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Solution structure and oligomeric state of the E. coli glycerol facilitator.

Hernando M, Orris G, Perodeau J, Lei S, Ferens FG, Patel TR, Stetefeld J, Nieuwkoop AJ, O'Neil JD.

Biochim Biophys Acta Biomembr. 2020 Jan 14:183191. doi: 10.1016/j.bbamem.2020.183191. [Epub ahead of print]


Hospitalization for mental health related ambulatory care sensitive conditions: what are the trends for First Nations in British Columbia?

Lavoie JG, Ward A, Wong ST, Ibrahim N, Morton D, O'Neil JD, Green M.

Int J Equity Health. 2018 Oct 3;17(1):156. doi: 10.1186/s12939-018-0860-7.


Improving health equity for ethnic minority women in Thai Nguyen, Vietnam: qualitative results from an mHealth intervention targeting maternal and infant health service access.

McBride B, O'Neil JD, Hue TT, Eni R, Nguyen CV, Nguyen LT.

J Public Health (Oxf). 2018 Dec 1;40(suppl_2):ii32-ii41. doi: 10.1093/pubmed/fdy165.


Nanoscale Assembly of High-Mobility Group AT-Hook 2 Protein with DNA Replication Fork.

Krahn N, Meier M, To V, Booy EP, McEleney K, O'Neil JD, McKenna SA, Patel TR, Stetefeld J.

Biophys J. 2017 Dec 19;113(12):2609-2620. doi: 10.1016/j.bpj.2017.10.026.


MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth.

O'Neil JD, Ammit AJ, Clark AR.

Int J Biochem Cell Biol. 2018 Jan;94:6-9. doi: 10.1016/j.biocel.2017.11.003. Epub 2017 Nov 8. Review.


Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin.

Tang T, Scambler TE, Smallie T, Cunliffe HE, Ross EA, Rosner DR, O'Neil JD, Clark AR.

Sci Rep. 2017 Jun 28;7(1):4350. doi: 10.1038/s41598-017-04100-1.


The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

Haneklaus M, O'Neil JD, Clark AR, Masters SL, O'Neill LAJ.

J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.


Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.

O'Neil JD, Ross EA, Ridley ML, Ding Q, Tang T, Rosner DR, Crowley T, Malhi D, Dean JL, Smallie T, Buckley CD, Clark AR.

Mol Cell Biol. 2017 May 16;37(11). pii: e00536-16. doi: 10.1128/MCB.00536-16. Print 2017 Jun 1.


Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts.

Crowley T, O'Neil JD, Adams H, Thomas AM, Filer A, Buckley CD, Clark AR.

Arthritis Res Ther. 2017 Feb 10;19(1):35. doi: 10.1186/s13075-017-1248-6.


Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate.

Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR.

Development. 2016 Nov 1;143(21):4027-4037. Epub 2016 Sep 15.


Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR.

Ann Rheum Dis. 2017 Mar;76(3):612-619. doi: 10.1136/annrheumdis-2016-209424. Epub 2016 Sep 5.


Managing Matajoosh: determinants of first Nations' cancer care decisions.

Lavoie JG, Kaufert J, Browne AJ, O'Neil JD.

BMC Health Serv Res. 2016 Aug 18;16(1):402. doi: 10.1186/s12913-016-1665-2.


Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.

Ross EA, Smallie T, Ding Q, O'Neil JD, Cunliffe HE, Tang T, Rosner DR, Klevernic I, Morrice NA, Monaco C, Cunningham AF, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):265-76. doi: 10.4049/jimmunol.1402826. Epub 2015 May 22.


Folding and stability of the aquaglyceroporin GlpF: Implications for human aqua(glycero)porin diseases.

Klein N, Neumann J, O'Neil JD, Schneider D.

Biochim Biophys Acta. 2015 Feb;1848(2):622-33. doi: 10.1016/j.bbamem.2014.11.015. Epub 2014 Nov 20. Review.


The effects of a protein osmolyte on the stability of the integral membrane protein glycerol facilitator.

Baturin S, Galka JJ, Piyadasa H, Gajjeraman S, O'Neil JD.

Biochem Cell Biol. 2014 Dec;92(6):564-75. doi: 10.1139/bcb-2014-0076. Epub 2014 Oct 7.


High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant.

Xu B, Chakraborty R, Eilers M, Dakshinamurti S, O'Neil JD, Smith SO, Bhullar RP, Chelikani P.

PLoS One. 2013 Sep 23;8(9):e76481. doi: 10.1371/journal.pone.0076481. eCollection 2013.


Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network.

Tarczyluk MA, Nagel DA, O'Neil JD, Parri HR, Tse EH, Coleman MD, Hill EJ.

J Cereb Blood Flow Metab. 2013 Sep;33(9):1386-93. doi: 10.1038/jcbfm.2013.81. Epub 2013 May 29.


Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development.

Hill EJ, Nagel DA, O'Neil JD, Torr E, Woehrling EK, Devitt A, Coleman MD.

PLoS One. 2013;8(3):e58822. doi: 10.1371/journal.pone.0058822. Epub 2013 Mar 19.


A preliminary investigation into the impact of a pesticide combination on human neuronal and glial cell lines in vitro.

Coleman MD, O'Neil JD, Woehrling EK, Ndunge OB, Hill EJ, Menache A, Reiss CJ.

PLoS One. 2012;7(8):e42768. doi: 10.1371/journal.pone.0042768. Epub 2012 Aug 3.


Is it worthwhile to invest in home care?

Lavoie JG, Forget EL, Dahl M, Martens PJ, O'Neil JD.

Healthc Policy. 2011 May;6(4):35-48.


Conformational dynamics of a membrane transport protein probed by H/D exchange and covalent labeling: the glycerol facilitator.

Pan Y, Piyadasa H, O'Neil JD, Konermann L.

J Mol Biol. 2012 Feb 24;416(3):400-13. doi: 10.1016/j.jmb.2011.12.052. Epub 2011 Dec 29.


Tat peptide-calmodulin binding studies and bioinformatics of HIV-1 protein-calmodulin interactions.

McQueen P, Donald LJ, Vo TN, Nguyen DH, Griffiths H, Shojania S, Standing KG, O'Neil JD.

Proteins. 2011 Jul;79(7):2233-46. doi: 10.1002/prot.23048. Epub 2011 May 10.


Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.

Owen TJ, O'Neil JD, Dawson CW, Hu C, Chen X, Yao Y, Wood VH, Mitchell LE, White RJ, Young LS, Arrand JR.

Mol Cancer. 2010 Sep 15;9:241. doi: 10.1186/1476-4598-9-241.


Have investments in on-reserve health services and initiatives promoting community control improved First Nations' health in Manitoba?

Lavoie JG, Forget EL, Prakash T, Dahl M, Martens P, O'Neil JD.

Soc Sci Med. 2010 Aug;71(4):717-24. doi: 10.1016/j.socscimed.2010.04.037. Epub 2010 May 25.


Intrinsic disorder and function of the HIV-1 Tat protein.

Shojania S, O'Neil JD.

Protein Pept Lett. 2010 Aug;17(8):999-1011.


Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Valentine R, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR, Young LS, O'Neil JD.

Mol Cancer. 2010 Jan 5;9:1. doi: 10.1186/1476-4598-9-1.


High yield expression and purification of HIV-1 Tat1-72 for structural studies.

Shojania S, Henry GD, Chen VC, Vo TN, Perreault H, O'Neil JD.

J Virol Methods. 2010 Mar;164(1-2):35-42. doi: 10.1016/j.jviromet.2009.11.021. Epub 2009 Nov 24.


The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation.

Shah KM, Stewart SE, Wei W, Woodman CB, O'Neil JD, Dawson CW, Young LS.

Oncogene. 2009 Nov 5;28(44):3903-14. doi: 10.1038/onc.2009.249. Epub 2009 Aug 31.


Alamethicin topology in phospholipid membranes by oriented solid-state NMR and EPR spectroscopies: a comparison.

Salnikov ES, De Zotti M, Formaggio F, Li X, Toniolo C, O'Neil JD, Raap J, Dzuba SA, Bechinger B.

J Phys Chem B. 2009 Mar 12;113(10):3034-42. doi: 10.1021/jp8101805.


Urea as a protein destabilizing agent in electrospray ionisation.

Donald LJ, Collado VM, Galka JJ, O'Neil JD, Duckworth HW, Loewen PC, Standing KG.

Rapid Commun Mass Spectrom. 2009 Mar;23(6):788-92. doi: 10.1002/rcm.3941.


The influence of sterols on the conformation of recombinant mitochondrial porin in detergent.

Bay DC, O'Neil JD, Court DA.

Biochem Cell Biol. 2008 Dec;86(6):539-45. doi: 10.1139/O08-132.


Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro.

O'Neil JD, Owen TJ, Wood VH, Date KL, Valentine R, Chukwuma MB, Arrand JR, Dawson CW, Young LS.

J Gen Virol. 2008 Nov;89(Pt 11):2833-42. doi: 10.1099/vir.0.2008/003392-0.


Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.

Morris MA, Dawson CW, Wei W, O'Neil JD, Stewart SE, Jia J, Bell AI, Young LS, Arrand JR.

J Gen Virol. 2008 Nov;89(Pt 11):2806-20. doi: 10.1099/vir.0.2008/003970-0.


Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy.

Salnikov ES, Friedrich H, Li X, Bertani P, Reissmann S, Hertweck C, O'Neil JD, Raap J, Bechinger B.

Biophys J. 2009 Jan;96(1):86-100. doi: 10.1529/biophysj.108.136242.


Stability of the glycerol facilitator in detergent solutions.

Galka JJ, Baturin SJ, Manley DM, Kehler AJ, O'Neil JD.

Biochemistry. 2008 Mar 18;47(11):3513-24. doi: 10.1021/bi7021409. Epub 2008 Feb 20.


Identifying indigenous peoples for health research in a global context: a review of perspectives and challenges.

Bartlett JG, Madariaga-Vignudo L, O'Neil JD, Kuhnlein HV.

Int J Circumpolar Health. 2007 Sep;66(4):287-307. Review.


Two-step folding of recombinant mitochondrial porin in detergent.

Bay DC, O'Neil JD, Court DA.

Biophys J. 2008 Jan 15;94(2):457-68. Epub 2007 Sep 14.


Effects of glycosylation of (2S,4R)-4-hydroxyproline on the conformation, kinetics, and thermodynamics of prolyl amide isomerization.

Owens NW, Braun C, O'Neil JD, Marat K, Schweizer F.

J Am Chem Soc. 2007 Sep 26;129(38):11670-1. Epub 2007 Sep 1. No abstract available.


Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFbeta signaling pathways.

Wood VH, O'Neil JD, Wei W, Stewart SE, Dawson CW, Young LS.

Oncogene. 2007 Jun 14;26(28):4135-47. Epub 2007 May 7.


Phase 1 clinical experience using intravenous administration of PV701, an oncolytic Newcastle disease virus.

Lorence RM, Roberts MS, O'Neil JD, Groene WS, Miller JA, Mueller SN, Bamat MK.

Curr Cancer Drug Targets. 2007 Mar;7(2):157-67. Review.


An optimized clinical regimen for the oncolytic virus PV701.

Hotte SJ, Lorence RM, Hirte HW, Polawski SR, Bamat MK, O'Neil JD, Roberts MS, Groene WS, Major PP.

Clin Cancer Res. 2007 Feb 1;13(3):977-85.


Bone density and bone area in Canadian Aboriginal women: the First Nations Bone Health Study.

Leslie WD, Metge CJ, Weiler HA, Doupe M, Wood Steiman P, O'Neil JD.

Osteoporos Int. 2006 Dec;17(12):1755-62. Epub 2006 Sep 8.


A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization.

Laurie SA, Bell JC, Atkins HL, Roach J, Bamat MK, O'Neil JD, Roberts MS, Groene WS, Lorence RM.

Clin Cancer Res. 2006 Apr 15;12(8):2555-62.


Functional characterization of the conserved "GLK" motif in mitochondrial porin from Neurospora crassa.

Runke G, Maier E, O'Neil JD, Benz R, Court DA.

J Bioenerg Biomembr. 2000 Dec;32(6):563-70.


Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death.

Dutton A, O'Neil JD, Milner AE, Reynolds GM, Starczynski J, Crocker J, Young LS, Murray PG.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6611-6. Epub 2004 Apr 19.


Preparation of glycerol facilitator for protein structure and folding studies in solution.

Manley D, O'Neil JD.

Methods Mol Biol. 2003;228:89-101. No abstract available.


Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers.

Pecora AL, Rizvi N, Cohen GI, Meropol NJ, Sterman D, Marshall JL, Goldberg S, Gross P, O'Neil JD, Groene WS, Roberts MS, Rabin H, Bamat MK, Lorence RM.

J Clin Oncol. 2002 May 1;20(9):2251-66.


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