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Items: 28


Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.

Hamza A, Driessen MRM, Tammpere E, O'Neil NJ, Hieter P.

Genetics. 2020 Mar;214(3):735-747. doi: 10.1534/genetics.119.302971. Epub 2020 Jan 14.


MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome.

Tyson JR, O'Neil NJ, Jain M, Olsen HE, Hieter P, Snutch TP.

Genome Res. 2018 Feb;28(2):266-274. doi: 10.1101/gr.221184.117. Epub 2017 Dec 22.


Synthetic lethality and cancer.

O'Neil NJ, Bailey ML, Hieter P.

Nat Rev Genet. 2017 Oct;18(10):613-623. doi: 10.1038/nrg.2017.47. Epub 2017 Jun 26. Review.


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.


Convex and Concave Encapsulation of Multiple Potassium Ions by Sumanenyl Anions.

Spisak SN, Wei Z, O'Neil NJ, Rogachev AY, Amaya T, Hirao T, Petrukhina MA.

J Am Chem Soc. 2015 Aug 12;137(31):9768-71. doi: 10.1021/jacs.5b06662. Epub 2015 Aug 4.


Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.

Li X, O'Neil NJ, Moshgabadi N, Hieter P.

Genetics. 2014 Jun;197(2):611-23. doi: 10.1534/genetics.114.161307. Epub 2014 Mar 20.


Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.

Bailey ML, O'Neil NJ, van Pel DM, Solomon DA, Waldman T, Hieter P.

Mol Cancer Ther. 2014 Mar;13(3):724-32. doi: 10.1158/1535-7163.MCT-13-0749. Epub 2013 Dec 19.


Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.

O'Neil NJ, Martin JS, Youds JL, Ward JD, Petalcorin MI, Rose AM, Boulton SJ.

PLoS Genet. 2013;9(7):e1003582. doi: 10.1371/journal.pgen.1003582. Epub 2013 Jul 18.


Synthetic lethality and cancer: cohesin and PARP at the replication fork.

O'Neil NJ, van Pel DM, Hieter P.

Trends Genet. 2013 May;29(5):290-7. doi: 10.1016/j.tig.2012.12.004. Epub 2013 Jan 18. Review.


Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.

Le Gallo M, O'Hara AJ, Rudd ML, Urick ME, Hansen NF, O'Neil NJ, Price JC, Zhang S, England BM, Godwin AK, Sgroi DC; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter P, Mullikin JC, Merino MJ, Bell DW.

Nat Genet. 2012 Dec;44(12):1310-5. doi: 10.1038/ng.2455. Epub 2012 Oct 28.


Synthetic lethality of cohesins with PARPs and replication fork mediators.

McLellan JL, O'Neil NJ, Barrett I, Ferree E, van Pel DM, Ushey K, Sipahimalani P, Bryan J, Rose AM, Hieter P.

PLoS Genet. 2012;8(3):e1002574. doi: 10.1371/journal.pgen.1002574. Epub 2012 Mar 8.


CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans.

Chung G, O'Neil NJ, Rose AM.

DNA Repair (Amst). 2011 Nov 10;10(11):1174-82. doi: 10.1016/j.dnarep.2011.09.011. Epub 2011 Oct 2.


Genomic sequence of a mutant strain of Caenorhabditis elegans with an altered recombination pattern.

Rose AM, O'Neil NJ, Bilenky M, Butterfield YS, Malhis N, Flibotte S, Jones MR, Marra M, Baillie DL, Jones SJ.

BMC Genomics. 2010 Feb 23;11:131. doi: 10.1186/1471-2164-11-131.


High-resolution array comparative genomic hybridization analysis reveals unanticipated complexity of genetic deficiencies on chromosome V in Caenorhabditis elegans.

Jones MR, Chua SY, O'Neil NJ, Johnsen RC, Rose AM, Baillie DL.

Mol Genet Genomics. 2009 Jul;282(1):37-46. doi: 10.1007/s00438-009-0444-8. Epub 2009 Mar 29.


RTEL1 maintains genomic stability by suppressing homologous recombination.

Barber LJ, Youds JL, Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB, Auclair M, Tissenbaum H, West SC, Rose AM, Boulton SJ.

Cell. 2008 Oct 17;135(2):261-71. doi: 10.1016/j.cell.2008.08.016.


Spectrum of mutational events in the absence of DOG-1/FANCJ in Caenorhabditis elegans.

Zhao Y, Tarailo-Graovac M, O'Neil NJ, Rose AM.

DNA Repair (Amst). 2008 Nov 1;7(11):1846-54. doi: 10.1016/j.dnarep.2008.07.011. Epub 2008 Aug 30.


DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.

Youds JL, Barber LJ, Ward JD, Collis SJ, O'Neil NJ, Boulton SJ, Rose AM.

Mol Cell Biol. 2008 Mar;28(5):1470-9. Epub 2007 Dec 17.


Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1.

Astin JW, O'Neil NJ, Kuwabara PE.

DNA Repair (Amst). 2008 Feb 1;7(2):267-80. Epub 2007 Nov 28.


Poly-G/poly-C tracts in the genomes of Caenorhabditis.

Zhao Y, O'Neil NJ, Rose AM.

BMC Genomics. 2007 Nov 7;8:403.


Identification and analysis of internal promoters in Caenorhabditis elegans operons.

Huang P, Pleasance ED, Maydan JS, Hunt-Newbury R, O'Neil NJ, Mah A, Baillie DL, Marra MA, Moerman DG, Jones SJ.

Genome Res. 2007 Oct;17(10):1478-85. Epub 2007 Aug 21.


TILLING is an effective reverse genetics technique for Caenorhabditis elegans.

Gilchrist EJ, O'Neil NJ, Rose AM, Zetka MC, Haughn GW.

BMC Genomics. 2006 Oct 18;7:262.


Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans.

Youds JL, O'Neil NJ, Rose AM.

Genetics. 2006 Jun;173(2):697-708. Epub 2006 Mar 17.


The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.

Kuervers LM, Jones CL, O'Neil NJ, Baillie DL.

Mol Genet Genomics. 2003 Nov;270(2):121-31. Epub 2003 Aug 5.


iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X.

Nat Genet. 2003 Feb;33(2):162-7. Epub 2003 Jan 13.


RNA-mediated interference as a tool for identifying drug targets.

O'Neil NJ, Martin RL, Tomlinson ML, Jones MR, Coulson A, Kuwabara PE.

Am J Pharmacogenomics. 2001;1(1):45-53. Review.


Identification and characterization of a serine hydroxymethyltransferase isoform in Caenorhabditis briggsae.

Vatcher GP, Barbazuk WB, O'Neil NJ, Marra MA, Ha T, Baillie DL.

Gene. 1999 Apr 16;230(2):137-44.


Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III.

Stewart HI, O'Neil NJ, Janke DL, Franz NW, Chamberlin HM, Howell AM, Gilchrist EJ, Ha TT, Kuervers LM, Vatcher GP, Danielson JL, Baillie DL.

Mol Gen Genet. 1998 Nov;260(2-3):280-8.


Interpreting a sequenced genome: toward a cosmid transgenic library of Caenorhabditis elegans.

Janke DL, Schein JE, Ha T, Franz NW, O'Neil NJ, Vatcher GP, Stewart HI, Kuervers LM, Baillie DL, Rose AM.

Genome Res. 1997 Oct;7(10):974-85.

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