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A guide to immunometabolism for immunologists. O'Neill LA et al. Nat Rev Immunol. (2016)

Macrophage Immunometabolism: Where Are We (Going)? Van den Bossche J et al. Trends Immunol. (2017)

Metabolic regulation of NLRP3. Hughes MM et al. Immunol Rev. (2018)

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Items: 1 to 50 of 659


Krebs Cycle Reborn in Macrophage Immunometabolism.

Ryan DG, O'Neill LAJ.

Annu Rev Immunol. 2020 Jan 27. doi: 10.1146/annurev-immunol-081619-104850. [Epub ahead of print]


Vision-related and health-related quality of life in patients with giant cell arteritis.

Ní Mhéalóid Á, Conway R, O'Neill L, Clyne B, Molloy E, Murphy CC.

Eur J Ophthalmol. 2020 Jan 20:1120672120901693. doi: 10.1177/1120672120901693. [Epub ahead of print]


ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming.

Williams NC, O'Neill LA.

Trends Immunol. 2020 Jan 13. pii: S1471-4906(19)30267-4. doi: 10.1016/ [Epub ahead of print]


Lateral Extra-articular Tenodesis Reduces Failure of Hamstring Tendon Autograft Anterior Cruciate Ligament Reconstruction: 2-Year Outcomes From the STABILITY Study Randomized Clinical Trial.

Getgood AMJ, Bryant DM, Litchfield R, Heard M, McCormack RG, Rezansoff A, Peterson D, Bardana D, MacDonald PB, Verdonk PCM, Spalding T; STABILITY Study Group, Willits K, Birmingham T, Hewison C, Wanlin S, Firth A, Pinto R, Martindale A, O'Neill L, Jennings M, Daniluk M, Boyer D, Zomar M, Moon K, Pritchett R, Payne K, Fan B, Mohan B, Buchko GM, Hiemstra LA, Kerslake S, Tynedal J, Stranges G, Mcrae S, Gullett L, Brown H, Legary A, Longo A, Christian M, Ferguson C, Mohtadi N, Barber R, Chan D, Campbell C, Garven A, Pulsifer K, Mayer M, Simunovic N, Duong A, Robinson D, Levy D, Skelly M, Shanmugaraj A, Howells F, Tough M, Spalding T, Thompson P, Metcalfe A, Asplin L, Dube A, Clarkson L, Brown J, Bolsover A, Bradshaw C, Belgrove L, Millan F, Turner S, Verdugo S, Lowe J, Dunne D, McGowan K, Suddens CM, Declercq G, Vuylsteke K, Van Haver M.

Am J Sports Med. 2020 Jan 15:363546519896333. doi: 10.1177/0363546519896333. [Epub ahead of print]


Efficacy of Cold Plasma for Direct Deposition of Antibiotics as a Novel Approach for Localized Delivery and Retention of Effect.

Los A, Ziuzina D, Boehm D, Han L, O'Sullivan D, O'Neill L, Bourke P.

Front Cell Infect Microbiol. 2019 Dec 20;9:428. doi: 10.3389/fcimb.2019.00428. eCollection 2019.


Threats to Patient Safety in the Inpatient Maternity Setting.

OʼNeill L, Miller LA, Rohan AJ.

MCN Am J Matern Child Nurs. 2019 Dec 4. doi: 10.1097/NMC.0000000000000603. [Epub ahead of print] No abstract available.


Pulmonary vein encirclement using an Ablation Index-guided point-by-point workflow: cardiovascular magnetic resonance assessment of left atrial scar formation.

O'Neill L, Karim R, Mukherjee RK, Whitaker J, Sim I, Harrison J, Razeghi O, Niederer S, Ismail T, Wright M, O'Neill MD, Williams SE.

Europace. 2019 Dec 1;21(12):1817-1823. doi: 10.1093/europace/euz226.


Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.

Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott EM, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KHG, O'Neill LAJ.

Cell Metab. 2019 Nov 20. pii: S1550-4131(19)30606-0. doi: 10.1016/j.cmet.2019.10.015. [Epub ahead of print]


Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α-FGF21 axis in mice.

Aljohani A, Khan MI, Bonneville A, Guo C, Jeffery J, O'Neill L, Syed DN, Lewis SA, Burhans M, Mukhtar H, Ntambi JM.

J Biol Chem. 2019 Dec 20;294(51):19475-19485. doi: 10.1074/jbc.RA119.009868. Epub 2019 Nov 5.


The landscape of somatic mutation in normal colorectal epithelial cells.

Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O'Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR.

Nature. 2019 Oct;574(7779):532-537. doi: 10.1038/s41586-019-1672-7. Epub 2019 Oct 23.


Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic resonance images using heart-specific flexible 3D printed acrylic scaffold combined with non-rigid registration.

Whitaker J, Neji R, Byrne N, Puyol-Antón E, Mukherjee RK, Williams SE, Chubb H, O'Neill L, Razeghi O, Connolly A, Rhode K, Niederer S, King A, Tschabrunn C, Anter E, Nezafat R, Bishop MJ, O'Neill M, Razavi R, Roujol S.

J Cardiovasc Magn Reson. 2019 Oct 10;21(1):62. doi: 10.1186/s12968-019-0574-z.


Contribution of primary care organisation and specialist care provider to variation in GP referrals for suspected cancer: ecological analysis of national data.

Burton C, O'Neill L, Oliver P, Murchie P.

BMJ Qual Saf. 2019 Oct 5. pii: bmjqs-2019-009469. doi: 10.1136/bmjqs-2019-009469. [Epub ahead of print]


Analysis of Histone Modifications in Rodent Pancreatic Islets by Native Chromatin Immunoprecipitation.

Sandovici I, Nicholas LM, O'Neill LP.

Methods Mol Biol. 2020;2076:199-213. doi: 10.1007/978-1-4939-9882-1_11.


Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ.

Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072.


Physical recovery in the first six months following oesophago-gastric cancer surgery. Identifying rehabilitative needs: a qualitative interview study.

O'Neill L, Bennett AE, Guinan E, Reynolds JV, Hussey J.

Disabil Rehabil. 2019 Sep 16:1-8. doi: 10.1080/09638288.2019.1663946. [Epub ahead of print]


Chestnut-crowned babbler calls are composed of meaningless shared building blocks.

Engesser S, Holub JL, O'Neill LG, Russell AF, Townsend SW.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19579-19584. doi: 10.1073/pnas.1819513116. Epub 2019 Sep 9.


Specific Inhibition of the NLRP3 Inflammasome as an Antiinflammatory Strategy in Cystic Fibrosis.

McElvaney OJ, Zaslona Z, Becker-Flegler K, Palsson-McDermott EM, Boland F, Gunaratnam C, Gulbins E, O'Neill LA, Reeves EP, McElvaney NG.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1381-1391. doi: 10.1164/rccm.201905-1013OC.


Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis.

O'Neill L, McCormick J, Gao W, Veale DJ, McCarthy GM, Murphy CC, Fearon U, Molloy ES.

Rheumatol Adv Pract. 2019 May 6;3(1):rkz011. doi: 10.1093/rap/rkz011. eCollection 2019.


An International Mutually Beneficial Global Surgery Rotation in Malawi.

Hayton RA, Garba LT, Teferi AN, O'Neill LR, Namm JP, Reeves ME.

J Grad Med Educ. 2019 Aug;11(4 Suppl):193-194. doi: 10.4300/JGME-D-18-01021. No abstract available.


Evaluation of protective and immune responses following vaccination with recombinant MIP and CPAF from Chlamydia abortus as novel vaccines for enzootic abortion of ewes.

O'Neill LM, Keane OM, Ross PJ, Nally JE, Seshu J, Markey B.

Vaccine. 2019 Aug 23;37(36):5428-5438. doi: 10.1016/j.vaccine.2019.06.088. Epub 2019 Jul 30.


A computerised system to evaluate patients with rheumatic diseases.

Luqmani R, O'Neill L, David J.

Future Healthc J. 2019 Mar;6(Suppl 1):80-81. doi: 10.7861/futurehosp.6-1-s80. No abstract available.


Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study.

Guinan EM, Bennett AE, Doyle SL, O'Neill L, Gannon J, Foley G, Elliott JA, O'Sullivan J, Reynolds JV, Hussey J.

BMC Cancer. 2019 Jul 12;19(1):682. doi: 10.1186/s12885-019-5888-6.


Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.

Ketelhuth DFJ, Lutgens E, Bäck M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC.

Cardiovasc Res. 2019 Jul 1;115(9):1385-1392. doi: 10.1093/cvr/cvz166.


Evaluation of a real-time magnetic resonance imaging-guided electrophysiology system for structural and electrophysiological ventricular tachycardia substrate assessment.

Mukherjee RK, Costa CM, Neji R, Harrison JL, Sim I, Williams SE, Whitaker J, Chubb H, O'Neill L, Schneider R, Lloyd T, Pohl T, Roujol S, Niederer SA, Razavi R, O'Neill MD.

Europace. 2019 Sep 1;21(9):1432-1441. doi: 10.1093/europace/euz165.


Reproducibility of Atrial Fibrosis Assessment Using CMR Imaging and an Open Source Platform.

Sim I, Razeghi O, Karim R, Chubb H, Whitaker J, O'Neill L, Mukherjee RK, Roney CH, Razavi R, Wright M, O'Neill M, Niederer S, Williams SE.

JACC Cardiovasc Imaging. 2019 Oct;12(10):2076-2077. doi: 10.1016/j.jcmg.2019.03.027. Epub 2019 Jun 12. No abstract available.


The Immunomodulatory Potential of the Metabolite Itaconate.

Hooftman A, O'Neill LAJ.

Trends Immunol. 2019 Aug;40(8):687-698. doi: 10.1016/ Epub 2019 Jun 6. Review.


Left atrial effective conducting size predicts atrial fibrillation vulnerability in persistent but not paroxysmal atrial fibrillation.

Williams SE, O'Neill L, Roney CH, Julia J, Metzner A, Reißmann B, Mukherjee RK, Sim I, Whitaker J, Wright M, Niederer S, Sohns C, O'Neill M.

J Cardiovasc Electrophysiol. 2019 Sep;30(9):1416-1427. doi: 10.1111/jce.13990. Epub 2019 Jun 18.


Limited Intragenerational Mobility of Surgical Caseload of Iowa Hospitals.

O'Neill L, Dexter F, Epstein RH.

J Med Syst. 2019 May 18;43(7):187. doi: 10.1007/s10916-019-1326-1.


Development and Validation of an Algorithm to Classify as Equivalent the Procedures in ICD-10-PCS That Differ Only by Laterality.

Epstein RH, Dexter F, O'Neill L.

Anesth Analg. 2019 Jun;128(6):1138-1144. doi: 10.1213/ANE.0000000000003340.


Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.

Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.


In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line.

Qasim Warraich M, Ghion A, Perdisatt L, O'Neill L, Casey A, O'Connor C.

Drug Chem Toxicol. 2019 Apr 17:1-11. doi: 10.1080/01480545.2019.1589492. [Epub ahead of print]


Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.

Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O'Neill L, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG.

Allergy. 2019 Oct;74(10):1920-1933. doi: 10.1111/all.13801. Epub 2019 Apr 29.


Letter to the editor-pREVEntion and regReSsive Effect of weight-loss and risk factor modification on Atrial Fibrillation: the REVERSE-AF study.

O'Hare D, O'Neill L, O'Neill MD, Williams SE.

Europace. 2019 Jun 1;21(6):990. doi: 10.1093/europace/euz023. No abstract available.


Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, Dawson KJ, Ju YS, Iorio F, Tubio JMC, Koh CC, Georgakopoulos-Soares I, Rodríguez-Martín B, Otlu B, O'Meara S, Butler AP, Menzies A, Bhosle SG, Raine K, Jones DR, Teague JW, Beal K, Latimer C, O'Neill L, Zamora J, Anderson E, Patel N, Maddison M, Ng BL, Graham J, Garnett MJ, McDermott U, Nik-Zainal S, Campbell PJ, Stratton MR.

Cell. 2019 Mar 7;176(6):1282-1294.e20. doi: 10.1016/j.cell.2019.02.012.


Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial.

Peters MJ, Woolfall K, Khan I, Deja E, Mouncey PR, Wulff J, Mason A, Agbeko RS, Draper ES, Fenn B, Gould DW, Koelewyn A, Klein N, Mackerness C, Martin S, O'Neill L, Ray S, Ramnarayan P, Tibby S, Thorburn K, Tume L, Watkins J, Wellman P, Harrison DA, Rowan KM; FEVER Investigators on behalf of the Paediatric Intensive Care Society Study Group (PICS-SG).

Crit Care. 2019 Mar 7;23(1):69. doi: 10.1186/s13054-019-2354-4.


Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing.

Gul SE, O'Neill L, Cassidy J, Naydenova I.

Sensors (Basel). 2019 Feb 28;19(5). pii: E1026. doi: 10.3390/s19051026.


Unscrambling variation in avian eggshell colour and patterning in a continent-wide study.

L'Herpiniere KL, O'Neill LG, Russell AF, Duursma DE, Griffith SC.

R Soc Open Sci. 2019 Jan 30;6(1):181269. doi: 10.1098/rsos.181269. eCollection 2019 Jan.


Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT.

Peters MJ, Khan I, Woolfall K, Deja E, Mouncey PR, Wulff J, Mason A, Agbeko R, Draper ES, Fenn B, Gould DW, Koelewyn A, Klein N, Mackerness C, Martin S, O'Neill L, Ramnarayan P, Tibby S, Tume L, Watkins J, Thorburn K, Wellman P, Harrison DA, Rowan KM.

Health Technol Assess. 2019 Feb;23(5):1-148. doi: 10.3310/hta23050.


Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production.

Geiger SS, Curtis AM, O'Neill LAJ, Siegel RM.

Immunology. 2019 Jun;157(2):122-136. doi: 10.1111/imm.13053. Epub 2019 Apr 16.


Experimental investigation of frequency and amplitude of density wave oscillations in vertical upflow boiling.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Mackey JR.

Int J Heat Mass Transf. 2018 Oct;125:1240-1263. doi: 10.1016/j.ijheatmasstransfer.2018.04.138. Epub 2018 May 16.


Mechanistic model to predict frequency and amplitude of Density Wave Oscillations in vertical upflow boiling.

O'Neill LE, Mudawar I.

Int J Heat Mass Transf. 2018 Sep;123:143-171. doi: 10.1016/j.ijheatmasstransfer.2018.02.078. Epub 2018 Mar 20.


Flow condensation pressure oscillations at different orientations.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Mackey JR.

Int J Heat Mass Transf. 2018 Dec;127:784-809. doi: 10.1016/j.ijheatmasstransfer.2018.07.072. Epub 2018 Jul 30.


Experimental investigation into the impact of density wave oscillations on flow boiling system dynamic behavior and stability.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Hall NR, Lokey A, Mackey JR.

Int J Heat Mass Transf. 2018 May;120:144-166. doi: 10.1016/j.ijheatmasstransfer.2017.12.011. Epub 2017 Dec 18.


Itaconate: the poster child of metabolic reprogramming in macrophage function.

O'Neill LAJ, Artyomov MN.

Nat Rev Immunol. 2019 May;19(5):273-281. doi: 10.1038/s41577-019-0128-5. Review.


Reflective practice groups: Are they useful for liaison psychiatry nurses working within the Emergency Department?

O'Neill L, Johnson J, Mandela R.

Arch Psychiatr Nurs. 2019 Feb;33(1):85-92. doi: 10.1016/j.apnu.2018.11.003. Epub 2018 Nov 19.


Malonylation of GAPDH is an inflammatory signal in macrophages.

Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA.

Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6.


Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort.

Conway R, O'Neill L, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Killeen RP, Heffernan EJ, Molloy ES.

Clin Exp Rheumatol. 2019 Mar-Apr;37 Suppl 117(2):72-78. Epub 2019 Jan 4.


Pharmacists Providing Palliative Care Services: Demonstrating a Positive Return on Investment.

Lehn JM, Gerkin RD, Kisiel SC, O'Neill L, Pinderhughes ST.

J Palliat Med. 2019 Jun;22(6):644-648. doi: 10.1089/jpm.2018.0082. Epub 2018 Dec 20.


Rocking the world of innate immunity: an interview with Luke O'Neill.

O'Neill LAJ.

Dis Model Mech. 2018 Nov 29;11(12). pii: dmm037838. doi: 10.1242/dmm.037838.


Patient-specific simulations predict efficacy of ablation of interatrial connections for treatment of persistent atrial fibrillation.

Roney CH, Williams SE, Cochet H, Mukherjee RK, O'Neill L, Sim I, Whitaker J, Razeghi O, Klein GJ, Vigmond EJ, O'Neill M, Niederer SA.

Europace. 2018 Nov 1;20(suppl_3):iii55-iii68. doi: 10.1093/europace/euy232.

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