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Antithrombin inhibition using nanobodies to correct bleeding in hemophilia.

O'Sullivan JM, O'Donnell JS.

EMBO Mol Med. 2020 Mar 25:e12143. doi: 10.15252/emmm.202012143. [Epub ahead of print]


Barrett's Registry Collaboration of academic centers in Ireland reveals high progression rate of low-grade dysplasia and low risk from nondysplastic Barrett's esophagus: report of the RIBBON network.

O'Byrne LM, Witherspoon J, Verhage RJJ, O'Brien M, Muldoon C, Ryan C, Buckley M, Murphy T, Reynolds R, Patchett S, Kay E, Azam H, Robb W, Arumugasamy M, Mathuna PM, Leyden J, Gargan S, Doherty G, Sheahan K, Collins C, Nath A, O'Sullivan J, Donohoe CL, Ravi N, O'Toole D, Reynolds JV.

Dis Esophagus. 2020 Mar 20. pii: doaa009. doi: 10.1093/dote/doaa009. [Epub ahead of print]


Gut microbiome transfer - finding the perfect fit.

Leong KSW, O'Sullivan JM, Derraik JGB, Cutfield WS.

Clin Endocrinol (Oxf). 2020 Mar 17. doi: 10.1111/cen.14183. [Epub ahead of print] Review.


Multi-omics Analysis of the Intermittent Fasting Response in Mice Identifies an Unexpected Role for HNF4α.

Hatchwell L, Harney DJ, Cielesh M, Young K, Koay YC, O'Sullivan JF, Larance M.

Cell Rep. 2020 Mar 10;30(10):3566-3582.e4. doi: 10.1016/j.celrep.2020.02.051.


Non-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression.

Thirion PG, Dunne MT, Kelly PJ, Flavin A, O'Sullivan JM, Hacking D, Sasiadek W, Small C, Pomeroy MM, Martin J, McArdle O, Parker I, O'Sullivan LS, Shannon AM, Clayton-Lea A, Collins CD, Stevenson MR, Alvarez-Iglesias A, Armstrong JG, Moriarty M.

Br J Cancer. 2020 Mar 11. doi: 10.1038/s41416-020-0768-z. [Epub ahead of print]


Effects of humeral intraosseous epinephrine in a pediatric hypovolemic cardiac arrest porcine model.

Neill MJ, Burgert JM, Blouin D, Tigges B, Rodden K, Roberts R, Anderson P, Hallquist T, Navarro J, O'Sullivan J, Johnson D.

Trauma Surg Acute Care Open. 2020 Feb 18;5(1):e000372. doi: 10.1136/tsaco-2019-000372. eCollection 2020.


Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions.

Gallagher LB, Dolan EB, O'Sullivan J, Levey R, Cavanagh BL, Kovarova L, Pravda M, Velebny V, Farrell T, O'Brien FJ, Duffy GP.

Acta Biomater. 2020 Mar 4. pii: S1742-7061(20)30131-8. doi: 10.1016/j.actbio.2020.02.043. [Epub ahead of print]


Too much of a good thing: hedonistic homoeostatic dysregulation and other behavioural consequences of excessive dopamine replacement therapy in Parkinson's disease.

O'Sullivan JD.

J Neurol Neurosurg Psychiatry. 2020 Mar 5. pii: jnnp-2019-322378. doi: 10.1136/jnnp-2019-322378. [Epub ahead of print] No abstract available.


Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.

Knuplez E, Krier-Burris R, Cao Y, Marsche G, O'Sullivan J, Bochner BS.

J Leukoc Biol. 2020 Mar 5. doi: 10.1002/JLB.3HI0120-381R. [Epub ahead of print]


Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.

Fazavana J, Brophy TM, Chion A, Cooke N, Terraube V, Cohen J, Parng C, Pittman D, Cunningham O, Lambert M, O'Donnell JS, O'Sullivan JM.

J Thromb Haemost. 2020 Feb 28. doi: 10.1111/jth.14785. [Epub ahead of print]


3D interactions with the GH locus in cellular signalling and cancer-related pathways.

Jain L, Fadason T, Schierding W, Vickers M, O'Sullivan JM, Perry JK.

J Mol Endocrinol. 2020 Feb 1. pii: JME-20-0010.R1. doi: 10.1530/JME-20-0010. [Epub ahead of print]


Comparison of woman-picked, expert-picked, and computer-picked Peak Day of cervical mucus with blinded urine luteinising hormone surge for concurrent identification of ovulation.

Stanford JB, Schliep KC, Chang CP, O'Sullivan JP, Porucznik CA.

Paediatr Perinat Epidemiol. 2020 Mar;34(2):105-113. doi: 10.1111/ppe.12642.


Erratum to "Observed high incidence of prostatic calculi with the potential to act as natural fiducials for prostate image guided radiotherapy" [Tech. Innov. Patient Support Radiat. Oncol. 9 (2019) 35-40].

O'Neill AGM, Osman SO, Jain S, Hounsell AR, O'Sullivan JM.

Tech Innov Patient Support Radiat Oncol. 2019 Dec 16;12:65. doi: 10.1016/j.tipsro.2019.10.005. eCollection 2019 Dec.


Observed high incidence of prostatic calculi with the potential to act as natural fiducials for prostate image guided radiotherapy.

O'Neill AGM, Osman SO, Jain S, Hounsell AR, O'Sullivan JM.

Tech Innov Patient Support Radiat Oncol. 2019 Mar 12;9:35-40. doi: 10.1016/j.tipsro.2019.01.004. eCollection 2019 Mar. Erratum in: Tech Innov Patient Support Radiat Oncol. 2019 Dec 16;12:65.


A core curriculum in the biological and biomedical sciences for dentistry.

Bennett JH, Beeley JA, Anderson P, Belfield L, Brand HS, Didilescu AC, Dymock D, Guven Y, Hector MP, Holbrook P, Jayasinghe JAP, O'Sullivan J, Riggio M, Roger-Leroi V, Scheven B, Sloan AJ, Vandamme K, Manzanares MC.

Eur J Dent Educ. 2020 Feb 20. doi: 10.1111/eje.12518. [Epub ahead of print]


Impact of low-head dams on bedload transport rates in coarse-bedded streams.

Casserly CM, Turner JN, O'Sullivan JJ, Bruen M, Bullock C, Atkinson S, Kelly-Quinn M.

Sci Total Environ. 2020 May 10;716:136908. doi: 10.1016/j.scitotenv.2020.136908. Epub 2020 Jan 24.


Corrigendum to Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial: Ann Oncol 2019; 30: 1992-2003.

Clarke NW, Ali A, Ingleby FC, Hoyle A, Amos CL, Attard G, Brawley CD, Calvert J, Chowdhury S, Cook A, Cross W, Dearnaley DP, Douis H, Gilbert D, Gillessen S, Jones RJ, Langley RE, MacNair A, Malik Z, Mason MD, Matheson D, Millman R, Parker CC, Ritchie AWS, Rush H, Russell JM, Brown J, Beesley S, Birtle A, Capaldi L, Gale J, Gibbs S, Lydon A, Nikapota A, Omlin A, O'Sullivan JM, Parikh O, Protheroe A, Rudman S, Srihari NN, Simms M, Tanguay JS, Tolan S, Wagstaff J, Wallace J, Wylie J, Zarkar A, Sydes MR, Parmar MKB, James ND; STAMPEDE investigators.

Ann Oncol. 2020 Mar;31(3):442. doi: 10.1016/j.annonc.2020.01.002. Epub 2020 Jan 31. No abstract available.


Low-dose photon counting CT reconstruction bias reduction with multi-energy alternating minimization algorithm.

Lu J, Zhang S, Politte DG, O'Sullivan JA.

Proc SPIE Int Soc Opt Eng. 2019 Jun;11072. pii: 110721Q. doi: 10.1117/12.2534897. Epub 2019 May 28.


Antipsychotics for preventing and treating delirium: not recommended.

Heneghan C, O'Sullivan J.

BMJ Evid Based Med. 2020 Feb 3. pii: bmjebm-2019-111293. doi: 10.1136/bmjebm-2019-111293. [Epub ahead of print] No abstract available.


Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers.

Buckley AM, Lynam-Lennon N, O'Neill H, O'Sullivan J.

Nat Rev Gastroenterol Hepatol. 2020 Jan 31. doi: 10.1038/s41575-019-0247-2. [Epub ahead of print] Review.


Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019.

Gillessen S, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Chi KN, Clarke N, Davis ID, de Bono J, Drake CG, Duran I, Eeles R, Efstathiou E, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, Gleave M, Halabi S, Heidenreich A, Heinrich D, Higano CTS, Hofman MS, Hussain M, James N, Kanesvaran R, Kantoff P, Khauli RB, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ost P, O'Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Reiter RE, Roach M, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Small E, Smith M, Soule H, Sternberg CN, Steuber T, Suzuki H, Sweeney C, Sydes MR, Taplin ME, Tombal B, Türkeri L, van Oort I, Zapatero A, Omlin A.

Eur Urol. 2020 Apr;77(4):508-547. doi: 10.1016/j.eururo.2020.01.012. Epub 2020 Jan 27.


Should blood pressure medications be taken at bedtime?

Heneghan C, O'Sullivan J, Mahtani KR.

BMJ Evid Based Med. 2020 Jan 28. pii: bmjebm-2019-111311. doi: 10.1136/bmjebm-2019-111311. [Epub ahead of print] No abstract available.


Can ethanol affect the cell structure - a dynamic molecular and Raman spectroscopy study.

Carvalho LFC, Dos Santos L, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto LP, Martin AA, Lyng FM, Byrne HJ.

Photodiagnosis Photodyn Ther. 2020 Jan 25:101675. doi: 10.1016/j.pdpdt.2020.101675. [Epub ahead of print]


Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control.

Boocock J, Leask M, Okada Y; Asian Genetic Epidemiology Network (AGEN) Consortium, Matsuo H, Kawamura Y, Shi Y, Li C, Mount DB, Mandal AK, Wang W, Cadzow M, Gosling AL, Major TJ, Horsfield JA, Choi HK, Fadason T, O'Sullivan J, Stahl EA, Merriman TR.

Hum Mol Genet. 2020 Jan 27. pii: ddaa013. doi: 10.1093/hmg/ddaa013. [Epub ahead of print]


A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum.

Brennan K, Martin K, FitzGerald SP, O'Sullivan J, Wu Y, Blanco A, Richardson C, Mc Gee MM.

Sci Rep. 2020 Jan 23;10(1):1039. doi: 10.1038/s41598-020-57497-7.


Eosinophil and mast cell Siglecs: From biology to drug target.

O'Sullivan JA, Chang AT, Youngblood BA, Bochner BS.

J Leukoc Biol. 2020 Jan 22. doi: 10.1002/JLB.2MR0120-352RR. [Epub ahead of print] Review.


Quality of life in people with dementia living in nursing homes: validation of an eight-item version of the QUALIDEM for intensive longitudinal assessment.

Junge S, Gellert P, O'Sullivan JL, Möller S, Voigt-Antons JN, Kuhlmey A, Nordheim J.

Qual Life Res. 2020 Jan 18. doi: 10.1007/s11136-020-02418-4. [Epub ahead of print]


β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells.

Malebari AM, Fayne D, Nathwani SM, O'Connell F, Noorani S, Twamley B, O'Boyle NM, O'Sullivan J, Zisterer DM, Meegan MJ.

Eur J Med Chem. 2020 Mar 1;189:112050. doi: 10.1016/j.ejmech.2020.112050. Epub 2020 Jan 10.


Highly Selective Fluorimetric Turn-Off Detection of Copper(II) by Two Different Mechanisms in Calix[4]arene-Based Chemosensors and Chemodosimeters.

O'Sullivan J, Colleran J, Twamley B, Heaney F.

Chempluschem. 2019 Oct;84(10):1610-1622. doi: 10.1002/cplu.201900448. Epub 2019 Sep 26.


Robotic automation of a UHPLC/MS-MS method profiling one-carbon metabolites, amino acids, and precursors in plasma.

Andraos S, Goy M, Albert BB, Kussmann M, Thorstensen EB, O'Sullivan JM.

Anal Biochem. 2020 Mar 1;592:113558. doi: 10.1016/j.ab.2019.113558. Epub 2020 Jan 3.


GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Couto Alves A, De Silva NMG, Karhunen V, Sovio U, Das S, Taal HR, Warrington NM, Lewin AM, Kaakinen M, Cousminer DL, Thiering E, Timpson NJ, Bond TA, Lowry E, Brown CD, Estivill X, Lindi V, Bradfield JP, Geller F, Speed D, Coin LJM, Loh M, Barton SJ, Beilin LJ, Bisgaard H, Bønnelykke K, Alili R, Hatoum IJ, Schramm K, Cartwright R, Charles MA, Salerno V, Clément K, Claringbould AAJ; BIOS Consortium, van Duijn CM, Moltchanova E, Eriksson JG, Elks C, Feenstra B, Flexeder C, Franks S, Frayling TM, Freathy RM, Elliott P, Widén E, Hakonarson H, Hattersley AT, Rodriguez A, Banterle M, Heinrich J, Heude B, Holloway JW, Hofman A, Hyppönen E, Inskip H, Kaplan LM, Hedman AK, Läärä E, Prokisch H, Grallert H, Lakka TA, Lawlor DA, Melbye M, Ahluwalia TS, Marinelli M, Millwood IY, Palmer LJ, Pennell CE, Perry JR, Ring SM, Savolainen MJ, Rivadeneira F, Standl M, Sunyer J, Tiesler CMT, Uitterlinden AG, Schierding W, O'Sullivan JM, Prokopenko I, Herzig KH, Smith GD, O'Reilly P, Felix JF, Buxton JL, Blakemore AIF, Ong KK, Jaddoe VWV, Grant SFA, Sebert S, McCarthy MI, Järvelin MR; Early Growth Genetics (EGG) Consortium.

Sci Adv. 2019 Sep 4;5(9):eaaw3095. doi: 10.1126/sciadv.aaw3095. eCollection 2019 Sep.


Extensive subclonal mutational diversity in human colorectal cancer and its significance.

Loeb LA, Kohrn BF, Loubet-Senear KJ, Dunn YJ, Ahn EH, O'Sullivan JN, Salk JJ, Bronner MP, Beckman RA.

Proc Natl Acad Sci U S A. 2019 Dec 5. pii: 201910301. doi: 10.1073/pnas.1910301116. [Epub ahead of print]


Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction.

O'Sullivan J, Finnie SL, Teenan O, Cairns C, Boyd A, Bailey MA, Thomson A, Hughes J, Bénézech C, Conway BR, Denby L.

Front Physiol. 2019 Nov 15;10:1365. doi: 10.3389/fphys.2019.01365. eCollection 2019.


Correction to: LC3B globular structures correlate with survival in esophageal adenocarcinoma.

El-Mashed S, O'Donovan TR, Kay EW, Abdallah AR, Cathcart MC, O'Sullivan J, O'Grady A, Reynolds J, O'Reilly S, O'Sullivan GC, McKenna SL.

BMC Cancer. 2019 Dec 3;19(1):1177. doi: 10.1186/s12885-019-6410-x.


Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota.

O'Sullivan JN, O'Connor PM, Rea MC, O'Sullivan O, Walsh CJ, Healy B, Mathur H, Field D, Hill C, Ross RP.

J Bacteriol. 2020 Jan 15;202(3). pii: e00639-19. doi: 10.1128/JB.00639-19. Print 2020 Jan 15.


Age is the most important clinical feature to help rule out cardiac syncope.

O'Sullivan J.

BMJ Evid Based Med. 2019 Nov 5. pii: bmjebm-2019-111270. doi: 10.1136/bmjebm-2019-111270. [Epub ahead of print] No abstract available.


Metabolites downstream of predicted loss-of-function variants inform relationship to disease.

Li M, Wang A, Quek LE, Vernon S, Figtree GA, Yang J, O'Sullivan JF.

Mol Genet Metab. 2019 Dec;128(4):476-482. doi: 10.1016/j.ymgme.2019.10.002. Epub 2019 Oct 17.


Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ.

Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29.


The risk of cardiovascular disease in prostate cancer patients receiving androgen deprivation therapies.

Cardwell CR, O'Sullivan JM, Jain S, Harbinson MT, Cook MB, Hicks BM, Mc Menamin ÚC.

Epidemiology. 2019 Oct 21. doi: 10.1097/EDE.0000000000001132. [Epub ahead of print]


Hierarchical Encoding of Attended Auditory Objects in Multi-talker Speech Perception.

O'Sullivan J, Herrero J, Smith E, Schevon C, McKhann GM, Sheth SA, Mehta AD, Mesgarani N.

Neuron. 2019 Dec 18;104(6):1195-1209.e3. doi: 10.1016/j.neuron.2019.09.007. Epub 2019 Oct 21.


The Radiation-Induced Bystander Effect (RIBE) and its Connections with the Hallmarks of Cancer.

Heeran AB, Berrigan HP, O'Sullivan J.

Radiat Res. 2019 Dec;192(6):668-679. doi: 10.1667/RR15489.1. Epub 2019 Oct 16. Review.


The poor outcome in high molecular risk, hydroxycarbamide-resistant/intolerant ET is not ameliorated by ruxolitinib.

O'Sullivan JM, Hamblin A, Yap C, Fox S, Boucher R, Panchal A, Alimam S, Dreau H, Howard K, Ware P, Cross NCP, McMullin MF, Harrison CN, Mead AJ.

Blood. 2019 Dec 5;134(23):2107-2111. doi: 10.1182/blood.2019001861. No abstract available.


Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial.

Clarke NW, Ali A, Ingleby FC, Hoyle A, Amos CL, Attard G, Brawley CD, Calvert J, Chowdhury S, Cook A, Cross W, Dearnaley DP, Douis H, Gilbert D, Gillessen S, Jones RJ, Langley RE, MacNair A, Malik Z, Mason MD, Matheson D, Millman R, Parker CC, Ritchie AWS, Rush H, Russell JM, Brown J, Beesley S, Birtle A, Capaldi L, Gale J, Gibbs S, Lydon A, Nikapota A, Omlin A, O'Sullivan JM, Parikh O, Protheroe A, Rudman S, Srihari NN, Simms M, Tanguay JS, Tolan S, Wagstaff J, Wallace J, Wylie J, Zarkar A, Sydes MR, Parmar MKB, James ND.

Ann Oncol. 2019 Dec 1;30(12):1992-2003. doi: 10.1093/annonc/mdz396. Erratum in: Ann Oncol. 2020 Mar;31(3):442.


Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

Chen NH, Ong CY, O'sullivan J, Ibranovic I, Davey K, Edwards JL, McEwan AG.

J Infect Dis. 2020 Jan 14;221(3):449-453. doi: 10.1093/infdis/jiz468.


Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: protocol for the longitudinal, prospective, BioHEART-CT cohort study.

Kott KA, Vernon ST, Hansen T, Yu C, Bubb KJ, Coffey S, Sullivan D, Yang J, O'Sullivan J, Chow C, Patel S, Chong J, Celermajer DS, Kritharides L, Grieve SM, Figtree GA.

BMJ Open. 2019 Sep 18;9(9):e028649. doi: 10.1136/bmjopen-2018-028649.


Differential Expression Profiles of Oxidative Stress Levels, 8-oxo-dG and 4-HNE, in Barrett's Esophagus Compared to Esophageal Adenocarcinoma.

O'Farrell NJ, Phelan JJ, Feighery R, Doyle B, Picardo SL, Ravi N, O'Toole D, Reynolds JV, O'Sullivan J.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4449. doi: 10.3390/ijms20184449.


A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells.

Nycholat CM, Duan S, Knuplez E, Worth C, Elich M, Yao A, O'Sullivan J, McBride R, Wei Y, Fernandes SM, Zhu Z, Schnaar RL, Bochner BS, Paulson JC.

J Am Chem Soc. 2019 Sep 11;141(36):14032-14037. doi: 10.1021/jacs.9b05769. Epub 2019 Aug 30.


A homozygous missense variant in CHRM3 associated with familial urinary bladder disease.

Beaman GM, Galatà G, Teik KW, Urquhart JE, Aishah A, O'Sullivan J, Bhaskar SS, Wood KA, Thomas HB, O'Keefe RT, Woolf AS, Stuart HM, Newman WG.

Clin Genet. 2019 Dec;96(6):515-520. doi: 10.1111/cge.13631. Epub 2019 Sep 11.


Exercise for advanced prostate cancer: a multicomponent, feasibility, trial protocol for men with metastatic castrate-resistant prostate cancer (EXACT).

Brown M, Murphy M, McDermott L, McAneney H, O'Sullivan JM, Jain S, Prue G.

Pilot Feasibility Stud. 2019 Aug 16;5:102. doi: 10.1186/s40814-019-0486-6. eCollection 2019.


The CuePed Trial: How Does Environmental Complexity Impact Cue Effectiveness? A Comparison of Tonic and Phasic Visual Cueing in Simple and Complex Environments in a Parkinson's Disease Population with Freezing of Gait.

Marsh R, Cole MH, Dissanayaka NNW, Au TR, Clewett S, O'Sullivan JD, Silburn PA.

Parkinsons Dis. 2019 Jul 24;2019:2478980. doi: 10.1155/2019/2478980. eCollection 2019.

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