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The Role of the AggR Regulon in the Virulence of the Shiga Toxin-Producing Enteroaggregative Escherichia coli Epidemic O104:H4 Strain in Mice.

Boisen N, Melton-Celsa AR, Hansen AM, Zangari T, Smith MA, Russo LM, Scheutz F, O'Brien AD, Nataro JP.

Front Microbiol. 2019 Aug 13;10:1824. doi: 10.3389/fmicb.2019.01824. eCollection 2019.


Shiga Toxin Type 1a (Stx1a) Reduces the Toxicity of the More Potent Stx2a In Vivo and In Vitro.

Petro CD, Trojnar E, Sinclair J, Liu ZM, Smith M, O'Brien AD, Melton-Celsa A.

Infect Immun. 2019 Mar 25;87(4). pii: e00787-18. doi: 10.1128/IAI.00787-18. Print 2019 Apr.


Expression and contribution to virulence of each polysaccharide capsule of Bacillus cereus strain G9241.

Scarff JM, Seldina YI, Vergis JM, Ventura CL, O'Brien AD.

PLoS One. 2018 Aug 22;13(8):e0202701. doi: 10.1371/journal.pone.0202701. eCollection 2018.


Certhrax Is an Antivirulence Factor for the Anthrax-Like Organism Bacillus cereus Strain G9241.

Seldina YI, Petro CD, Servetas SL, Vergis JM, Ventura CL, Merrell DS, O'Brien AD.

Infect Immun. 2018 May 22;86(6). pii: e00207-18. doi: 10.1128/IAI.00207-18. Print 2018 Jun.


The roles of AtxA orthologs in virulence of anthrax-like Bacillus cereus G9241.

Scarff JM, Raynor MJ, Seldina YI, Ventura CL, Koehler TM, O'Brien AD.

Mol Microbiol. 2016 Nov;102(4):545-561. doi: 10.1111/mmi.13478. Epub 2016 Sep 4.


Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a.

Russo LM, Melton-Celsa AR, O'Brien AD.

J Infect Dis. 2016 Apr 15;213(8):1271-9. doi: 10.1093/infdis/jiv557. Epub 2016 Jan 6.


Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice.

Russo LM, Abdeltawab NF, O'Brien AD, Kotb M, Melton-Celsa AR.

BMC Genomics. 2015 Nov 16;16:947. doi: 10.1186/s12864-015-2127-7.


Virulence Potential of Activatable Shiga Toxin 2d-Producing Escherichia coli Isolates from Fresh Produce.

Melton-Celsa AR, O'Brien AD, Feng PC.

J Food Prot. 2015 Nov;78(11):2085-8. doi: 10.4315/0362-028X.JFP-15-180.


Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin.

Bunger JC, Melton-Celsa AR, Maynard EL, O'Brien AD.

Toxins (Basel). 2015 Jun 23;7(6):2306-20. doi: 10.3390/toxins7062306.


New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli.

Melton-Celsa AR, O'Brien AD.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.EHEC-0013-2013. Review.


Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combination.

Boisen N, Melton-Celsa AR, Scheutz F, O'Brien AD, Nataro JP.

Gut Microbes. 2015 Jul 4;6(4):272-8. doi: 10.1080/19490976.2015.1054591. Epub 2015 Jun 3. Review.


Protective efficacy and pharmacokinetics of human/mouse chimeric anti-Stx1 and anti-Stx2 antibodies in mice.

Melton-Celsa AR, Carvalho HM, Thuning-Roberson C, O'Brien AD.

Clin Vaccine Immunol. 2015 Apr;22(4):448-55. doi: 10.1128/CVI.00022-15. Epub 2015 Feb 25.


Antibodies against hemolysin and cytotoxic necrotizing factor type 1 (CNF1) reduce bladder inflammation in a mouse model of urinary tract infection with toxigenic uropathogenic Escherichia coli.

Smith MA, Weingarten RA, Russo LM, Ventura CL, O'Brien AD.

Infect Immun. 2015 Apr;83(4):1661-73. doi: 10.1128/IAI.02848-14. Epub 2015 Feb 9.


Overview and Historical Perspectives.

Kaper JB, O'Brien AD.

Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.EHEC-0028-2014. Review.


Enhanced virulence of the Escherichia coli O157:H7 spinach-associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin.

Zangari T, Melton-Celsa AR, Panda A, Smith MA, Tatarov I, De Tolla L, O'Brien AD.

Infect Immun. 2014 Dec;82(12):4968-77. doi: 10.1128/IAI.02361-14. Epub 2014 Sep 15.


The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer.

Boisen N, Hansen AM, Melton-Celsa AR, Zangari T, Mortensen NP, Kaper JB, O'Brien AD, Nataro JP.

J Infect Dis. 2014 Dec 15;210(12):1909-19. doi: 10.1093/infdis/jiu399. Epub 2014 Jul 18.


Comparisons of native Shiga toxins (Stxs) type 1 and 2 with chimeric toxins indicate that the source of the binding subunit dictates degree of toxicity.

Russo LM, Melton-Celsa AR, Smith MJ, O'Brien AD.

PLoS One. 2014 Mar 26;9(3):e93463. doi: 10.1371/journal.pone.0093463. eCollection 2014.


Oral intoxication of mice with Shiga toxin type 2a (Stx2a) and protection by anti-Stx2a monoclonal antibody 11E10.

Russo LM, Melton-Celsa AR, Smith MA, Smith MJ, O'Brien AD.

Infect Immun. 2014 Mar;82(3):1213-21. doi: 10.1128/IAI.01264-13. Epub 2013 Dec 30.


Shiga toxin type 2dact displays increased binding to globotriaosylceramide in vitro and increased lethality in mice after activation by elastase.

Bunger JC, Melton-Celsa AR, O'Brien AD.

Toxins (Basel). 2013 Nov 8;5(11):2074-92. doi: 10.3390/toxins5112074.


Helmet-Cam: tool for assessing miners' respirable dust exposure.

Cecala AB, Reed WR, Joy GJ, Westmoreland SC, O'Brien AD.

Min Eng. 2013 Sep;65(9):78-84.


When a healthy diet turns deadly.

Zumbrun SD, Melton-Celsa AR, O'Brien AD.

Gut Microbes. 2014 Jan-Feb;5(1):40-3. doi: 10.4161/gmic.26263. Epub 2013 Jan 1.


Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys.

Flora AD, Teel LD, Smith MA, Sinclair JF, Melton-Celsa AR, O'Brien AD.

PLoS One. 2013 Jul 17;8(7):e69706. doi: 10.1371/journal.pone.0069706. Print 2013.


Dietary choice affects Shiga toxin-producing Escherichia coli (STEC) O157:H7 colonization and disease.

Zumbrun SD, Melton-Celsa AR, Smith MA, Gilbreath JJ, Merrell DS, O'Brien AD.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):E2126-33. doi: 10.1073/pnas.1222014110. Epub 2013 May 20.


Virulence of the Shiga toxin type 2-expressing Escherichia coli O104:H4 German outbreak isolate in two animal models.

Zangari T, Melton-Celsa AR, Panda A, Boisen N, Smith MA, Tatarov I, De Tolla LJ, Nataro JP, O'Brien AD.

Infect Immun. 2013 May;81(5):1562-74. doi: 10.1128/IAI.01310-12. Epub 2013 Feb 25.


Immunization of mice with formalin-inactivated spores from avirulent Bacillus cereus strains provides significant protection from challenge with Bacillus anthracis Ames.

Vergis JM, Cote CK, Bozue J, Alem F, Ventura CL, Welkos SL, O'Brien AD.

Clin Vaccine Immunol. 2013 Jan;20(1):56-65. doi: 10.1128/CVI.00550-12. Epub 2012 Oct 31.


Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder.

Garcia TA, Ventura CL, Smith MA, Merrell DS, O'Brien AD.

Infect Immun. 2013 Jan;81(1):99-109. doi: 10.1128/IAI.00605-12. Epub 2012 Oct 22.


A novel murine infection model for Shiga toxin-producing Escherichia coli.

Mallick EM, McBee ME, Vanguri VK, Melton-Celsa AR, Schlieper K, Karalius BJ, O'Brien AD, Butterton JR, Leong JM, Schauer DB.

J Clin Invest. 2012 Nov;122(11):4012-24. doi: 10.1172/JCI62746. Epub 2012 Oct 8.


Host cell cytotoxicity and cytoskeleton disruption by CerADPr, an ADP-ribosyltransferase of Bacillus cereus G9241.

Simon NC, Vergis JM, Ebrahimi AV, Ventura CL, O'Brien AD, Barbieri JT.

Biochemistry. 2013 Apr 2;52(13):2309-18. doi: 10.1021/bi300692g. Epub 2013 Mar 20.


Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia.

Cote CK, Kaatz L, Reinhardt J, Bozue J, Tobery SA, Bassett AD, Sanz P, Darnell SC, Alem F, O'Brien AD, Welkos SL.

J Med Microbiol. 2012 Oct;61(Pt 10):1380-92. doi: 10.1099/jmm.0.045393-0. Epub 2012 Jul 5.


Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature.

Scheutz F, Teel LD, Beutin L, PiƩrard D, Buvens G, Karch H, Mellmann A, Caprioli A, Tozzoli R, Morabito S, Strockbine NA, Melton-Celsa AR, Sanchez M, Persson S, O'Brien AD.

J Clin Microbiol. 2012 Sep;50(9):2951-63. doi: 10.1128/JCM.00860-12. Epub 2012 Jul 3.


Bacillus cereus G9241 makes anthrax toxin and capsule like highly virulent B. anthracis Ames but behaves like attenuated toxigenic nonencapsulated B. anthracis Sterne in rabbits and mice.

Wilson MK, Vergis JM, Alem F, Palmer JR, Keane-Myers AM, Brahmbhatt TN, Ventura CL, O'Brien AD.

Infect Immun. 2011 Aug;79(8):3012-9. doi: 10.1128/IAI.00205-11. Epub 2011 May 16.


Mouse models of Escherichia coli O157:H7 infection and shiga toxin injection.

Mohawk KL, O'Brien AD.

J Biomed Biotechnol. 2011;2011:258185. doi: 10.1155/2011/258185. Epub 2011 Jan 3. Review.


Human intestinal tissue and cultured colonic cells contain globotriaosylceramide synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide.

Zumbrun SD, Hanson L, Sinclair JF, Freedy J, Melton-Celsa AR, Rodriguez-Canales J, Hanson JC, O'Brien AD.

Infect Immun. 2010 Nov;78(11):4488-99. doi: 10.1128/IAI.00620-10. Epub 2010 Aug 23.


Neutralizing antibodies to Shiga toxin type 2 (Stx2) reduce colonization of mice by Stx2-expressing Escherichia coli O157:H7.

Mohawk KL, Melton-Celsa AR, Robinson CM, O'Brien AD.

Vaccine. 2010 Jul 5;28(30):4777-85. doi: 10.1016/j.vaccine.2010.04.099. Epub 2010 May 14.


Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits.

Panda A, Tatarov I, Melton-Celsa AR, Kolappaswamy K, Kriel EH, Petkov D, Coksaygan T, Livio S, McLeod CG, Nataro JP, O'Brien AD, DeTolla LJ.

Comp Med. 2010 Feb;60(1):31-7.


Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora.

Mohawk KL, Melton-Celsa AR, Zangari T, Carroll EE, O'Brien AD.

Microb Pathog. 2010 Mar-Apr;48(3-4):131-42. doi: 10.1016/j.micpath.2010.01.003. Epub 2010 Jan 22.


Anthrax vaccination strategies.

Cybulski RJ Jr, Sanz P, O'Brien AD.

Mol Aspects Med. 2009 Dec;30(6):490-502. doi: 10.1016/j.mam.2009.08.006. Epub 2009 Sep 1. Review.


Monoclonal antibody 11E10, which neutralizes shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin.

Smith MJ, Melton-Celsa AR, Sinclair JF, Carvalho HM, Robinson CM, O'Brien AD.

Infect Immun. 2009 Jul;77(7):2730-40. doi: 10.1128/IAI.00005-09. Epub 2009 May 11.


Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli.

Crawford MA, Zhu Y, Green CS, Burdick MD, Sanz P, Alem F, O'Brien AD, Mehrad B, Strieter RM, Hughes MA.

Infect Immun. 2009 Apr;77(4):1664-78. doi: 10.1128/IAI.01208-08. Epub 2009 Jan 29.


Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress.

Cybulski RJ Jr, Sanz P, Alem F, Stibitz S, Bull RL, O'Brien AD.

Infect Immun. 2009 Jan;77(1):274-85. doi: 10.1128/IAI.00515-08. Epub 2008 Oct 27.


Cytotoxic necrotizing factor type 1-neutralizing monoclonal antibody NG8 recognizes three amino acids in a C-terminal region of the toxin and reduces toxin binding to HEp-2 cells.

Grande KK, Meysick KC, Rasmussen SB, O'Brien AD.

Infect Immun. 2009 Jan;77(1):170-9. doi: 10.1128/IAI.00943-08. Epub 2008 Oct 27.


Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody.

Sauter KA, Melton-Celsa AR, Larkin K, Troxell ML, O'Brien AD, Magun BE.

Infect Immun. 2008 Oct;76(10):4469-78. doi: 10.1128/IAI.00592-08. Epub 2008 Aug 11.


Identification and characterization of Shiga toxin type 2 variants in Escherichia coli isolates from animals, food, and humans.

Zheng J, Cui S, Teel LD, Zhao S, Singh R, O'Brien AD, Meng J.

Appl Environ Microbiol. 2008 Sep;74(18):5645-52. doi: 10.1128/AEM.00503-08. Epub 2008 Jul 25.


Recombinant Bacillus anthracis spore proteins enhance protection of mice primed with suboptimal amounts of protective antigen.

Cybulski RJ Jr, Sanz P, McDaniel D, Darnell S, Bull RL, O'Brien AD.

Vaccine. 2008 Sep 8;26(38):4927-39. doi: 10.1016/j.vaccine.2008.07.015. Epub 2008 Jul 25.


Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis.

Alcantara Warren C, Destura RV, Sevilleja JE, Barroso LF, Carvalho H, Barrett LJ, O'Brien AD, Guerrant RL.

J Infect Dis. 2008 Jul 1;198(1):143-9. doi: 10.1086/588819.


Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice.

Smith YC, Rasmussen SB, Grande KK, Conran RM, O'Brien AD.

Infect Immun. 2008 Jul;76(7):2978-90. doi: 10.1128/IAI.00075-08. Epub 2008 Apr 28.


Detection of Bacillus anthracis spore germination in vivo by bioluminescence imaging.

Sanz P, Teel LD, Alem F, Carvalho HM, Darnell SC, O'Brien AD.

Infect Immun. 2008 Mar;76(3):1036-47. doi: 10.1128/IAI.00985-07. Epub 2008 Jan 14.


Recombinant exosporium protein BclA of Bacillus anthracis is effective as a booster for mice primed with suboptimal amounts of protective antigen.

Brahmbhatt TN, Darnell SC, Carvalho HM, Sanz P, Kang TJ, Bull RL, Rasmussen SB, Cross AS, O'Brien AD.

Infect Immun. 2007 Nov;75(11):5240-7. Epub 2007 Sep 4.


Two domains of cytotoxic necrotizing factor type 1 bind the cellular receptor, laminin receptor precursor protein.

McNichol BA, Rasmussen SB, Carvalho HM, Meysick KC, O'Brien AD.

Infect Immun. 2007 Nov;75(11):5095-104. Epub 2007 Aug 20.


Bacillus anthracis exosporium protein BclA affects spore germination, interaction with extracellular matrix proteins, and hydrophobicity.

Brahmbhatt TN, Janes BK, Stibitz ES, Darnell SC, Sanz P, Rasmussen SB, O'Brien AD.

Infect Immun. 2007 Nov;75(11):5233-9. Epub 2007 Aug 20.

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