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Molecular analysis of an ancient Thule population at Nuvuk, Point Barrow, Alaska.

Tackney J, Jensen AM, Kisielinski C, O'Rourke DH.

Am J Phys Anthropol. 2019 Feb;168(2):303-317. doi: 10.1002/ajpa.23746.


Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity.

Sabir AJ, Adams TE, O'Rourke D, Devlin JM, Noormohammadi AH.

Vet Microbiol. 2019 Jan;228:252-258. doi: 10.1016/j.vetmic.2018.12.010. Epub 2018 Dec 11.


AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival.

Cosimo E, Tarafdar A, Moles MW, Holroyd AK, Malik N, Catherwood MA, Hay J, Dunn KM, Macdonald AM, Guichard SM, O'Rourke DM, Leach MT, Sansom OJ, Cosulich SC, McCaig AM, Michie AM.

Clin Cancer Res. 2018 Dec 17. pii: clincanres.2036.2018. doi: 10.1158/1078-0432.CCR-18-2036. [Epub ahead of print]


Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma.

Verma G, Chawla S, Mohan S, Wang S, Nasrallah M, Sheriff S, Desai A, Brem S, O'Rourke DM, Wolf RL, Maudsley AA, Poptani H.

NMR Biomed. 2019 Feb;32(2):e4042. doi: 10.1002/nbm.4042. Epub 2018 Dec 17.


Relation of Venous Thromboembolism Risk to Ischemic Stroke Risk in Hospitalized Patients with Cancer.

Corley AM, Sullivan MJ, Friedman SE, O'Rourke DJ, Palac RT, Gemignani AS.

Am J Cardiol. 2018 Nov 24. pii: S0002-9149(18)32089-7. doi: 10.1016/j.amjcard.2018.11.008. [Epub ahead of print]


Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma.

Wang S, O'Rourke DM, Chawla S, Verma G, Nasrallah MP, Morrissette JJD, Plesa G, June CH, Brem S, Maloney E, Desai A, Wolf RL, Poptani H, Mohan S.

Br J Cancer. 2019 Jan;120(1):54-56. doi: 10.1038/s41416-018-0342-0. Epub 2018 Nov 27.


Virtual trial to evaluate the robustness of cementless femoral stems to patient and surgical variation.

Al-Dirini RMA, Martelli S, O'Rourke D, Huff D, Zhang J, Clement JG, Besier T, Taylor M.

J Biomech. 2019 Jan 3;82:346-356. doi: 10.1016/j.jbiomech.2018.11.013. Epub 2018 Nov 15.


Regulatory and Health Technology Assessment Considerations for Disease-Modifying Drugs in Alzheimer's Disease.

Bouvy JC, Jonsson P, O'Rourke D, Chadha AS, Hedberg N, Makady A, Xoxi E, Wied CG, Schiel A, Long R, Gallacher J.

CNS Drugs. 2018 Dec;32(12):1085-1090. doi: 10.1007/s40263-018-0581-x.


Nontraditional Laboratory Animal Species (Cephalopods, Fish, Amphibians, Reptiles, and Birds).

O'Rourke DP, Baccanale CL, Stoskopf MK.

ILAR J. 2018 Nov 21. doi: 10.1093/ilar/ily003. [Epub ahead of print]


Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma.

Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP.

J Neurooncol. 2018 Nov 16. doi: 10.1007/s11060-018-03050-6. [Epub ahead of print]


Sampling strategies for approximating patient variability in population-based finite element studies of total hip replacement.

O'Rourke D, Bottema M, Taylor M.

Int J Numer Method Biomed Eng. 2018 Nov 5:e3168. doi: 10.1002/cnm.3168. [Epub ahead of print]


New Frontiers in the Treatment of Spinal Muscular Atrophy.

Power CL, O'Rourke DJ.

Ir Med J. 2018 Mar 14;111(3):705. No abstract available.


RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma.

Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, Desai AS.

J Neurooncol. 2018 Oct 23. doi: 10.1007/s11060-018-03010-0. [Epub ahead of print]


Circulating Glioma Cells Exhibit Stem Cell-like Properties.

Liu T, Xu H, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y.

Cancer Res. 2018 Dec 1;78(23):6632-6642. doi: 10.1158/0008-5472.CAN-18-0650. Epub 2018 Oct 15.


Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas.

Yin Y, Boesteanu AC, Binder ZA, Xu C, Reid RA, Rodriguez JL, Cook DR, Thokala R, Blouch K, McGettigan-Croce B, Zhang L, Konradt C, Cogdill AP, Panjwani MK, Jiang S, Migliorini D, Dahmane N, Posey AD Jr, June CH, Mason NJ, Lin Z, O'Rourke DM, Johnson LA.

Mol Ther Oncolytics. 2018 Aug 28;11:20-38. doi: 10.1016/j.omto.2018.08.002. eCollection 2018 Dec 21.


PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma.

Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y.

Nat Commun. 2018 Aug 27;9(1):3439. doi: 10.1038/s41467-018-05982-z.


An early analysis of the cost-effectiveness of a diagnostic classifier for risk stratification of haematuria patients (DCRSHP) compared to flexible cystoscopy in the diagnosis of bladder cancer.

Sutton AJ, Lamont JV, Evans RM, Williamson K, O'Rourke D, Duggan B, Sagoo GS, Reid CN, Ruddock MW.

PLoS One. 2018 Aug 23;13(8):e0202796. doi: 10.1371/journal.pone.0202796. eCollection 2018.


Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM.

Cancer Cell. 2018 Jul 9;34(1):163-177.e7. doi: 10.1016/j.ccell.2018.06.006.


Biomechanical Robustness of a Contemporary Cementless Stem to Surgical Variation in Stem Size and Position.

Al-Dirini RMA, O'Rourke D, Huff D, Martelli S, Taylor M.

J Biomech Eng. 2018 Sep 1;140(9). doi: 10.1115/1.4039824.


Nontraditional Species.

O’Rourke DP, Cox JD, Baumann DP.

In: Weichbrod RH, Thompson GAH, Norton JN, editors. Management of Animal Care and Use Programs in Research, Education, and Testing. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 25.


Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk.

Hlusko LJ, Carlson JP, Chaplin G, Elias SA, Hoffecker JF, Huffman M, Jablonski NG, Monson TA, O'Rourke DH, Pilloud MA, Scott GR.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4426-E4432. doi: 10.1073/pnas.1711788115. Epub 2018 Apr 23.


Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI.

Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA.

J Magn Reson Imaging. 2019 Jan;49(1):184-194. doi: 10.1002/jmri.26053. Epub 2018 Apr 20.


Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer.

Nesbitt H, Sheng Y, Kamila S, Logan K, Thomas K, Callan B, Taylor MA, Love M, O'Rourke D, Kelly P, Beguin E, Stride E, McHale AP, Callan JF.

J Control Release. 2018 Jun 10;279:8-16. doi: 10.1016/j.jconrel.2018.04.018. Epub 2018 Apr 11.


In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C.

Neuro Oncol. 2018 Jul 5;20(8):1068-1079. doi: 10.1093/neuonc/noy033.


Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.

Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C.

Sci Rep. 2018 Mar 23;8(1):5087. doi: 10.1038/s41598-018-22739-2.


CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges.

Bagley SJ, Desai AS, Linette GP, June CH, O'Rourke DM.

Neuro Oncol. 2018 Oct 9;20(11):1429-1438. doi: 10.1093/neuonc/noy032.


Treatment outcome of twenty-two patients with guanidinoacetate methyltransferase deficiency: An international retrospective cohort study.

Khaikin Y, Sidky S, Abdenur J, Anastasi A, Ballhausen D, Buoni S, Chan A, Cheillan D, Dorison N, Goldenberg A, Goldstein J, Hofstede FC, Jacquemont ML, Koeberl DD, Lion-Francois L, Lund AM, Mention K, Mundy H, O'Rourke D, Pitelet G, Raspall-Chaure M, Tassini M, Billette de Villemeur T, Williams M, Salomons GS, Mercimek-Andrews S.

Eur J Paediatr Neurol. 2018 May;22(3):369-379. doi: 10.1016/j.ejpn.2018.02.007. Epub 2018 Feb 16.


Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.

Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y.

Nat Commun. 2018 Feb 8;9(1):559. doi: 10.1038/s41467-018-03050-0.


Chronologic Analysis of Gross and Histologic Lesions Induced by Field Strains of FAdV-1, FAdV-8b, and FAdV-11 in Six-Week-Old Chickens.

Steer-Cope P, Sandy J, O'Rourke D, Scott P, Browning G, Noormohammadi A.

Avian Dis. 2017 Dec;61(4):512-519. doi: 10.1637/11718-072317-Reg.1.


Influence of varying stem and metaphyseal sleeve size on the primary stability of cementless revision tibial trays used to reconstruct AORI IIA defects. A simulation study.

Awadalla M, Al-Dirini RMA, O'Rourke D, Solomon LB, Heldreth M, Taylor M.

J Orthop Res. 2018 Jul;36(7):1876-1886. doi: 10.1002/jor.23851. Epub 2018 Feb 13.


Shared Attributes of Responsibility and Emotion in Patients With Lung Cancer and Family Caregivers

O'Rourke DJ, Lobchuk MM, Ahmed R.

Oncol Nurs Forum. 2018 Jan 1;45(1):33-44. doi: 10.1188/18.ONF.33-44.


The Temple Star Transitional Model of Care for epilepsy; the outcome of a quality improvement project.

Crowley SL, Byrne S, McNulty S, Keating K, Nestor T, Owen Y, O'Rourke D, Lynch B, Shahwan A, King MD.

Epilepsy Behav. 2018 Feb;79:4-8. doi: 10.1016/j.yebeh.2017.10.043. Epub 2017 Dec 7.


Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing.

Morris J, Na YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J.

Cell Rep. 2017 Dec 5;21(10):2706-2713. doi: 10.1016/j.celrep.2017.11.031.


The physiological effects of slow breathing in the healthy human.

Russo MA, Santarelli DM, O'Rourke D.

Breathe (Sheff). 2017 Dec;13(4):298-309. doi: 10.1183/20734735.009817.


Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply.

Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH.

Lancet Oncol. 2017 Dec;18(12):e709-e710. doi: 10.1016/S1470-2045(17)30856-2. No abstract available.


Engineering Chimeric Antigen Receptor T cells to Treat Glioblastoma.

Choi BD, O'Rourke DM, Maus MV.

J Target Ther Cancer. 2017 Aug;6(4):22-25.


Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

Jain S, Lyons CA, Walker SM, McQuaid S, Hynes SO, Mitchell DM, Pang B, Logan GE, McCavigan AM, O'Rourke D, McArt DG, McDade SS, Mills IG, Prise KM, Knight LA, Steele CJ, Medlow PW, Berge V, Katz B, Loblaw DA, Harkin DP, James JA, O'Sullivan JM, Kennedy RD, Waugh DJ.

Ann Oncol. 2018 Jan 1;29(1):215-222. doi: 10.1093/annonc/mdx637.


Pyelonephritis can lead to life-threatening complications.

Keenan DB, O'Rourke DM, Courtney AE.

Practitioner. 2017 Feb;261(1801):17-20.


SHP2 regulates proliferation and tumorigenicity of glioma stem cells.

Roccograndi L, Binder ZA, Zhang L, Aceto N, Zhang Z, Bentires-Alj M, Nakano I, Dahmane N, O'Rourke DM.

J Neurooncol. 2017 Dec;135(3):487-496. doi: 10.1007/s11060-017-2610-x. Epub 2017 Aug 29.


Veterinary pharmacovigilance in Europe: a survey of veterinary practitioners.

De Briyne N, Gopal R, Diesel G, Iatridou D, O'Rourke D.

Vet Rec Open. 2017 Jul 19;4(1):e000224. doi: 10.1136/vetreco-2017-000224. eCollection 2017.


Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.

Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH; ACT IV trial investigators.

Lancet Oncol. 2017 Oct;18(10):1373-1385. doi: 10.1016/S1470-2045(17)30517-X. Epub 2017 Aug 23.


Primary stability of a cementless acetabular cup in a cohort of patient-specific finite element models.

O'Rourke D, Al-Dirini RM, Taylor M.

J Orthop Res. 2018 Mar;36(3):1012-1023. doi: 10.1002/jor.23709. Epub 2017 Sep 12.


Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancer.

Sheng Y, Beguin E, Nesbitt H, Kamila S, Owen J, Barnsley LC, Callan B, O'Kane C, Nomikou N, Hamoudi R, Taylor MA, Love M, Kelly P, O'Rourke D, Stride E, McHale AP, Callan JF.

J Control Release. 2017 Sep 28;262:192-200. doi: 10.1016/j.jconrel.2017.07.040. Epub 2017 Jul 29.


A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaaa0984. doi: 10.1126/scitranslmed.aaa0984.


In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C.

Clin Cancer Res. 2017 Aug 15;23(16):4724-4734. doi: 10.1158/1078-0432.CCR-16-1871. Epub 2017 Apr 20.


Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy.

Bloch O, Lim M, Sughrue ME, Komotar RJ, Abrahams JM, O'Rourke DM, D'Ambrosio A, Bruce JN, Parsa AT.

Clin Cancer Res. 2017 Jul 15;23(14):3575-3584. doi: 10.1158/1078-0432.CCR-16-1369. Epub 2017 Feb 13.


Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics.

Spaethling JM, Na YJ, Lee J, Ulyanova AV, Baltuch GH, Bell TJ, Brem S, Chen HI, Dueck H, Fisher SA, Garcia MP, Khaladkar M, Kung DK, Lucas TH Jr, O'Rourke DM, Stefanik D, Wang J, Wolf JA, Bartfai T, Grady MS, Sul JY, Kim J, Eberwine JH.

Cell Rep. 2017 Jan 17;18(3):791-803. doi: 10.1016/j.celrep.2016.12.066.


GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.

Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O'Rourke D, Yang LV.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):569-584. doi: 10.1016/j.bbadis.2016.12.005. Epub 2016 Dec 7.


Possible toxicity following embolization of congenital giant vertex hemangioma: case report.

Kieran I, Zakaria Z, Kaliaperumal C, O'Rourke D, O'Hare A, Laffan E, Caird J, King MD, Murray DJ.

J Neurosurg Pediatr. 2017 Mar;19(3):296-299. doi: 10.3171/2016.5.PEDS13345. Epub 2016 Dec 9.


A Computational Efficient Method to Assess the Sensitivity of Finite-Element Models: An Illustration With the Hemipelvis.

O'Rourke D, Martelli S, Bottema M, Taylor M.

J Biomech Eng. 2016 Dec 1;138(12). doi: 10.1115/1.4034831.


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