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Items: 1 to 50 of 231

1.

Effect of Photobiomodulation in Rescuing Lipopolysaccharide-Induced Dopaminergic Cell Loss in the Male Sprague-Dawley Rat.

O'Brien JA, Austin PJ.

Biomolecules. 2019 Aug 19;9(8). pii: E381. doi: 10.3390/biom9080381.

2.

EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation.

Liu H, Sun Y, Qi X, Gordon RE, O'Brien JA, Yuan H, Zhang J, Wang Z, Zhang M, Song Y, Yu C, Gu C.

Front Oncol. 2019 Jul 16;9:641. doi: 10.3389/fonc.2019.00641. eCollection 2019.

3.

COI1-dependent jasmonate signalling affects growth, metabolite production and cell wall protein composition in arabidopsis.

Bömer M, O'Brien JA, Pérez-Salamó I, Krasauskas J, Finch P, Briones A, Daudi A, Souda P, Tsui TL, Whitelegge JP, Paul Bolwell G, Devoto A.

Ann Bot. 2018 Dec 31;122(7):1117-1129. doi: 10.1093/aob/mcy109.

4.

miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2-Versican Pathway.

Salem M, O'Brien JA, Bernaudo S, Shawer H, Ye G, Brkić J, Amleh A, Vanderhyden BC, Refky B, Yang BB, Krylov SN, Peng C.

Cancer Res. 2018 Aug 1;78(15):4175-4190. doi: 10.1158/0008-5472.CAN-17-3014. Epub 2018 May 10.

5.

Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.

Liu Y, Yuelling LW, Wang Y, Du F, Gordon RE, O'Brien JA, Ng JMY, Robins S, Lee EH, Liu H, Curran T, Yang ZJ.

Cancer Res. 2017 Dec 1;77(23):6692-6703. doi: 10.1158/0008-5472.CAN-17-1463. Epub 2017 Oct 6.

6.

Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.

Skudlarek JW, DiMarco CN, Babaoglu K, Roecker AJ, Bruno JG, Pausch MA, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Wuelfing WP, Garson SL, Fox SV, Savitz AT, Harrell CM, Gotter AL, Winrow CJ, Renger JJ, Kuduk SD, Coleman PJ.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1364-1370. doi: 10.1016/j.bmcl.2017.02.012. Epub 2017 Feb 9.

PMID:
28216403
7.

Nitrate Transport, Sensing, and Responses in Plants.

O'Brien JA, Vega A, Bouguyon E, Krouk G, Gojon A, Coruzzi G, Gutiérrez RA.

Mol Plant. 2016 Jun 6;9(6):837-56. doi: 10.1016/j.molp.2016.05.004. Epub 2016 May 19. Review.

8.

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI.

Pero JE, Rossi MA, Kelly MJ 3rd, Lehman HD, Layton ME, Garbaccio RM, O'Brien JA, Magliaro BC, Uslaner JM, Huszar SL, Fillgrove KL, Tang C, Kuo Y, Joyce LA, Sherer EC, Jacobson MA.

ACS Med Chem Lett. 2016 Jan 10;7(3):312-7. doi: 10.1021/acsmedchemlett.5b00459. eCollection 2016 Mar 10.

9.

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

Layton ME, Reif AJ, Hartingh TJ, Rodzinak K, Dudkin V, Wang C, Arrington K, Kelly MJ 3rd, Garbaccio RM, O'Brien JA, Magliaro BC, Uslaner JM, Huszar SL, Fillgrove KL, Tang C, Kuo Y, Jacobson MA.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1260-4. doi: 10.1016/j.bmcl.2016.01.021. Epub 2016 Jan 11.

PMID:
26810316
10.

Prospective Validation of the Ottawa 3DY Scale by Geriatric Emergency Management Nurses to Identify Impaired Cognition in Older Emergency Department Patients.

Wilding L, Eagles D, Molnar F, O'Brien JA, Dalziel WB, Moors J, Stiell I.

Ann Emerg Med. 2016 Feb;67(2):157-63. doi: 10.1016/j.annemergmed.2015.09.008. Epub 2015 Nov 19.

PMID:
26607333
11.

Cytokinin response factors regulate PIN-FORMED auxin transporters.

Šimášková M, O'Brien JA, Khan M, Van Noorden G, Ötvös K, Vieten A, De Clercq I, Van Haperen JMA, Cuesta C, Hoyerová K, Vanneste S, Marhavý P, Wabnik K, Van Breusegem F, Nowack M, Murphy A, Friml J, Weijers D, Beeckman T, Benková E.

Nat Commun. 2015 Nov 6;6:8717. doi: 10.1038/ncomms9717.

PMID:
26541513
12.

Breast-Conserving Surgery in Bilateral Breast Cancer.

O'Brien JA, Ho A, Wright GP, Stempel M, Patil S, Krause K, Morrow M, Gemignani ML.

Ann Surg Oncol. 2015 Oct;22(10):3389-96. doi: 10.1245/s10434-015-4746-2. Epub 2015 Aug 12.

13.

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.

Kuduk SD, Skudlarek JW, DiMarco CN, Bruno JG, Pausch MH, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Garson SL, Savitz AT, Harrell CM, Gotter AL, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2488-92. doi: 10.1016/j.bmcl.2015.04.066. Epub 2015 Apr 29.

PMID:
25981685
14.

Novel tools for genetic manipulation of follicle stem cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation.

Hartman TR, Ventresca EM, Hopkins A, Zinshteyn D, Singh T, O'Brien JA, Neubert BC, Hartman MG, Schofield HK, Stavrides KP, Talbot DE, Riggs DJ, Pritchard C, O'Reilly AM.

Genetics. 2015 Apr;199(4):935-57. doi: 10.1534/genetics.114.173617. Epub 2015 Feb 12.

15.

The patient relations and service recovery guide: a colorful approach to handling upset and angry patients.

O'Brien JA.

Am J Orthop (Belle Mead NJ). 2015 Jan;44(1):43-6. No abstract available.

PMID:
25566557
16.

Regioselective biolistic targeting in organotypic brain slices using a modified gene gun.

Arsenault J, Nagy A, Henderson JT, O'Brien JA.

J Vis Exp. 2014 Oct 24;(92):e52148. doi: 10.3791/52148.

17.

To outsource or not to outsource your physical therapy service line management?

O'Brien JA.

Am J Orthop (Belle Mead NJ). 2014 Nov;43(11):524-6. No abstract available.

PMID:
25379751
18.

Testing the effectiveness of a self-efficacy based exercise intervention for adults with venous leg ulcers: protocol of a randomised controlled trial.

O'Brien JA, Finlayson KJ, Kerr G, Edwards HE.

BMC Dermatol. 2014 Oct 3;14:16. doi: 10.1186/1471-5945-14-16.

19.

Patient portal in your orthopedic surgery practice: you can so do this.

O'Brien JA.

Am J Orthop (Belle Mead NJ). 2014 Sep;43(9):426-9. No abstract available.

PMID:
25251530
20.

Banking: shop and compare.

O'Brien JA, DeJarnette S.

J Med Pract Manage. 2014 May-Jun;29(6):351-5.

PMID:
25108982
21.

Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation: a randomized clinical trial.

Koegelenberg CF, Noor F, Bateman ED, van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM.

JAMA. 2014 Jul;312(2):155-61. doi: 10.1001/jama.2014.7195.

PMID:
25005652
22.

Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.

Kuduk SD, Skudlarek JW, Di Marco CN, Bruno JG, Pausch MA, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Gotter AL, Winrow CJ, Renger JJ, Coleman PJ.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1784-9. doi: 10.1016/j.bmcl.2014.02.026. Epub 2014 Feb 19.

PMID:
24630562
23.

Coming out ahead: the cost effectiveness of external cephalic version using spinal anesthesia.

O'Brien JA, Adashi EY.

Isr J Health Policy Res. 2014 Feb 24;3(1):6. doi: 10.1186/2045-4015-3-6.

24.

Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells.

Arsenault J, Cuijpers SA, Ferrari E, Niranjan D, Rust A, Leese C, O'Brien JA, Binz T, Davletov B.

J Neurochem. 2014 Jun;129(5):781-91. doi: 10.1111/jnc.12645. Epub 2014 Jan 23.

25.

Optimized heterologous transfection of viable adult organotypic brain slices using an enhanced gene gun.

Arsenault J, O'Brien JA.

BMC Res Notes. 2013 Dec 19;6:544. doi: 10.1186/1756-0500-6-544.

26.

Cytokinin cross-talking during biotic and abiotic stress responses.

O'Brien JA, Benková E.

Front Plant Sci. 2013 Nov 19;4:451. doi: 10.3389/fpls.2013.00451. Review.

27.

Leukemic stem cells: a review.

O'Brien JA, Rizzieri DA.

Cancer Invest. 2013 May;31(4):215-20. doi: 10.3109/07357907.2012.700986. Epub 2013 Mar 8. Review.

PMID:
23473080
28.

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.

Parmentier-Batteur S, Hutson PH, Menzel K, Uslaner JM, Mattson BA, O'Brien JA, Magliaro BC, Forest T, Stump CA, Tynebor RM, Anthony NJ, Tucker TJ, Zhang XF, Gomez R, Huszar SL, Lambeng N, Fauré H, Le Poul E, Poli S, Rosahl TW, Rocher JP, Hargreaves R, Williams TM.

Neuropharmacology. 2014 Jul;82:161-73. doi: 10.1016/j.neuropharm.2012.12.003. Epub 2013 Jan 2.

PMID:
23291536
29.

Biolistic transfection of neurons in organotypic brain slices.

O'Brien JA, Lummis SC.

Methods Mol Biol. 2013;940:157-66. doi: 10.1007/978-1-62703-110-3_13.

PMID:
23104341
30.

Reactive oxygen species and their role in plant defence and cell wall metabolism.

O'Brien JA, Daudi A, Butt VS, Bolwell GP.

Planta. 2012 Sep;236(3):765-79. doi: 10.1007/s00425-012-1696-9. Epub 2012 Jul 6. Review.

PMID:
22767200
31.

The effectiveness of a four-layer compression bandage system in comparison with Class 3 compression hosiery on healing and quality of life in patients with venous leg ulcers: a randomised controlled trial.

Finlayson KJ, Courtney MD, Gibb MA, O'Brien JA, Parker CN, Edwards HE.

Int Wound J. 2014 Feb;11(1):21-7. doi: 10.1111/j.1742-481X.2012.01033.x. Epub 2012 Jun 21.

PMID:
22716129
32.

A peroxidase-dependent apoplastic oxidative burst in cultured Arabidopsis cells functions in MAMP-elicited defense.

O'Brien JA, Daudi A, Finch P, Butt VS, Whitelegge JP, Souda P, Ausubel FM, Bolwell GP.

Plant Physiol. 2012 Apr;158(4):2013-27. doi: 10.1104/pp.111.190140. Epub 2012 Feb 7.

33.

The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.

Daudi A, Cheng Z, O'Brien JA, Mammarella N, Khan S, Ausubel FM, Bolwell GP.

Plant Cell. 2012 Jan;24(1):275-87. doi: 10.1105/tpc.111.093039. Epub 2012 Jan 13.

34.

Detection of Hydrogen Peroxide by DAB Staining in Arabidopsis Leaves.

Daudi A, O'Brien JA.

Bio Protoc. 2012;2(18). pii: e263. Epub 2012 Sep 20.

35.

Diurnal patterns of water use in Eucalyptus victrix indicate pronounced desiccation-rehydration cycles despite unlimited water supply.

Pfautsch S, Keitel C, Turnbull TL, Braimbridge MJ, Wright TE, Simpson RR, O'Brien JA, Adams MA.

Tree Physiol. 2011 Oct;31(10):1041-51. doi: 10.1093/treephys/tpr082. Epub 2011 Sep 10.

PMID:
21908853
36.

Outcomes from a labor and delivery team training program with simulation component.

Phipps MG, Lindquist DG, McConaughey E, O'Brien JA, Raker CA, Paglia MJ.

Am J Obstet Gynecol. 2012 Jan;206(1):3-9. doi: 10.1016/j.ajog.2011.06.046. Epub 2011 Jun 21. Review.

PMID:
21840493
37.

A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.

Maywood ES, Chesham JE, O'Brien JA, Hastings MH.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14306-11. doi: 10.1073/pnas.1101767108. Epub 2011 Jul 25.

38.
39.

Fleur-de-lis panniculectomy after bariatric surgery: our experience.

O'Brien JA, Broderick GB, Hurwitz ZM, Montilla R, Castle J, Dunn RM, Akyurek M, Lalikos JF.

Ann Plast Surg. 2012 Jan;68(1):74-8. doi: 10.1097/SAP.0b013e31820eb92d.

PMID:
21587047
40.

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS.

PLoS One. 2011 Feb 24;6(2):e17152. doi: 10.1371/journal.pone.0017152.

41.

Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.

Parmentier-Batteur S, O'Brien JA, Doran S, Nguyen SJ, Flick RB, Uslaner JM, Chen H, Finger EN, Williams TM, Jacobson MA, Hutson PH.

Neuropharmacology. 2012 Mar;62(3):1453-60. doi: 10.1016/j.neuropharm.2010.11.013. Epub 2010 Nov 26.

PMID:
21112344
42.

Recruit and hire the best fit for your practice.

O'Brien JA.

J Med Pract Manage. 2010 Sep-Oct;26(2):113-8.

PMID:
21090208
43.

Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.

Garbaccio RM, Brnardic EJ, Fraley ME, Hartman GD, Hutson PH, O'Brien JA, Magliaro BC, Uslaner JM, Huszar SL, Fillgrove KL, Small JH, Tang C, Kuo Y, Jacobson MA.

ACS Med Chem Lett. 2010 Jul 12;1(8):406-10. doi: 10.1021/ml100115a. eCollection 2010 Nov 11.

44.

The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.

Jacobson MA, Kreatsoulas C, Pascarella DM, O'Brien JA, Sur C.

Mol Pharmacol. 2010 Oct;78(4):648-57. doi: 10.1124/mol.110.065771. Epub 2010 Jul 21.

PMID:
20660086
45.

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.

Brnardic EJ, Fraley ME, Garbaccio RM, Layton ME, Sanders JM, Culberson C, Jacobson MA, Magliaro BC, Hutson PH, O'Brien JA, Huszar SL, Uslaner JM, Fillgrove KL, Tang C, Kuo Y, Sur SM, Hartman GD.

Bioorg Med Chem Lett. 2010 May 15;20(10):3129-33. doi: 10.1016/j.bmcl.2010.03.089. Epub 2010 Mar 31.

PMID:
20409708
46.

Long-term histologic and mechanical results of a Permacol™ abdominal wall explant.

O'Brien JA, Ignotz R, Montilla R, Broderick GB, Christakis A, Dunn RM.

Hernia. 2011 Apr;15(2):211-5. doi: 10.1007/s10029-010-0628-5. Epub 2010 Jan 21.

PMID:
20091328
47.

Economic evaluation of atorvastatin for prevention of recurrent stroke based on the SPARCL trial.

Kongnakorn T, Ward A, Roberts CS, O'Brien JA, Proskorovsky I, Caro JJ.

Value Health. 2009 Sep;12(6):880-7. doi: 10.1111/j.1524-4733.2009.00531.x. Epub 2009 Mar 11.

48.

Outcomes of patients who undergo aggressive induction therapy for secondary acute myeloid leukemia.

Rizzieri DA, O'Brien JA, Broadwater G, Decastro CM, Dev P, Diehl L, Beaven A, Lagoo A, Gockerman JP, Chao NJ, Moore JO.

Cancer. 2009 Jul 1;115(13):2922-9. doi: 10.1002/cncr.24379.

49.

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

Zhao Z, Leister WH, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Hartman GD, Lindsley CW, Wolkenberg SE.

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1488-91. doi: 10.1016/j.bmcl.2008.12.115. Epub 2009 Jan 9.

PMID:
19179073
50.

Treating relapsing multiple sclerosis with subcutaneous versus intramuscular interferon-beta-1a: modelling the clinical and economic implications.

Guo S, Bozkaya D, Ward A, O'Brien JA, Ishak K, Bennett R, Al-Sabbagh A, Meletiche DM.

Pharmacoeconomics. 2009;27(1):39-53. doi: 10.2165/00019053-200927010-00005.

PMID:
19178123

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