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Microdroplet Fusion Chemistry for Charge State Reduction of Synthetic Polymers via Bipolar Dual Spray with Anionic Reagents.

Stutzman JR, Bain RM, Hagenhoff S, Woodward WH, O'Brien JP, Lesniak M.

J Am Soc Mass Spectrom. 2019 Sep;30(9):1742-1749. doi: 10.1007/s13361-019-02236-0. Epub 2019 May 28.


Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers.

Wang F, Gu Y, O'Brien JP, Yi SM, Yalcin SE, Srikanth V, Shen C, Vu D, Ing NL, Hochbaum AI, Egelman EH, Malvankar NS.

Cell. 2019 Apr 4;177(2):361-369.e10. doi: 10.1016/j.cell.2019.03.029.


Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer.

Yochum ZA, Cades J, Wang H, Chatterjee S, Simons BW, O'Brien JP, Khetarpal SK, Lemtiri-Chlieh G, Myers KV, Huang EH, Rudin CM, Tran PT, Burns TF.

Oncogene. 2019 Jan;38(5):656-670. doi: 10.1038/s41388-018-0482-y. Epub 2018 Aug 31.


Ultrasound propagation through dilute polydisperse microbubble suspensions.

Ovenden NC, O'Brien JP, Stride E.

J Acoust Soc Am. 2017 Sep;142(3):1236. doi: 10.1121/1.4998574.


A Simple and Low-Cost Procedure for Growing Geobacter sulfurreducens Cell Cultures and Biofilms in Bioelectrochemical Systems.

O'Brien JP, Malvankar NS.

Curr Protoc Microbiol. 2016 Nov 18;43:A.4K.1-A.4K.27. doi: 10.1002/cpmc.20.


Fragmentation of Protonated N-(3-Aminophenyl)Benzamide and Its Derivatives in Gas Phase.

Zu C, Mukhopadhyay S, Hanley PS, Xia S, Bell BM, Grigg D, Gilbert JR, O'Brien JP.

J Am Soc Mass Spectrom. 2016 May;27(5):917-26. doi: 10.1007/s13361-016-1342-z. Epub 2016 Mar 17.


Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG.

Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007. Epub 2016 Feb 4.


Nurses' and Nursing Students' Knowledge and Attitudes regarding Pediatric Pain.

Ortiz MI, Ponce-Monter HA, Rangel-Flores E, Castro-Gamez B, Romero-Quezada LC, O'Brien JP, Romo-Hernández G, Escamilla-Acosta MA.

Nurs Res Pract. 2015;2015:210860. doi: 10.1155/2015/210860. Epub 2015 Oct 12.


Phase 1b study of lenvatinib (E7080) in combination with temozolomide for treatment of advanced melanoma.

Hong DS, Kurzrock R, Falchook GS, Andresen C, Kwak J, Ren M, Xu L, George GC, Kim KB, Nguyen LM, O'Brien JP, Nemunaitis J.

Oncotarget. 2015 Dec 15;6(40):43127-34. doi: 10.18632/oncotarget.5756.


A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer.

Schlumberger M, Jarzab B, Cabanillas ME, Robinson B, Pacini F, Ball DW, McCaffrey J, Newbold K, Allison R, Martins RG, Licitra LF, Shah MH, Bodenner D, Elisei R, Burmeister L, Funahashi Y, Ren M, O'Brien JP, Sherman SI.

Clin Cancer Res. 2016 Jan 1;22(1):44-53. doi: 10.1158/1078-0432.CCR-15-1127. Epub 2015 Aug 26.


Correction to structural characterization of gangliosides and glycolipids via ultraviolet photodissociation mass spectrometry.

O'Brien JP, Brodbelt JS.

Anal Chem. 2015 Aug 18;87(16):8592. doi: 10.1021/acs.analchem.5b02813. Epub 2015 Aug 5. No abstract available.


Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma.

Hong DS, Kurzrock R, Wheler JJ, Naing A, Falchook GS, Fu S, Kim KB, Davies MA, Nguyen LM, George GC, Xu L, Shumaker R, Ren M, Mink J, Bedell C, Andresen C, Sachdev P, O'Brien JP, Nemunaitis J.

Clin Cancer Res. 2015 Nov 1;21(21):4801-10. doi: 10.1158/1078-0432.CCR-14-3063. Epub 2015 Jul 13.


A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.

Cabanillas ME, Schlumberger M, Jarzab B, Martins RG, Pacini F, Robinson B, McCaffrey JC, Shah MH, Bodenner DL, Topliss D, Andresen C, O'Brien JP, Ren M, Funahashi Y, Allison R, Elisei R, Newbold K, Licitra LF, Sherman SI, Ball DW.

Cancer. 2015 Aug 15;121(16):2749-56. doi: 10.1002/cncr.29395. Epub 2015 Apr 24.


Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system.

Nowicki EM, O'Brien JP, Brodbelt JS, Trent MS.

Mol Microbiol. 2015 Jul;97(1):166-78. doi: 10.1111/mmi.13018. Epub 2015 May 9.


Recommendations for research studies on treatment of idiopathic scoliosis: Consensus 2014 between SOSORT and SRS non-operative management committee.

Negrini S, Hresko TM, O'Brien JP, Price N; SOSORT Boards; SRS Non-Operative Committee.

Scoliosis. 2015 Mar 7;10:8. doi: 10.1186/s13013-014-0025-4. eCollection 2015. Review.


Top-Down Strategies for the Structural Elucidation of Intact Gram-negative Bacterial Endotoxins.

O'Brien JP, Needham BD, Brown DB, Trent MS, Brodbelt JS.

Chem Sci. 2014 Nov 1;5(11):4291-4301.


Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and co-ordinated control of outer membrane modification.

Nowicki EM, O'Brien JP, Brodbelt JS, Trent MS.

Mol Microbiol. 2014 Nov;94(3):728-41. doi: 10.1111/mmi.12796. Epub 2014 Sep 30.


Letter to the editor concerning: "active self-correction and task-oriented exercises reduce spinal deformity and improve quality of life in subjects with mild adolescent idiopathic scoliosis. Results of a randomised controlled trial" by Monticone M, Ambrosini E, Cazzaniga D, Rocca B, Ferrante S (2014). Eur Spine J; DOI:10.1007/s00586-014-3241-y.

Negrini S, Bettany-Saltikov J, De Mauroy JC, Durmala J, Grivas TB, Knott P, Kotwicki T, Maruyama T, O'Brien JP, Parent E, Rigo M, Romano M, Stikeleather L, Villagrasa M, Zaina F.

Eur Spine J. 2014 Oct;23(10):2218-20. doi: 10.1007/s00586-014-3464-y. Epub 2014 Aug 23. No abstract available.


Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry.

O'Brien JP, Li W, Zhang Y, Brodbelt JS.

J Am Chem Soc. 2014 Sep 17;136(37):12920-8. doi: 10.1021/ja505217w. Epub 2014 Sep 3.


The molecular mechanism of eukaryotic elongation factor 2 kinase activation.

Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN.

J Biol Chem. 2014 Aug 22;289(34):23901-16. doi: 10.1074/jbc.M114.577148. Epub 2014 Jul 10.


SOSORT 2012 consensus paper: reducing x-ray exposure in pediatric patients with scoliosis.

Knott P, Pappo E, Cameron M, Demauroy J, Rivard C, Kotwicki T, Zaina F, Wynne J, Stikeleather L, Bettany-Saltikov J, Grivas TB, Durmala J, Maruyama T, Negrini S, O'Brien JP, Rigo M.

Scoliosis. 2014 Apr 25;9:4. doi: 10.1186/1748-7161-9-4. eCollection 2014. Review.


Actual evidence in the medical approach to adolescents with idiopathic scoliosis.

Negrini S, De Mauroy JC, Grivas TB, Knott P, Kotwicki T, Maruyama T, O'Brien JP, Rigo M, Zaina F.

Eur J Phys Rehabil Med. 2014 Feb;50(1):87-92. Review.


193 nm ultraviolet photodissociation mass spectrometry for the structural elucidation of lipid A compounds in complex mixtures.

O'Brien JP, Needham BD, Henderson JC, Nowicki EM, Trent MS, Brodbelt JS.

Anal Chem. 2014 Feb 18;86(4):2138-45. doi: 10.1021/ac403796n. Epub 2014 Feb 4.


Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity.

Rubin EJ, O'Brien JP, Ivanov PL, Brodbelt JS, Trent MS.

Mol Microbiol. 2014 Mar;91(5):887-99. doi: 10.1111/mmi.12501. Epub 2014 Jan 14.


Evaluating the conformation and binding interface of cap-binding proteins and complexes via ultraviolet photodissociation mass spectrometry.

O'Brien JP, Mayberry LK, Murphy PA, Browning KS, Brodbelt JS.

J Proteome Res. 2013 Dec 6;12(12):5867-77. doi: 10.1021/pr400869u. Epub 2013 Nov 14.


Isolation and chemical characterization of lipid A from gram-negative bacteria.

Henderson JC, O'Brien JP, Brodbelt JS, Trent MS.

J Vis Exp. 2013 Sep 16;(79):e50623. doi: 10.3791/50623.


Structural characterization of gangliosides and glycolipids via ultraviolet photodissociation mass spectrometry.

O'Brien JP, Brodbelt JS.

Anal Chem. 2013 Nov 5;85(21):10399-407. doi: 10.1021/ac402379y. Epub 2013 Oct 21. Erratum in: Anal Chem. 2015 Aug 18;87(16):8592.


Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.

Eskens FA, Ramos FJ, Burger H, O'Brien JP, Piera A, de Jonge MJ, Mizui Y, Wiemer EA, Carreras MJ, Baselga J, Tabernero J.

Clin Cancer Res. 2013 Nov 15;19(22):6296-304. doi: 10.1158/1078-0432.CCR-13-0485. Epub 2013 Aug 27.


Surfactant shedding and gas diffusion during pulsed ultrasound through a microbubble contrast agent suspension.

O'Brien JP, Stride E, Ovenden N.

J Acoust Soc Am. 2013 Aug;134(2):1416-27. doi: 10.1121/1.4812860.


Chromogenic chemical probe for protein structural characterization via ultraviolet photodissociation mass spectrometry.

O'Brien JP, Pruet JM, Brodbelt JS.

Anal Chem. 2013 Aug 6;85(15):7391-7. doi: 10.1021/ac401305f. Epub 2013 Jul 29. Erratum in: Anal Chem. 2013 Nov 19;85(22):11160.


Sustaining enrollment in health insurance for vulnerable populations: lessons from Massachusetts.

Capoccia V, Croze C, Cohen M, O'Brien JP.

Psychiatr Serv. 2013 Apr 1;64(4):360-5. doi: 10.1176/


EptC of Campylobacter jejuni mediates phenotypes involved in host interactions and virulence.

Cullen TW, O'Brien JP, Hendrixson DR, Giles DK, Hobb RI, Thompson SA, Brodbelt JS, Trent MS.

Infect Immun. 2013 Feb;81(2):430-40. doi: 10.1128/IAI.01046-12. Epub 2012 Nov 26.


A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours.

Boss DS, Glen H, Beijnen JH, Keesen M, Morrison R, Tait B, Copalu W, Mazur A, Wanders J, O'Brien JP, Schellens JH, Evans TR.

Br J Cancer. 2012 May 8;106(10):1598-604. doi: 10.1038/bjc.2012.154. Epub 2012 Apr 19.


Mapping protein surface accessibility via an electron transfer dissociation selectively cleavable hydrazone probe.

Vasicek L, O'Brien JP, Browning KS, Tao Z, Liu HW, Brodbelt JS.

Mol Cell Proteomics. 2012 Jul;11(7):O111.015826. doi: 10.1074/mcp.O111.015826. Epub 2012 Mar 5.


Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.

Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN.

Biochemistry. 2012 Mar 20;51(11):2232-45. doi: 10.1021/bi201788e. Epub 2012 Mar 6.


2011 SOSORT guidelines: Orthopaedic and Rehabilitation treatment of idiopathic scoliosis during growth.

Negrini S, Aulisa AG, Aulisa L, Circo AB, de Mauroy JC, Durmala J, Grivas TB, Knott P, Kotwicki T, Maruyama T, Minozzi S, O'Brien JP, Papadopoulos D, Rigo M, Rivard CH, Romano M, Wynne JH, Villagrasa M, Weiss HR, Zaina F.

Scoliosis. 2012 Jan 20;7(1):3. doi: 10.1186/1748-7161-7-3.


Accounting for the stability of microbubbles to multi-pulse excitation using a lipid-shedding model.

O'Brien JP, Ovenden N, Stride E.

J Acoust Soc Am. 2011 Oct;130(4):EL180-5. doi: 10.1121/1.3630219.


Suggestions for improvement of school screening for idiopathic scoliosis.

Grivas TB, Vasiliadis ES, O'brien JP.

Stud Health Technol Inform. 2008;140:245-8.


A century of spine surgery: what can patients expect?

Hawes MC, O'Brien JP.

Disabil Rehabil. 2008;30(10):808-17. doi: 10.1080/09638280801889972. Review.


How to improve the effectiveness of school screening for idiopathic scoliosis.

Grivas TB, Vasiliadis ES, O'Brien JP.

Stud Health Technol Inform. 2008;135:115-21. Review.


Scoliosis and the human genome project.

Hawes MC, O'Brien JP.

Stud Health Technol Inform. 2008;135:97-111. Review.


SOSORT consensus paper: school screening for scoliosis. Where are we today?

Grivas TB, Wade MH, Negrini S, O'Brien JP, Maruyama T, Hawes MC, Rigo M, Weiss HR, Kotwicki T, Vasiliadis ES, Sulam LN, Neuhous T.

Scoliosis. 2007 Nov 26;2:17.


Anatomy of the heart at multidetector CT: what the radiologist needs to know.

O'Brien JP, Srichai MB, Hecht EM, Kim DC, Jacobs JE.

Radiographics. 2007 Nov-Dec;27(6):1569-82. Review.


The NHL-15 protocol for aggressive non-Hodgkin's lymphomas: a sequential dose-dense, dose-intense regimen of doxorubicin, vincristine and high-dose cyclophosphamide.

Portlock CS, Qin J, Schaindlin P, Roistacher N, Myers J, Filippa D, Louie D, Zelenetz AD, O'Brien JP, Moskowitz C, Norton L, Yahalom J, Straus DJ, Bertino JR.

Ann Oncol. 2004 Oct;15(10):1495-503.


Nerve growth factor expression and innervation of the painful intervertebral disc.

Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, Ross ER, O'Brien JP, Hoyland JA.

J Pathol. 2002 Jul;197(3):286-92.


Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment.

Richon VM, O'Brien JP.

Clin Cancer Res. 2002 Mar;8(3):662-4. No abstract available.


The use of allograft (and avoidance of autograft) in anterior lumbar interbody fusion: a critical analysis.

Sarwat AM, O'Brien JP, Renton P, Sutcliffe JC.

Eur Spine J. 2001 Jun;10(3):237-41.


A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model.

Moskowitz CH, Nimer SD, Zelenetz AD, Trippett T, Hedrick EE, Filippa DA, Louie D, Gonzales M, Walits J, Coady-Lyons N, Qin J, Frank R, Bertino JR, Goy A, Noy A, O'Brien JP, Straus D, Portlock CS, Yahalom J.

Blood. 2001 Feb 1;97(3):616-23.


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