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Items: 23


Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM.

Sci Signal. 2019 Aug 13;12(594). pii: eaaw2939. doi: 10.1126/scisignal.aaw2939.


Stability and flexibility in cognitive control: Interindividual dynamics and task context processing.

Serrien DJ, O'Regan L.

PLoS One. 2019 Jul 10;14(7):e0219397. doi: 10.1371/journal.pone.0219397. eCollection 2019.


Individual Differences and Hemispheric Asymmetries for Language and Spatial Attention.

O'Regan L, Serrien DJ.

Front Hum Neurosci. 2018 Oct 4;12:380. doi: 10.3389/fnhum.2018.00380. eCollection 2018.


Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Mukherjee M, Sabir S, O'Regan L, Sampson J, Richards MW, Huguenin-Dezot N, Ault JR, Chin JW, Zhuravleva A, Fry AM, Bayliss R.

Sci Signal. 2018 Aug 14;11(543). pii: eaao2464. doi: 10.1126/scisignal.aao2464.


Motor Timing and Covariation with Time Perception: Investigating the Role of Handedness.

O'Regan L, Spapé MM, Serrien DJ.

Front Behav Neurosci. 2017 Aug 15;11:147. doi: 10.3389/fnbeh.2017.00147. eCollection 2017.


Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM.

Cancer Res. 2017 Sep 15;77(18):4785-4796. doi: 10.1158/0008-5472.CAN-16-3233. Epub 2017 Jul 18.


EML proteins in microtubule regulation and human disease.

Fry AM, O'Regan L, Montgomery J, Adib R, Bayliss R.

Biochem Soc Trans. 2016 Oct 15;44(5):1281-1288. Review.


Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases.

Prosser SL, O'Regan L, Fry AM.

Mol Cell Oncol. 2015 Jul 6;3(3):e1062952. doi: 10.1080/23723556.2015.1062952. eCollection 2016 May.


Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.

Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R.

Nat Commun. 2015 Nov 2;6:8771. doi: 10.1038/ncomms9771.


Hsp70 proteins in mitosis and disease.

O'Regan L, Sampson J, Fry AM.

Oncotarget. 2015 Oct 20;6(32):32293-4. doi: 10.18632/oncotarget.5965. No abstract available.


Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.


Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R.

Biochem J. 2015 May 1;467(3):529-36. doi: 10.1042/BJ20150039.


Event-related brain potentials reveal correlates of the transformation of stimulus functions through derived relations in healthy humans.

O'Regan LM, Farina FR, Hussey I, Roche RA.

Brain Res. 2015 Mar 2;1599:168-77. doi: 10.1016/j.brainres.2014.12.044. Epub 2014 Dec 30.


Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5. doi: 10.1073/pnas.1321330111. Epub 2014 Jun 23.


Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.

Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi: 10.1073/pnas.1322892111. Epub 2014 Mar 24.


Cell cycle regulation by the NEK family of protein kinases.

Fry AM, O'Regan L, Sabir SR, Bayliss R.

J Cell Sci. 2012 Oct 1;125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review.


An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R.

Mol Cell. 2009 Nov 25;36(4):560-70. doi: 10.1016/j.molcel.2009.09.038.


Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia.

Islam MS, Anoop P, Datta-Nemdharry P, Sage D, Gordon-Smith EC, Turner D, Wiltshire S, O'Regan L, Marsh JC.

Bone Marrow Transplant. 2010 May;45(5):886-94. doi: 10.1038/bmt.2009.267. Epub 2009 Oct 12.


The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

O'Regan L, Fry AM.

Mol Cell Biol. 2009 Jul;29(14):3975-90. doi: 10.1128/MCB.01867-08. Epub 2009 May 4.


An unusual cause of acute abdomen following allogeneic transplantation: a zoonotic disease revisited.

Buyck HC, Holliman R, Else J, O'Regan L, Willis F, Grubnic S, Marsh J, Chakrabarti S.

Bone Marrow Transplant. 2008 Jun;41(12):1069-70. doi: 10.1038/bmt.2008.29. Epub 2008 Mar 3. No abstract available.


Mitotic regulation by NIMA-related kinases.

O'regan L, Blot J, Fry AM.

Cell Div. 2007 Aug 29;2:25.


Alprazolam is relatively more toxic than other benzodiazepines in overdose.

Isbister GK, O'Regan L, Sibbritt D, Whyte IM.

Br J Clin Pharmacol. 2004 Jul;58(1):88-95. Review.


AIDS education.

McCamish M, Buckham C, O'Dell B, O'Regan L.

Med J Aust. 1988 Oct 17;149(8):445. No abstract available.


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