.1016/S1474-4422(19)30153-X. [Epub ahead of print] Review.


11 C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia.

Nicastro N, Surendranathan A, Mak E, Rowe JB, O'Brien JT.

Ann Clin Transl Neurol. 2019 Sep 10. doi: 10.1002/acn3.50877. [Epub ahead of print]


Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance.

Passamonti L, Tsvetanov KA, Jones PS, Bevan-Jones WR, Arnold R, Borchert RJ, Mak E, Su L, O'Brien JT, Rowe JB.

J Neurosci. 2019 Sep 4;39(36):7218-7226. doi: 10.1523/JNEUROSCI.2574-18.2019. Epub 2019 Jul 18.


Inflammation and cerebral small vessel disease: A systematic review.

Low A, Mak E, Rowe JB, Markus HS, O'Brien JT.

Ageing Res Rev. 2019 Aug;53:100916. doi: 10.1016/j.arr.2019.100916. Epub 2019 Jun 10. Review.


A comparison of visual and semiquantitative analysis methods for planar cardiac 123I-MIBG scintigraphy in dementia with Lewy bodies.

Roberts G, Kane JPM, Lloyd JJ, Petrides GS, Howe K, O'Brien JT, Thomas AJ.

Nucl Med Commun. 2019 Jul;40(7):734-743. doi: 10.1097/MNM.0000000000001024.


Are neuropsychiatric symptoms modifiable risk factors for cognitive decline in Alzheimer's disease and vascular dementia?

Savulich G, O'Brien JT, Sahakian BJ.

Br J Psychiatry. 2019 Apr 30:1-3. doi: 10.1192/bjp.2019.98. [Epub ahead of print]


Structural correlates of attention dysfunction in Lewy body dementia and Alzheimer's disease: an ex-Gaussian analysis.

Schumacher J, Cromarty R, Gallagher P, Firbank MJ, Thomas AJ, Kaiser M, Blamire AM, O'Brien JT, Peraza LR, Taylor JP.

J Neurol. 2019 Jul;266(7):1716-1726. doi: 10.1007/s00415-019-09323-y. Epub 2019 Apr 21.


Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease.

Schumacher J, Peraza LR, Firbank M, Thomas AJ, Kaiser M, Gallagher P, O'Brien JT, Blamire AM, Taylor JP.

Neuroimage Clin. 2019;22:101812. doi: 10.1016/j.nicl.2019.101812. Epub 2019 Apr 3.


Dysfunctional brain dynamics and their origin in Lewy body dementia.

Schumacher J, Peraza LR, Firbank M, Thomas AJ, Kaiser M, Gallagher P, O'Brien JT, Blamire AM, Taylor JP.

Brain. 2019 Jun 1;142(6):1767-1782. doi: 10.1093/brain/awz069.


Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer's Disease.

Sheikh-Bahaei N, Manavaki R, Sajjadi SA, Priest AN, O'Brien JT, Gillard JH.

J Alzheimers Dis. 2019;68(4):1489-1497. doi: 10.3233/JAD-180443.


Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies.

Durcan R, Donaghy PC, Barnett NA, Olsen K, Yarnall AJ, Taylor JP, McKeith I, O'Brien JT, Thomas AJ.

Int J Geriatr Psychiatry. 2019 Jul;34(7):990-998. doi: 10.1002/gps.5100. Epub 2019 Apr 24.


123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.

Roberts G, Lloyd JJ, Petrides GS, Donaghy PC, Kane JPM, Durcan R, Lawley S, Howe K, Sims AJ, Taylor JP, O'Brien JT, Thomas AJ.

Ann Nucl Med. 2019 Jun;33(6):434-443. doi: 10.1007/s12149-019-01352-x. Epub 2019 Mar 21.


Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer's disease.

King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ.

Int Psychogeriatr. 2019 Apr;31(4):551-560. doi: 10.1017/S1041610218001126. Epub 2019 Mar 11.


In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

Bevan-Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FI, O'Brien JT, Rowe JB.

Ann Clin Transl Neurol. 2019 Jan 2;6(2):373-378. doi: 10.1002/acn3.683. eCollection 2019 Feb.


Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.

Wilkinson T, Schnier C, Bush K, Rannikmäe K, Henshall DE, Lerpiniere C, Allen NE, Flaig R, Russ TC, Bathgate D, Pal S, O'Brien JT, Sudlow CLM; Dementias Platform UK and UK Biobank.

Eur J Epidemiol. 2019 Jun;34(6):557-565. doi: 10.1007/s10654-019-00499-1. Epub 2019 Feb 26.


Clinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies.

Moylett S, Price A, Cardinal RN, Aarsland D, Mueller C, Stewart R, O'Brien JT.

J Alzheimers Dis. 2019;67(3):995-1005. doi: 10.3233/JAD-180877.


123I-MIBG scintigraphy utility and cut-off value in a clinically representative dementia cohort.

Kane JPM, Roberts G, Petrides GS, Lloyd JJ, O'Brien JT, Thomas AJ.

Parkinsonism Relat Disord. 2019 May;62:79-84. doi: 10.1016/j.parkreldis.2019.01.024. Epub 2019 Jan 26.


Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.


Survival time and differences between dementia with Lewy bodies and Alzheimer's disease following diagnosis: A meta-analysis of longitudinal studies.

Mueller C, Soysal P, Rongve A, Isik AT, Thompson T, Maggi S, Smith L, Basso C, Stewart R, Ballard C, O'Brien JT, Aarsland D, Stubbs B, Veronese N.

Ageing Res Rev. 2019 Mar;50:72-80. doi: 10.1016/j.arr.2019.01.005. Epub 2019 Jan 6. Review.


Dementia with Lewy bodies - from scientific knowledge to clinical insights.

Arnaoutoglou NA, O'Brien JT, Underwood BR.

Nat Rev Neurol. 2019 Feb;15(2):103-112. doi: 10.1038/s41582-018-0107-7. Review.


Structural Brain Correlates of Attention Dysfunction in Lewy Body Dementias and Alzheimer's Disease.

Cromarty RA, Schumacher J, Graziadio S, Gallagher P, Killen A, Firbank MJ, Blamire A, Kaiser M, Thomas AJ, O'Brien JT, Peraza LR, Taylor JP.

Front Aging Neurosci. 2018 Oct 30;10:347. doi: 10.3389/fnagi.2018.00347. eCollection 2018.


The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease.

FitzGerald JM, Perera G, Chang-Tave A, Price A, Rajkumar AP, Bhattarai M, O'Brien JT, Ballard C, Aarsland D, Stewart R, Mueller C.

J Am Med Dir Assoc. 2019 May;20(5):604-609. doi: 10.1016/j.jamda.2018.09.021. Epub 2018 Nov 15.


In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.

Mak E, Bethlehem RAI, Romero-Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan-Jones RW, Passamonti L, Vázquez Rodríguez P, Su L, Arnold R, Williams GB, Hong YT, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT.

Alzheimers Dement (Amst). 2018 Sep 17;10:678-687. doi: 10.1016/j.dadm.2018.08.005. eCollection 2018.


Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, Vázquez Rodríguez P, Bevan-Jones WR, Brain SAE, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT.

Brain. 2018 Dec 1;141(12):3415-3427. doi: 10.1093/brain/awy265.


Management of visual hallucinations in dementia and Parkinson's disease.

Swann P, O'Brien JT.

Int Psychogeriatr. 2019 Jun;31(6):815-836. doi: 10.1017/S1041610218001400. Epub 2018 Nov 6.


[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

Bevan-Jones RW, Cope TE, Jones SP, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FA, Patterson K, O'Brien JT, Rowe JB.

Ann Clin Transl Neurol. 2018 Sep 14;5(10):1292-1296. doi: 10.1002/acn3.631. eCollection 2018 Oct.


Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies.

Mak E, Donaghy PC, McKiernan E, Firbank MJ, Lloyd J, Petrides GS, Thomas AJ, O'Brien JT.

Neurobiol Aging. 2019 Jan;73:74-81. doi: 10.1016/j.neurobiolaging.2018.09.004. Epub 2018 Sep 12.


A new visual rating scale for Ioflupane imaging in Lewy body disease.

Lloyd JJ, Petrides G, Donaghy PC, Colloby SJ, Attems J, O'Brien JT, Roberts G, Thomas AJ.

Neuroimage Clin. 2018;20:823-829. doi: 10.1016/j.nicl.2018.09.012. Epub 2018 Sep 20.


Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer's Disease: The PREVENT Dementia Study.

Ritchie K, Carrière I, Howett D, Su L, Hornberger M, O'Brien JT, Ritchie CW, Chan D.

J Alzheimers Dis. 2018;65(3):885-896. doi: 10.3233/JAD-180432.


Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.

Pang CC, Kiecker C, O'Brien JT, Noble W, Chang RC.

Neuroscientist. 2019 Apr;25(2):167-180. doi: 10.1177/1073858418778747. Epub 2018 Jun 5. Review.


Hospitalization in people with dementia with Lewy bodies: Frequency, duration, and cost implications.

Mueller C, Perera G, Rajkumar AP, Bhattarai M, Price A, O'Brien JT, Ballard C, Stewart R, Aarsland D.

Alzheimers Dement (Amst). 2017 Dec 27;10:143-152. doi: 10.1016/j.dadm.2017.12.001. eCollection 2018.


[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

Passamonti L, Rodríguez PV, Hong YT, Allinson KSJ, Bevan-Jones WR, Williamson D, Jones PS, Arnold R, Borchert RJ, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB.

Neurology. 2018 May 29;90(22):e1989-e1996. doi: 10.1212/WNL.0000000000005610. Epub 2018 Apr 27.


Longitudinal diffusion tensor imaging changes in early Parkinson's disease: ICICLE-PD study.

Minett T, Su L, Mak E, Williams G, Firbank M, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn D, O'Brien JT.

J Neurol. 2018 Jul;265(7):1528-1539. doi: 10.1007/s00415-018-8873-0. Epub 2018 Apr 25.


Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies.

Thomas AJ, Donaghy P, Roberts G, Colloby SJ, Barnett NA, Petrides G, Lloyd J, Olsen K, Taylor JP, McKeith I, O'Brien JT.

Psychol Med. 2019 Feb;49(3):396-402. doi: 10.1017/S0033291718000995. Epub 2018 Apr 25.


Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies.

Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT.

Mov Disord. 2018 Jul;33(7):1130-1138. doi: 10.1002/mds.27403. Epub 2018 Apr 19.


Clinical imaging in dementia with Lewy bodies.

Surendranathan A, O'Brien JT.

Evid Based Ment Health. 2018 May;21(2):61-65. doi: 10.1136/eb-2017-102848. Epub 2018 Mar 29. Review.


Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer's disease patients.

Peraza LR, Cromarty R, Kobeleva X, Firbank MJ, Killen A, Graziadio S, Thomas AJ, O'Brien JT, Taylor JP.

Sci Rep. 2018 Mar 15;8(1):4637. doi: 10.1038/s41598-018-22984-5.


Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease.

Sheikh-Bahaei N, Sajjadi SA, Manavaki R, McLean M, O'Brien JT, Gillard JH.

Ann Neurol. 2018 Apr;83(4):771-778. doi: 10.1002/ana.25202. Epub 2018 Apr 10.


Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial.

Croall ID, Tozer DJ, Moynihan B, Khan U, O'Brien JT, Morris RG, Cambridge VC, Barrick TR, Blamire AM, Ford GA, Markus HS; PRESERVE Study Team.

JAMA Neurol. 2018 Jun 1;75(6):720-727. doi: 10.1001/jamaneurol.2017.5153.


Clinical prevalence of Lewy body dementia.

Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O'Brien JT.

Alzheimers Res Ther. 2018 Feb 15;10(1):19. doi: 10.1186/s13195-018-0350-6.


Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies.

Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Colloby SJ, Lloyd J, Petrides G, McKeith IG, Thomas AJ.

Psychol Med. 2018 Oct;48(14):2384-2390. doi: 10.1017/S0033291717003956. Epub 2018 Jan 24.


Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.

Cope TE, Rittman T, Borchert RJ, Jones PS, Vatansever D, Allinson K, Passamonti L, Vazquez Rodriguez P, Bevan-Jones WR, O'Brien JT, Rowe JB.

Brain. 2018 Feb 1;141(2):550-567. doi: 10.1093/brain/awx347.


Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.

King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ.

J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):339-345. doi: 10.1136/jnnp-2017-317134. Epub 2017 Dec 16.


Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis.

Schumacher J, Peraza LR, Firbank M, Thomas AJ, Kaiser M, Gallagher P, O'Brien JT, Blamire AM, Taylor JP.

Hum Brain Mapp. 2018 Mar;39(3):1118-1129. doi: 10.1002/hbm.23901. Epub 2017 Nov 29.


Hippocampal Stratum Radiatum, Lacunosum, and Moleculare Sparing in Mild Cognitive Impairment.

Su L, Hayes L, Soteriades S, Williams G, Brain SAE, Firbank MJ, Longoni G, Arnold RJ, Rowe JB, O'Brien JT.

J Alzheimers Dis. 2018;61(1):415-424. doi: 10.3233/JAD-170344.


Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.

Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW, O'Brien JT.

Alzheimers Dement. 2018 Feb;14(2):253-258. doi: 10.1016/j.jalz.2017.08.017. Epub 2017 Nov 21.


Non-pharmacological interventions for Lewy body dementia: a systematic review.

Connors MH, Quinto L, McKeith I, Brodaty H, Allan L, Bamford C, Thomas A, Taylor JP, O'Brien JT.

Psychol Med. 2018 Aug;48(11):1749-1758. doi: 10.1017/S0033291717003257. Epub 2017 Nov 16.


Mortality in dementia with Lewy bodies compared with Alzheimer's dementia: a retrospective naturalistic cohort study.

Price A, Farooq R, Yuan JM, Menon VB, Cardinal RN, O'Brien JT.

BMJ Open. 2017 Nov 3;7(11):e017504. doi: 10.1136/bmjopen-2017-017504.


Long reaction times are associated with delayed brain activity in lewy body dementia.

Firbank MJ, O'Brien JT, Taylor JP.

Hum Brain Mapp. 2018 Feb;39(2):633-643. doi: 10.1002/hbm.23866. Epub 2017 Nov 2.

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