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Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

Andrews D, Oliviero G, De Chiara L, Watson A, Rochford E, Wynne K, Kennedy C, Clerkin S, Doyle B, Godson C, Connell P, O'Brien C, Cagney G, Crean J.

FASEB J. 2019 Feb 19:fj201800566RR. doi: 10.1096/fj.201800566RR. [Epub ahead of print]


Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals.

Rhee C, Jones TM, Hamad Y, Pande A, Varon J, O'Brien C, Anderson DJ, Warren DK, Dantes RB, Epstein L, Klompas M; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program.

JAMA Netw Open. 2019 Feb 1;2(2):e187571. doi: 10.1001/jamanetworkopen.2018.7571.


Assessment and Management of HIV-Associated Cognitive Impairment: Experience from a Multidisciplinary Memory Service for People Living with HIV.

Alford K, Banerjee S, Nixon E, O'Brien C, Pounds O, Butler A, Elphick C, Henshaw P, Anderson S, Vera JH.

Brain Sci. 2019 Feb 8;9(2). pii: E37. doi: 10.3390/brainsci9020037.


An integrated platform for mucin-type o-glycosylation network generation and visualization.

Le T, O'Brien C, Gupta U, Sousa G, Daoutidis P, Hu WS.

Biotechnol Bioeng. 2019 Feb 10. doi: 10.1002/bit.26952. [Epub ahead of print]


Nexus of despair: A network analysis of suicidal ideation among veterans.

Simons JS, Simons RM, Walters KJ, Keith JA, O'Brien C, Andal K, Stoltenberg SF.

Arch Suicide Res. 2019 Feb 8:1-44. doi: 10.1080/13811118.2019.1574689. [Epub ahead of print]


IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection.

O'Brien CA, Batista SJ, Still KM, Harris TH.

J Immunol. 2019 Feb 4. pii: ji1801229. doi: 10.4049/jimmunol.1801229. [Epub ahead of print]


A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.

Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J.

Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1.


Characterizing Treatment Effects of Valbenazine for Tardive Dyskinesia: Additional Results From the KINECT 3 Study.

Correll CU, Cutler AJ, Kane JM, McEvoy JP, Liang GS, O'Brien CF.

J Clin Psychiatry. 2018 Dec 18;80(1). pii: 18m12278. doi: 10.4088/JCP.18m12278.


Development of the Revised Opioid Risk Tool to Predict Opioid Use Disorder in Patients with Chronic Non-Malignant Pain.

Cheatle MD, Compton PA, Dhingra L, Wasser TE, O'Brien CP.

J Pain. 2019 Jan 25. pii: S1526-5900(18)30622-9. doi: 10.1016/j.jpain.2019.01.011. [Epub ahead of print]


Alpine Ski Racing Injuries.

Tarka MC, Davey A, Lonza GC, O'Brien CM, Delaney JP, Endres NK.

Sports Health. 2019 Jan 28:1941738119825842. doi: 10.1177/1941738119825842. [Epub ahead of print]


Coverage-Versus-Length Plots, a Simple Quality Control Step for de Novo Yeast Genome Sequence Assemblies.

Douglass AP, O'Brien CE, Offei B, Coughlan AY, Ortiz-Merino RA, Butler G, Byrne KP, Wolfe KH.

G3 (Bethesda). 2019 Jan 23. pii: g3.200745.2018. doi: 10.1534/g3.118.200745. [Epub ahead of print]


A systematic review of the amount and timing of light in association with objective and subjective sleep outcomes in community-dwelling adults.

Dautovich ND, Schreiber DR, Imel JL, Tighe CA, Shoji KD, Cyrus J, Bryant N, Lisech A, O'Brien C, Dzierzewski JM.

Sleep Health. 2019 Feb;5(1):31-48. doi: 10.1016/j.sleh.2018.09.006. Epub 2018 Oct 15. Review.


Cost-Efficient and Easy to Perform PCR-Based Assay to Identify Met Exon 14 Skipping in Formalin-Fixed Paraffin-Embedded (FFPE) Non-Small Cell Lung Cancer (NSCLC) Samples.

O'Brien O, Wright MC, O'Brien C, Geoghegan O, Leonard N, Nicholson S, Cuffe S, Fabre A, Jochum W, Joerger M, Gray SG, Finn SP.

Diagnostics (Basel). 2019 Jan 18;9(1). pii: E13. doi: 10.3390/diagnostics9010013.


Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.

Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T.

Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4.


An antioxidant stabilized, chemically cross-linked UHMWPE with superior toughness.

Oral E, Wannomae KK, Bichara DA, Micheli B, Doshi BN, O'Brien C, Nielsen GP, Muratoglu OK.

J Biomed Mater Res B Appl Biomater. 2018 Dec 26. doi: 10.1002/jbm.b.34287. [Epub ahead of print]


Improved Cardiopulmonary Resuscitation Performance With CODE ACES2: A Resuscitation Quality Bundle.

Hunt EA, Jeffers J, McNamara L, Newton H, Ford K, Bernier M, Tucker EW, Jones K, O'Brien C, Dodge P, Vanderwagen S, Salamone C, Pegram T, Rosen M, Griffis HM, Duval-Arnould J.

J Am Heart Assoc. 2018 Dec 18;7(24):e009860. doi: 10.1161/JAHA.118.009860.


Incidence of future arrests in adults involved in the criminal justice system with opioid use disorder receiving extended release naltrexone compared to treatment as usual.

Soares WE 3rd, Wilson D, Gordon MS, Lee JD, Nunes EV, O'Brien CP, Shroff M, Friedmann PD.

Drug Alcohol Depend. 2019 Jan 1;194:482-486. doi: 10.1016/j.drugalcdep.2018.10.035. Epub 2018 Dec 3.


A highly sensitive method for detecting Cryptosporidium parvum oocysts recovered from source and finished water using RT-PCR directed to Cryspovirus RNA.

de Souza MS, O'Brien C, Santin M, Jenkins M.

J Microbiol Methods. 2019 Jan;156:77-80. doi: 10.1016/j.mimet.2018.11.022. Epub 2018 Nov 30.


A Study of Social Media Utilization by Individuals With Tinnitus.

Deshpande AK, Deshpande SB, O'Brien C.

Am J Audiol. 2018 Dec 6;27(4):559-569. doi: 10.1044/2018_AJA-18-0033.


Integrated Pediatric Health Care in Pennsylvania: A Survey of Primary Care and Behavioral Health Providers.

Kolko DJ, Torres E, Rumbarger K, James E, Turchi R, Bumgardner C, O'Brien C.

Clin Pediatr (Phila). 2018 Nov 17:9922818810881. doi: 10.1177/0009922818810881. [Epub ahead of print]


Sensitive tumour detection and classification using plasma cell-free DNA methylomes.

Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TDS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O'Kane GM, Liu J, Mansour M, McPherson JD, O'Brien C, Leighl N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ, De Carvalho DD.

Nature. 2018 Nov;563(7732):579-583. doi: 10.1038/s41586-018-0703-0. Epub 2018 Nov 14.


Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy.

Masson LE, O'Brien CM, Pence IJ, Herington JL, Reese J, van Leeuwen TG, Mahadevan-Jansen A.

Analyst. 2018 Dec 3;143(24):6049-6060. doi: 10.1039/c8an01989d.


New nanoscale toughening mechanisms mitigate embrittlement in binary nanocrystalline alloys.

Heckman NM, Foiles SM, O'Brien CJ, Chandross M, Barr CM, Argibay N, Hattar K, Lu P, Adams DP, Boyce BL.

Nanoscale. 2018 Dec 7;10(45):21231-21243. doi: 10.1039/c8nr06419a. Epub 2018 Nov 12.


Diversity and distribution of Klebsiella capsules in Escherichia coli.

Nanayakkara BS, O'Brien CL, Gordon DM.

Environ Microbiol Rep. 2018 Nov 8. doi: 10.1111/1758-2229.12710. [Epub ahead of print]


Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Trial of Synthetic Preimplantation Factor in Autoimmune Hepatitis.

O'Brien CB, Barnea ER, Martin P, Levy C, Sharabi E, Bhamidimarri KR, Martin E, Arosemena L, Schiff ER.

Hepatol Commun. 2018 Sep 26;2(10):1235-1246. doi: 10.1002/hep4.1239. eCollection 2018 Oct.


Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis.

McCarty TR, O'Brien CR, Gremida A, Ling C, Rustagi T.

Endosc Int Open. 2018 Nov;6(11):E1369-E1378. doi: 10.1055/a-0732-5060. Epub 2018 Nov 7.


The effect of maternal obesity on fetal biometry, body composition and growth velocity.

O'Brien CM, Louise J, Deussen A, Grivell R, Dodd JM.

J Matern Fetal Neonatal Med. 2018 Nov 4:1-311. doi: 10.1080/14767058.2018.1543658. [Epub ahead of print]


Pilot Study to Compare the Use of End-Tidal Carbon Dioxide-Guided and Diastolic Blood Pressure-Guided Chest Compression Delivery in a Swine Model of Neonatal Asphyxial Cardiac Arrest.

O'Brien CE, Reyes M, Santos PT, Heitmiller SE, Kulikowicz E, Kudchadkar SR, Lee JK, Hunt EA, Koehler RC, Shaffner DH.

J Am Heart Assoc. 2018 Oct 2;7(19):e009728. doi: 10.1161/JAHA.118.009728.


Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets.

Santos PT, O'Brien CE, Chen MW, Hopkins CD, Adams S, Kulikowicz E, Singh R, Koehler RC, Martin LJ, Lee JK.

J Am Heart Assoc. 2018 Oct 16;7(20):e009415. doi: 10.1161/JAHA.118.009415.


An evaluation of the Fondo de Inclusión Social Energético program to promote access to liquefied petroleum gas in Peru.

Pollard SL, Williams KN, O'Brien CJ, Winiker A, Puzzolo E, Kephart JL, Fandiño-Del-Rio M, Tarazona-Meza C, Grigsby M, Chiang M, Checkley W.

Energy Sustain Dev. 2018 Oct;46:82-93. doi: 10.1016/j.esd.2018.06.001.


The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo.

Colmant AMG, Hall-Mendelin S, Ritchie SA, Bielefeldt-Ohmann H, Harrison JJ, Newton ND, O'Brien CA, Cazier C, Johansen CA, Hobson-Peters J, Hall RA, van den Hurk AF.

PLoS Negl Trop Dis. 2018 Oct 24;12(10):e0006886. doi: 10.1371/journal.pntd.0006886. eCollection 2018 Oct.


Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury.

O'Grady KP, Kavanaugh TE, Cho H, Ye H, Gupta MK, Madonna MC, Lee J, O'Brien CM, Skala MC, Hasty KA, Duvall CL.

ACS Biomater Sci Eng. 2018 Apr 9;4(4):1251-1264. doi: 10.1021/acsbiomaterials.6b00804. Epub 2017 Apr 6.


Key Findings and Implications of a Recent Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.

Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O'Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D.

Nutrients. 2018 Oct 18;10(10). pii: E1536. doi: 10.3390/nu10101536.


To investigate dose reduction and comparability of standard dose CT vs Ultra low dose CT in evaluating pulmonary emphysema.

O'Brien C, Kok HK, Kelly B, Kumamaru K, Sahadevan A, Lane S, Buckley O.

Clin Imaging. 2019 Jan - Feb;53:115-119. doi: 10.1016/j.clinimag.2018.10.012. Epub 2018 Oct 14.


The microbiome of Crohn's disease aphthous ulcers.

O'Brien CL, Kiely CJ, Pavli P.

Gut Pathog. 2018 Oct 10;10:44. doi: 10.1186/s13099-018-0265-6. eCollection 2018.


APPE Evaluations are Positively Associated with MMI, Pre-pharmacy GPA and Pharmacy GPA.

Heldenbrand SD, Dayer LE, Martin BC, O'Brien C, Choi AN, Gubbins PO, Hawthorne J, Ramey M, Willis K, Flowers SK.

Am J Pharm Educ. 2018 Sep;82(7):6326. doi: 10.5688/ajpe6326.


Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls.

Le Baut G, O'Brien C, Pavli P, Roy M, Seksik P, Tréton X, Nancey S, Barnich N, Bezault M, Auzolle C, Cazals-Hatem D, Viala J, Allez M; REMIND GROUP, Hugot JP, Dumay A.

Front Cell Infect Microbiol. 2018 Sep 21;8:336. doi: 10.3389/fcimb.2018.00336. eCollection 2018.


Nutritional supplementation in the treatment of glaucoma: A systematic review.

Loskutova E, O'Brien C, Loskutov I, Loughman J.

Surv Ophthalmol. 2019 Mar - Apr;64(2):195-216. doi: 10.1016/j.survophthal.2018.09.005. Epub 2018 Oct 6. Review.


PTSD symptoms and alcohol-related problems among veterans: Temporal associations and vulnerability.

Simons JS, Simons RM, Keith JA, Grimm KJ, Stoltenberg SF, O'Brien C, Andal K.

J Abnorm Psychol. 2018 Nov;127(8):733-750. doi: 10.1037/abn0000376. Epub 2018 Oct 4.


Development of a visually guided Raman spectroscopy probe for cervical assessment during pregnancy.

O'Brien CM, Cochran KJ, Masson LE, Goldberg M, Marple E, Bennett KA, Reese J, Slaughter JC, Newton JM, Mahadevan-Jansen A.

J Biophotonics. 2019 Feb;12(2):e201800138. doi: 10.1002/jbio.201800138. Epub 2018 Oct 29.


Minimal Impact of Implemented Early Warning Score and Best Practice Alert for Patient Deterioration.

Bedoya AD, Clement ME, Phelan M, Steorts RC, O'Brien C, Goldstein BA.

Crit Care Med. 2019 Jan;47(1):49-55. doi: 10.1097/CCM.0000000000003439.


Establishment of a patient-centered communication course to address curricular gaps.

O'Brien CE, Stafford R, Franks AM.

Curr Pharm Teach Learn. 2018 Jul;10(7):933-939. doi: 10.1016/j.cptl.2018.04.008. Epub 2018 Apr 30.


Cross-sectional analysis of sleep-promoting and wake-promoting drug use on health, fatigue-related error, and near-crashes in police officers.

Ogeil RP, Barger LK, Lockley SW, O'Brien CS, Sullivan JP, Qadri S, Lubman DI, Czeisler CA, Rajaratnam SMW.

BMJ Open. 2018 Sep 19;8(9):e022041. doi: 10.1136/bmjopen-2018-022041.


Predicting recovery from exertional heat strain in military working dogs.

O'Brien C, Berglund LG.

J Therm Biol. 2018 Aug;76:45-51. doi: 10.1016/j.jtherbio.2018.07.001. Epub 2018 Jul 5.


Evaluation of Home Medication Reconciliation by Clinical Pharmacists for Adult and Pediatric Cystic Fibrosis Patients.

Louie JM, Hong LT, Garavaglia LR, Pinal DI, O'Brien CE.

Pharmacy (Basel). 2018 Aug 23;6(3). pii: E91. doi: 10.3390/pharmacy6030091.


Effect of localized microclimate heating on peripheral skin temperatures and manual dexterity during cold exposure.

Castellani JW, Yurkevicius BR, Jones ML, Driscoll TJ, Cowell CM, Smith L, Xu X, O'Brien C.

J Appl Physiol (1985). 2018 Nov 1;125(5):1498-1510. doi: 10.1152/japplphysiol.00513.2018. Epub 2018 Aug 23.


Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim).

Zimmerman SM, Heard-Lipsmeyer ME, Dimori M, Thostenson JD, Mannen EM, O'Brien CA, Morello R.

Bone Rep. 2018 Jul 2;9:61-73. doi: 10.1016/j.bonr.2018.06.008. eCollection 2018 Dec.


A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma.

Kollmeier AP, Barnathan ES, O'Brien C, Chen B, Xia YK, Zhou B, Loza MJ, Silkoff PE, Ge M, Thurmond RL.

Ann Allergy Asthma Immunol. 2018 Nov;121(5):568-574. doi: 10.1016/j.anai.2018.08.001. Epub 2018 Aug 11.


Improving diagnostic accuracy in clinically ambiguous paediatric appendicitis: a retrospective review of ultrasound and pathology findings with focus on the non-visualised appendix.

Kelly BS, Bollard SM, Weir A, O'Brien C, Mullen D, Kerin M, McCarthy P.

Br J Radiol. 2018 Sep 12:20180585. doi: 10.1259/bjr.20180585. [Epub ahead of print]


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