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Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2019 Oct 17;24:102025. doi: 10.1016/j.nicl.2019.102025. [Epub ahead of print]


Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.

Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2019;23:101848. doi: 10.1016/j.nicl.2019.101848. Epub 2019 May 2.


18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD.

Alzheimers Res Ther. 2019 Jan 31;11(1):13. doi: 10.1186/s13195-019-0470-7.


Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C Jr, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD.

Alzheimers Dement. 2019 Feb;15(2):205-216. doi: 10.1016/j.jalz.2018.09.001. Epub 2018 Oct 19.


Geomagnetic field influences upward movement of young Chinook salmon emerging from nests.

Putman NF, Scanlan MM, Pollock AM, O'Neil JP, Couture RB, Stoner JS, Quinn TP, Lohmann KJ, Noakes DLG.

Biol Lett. 2018 Feb;14(2). pii: 20170752. doi: 10.1098/rsbl.2017.0752.


Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML.

JAMA Neurol. 2018 Mar 1;75(3):342-352. doi: 10.1001/jamaneurol.2017.4309.


Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, Boxer AL, Cha J, Karydas A, Jerome G, Maass A, Mensing A, Miller ZA, O'Neil JP, Pham J, Rosen HJ, Tsai R, Visani AV, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2018 Jan 23;90(4):e282-e290. doi: 10.1212/WNL.0000000000004860. Epub 2017 Dec 27.


Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2017 Sep 25;17:452-464. doi: 10.1016/j.nicl.2017.09.016. eCollection 2018.


Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD.

Brain. 2017 Dec 1;140(12):3286-3300. doi: 10.1093/brain/awx243.


Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT.

Huber JS, Hernandez AM, Janabi M, O'Neil JP, Brennan KM, Murphy ST, Seo Y, Gullberg GT.

Mol Imaging. 2017 Jan-Dec;16:1536012117724558. doi: 10.1177/1536012117724558.


Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release.

Berry AS, Shah VD, Furman DJ, White RL 3rd, Baker SL, O'Neil JP, Janabi M, D'Esposito M, Jagust WJ.

Neuropsychopharmacology. 2018 May;43(6):1201-1211. doi: 10.1038/npp.2017.180. Epub 2017 Aug 17.


A catalytic fluoride-rebound mechanism for C(sp3)-CF3 bond formation.

Levin MD, Chen TQ, Neubig ME, Hong CM, Theulier CA, Kobylianskii IJ, Janabi M, O'Neil JP, Toste FD.

Science. 2017 Jun 23;356(6344):1272-1276. doi: 10.1126/science.aan1411.


Amyloid and tau PET demonstrate region-specific associations in normal older people.

Lockhart SN, Schöll M, Baker SL, Ayakta N, Swinnerton KN, Bell RK, Mellinger TJ, Shah VD, O'Neil JP, Janabi M, Jagust WJ.

Neuroimage. 2017 Apr 15;150:191-199. doi: 10.1016/j.neuroimage.2017.02.051. Epub 2017 Feb 21.


Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD.

Neurology. 2017 Feb 21;88(8):758-766. doi: 10.1212/WNL.0000000000003636. Epub 2017 Jan 27.


Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.

Seo SW, Ayakta N, Grinberg LT, Villeneuve S, Lehmann M, Reed B, DeCarli C, Miller BL, Rosen HJ, Boxer AL, O'Neil JP, Jin LW, Seeley WW, Jagust WJ, Rabinovici GD.

Neuroimage Clin. 2016 Nov 11;13:130-137. eCollection 2017.


Aging Affects Dopaminergic Neural Mechanisms of Cognitive Flexibility.

Berry AS, Shah VD, Baker SL, Vogel JW, O'Neil JP, Janabi M, Schwimmer HD, Marks SM, Jagust WJ.

J Neurosci. 2016 Dec 14;36(50):12559-12569. Epub 2016 Nov 2.


Biodistribution of Antibody-MS2 Viral Capsid Conjugates in Breast Cancer Models.

Aanei IL, ElSohly AM, Farkas ME, Netirojjanakul C, Regan M, Taylor Murphy S, O'Neil JP, Seo Y, Francis MB.

Mol Pharm. 2016 Nov 7;13(11):3764-3772. Epub 2016 Sep 30.


Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD.

Brain. 2016 May;139(Pt 5):1551-67. doi: 10.1093/brain/aww027. Epub 2016 Mar 8.


PET Imaging of Tau Deposition in the Aging Human Brain.

Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ.

Neuron. 2016 Mar 2;89(5):971-982. doi: 10.1016/j.neuron.2016.01.028.


Measured bremsstrahlung photonuclear production of 99Mo ((99m)Tc) with 34 MeV to 1.7 GeV electrons.

Roberts AD, Geddes CGR, Matlis N, Nakamura K, O'Neil JP, Shaw BH, Steinke S, van Tilborg J, Leemans WP.

Appl Radiat Isot. 2015 Feb;96:122-128. doi: 10.1016/j.apradiso.2014.11.008. Epub 2014 Nov 14.


Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.

Ossenkoppele R, Schonhaut DR, Baker SL, O'Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD.

Ann Neurol. 2015 Feb;77(2):338-42. doi: 10.1002/ana.24321. Epub 2014 Dec 17.


Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability.

Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ.

Cereb Cortex. 2016 Feb;26(2):695-707. doi: 10.1093/cercor/bhu259. Epub 2014 Nov 7.


Neural compensation in older people with brain amyloid-β deposition.

Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ.

Nat Neurosci. 2014 Oct;17(10):1316-8. doi: 10.1038/nn.3806. Epub 2014 Sep 14.


Chemical stability of (99m)Tc-DTPA under aerobic and microbially mediated Fe(III)-reducing conditions in porous media.

Slowey AJ, Vandehey NT, O'Neil JP, Boutchko R, Moses WW, Nico PS.

Appl Radiat Isot. 2014 Dec;94:175-181. doi: 10.1016/j.apradiso.2014.08.005. Epub 2014 Aug 19.


Capturing [¹¹C]CO₂ for use in aqueous applications.

Vandehey NT, O'Neil JP.

Appl Radiat Isot. 2014 Aug;90:74-8. doi: 10.1016/j.apradiso.2014.03.013. Epub 2014 Mar 20.


An inherited magnetic map guides ocean navigation in juvenile Pacific salmon.

Putman NF, Scanlan MM, Billman EJ, O'Neil JP, Couture RB, Quinn TP, Lohmann KJ, Noakes DL.

Curr Biol. 2014 Feb 17;24(4):446-50. doi: 10.1016/j.cub.2014.01.017. Epub 2014 Feb 6.


Practical utility of amyloid and FDG-PET in an academic dementia center.

Sánchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2014 Jan 21;82(3):230-8. doi: 10.1212/WNL.0000000000000032. Epub 2013 Dec 18.


Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry.

Mitchell JM, O'Neil JP, Jagust WJ, Fields HL.

Clin Transl Sci. 2013 Oct;6(5):400-3. doi: 10.1111/cts.12075. Epub 2013 Jun 13.


Longitudinal evaluation of left ventricular substrate metabolism, perfusion, and dysfunction in the spontaneously hypertensive rat model of hypertrophy using small-animal PET/CT imaging.

Hernandez AM, Huber JS, Murphy ST, Janabi M, Zeng GL, Brennan KM, O'Neil JP, Seo Y, Gullberg GT.

J Nucl Med. 2013 Nov;54(11):1938-45. doi: 10.2967/jnumed.113.120105. Epub 2013 Oct 3.


Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients.

Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O'Neil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD.

J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):266-73. doi: 10.1136/jnnp-2013-305858. Epub 2013 Aug 21.


PET Imaging and biodistribution of chemically modified bacteriophage MS2.

Farkas ME, Aanei IL, Behrens CR, Tong GJ, Murphy ST, O'Neil JP, Francis MB.

Mol Pharm. 2013 Jan 7;10(1):69-76. doi: 10.1021/mp3003754. Epub 2012 Dec 26.


Genetic effects on behavior are mediated by neurotransmitters and large-scale neural networks.

Dang LC, O'Neil JP, Jagust WJ.

Neuroimage. 2013 Feb 1;66:203-14. doi: 10.1016/j.neuroimage.2012.10.090. Epub 2012 Nov 8.


Monitoring Tc dynamics in a bioreduced sediment: an investigation with gamma camera imaging of (99m)Tc-pertechnetate and (99m)Tc-DTPA.

Vandehey NT, O'Neil JP, Slowey AJ, Boutchko R, Druhan JL, Moses WW, Nico PS.

Environ Sci Technol. 2012 Nov 20;46(22):12583-90. doi: 10.1021/es302313h. Epub 2012 Nov 2.


Dopamine supports coupling of attention-related networks.

Dang LC, O'Neil JP, Jagust WJ.

J Neurosci. 2012 Jul 11;32(28):9582-7. doi: 10.1523/JNEUROSCI.0909-12.2012.


Striatal dopamine influences the default mode network to affect shifting between object features.

Dang LC, Donde A, Madison C, O'Neil JP, Jagust WJ.

J Cogn Neurosci. 2012 Sep;24(9):1960-70. doi: 10.1162/jocn_a_00252. Epub 2012 May 29.


Association of lifetime cognitive engagement and low β-amyloid deposition.

Landau SM, Marks SM, Mormino EC, Rabinovici GD, Oh H, O'Neil JP, Wilson RS, Jagust WJ.

Arch Neurol. 2012 May;69(5):623-29.


Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens.

Mitchell JM, O'Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL.

Sci Transl Med. 2012 Jan 11;4(116):116ra6. doi: 10.1126/scitranslmed.3002902.


Imaging and modeling of flow in porous media using clinical nuclear emission tomography systems and computational fluid dynamics.

Boutchko R, Rayz VL, Vandehey NT, O'Neil JP, Budinger TF, Nico PS, Druhan JL, Saloner DA, Gullberg GT, Moses WW.

J Appl Geophy. 2012 Jan;76:74-81.


Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.

Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ.

Neurology. 2011 Dec 6;77(23):2034-42. doi: 10.1212/WNL.0b013e31823b9c5e. Epub 2011 Nov 30.


Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution.

Rosenbloom MH, Alkalay A, Agarwal N, Baker SL, O'Neil JP, Janabi M, Yen IV, Growdon M, Jang J, Madison C, Mormino EC, Rosen HJ, Gorno-Tempini ML, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD.

Neurology. 2011 May 24;76(21):1789-96. doi: 10.1212/WNL.0b013e31821cccad. Epub 2011 Apr 27.


Dopamine and frontostriatal networks in cognitive aging.

Klostermann EC, Braskie MN, Landau SM, O'Neil JP, Jagust WJ.

Neurobiol Aging. 2012 Mar;33(3):623.e15-24. doi: 10.1016/j.neurobiolaging.2011.03.002. Epub 2011 Apr 20.


Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes.

Vasdev N, Dorff PN, O'Neil JP, Chin FT, Hanrahan S, VanBrocklin HF.

Bioorg Med Chem. 2011 May 1;19(9):2959-65. doi: 10.1016/j.bmc.2011.03.032. Epub 2011 Mar 21.


Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults.

Braskie MN, Landau SM, Wilcox CE, Taylor SD, O'Neil JP, Baker SL, Madison CM, Jagust WJ.

Hum Brain Mapp. 2011 Jun;32(6):947-61. doi: 10.1002/hbm.21081. Epub 2010 Jun 24.


Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden.

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O'Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ.

Brain. 2010 Feb;133(Pt 2):512-28. doi: 10.1093/brain/awp326. Epub 2010 Jan 15.


Relationship of striatal dopamine synthesis capacity to age and cognition.

Braskie MN, Wilcox CE, Landau SM, O'Neil JP, Baker SL, Madison CM, Kluth JT, Jagust WJ.

J Neurosci. 2008 Dec 24;28(52):14320-8. doi: 10.1523/JNEUROSCI.3729-08.2008.


Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia.

Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, O'Neil JP, Lal RA, Dronkers NF, Miller BL, Gorno-Tempini ML.

Ann Neurol. 2008 Oct;64(4):388-401. doi: 10.1002/ana.21451.


PET 6-[F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates.

Eberling JL, Bankiewicz KS, O'Neil JP, Jagust WJ.

Front Hum Neurosci. 2008 Mar 28;1:9. doi: 10.3389/neuro.09.009.2007. eCollection 2007.


Striatal dopamine and working memory.

Landau SM, Lal R, O'Neil JP, Baker S, Jagust WJ.

Cereb Cortex. 2009 Feb;19(2):445-54. doi: 10.1093/cercor/bhn095. Epub 2008 Jun 11.


Genome-free viral capsids as carriers for positron emission tomography radiolabels.

Hooker JM, O'Neil JP, Romanini DW, Taylor SE, Francis MB.

Mol Imaging Biol. 2008 Jul-Aug;10(4):182-91. doi: 10.1007/s11307-008-0136-5. Epub 2008 Apr 25.


Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease.

Boxer AL, Rabinovici GD, Kepe V, Goldman J, Furst AJ, Huang SC, Baker SL, O'neil JP, Chui H, Geschwind MD, Small GW, Barrio JR, Jagust W, Miller BL.

Neurology. 2007 Jul 17;69(3):283-90.


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