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Items: 1 to 50 of 216

1.

Soil Salinity and pH Drive Soil Bacterial Community Composition and Diversity Along a Lateritic Slope in the Avon River Critical Zone Observatory, Western Australia.

O'Brien FJM, Almaraz M, Foster MA, Hill AF, Huber DP, King EK, Langford H, Lowe MA, Mickan BS, Miller VS, Moore OW, Mathes F, Gleeson D, Leopold M.

Front Microbiol. 2019 Jul 2;10:1486. doi: 10.3389/fmicb.2019.01486. eCollection 2019.

2.

Rapid healing of a critical-sized bone defect using a collagen-hydroxyapatite scaffold to facilitate low dose, combinatorial growth factor delivery.

Walsh DP, Raftery RM, Chen G, Heise A, O'Brien FJ, Cryan SA.

J Tissue Eng Regen Med. 2019 Jul 15. doi: 10.1002/term.2934. [Epub ahead of print]

PMID:
31306563
3.

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering.

Raftery RM, Walsh DP, Blokpoel Ferreras L, Mencía Castaño I, Chen G, LeMoine M, Osman G, Shakesheff KM, Dixon JE, O'Brien FJ.

Biomaterials. 2019 Sep;216:119277. doi: 10.1016/j.biomaterials.2019.119277. Epub 2019 Jun 13.

PMID:
31252371
4.

Transfection of autologous host cells in vivo using gene activated collagen scaffolds incorporating star-polypeptides.

Walsh DP, Raftery RM, Castaño IM, Murphy R, Cavanagh B, Heise A, O'Brien FJ, Cryan SA.

J Control Release. 2019 Jun 28;304:191-203. doi: 10.1016/j.jconrel.2019.05.009. Epub 2019 May 8.

PMID:
31075346
5.

Controlling the dose-dependent, synergistic and temporal effects of NGF and GDNF by encapsulation in PLGA microparticles for use in nerve guidance conduits for the repair of large peripheral nerve defects.

Lackington WA, Kočí Z, Alekseeva T, Hibbitts AJ, Kneafsey SL, Chen G, O'Brien FJ.

J Control Release. 2019 Jun 28;304:51-64. doi: 10.1016/j.jconrel.2019.05.001. Epub 2019 May 2.

PMID:
31054993
6.

Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair.

Kelly DC, Raftery RM, Curtin CM, O'Driscoll CM, O'Brien FJ.

J Orthop Res. 2019 May 1. doi: 10.1002/jor.24321. [Epub ahead of print] Review.

PMID:
31042304
7.

Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues.

Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman FE, Cunniffe GM, Dunne NJ, McCarthy HO, Nicolosi V, O'Brien FJ, Kelly DJ.

J Control Release. 2019 May 10;301:13-27. doi: 10.1016/j.jconrel.2019.03.006. Epub 2019 Mar 8.

PMID:
30853527
8.

Material stiffness influences the polarization state, function and migration mode of macrophages.

Sridharan R, Cavanagh B, Cameron AR, Kelly DJ, O'Brien FJ.

Acta Biomater. 2019 Apr 15;89:47-59. doi: 10.1016/j.actbio.2019.02.048. Epub 2019 Feb 28.

PMID:
30826478
9.

Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

Ryan EJ, Ryan AJ, González-Vázquez A, Philippart A, Ciraldo FE, Hobbs C, Nicolosi V, Boccaccini AR, Kearney CJ, O'Brien FJ.

Biomaterials. 2019 Mar;197:405-416. doi: 10.1016/j.biomaterials.2019.01.031. Epub 2019 Jan 23.

PMID:
30708184
10.

Platelet-derived growth factor stabilises vascularisation in collagen-glycosaminoglycan scaffolds in vitro.

do Amaral RJFC, Cavanagh B, O'Brien FJ, Kearney CJ.

J Tissue Eng Regen Med. 2019 Feb;13(2):261-273. doi: 10.1002/term.2789. Epub 2019 Jan 24.

PMID:
30554484
11.

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues.

Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ.

Biomaterials. 2019 Jan;188:63-73. doi: 10.1016/j.biomaterials.2018.09.044. Epub 2018 Oct 4.

PMID:
30321864
12.

Rhizosphere Bacterial Communities Differ According to Fertilizer Regimes and Cabbage (Brassica oleracea var. capitata L.) Harvest Time, but Not Aphid Herbivory.

O'Brien FJM, Dumont MG, Webb JS, Poppy GM.

Front Microbiol. 2018 Jul 23;9:1620. doi: 10.3389/fmicb.2018.01620. eCollection 2018.

13.

Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration.

Cunnane EM, Weinbaum JS, O'Brien FJ, Vorp DA.

Front Cardiovasc Med. 2018 Jul 3;5:86. doi: 10.3389/fcvm.2018.00086. eCollection 2018. Review.

14.

Staphylococcus aureus protein A causes osteoblasts to hyper-mineralise in a 3D extra-cellular matrix environment.

Kavanagh N, O'Brien FJ, Kerrigan SW.

PLoS One. 2018 Jun 21;13(6):e0198837. doi: 10.1371/journal.pone.0198837. eCollection 2018.

15.

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun.

Lackington WA, Raftery RM, O'Brien FJ.

Acta Biomater. 2018 Jul 15;75:115-128. doi: 10.1016/j.actbio.2018.06.014. Epub 2018 Jun 7.

PMID:
29885855
16.

Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair.

Raftery RM, Mencía-Castaño I, Sperger S, Chen G, Cavanagh B, Feichtinger GA, Redl H, Hacobian A, O'Brien FJ.

J Control Release. 2018 Aug 10;283:20-31. doi: 10.1016/j.jconrel.2018.05.022. Epub 2018 May 19.

17.

Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates.

Haugh MG, Vaughan TJ, Madl CM, Raftery RM, McNamara LM, O'Brien FJ, Heilshorn SC.

Biomaterials. 2018 Jul;171:23-33. doi: 10.1016/j.biomaterials.2018.04.026. Epub 2018 Apr 16.

18.

Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells.

Walsh DP, Murphy RD, Panarella A, Raftery RM, Cavanagh B, Simpson JC, O'Brien FJ, Heise A, Cryan SA.

Mol Pharm. 2018 May 7;15(5):1878-1891. doi: 10.1021/acs.molpharmaceut.8b00044. Epub 2018 Apr 6.

PMID:
29590755
19.

Pro-angiogenic impact of SDF-1α gene-activated collagen-based scaffolds in stem cell driven angiogenesis.

Laiva AL, Raftery RM, Keogh MB, O'Brien FJ.

Int J Pharm. 2018 Jun 15;544(2):372-379. doi: 10.1016/j.ijpharm.2018.03.032. Epub 2018 Mar 17.

PMID:
29555441
20.

Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity.

Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Garciarena CD, Vega-Mayoral V, Loskill P, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ.

Adv Mater. 2018 Apr;30(15):e1706442. doi: 10.1002/adma.201706442. Epub 2018 Mar 5.

PMID:
29504165
21.

Harnessing an Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering.

Mencía Castaño I, Curtin CM, Duffy GP, O'Brien FJ.

Tissue Eng Part A. 2019 Jan;25(1-2):24-33. doi: 10.1089/ten.TEA.2017.0460. Epub 2018 Apr 10.

PMID:
29490603
22.

A physiologically relevant 3D collagen-based scaffold-neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models.

Curtin C, Nolan JC, Conlon R, Deneweth L, Gallagher C, Tan YJ, Cavanagh BL, Asraf AZ, Harvey H, Miller-Delaney S, Shohet J, Bray I, O'Brien FJ, Stallings RL, Piskareva O.

Acta Biomater. 2018 Apr 1;70:84-97. doi: 10.1016/j.actbio.2018.02.004. Epub 2018 Feb 12.

23.

Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions.

Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O'Rourke S, Cahill KC, Kearney CJ, O'Brien FJ, Kerrigan SW.

Clin Microbiol Rev. 2018 Feb 14;31(2). pii: e00084-17. doi: 10.1128/CMR.00084-17. Print 2018 Apr. Review.

24.

An endochondral ossification approach to early stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair.

Matsiko A, Thompson EM, Lloyd-Griffith C, Cunniffe GM, Vinardell T, Gleeson JP, Kelly DJ, O'Brien FJ.

J Tissue Eng Regen Med. 2018 Apr;12(4):e2147-e2150. doi: 10.1002/term.2638. Epub 2018 Mar 8.

PMID:
29327428
25.

A Short History of Bioengineering Research in Ireland.

Kelly DJ, O'Brien FJ, Prendergast PJ.

J Biomech Eng. 2018 Feb 1;140(2). doi: 10.1115/1.4038789.

PMID:
29260188
26.

Scaffold-Based microRNA Therapies in Regenerative Medicine and Cancer.

Curtin CM, Castaño IM, O'Brien FJ.

Adv Healthc Mater. 2018 Jan;7(1). doi: 10.1002/adhm.201700695. Epub 2017 Oct 25. Review.

PMID:
29068566
27.

Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency.

Caraher MC, Sophocleous A, Beattie JR, O'Driscoll O, Cummins NM, Brennan O, O'Brien FJ, Ralston SH, Bell SEJ, Towler M, Idris AI.

Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):398-406. doi: 10.1016/j.bbadis.2017.10.020. Epub 2017 Oct 21.

28.

Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in critical-sized bone defects.

Raftery RM, Mencía Castaño I, Chen G, Cavanagh B, Quinn B, Curtin CM, Cryan SA, O'Brien FJ.

Biomaterials. 2017 Dec;149:116-127. doi: 10.1016/j.biomaterials.2017.09.036. Epub 2017 Oct 4.

PMID:
29024837
29.

Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy.

do Amaral RJFC, Almeida HV, Kelly DJ, O'Brien FJ, Kearney CJ.

Stem Cells Int. 2017;2017:6843727. doi: 10.1155/2017/6843727. Epub 2017 Sep 6. Review.

30.

A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair.

Ryan AJ, Lackington WA, Hibbitts AJ, Matheson A, Alekseeva T, Stejskalova A, Roche P, O'Brien FJ.

Adv Healthc Mater. 2017 Dec;6(24). doi: 10.1002/adhm.201700954. Epub 2017 Oct 4.

PMID:
28975768
31.

Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo.

Roche P, Alekseeva T, Widaa A, Ryan A, Matsiko A, Walsh M, Duffy GP, O'Brien FJ.

Stem Cells Transl Med. 2017 Oct;6(10):1894-1904. doi: 10.1002/sctm.16-0420.

32.

An efficient, non-viral dendritic vector for gene delivery in tissue engineering.

Walsh DP, Heise A, O'Brien FJ, Cryan SA.

Gene Ther. 2017 Nov;24(11):681-691. doi: 10.1038/gt.2017.58. Epub 2017 Sep 14.

PMID:
28905887
33.

Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis.

Barreto S, González-Vázquez A, R Cameron A, O'Brien FJ, Murray DJ.

Sci Rep. 2017 Sep 13;7(1):11494. doi: 10.1038/s41598-017-11801-0.

34.

Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation.

Ryan AJ, O'Neill HS, Duffy GP, O'Brien FJ.

Curr Opin Pharmacol. 2017 Oct;36:66-71. doi: 10.1016/j.coph.2017.07.013. Epub 2017 Aug 31. Review.

PMID:
28865291
35.

Tissue engineered extracellular matrices (ECMs) in urology: Evolution and future directions.

Davis NF, Cunnane EM, O'Brien FJ, Mulvihill JJ, Walsh MT.

Surgeon. 2018 Feb;16(1):55-65. doi: 10.1016/j.surge.2017.07.002. Epub 2017 Aug 12. Review.

PMID:
28811169
36.

Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds.

Brougham CM, Levingstone TJ, Shen N, Cooney GM, Jockenhoevel S, Flanagan TC, O'Brien FJ.

Adv Healthc Mater. 2017 Nov;6(21). doi: 10.1002/adhm.201700598. Epub 2017 Jul 31.

PMID:
28758358
37.

A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis.

Brennan O, Sweeney J, O'Meara B, Widaa A, Bonnier F, Byrne HJ, O'Gorman DM, O'Brien FJ.

Calcif Tissue Int. 2017 Oct;101(4):445-455. doi: 10.1007/s00223-017-0299-7. Epub 2017 Jun 24.

PMID:
28647775
38.

The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation.

Lebre F, Sridharan R, Sawkins MJ, Kelly DJ, O'Brien FJ, Lavelle EC.

Sci Rep. 2017 Jun 7;7(1):2922. doi: 10.1038/s41598-017-03086-0.

39.

Innovations in gene and growth factor delivery systems for diabetic wound healing.

Laiva AL, O'Brien FJ, Keogh MB.

J Tissue Eng Regen Med. 2018 Jan;12(1):e296-e312. doi: 10.1002/term.2443. Epub 2017 Sep 21. Review.

40.

Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector.

Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi V, O'Brien FJ, Kelly DJ.

Acta Biomater. 2017 Jun;55:226-238. doi: 10.1016/j.actbio.2017.03.044. Epub 2017 Mar 29.

PMID:
28363788
41.

Identification of the mechanisms by which age alters the mechanosensitivity of mesenchymal stromal cells on substrates of differing stiffness: Implications for osteogenesis and angiogenesis.

Barreto S, Gonzalez-Vazquez A, Cameron AR, Cavanagh B, Murray DJ, O'Brien FJ.

Acta Biomater. 2017 Apr 15;53:59-69. doi: 10.1016/j.actbio.2017.02.031. Epub 2017 Feb 16.

PMID:
28216301
42.

Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

Cunniffe GM, Díaz-Payno PJ, Ramey JS, Mahon OR, Dunne A, Thompson EM, O'Brien FJ, Kelly DJ.

Eur Cell Mater. 2017 Feb 14;33:130-142. doi: 10.22203/eCM.v033a10.

43.

Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model.

Evans JC, Malhotra M, Fitzgerald KA, Guo J, Cronin MF, Curtin CM, O'Brien FJ, Darcy R, O'Driscoll CM.

Mol Pharm. 2017 Jan 3;14(1):42-52. doi: 10.1021/acs.molpharmaceut.6b00646. Epub 2016 Nov 23.

PMID:
28043128
44.

A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation.

O'Neill HS, O'Sullivan J, Porteous N, Ruiz-Hernandez E, Kelly HM, O'Brien FJ, Duffy GP.

J Tissue Eng Regen Med. 2018 Jan;12(1):e384-e394. doi: 10.1002/term.2392. Epub 2017 Jun 19.

PMID:
27943590
45.

A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents.

O'Neill HS, Herron CC, Hastings CL, Deckers R, Lopez Noriega A, Kelly HM, Hennink WE, McDonnell CO, O'Brien FJ, Ruiz-Hernández E, Duffy GP.

Acta Biomater. 2017 Jan 15;48:110-119. doi: 10.1016/j.actbio.2016.10.001. Epub 2016 Oct 20.

PMID:
27773752
46.

More Dialysis Has Not Proven Much Better.

O'Brien FJ, Fong KD, Sirich TL, Meyer TW.

Semin Dial. 2016 Nov;29(6):481-490. doi: 10.1111/sdi.12533. Epub 2016 Aug 24.

PMID:
27556575
47.

Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering.

Almeida HV, Sathy BN, Dudurych I, Buckley CT, O'Brien FJ, Kelly DJ.

Tissue Eng Part A. 2017 Jan;23(1-2):55-68. doi: 10.1089/ten.TEA.2016.0055. Epub 2016 Nov 22.

PMID:
27712409
48.

Content-Dependent Osteogenic Response of Nanohydroxyapatite: An in Vitro and in Vivo Assessment within Collagen-Based Scaffolds.

Cunniffe GM, Curtin CM, Thompson EM, Dickson GR, O'Brien FJ.

ACS Appl Mater Interfaces. 2016 Sep 14;8(36):23477-88. doi: 10.1021/acsami.6b06596. Epub 2016 Aug 30.

PMID:
27537605
49.

Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality.

Raftery RM, Woods B, Marques ALP, Moreira-Silva J, Silva TH, Cryan SA, Reis RL, O'Brien FJ.

Acta Biomater. 2016 Oct 1;43:160-169. doi: 10.1016/j.actbio.2016.07.009. Epub 2016 Jul 8.

PMID:
27402181
50.

Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds.

Almeida HV, Mulhall KJ, O'Brien FJ, Kelly DJ.

J Tissue Eng Regen Med. 2017 Nov;11(11):2979-2987. doi: 10.1002/term.2199. Epub 2016 Jul 12.

PMID:
27402022

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