Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 87


Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice.

Trivedi PM, Fynch S, Kennedy LM, Chee J, Krishnamurthy B, O'Reilly LA, Strasser A, Kay TWH, Thomas HE.

Cell Death Discov. 2019 Sep 23;5:136. doi: 10.1038/s41420-019-0217-z. eCollection 2019.


CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3+ regulatory T cells.

Policheni A, Horikawa K, Milla L, Kofler J, Bouillet P, Belz GT, O'Reilly LA, Goodnow CC, Strasser A, Gray DH.

Immunol Cell Biol. 2019 Sep;97(8):740-752. doi: 10.1111/imcb.12268. Epub 2019 Jun 26.


Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development.

Aubrey BJ, Janic A, Chen Y, Chang C, Lieschke EC, Diepstraten ST, Kueh AJ, Bernardini JP, Dewson G, O'Reilly LA, Whitehead L, Voss AK, Smyth GK, Strasser A, Kelly GL.

Genes Dev. 2018 Nov 1;32(21-22):1420-1429. doi: 10.1101/gad.314286.118. Epub 2018 Oct 26.


Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis.

Salvamoser R, Brinkmann K, O'Reilly LA, Whitehead L, Strasser A, Herold MJ.

Cell Death Differ. 2019 Jun;26(6):1124-1137. doi: 10.1038/s41418-018-0188-2. Epub 2018 Aug 28.


Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A.

Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003.


Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus.

Lotti R, Shu E, Petrachi T, Marconi A, Palazzo E, Quadri M, Lin A, O'Reilly LA, Pincelli C.

Front Immunol. 2018 Feb 26;9:370. doi: 10.3389/fimmu.2018.00370. eCollection 2018.


Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.

Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D.

Nat Commun. 2017 Sep 7;8(1):480. doi: 10.1038/s41467-017-00566-9.


Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.

Teh CE, Lalaoui N, Jain R, Policheni AN, Heinlein M, Alvarez-Diaz S, Sheridan JM, Rieser E, Deuser S, Darding M, Koay HF, Hu Y, Kupresanin F, O'Reilly LA, Godfrey DI, Smyth GK, Bouillet P, Strasser A, Walczak H, Silke J, Gray DH.

Nat Commun. 2016 Nov 18;7:13353. doi: 10.1038/ncomms13353.


Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.

Anstee NS, Vandenberg CJ, Campbell KJ, Hughes PD, O'Reilly LA, Cory S.

Cell Death Differ. 2017 Mar;24(3):397-408. doi: 10.1038/cdd.2016.125. Epub 2016 Nov 4.


Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.


The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A.

Immunity. 2016 Sep 20;45(3):513-526. doi: 10.1016/j.immuni.2016.07.016. Epub 2016 Aug 11.


NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R.

J Exp Med. 2016 Apr 4;213(4):621-41. doi: 10.1084/jem.20151182. Epub 2016 Mar 28.


BCL2-modifying factor promotes germ cell loss during murine oogenesis.

Vaithiyanathan K, Liew SH, Zerafa N, Gamage T, Cook M, O'Reilly LA, Bouillet P, Scott CL, Strasser A, Findlay JK, Hutt KJ.

Reproduction. 2016 May;151(5):553-62. doi: 10.1530/REP-15-0561. Epub 2016 Feb 25.


Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK.

Ke F, Grabow S, Kelly GL, Lin A, O'Reilly LA, Strasser A.

Cell Death Dis. 2015 Oct 22;6:e1938. doi: 10.1038/cddis.2015.304.


Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.

Lacey D, Hickey P, Arhatari BD, O'Reilly LA, Rohrbeck L, Kiriazis H, Du XJ, Bouillet P.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9698-703. doi: 10.1073/pnas.1508399112. Epub 2015 Jul 20.


bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.

Duckworth CA, Abuderman AA, Burkitt MD, Williams JM, O'Reilly LA, Pritchard DM.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G420-30. doi: 10.1152/ajpgi.00404.2014. Epub 2015 Jul 9.


Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.

Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA.

Immunol Cell Biol. 2016 Jan;94(1):66-78. doi: 10.1038/icb.2015.66. Epub 2015 Jun 18.


FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R.

Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12.


NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.

Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O'Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM.

J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.


Characterisation of a novel A1-specific monoclonal antibody.

Lang MJ, Brennan MS, O'Reilly LA, Ottina E, Czabotar PE, Whitlock E, Fairlie WD, Tai L, Strasser A, Herold MJ.

Cell Death Dis. 2014 Dec 4;5:e1553. doi: 10.1038/cddis.2014.519. No abstract available.


Fas regulates neutrophil lifespan during viral and bacterial infection.

O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, Cengia L, Dias S, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA.

J Leukoc Biol. 2015 Feb;97(2):321-6. doi: 10.1189/jlb.3AB1113-594RR. Epub 2014 Dec 3.


TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M, O'Reilly LA, Smyth MJ, Trapani JA, Hill GR, Andoniou CE, Degli-Esposti MA.

Immunity. 2014 Oct 16;41(4):646-56. doi: 10.1016/j.immuni.2014.09.013.


Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.

O'Reilly LA, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray DH, Gerondakis S, Strasser A.

Cell Death Differ. 2015 May;22(5):767-78. doi: 10.1038/cdd.2014.168. Epub 2014 Oct 31.


Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA.

Herold MJ, O'Reilly LA, Lin A, Srivastava R, Doerflinger M, Bouillet P, Strasser A, Puthalakath H.

Cell Death Dis. 2014 Jul 31;5:e1354. doi: 10.1038/cddis.2014.290. No abstract available.


Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

Gangoda L, Doerflinger M, Srivastava R, Narayan N, Edgington LE, Orian J, Hawkins C, O'Reilly LA, Gu H, Bogyo M, Ekert P, Strasser A, Puthalakath H.

Cell Death Differ. 2014 Nov;21(11):1815-24. doi: 10.1038/cdd.2014.98. Epub 2014 Jul 11.


Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.


Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Josefsson EC, Burnett DL, Lebois M, Debrincat MA, White MJ, Henley KJ, Lane RM, Moujalled D, Preston SP, O'Reilly LA, Pellegrini M, Metcalf D, Strasser A, Kile BT.

Nat Commun. 2014 Mar 17;5:3455. doi: 10.1038/ncomms4455.


Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.

Afshar-Sterle S, Zotos D, Bernard NJ, Scherger AK, Rödling L, Alsop AE, Walker J, Masson F, Belz GT, Corcoran LM, O'Reilly LA, Strasser A, Smyth MJ, Johnstone R, Tarlinton DM, Nutt SL, Kallies A.

Nat Med. 2014 Mar;20(3):283-90. doi: 10.1038/nm.3442. Epub 2014 Feb 2.


ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

Sandow JJ, Dorstyn L, O'Reilly LA, Tailler M, Kumar S, Strasser A, Ekert PG.

Cell Death Differ. 2014 Mar;21(3):475-80. doi: 10.1038/cdd.2013.168. Epub 2013 Nov 29.


A type III effector antagonizes death receptor signalling during bacterial gut infection.

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL.

Nature. 2013 Sep 12;501(7466):247-51. doi: 10.1038/nature12524.


The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.

Figgett WA, Fairfax K, Vincent FB, Le Page MA, Katik I, Deliyanti D, Quah PS, Verma P, Grumont R, Gerondakis S, Hertzog P, O'Reilly LA, Strasser A, Mackay F.

Immunity. 2013 Sep 19;39(3):573-83. doi: 10.1016/j.immuni.2013.05.019. Epub 2013 Sep 5.


Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease.

Mason KD, Lin A, Robb L, Josefsson EC, Henley KJ, Gray DH, Kile BT, Roberts AW, Strasser A, Huang DC, Waring P, O'Reilly LA.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2599-604. doi: 10.1073/pnas.1215097110. Epub 2013 Jan 24.


The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.

Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.

Immunity. 2012 Sep 21;37(3):451-62. doi: 10.1016/j.immuni.2012.05.030. Epub 2012 Sep 6.


Is BID required for NOD signalling?

Nachbur U, Vince JE, O'Reilly LA, Strasser A, Silke J.

Nature. 2012 Aug 23;488(7412):E4-6; discussion E6-8. doi: 10.1038/nature11366. No abstract available. Erratum in: Nature. 2012 Nov 29;491(7426):784.


The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.

Zhang JG, Czabotar PE, Policheni AN, Caminschi I, Wan SS, Kitsoulis S, Tullett KM, Robin AY, Brammananth R, van Delft MF, Lu J, O'Reilly LA, Josefsson EC, Kile BT, Chin WJ, Mintern JD, Olshina MA, Wong W, Baum J, Wright MD, Huang DC, Mohandas N, Coppel RL, Colman PM, Nicola NA, Shortman K, Lahoud MH.

Immunity. 2012 Apr 20;36(4):646-57. doi: 10.1016/j.immuni.2012.03.009. Epub 2012 Apr 5.


BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

Ke F, Voss A, Kerr JB, O'Reilly LA, Tai L, Echeverry N, Bouillet P, Strasser A, Kaufmann T.

Cell Death Differ. 2012 Jun;19(6):915-25. doi: 10.1038/cdd.2011.210. Epub 2012 Jan 27. Erratum in: Cell Death Differ. 2013 Jan;20(1):183.


Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT.

J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12.


Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.

Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13135-40. doi: 10.1073/pnas.1110358108. Epub 2011 Jul 18.


Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.

Fuertes Marraco SA, Scott CL, Bouillet P, Ives A, Masina S, Vremec D, Jansen ES, O'Reilly LA, Schneider P, Fasel N, Shortman K, Strasser A, Acha-Orbea H.

PLoS One. 2011;6(6):e20189. doi: 10.1371/journal.pone.0020189. Epub 2011 Jun 2.


Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.

Naik E, O'Reilly LA, Asselin-Labat ML, Merino D, Lin A, Cook M, Coultas L, Bouillet P, Adams JM, Strasser A.

J Exp Med. 2011 Jul 4;208(7):1351-8. doi: 10.1084/jem.20100951. Epub 2011 Jun 6.


The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.

Mérino D, Giam M, Hughes PD, Siggs OM, Heger K, O'Reilly LA, Adams JM, Strasser A, Lee EF, Fairlie WD, Bouillet P.

J Cell Biol. 2009 Aug 10;186(3):355-62. doi: 10.1083/jcb.200905153. Epub 2009 Aug 3.


CD95, BIM and T cell homeostasis.

Bouillet P, O'Reilly LA.

Nat Rev Immunol. 2009 Jul;9(7):514-9. doi: 10.1038/nri2570. Review.


MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

O'Reilly LA, Kruse EA, Puthalakath H, Kelly PN, Kaufmann T, Huang DC, Strasser A.

J Immunol. 2009 Jul 1;183(1):261-9. doi: 10.4049/jimmunol.0803853.


Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP.

Blood. 2009 Jul 16;114(3):663-6. doi: 10.1182/blood-2009-01-200345. Epub 2009 Apr 22.


Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium.

Shackleton M, O'Reilly LA, Sutherland KD, Bath ML, Ellis S, Strasser A, Visvader JE, Lindeman GJ.

Dev Dyn. 2009 Apr;238(4):1010-6. doi: 10.1002/dvdy.21917.


Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG.

Cell Death Differ. 2009 Apr;16(4):555-63. doi: 10.1038/cdd.2008.179. Epub 2008 Dec 12.


What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.

Strasser A, Puthalakath H, O'Reilly LA, Bouillet P.

Immunol Cell Biol. 2008 Jan;86(1):57-66. Epub 2007 Nov 20. Review.


ER stress triggers apoptosis by activating BH3-only protein Bim.

Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.

Cell. 2007 Jun 29;129(7):1337-49.


Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.

Kuroda J, Kimura S, Strasser A, Andreeff M, O'Reilly LA, Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M, Tanaka R, Tabe Y, Taniwaki M, Maekawa T.

Cell Death Differ. 2007 Sep;14(9):1667-77. Epub 2007 May 18.


Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA.

Gugasyan R, Christou A, O'Reilly LA, Strasser A, Gerondakis S.

Cell Death Differ. 2006 Jul;13(7):1235-7. Epub 2006 Feb 17. No abstract available.

Supplemental Content

Loading ...
Support Center