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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M.

Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun.


Diagnostic performance of a new anti-carbamylated protein assay in rheumatic diseases.

Shi J, Milo J, Brady K, Bentow C, Conklin J, O'Malley T, Poling D, Ibarra C, Mahler M, Dervieux T.

Scand J Rheumatol. 2018 Nov 13:1-2. doi: 10.1080/03009742.2018.1530372. [Epub ahead of print] No abstract available.


Cell-bound complement activation products (CB-CAPs) have high sensitivity and specificity in pediatric-onset systemic lupus erythematosus and correlate with disease activity.

Hui-Yuen JS, Gartshteyn Y, Ma M, O'Malley T, Conklin J, Eichenfield AH, Imundo LF, Dervieux T, Askanase AD.

Lupus. 2018 Dec;27(14):2262-2268. doi: 10.1177/0961203318809181. Epub 2018 Oct 30.


Significant Association of Aldosterone and Liver Fat Among HIV-Infected Individuals With Metabolic Dysregulation.

Srinivasa S, Fitch KV, Quadri N, Maehler P, O'Malley TK, Martinez-Salazar EL, Burdo TH, Feldpausch M, Torriani M, Adler GK, Grinspoon SK.

J Endocr Soc. 2018 Sep 3;2(10):1147-1157. doi: 10.1210/js.2018-00194. eCollection 2018 Oct 1.


An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM.

Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w.


Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.

Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T.

BMC Res Notes. 2018 Jun 28;11(1):416. doi: 10.1186/s13104-018-3526-z.


Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals.

Srinivasa S, Aulinas A, O'Malley T, Maehler P, Adler GK, Grinspoon SK, Lawson EA.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E671-E675. doi: 10.1152/ajpendo.00190.2018. Epub 2018 Jun 26.


Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ.

Cell Rep. 2018 May 15;23(7):1932-1938. doi: 10.1016/j.celrep.2018.04.040.


Production and Use of Recombinant Aβ for Aggregation Studies.

O'Malley TT, Linse S, Walsh DM.

Methods Mol Biol. 2018;1777:307-320. doi: 10.1007/978-1-4939-7811-3_19.


Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM.

Acta Neuropathol. 2018 Jul;136(1):19-40. doi: 10.1007/s00401-018-1846-7. Epub 2018 Apr 23.


Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV.

Srinivasa S, Fitch KV, Wong K, O'Malley TK, Maehler P, Branch KL, Looby SE, Burdo TH, Martinez-Salazar EL, Torriani M, Lyons SH, Weiss J, Feldpausch M, Stanley TL, Adler GK, Grinspoon SK.

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2376-2384. doi: 10.1210/jc.2018-00330.


Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels.

O'Malley T, Alling T, Early JV, Wescott HA, Kumar A, Moraski GC, Miller MJ, Masquelin T, Hipskind PA, Parish T.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02439-17. doi: 10.1128/AAC.02439-17. Print 2018 Jun.


#MaybeHeDoesntHitYou: Social Media Underscore the Realities of Intimate Partner Violence.

McCauley HL, Bonomi AE, Maas MK, Bogen KW, O'Malley TL.

J Womens Health (Larchmt). 2018 Jul;27(7):885-891. doi: 10.1089/jwh.2017.6560. Epub 2018 Mar 22.


The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Tuberculosis (Edinb). 2018 Jan;108:96-98. doi: 10.1016/ Epub 2017 Nov 7.


Performance Characteristics of Different Anti-Double-Stranded DNA Antibody Assays in the Monitoring of Systemic Lupus Erythematosus.

Mahler M, Bentow C, O'Malley T, Ibarra C, Conklin J, Aure MAR, Dervieux T.

J Immunol Res. 2017;2017:1720902. doi: 10.1155/2017/1720902. Epub 2017 Dec 31.


Preventing Violence: A Public Health Participatory Approach to Homicide Reviews.

O'Malley TL, Documét PI, Burke JG, Garland R, Terry A, Slade RL Sr, Albert SM.

Health Promot Pract. 2018 May;19(3):427-436. doi: 10.1177/1524839917697914. Epub 2017 Mar 7.


Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.

Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T.

ACS Infect Dis. 2017 Dec 8;3(12):898-916. doi: 10.1021/acsinfecdis.7b00112. Epub 2017 Oct 31.


Epicardial adipose tissue volume and cardiovascular risk indices among asymptomatic women with and without HIV.

Srinivasa S, Lu MT, Fitch KV, Hallett TR, O'Malley TK, Stone LA, Martin A, Coromilas AJ, Burdo TH, Triant VA, Lo J, Looby SE, Neilan TG, Zanni MV.

Antivir Ther. 2018;23(1):1-9. doi: 10.3851/IMP3193.


Perioperative Management of Factor V Leiden and Pancreatic Adenocarcinoma.

O'Malley TJ, Sooppan R, Yeo CJ.

J Pancreat Cancer. 2017 Aug 1;3(1):53-57. doi: 10.1089/pancan.2017.0010. eCollection 2017.


Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males.

O'Malley T, Myette-Cote E, Durrer C, Little JP.

Appl Physiol Nutr Metab. 2017 Oct;42(10):1031-1035. doi: 10.1139/apnm-2016-0641. Epub 2017 Jul 27.


A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.

Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e01205-17. doi: 10.1128/AAC.01205-17. Print 2017 Sep.


Buckle of the bariatric surgery belt: an analysis of regional disparities in bariatric surgery.

Hennings DL, O'Malley TJ, Baimas-George M, Al-Qurayshi Z, Kandil E, DuCoin C.

Surg Obes Relat Dis. 2017 Aug;13(8):1290-1295. doi: 10.1016/j.soard.2017.03.027. Epub 2017 Apr 6.


Acute hyperinsulinemia effects on systemic markers of immune activation in HIV.

O'Malley TK, Burdo TH, Robinson JA, Fitch KV, Grinspoon SK, Srinivasa S.

AIDS. 2017 Jul 31;31(12):1771-1773. doi: 10.1097/QAD.0000000000001545.


Capillary blood collected on volumetric absorptive microsampling (VAMS) device for monitoring hydroxychloroquine in rheumatoid arthritis patients.

Qu Y, Brady K, Apilado R, O'Malley T, Reddy S, Chitkara P, Ibarra C, Alexander RV, Dervieux T.

J Pharm Biomed Anal. 2017 Jun 5;140:334-341. doi: 10.1016/j.jpba.2017.03.047. Epub 2017 Mar 27.


Validation of a multi-analyte panel with cell-bound complement activation products for systemic lupus erythematosus.

Dervieux T, Conklin J, Ligayon JA, Wolover L, O'Malley T, Alexander RV, Weinstein A, Ibarra CA.

J Immunol Methods. 2017 Jul;446:54-59. doi: 10.1016/j.jim.2017.04.001. Epub 2017 Apr 5.


Housing Relocation Policy and Violence: A Literature Review.

Casas A, Duell J, O'Malley T, Documet P, Garland R, Albert S, Fabio A.

Trauma Violence Abuse. 2016 Dec;17(5):601-610. Epub 2015 Sep 6. Review.


The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer.

O'Malley TT, Witbold WM 3rd, Linse S, Walsh DM.

Biochemistry. 2016 Nov 8;55(44):6150-6161. Epub 2016 Oct 26.


A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.

Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T.

ACS Infect Dis. 2016 Dec 9;2(12):893-902. Epub 2016 Sep 19.


Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.


A systematic review of microfinance and women's health literature: Directions for future research.

O'Malley TL, Burke JG.

Glob Public Health. 2017 Nov;12(11):1433-1460. doi: 10.1080/17441692.2016.1170181. Epub 2016 Apr 15. Review.


Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S.

Neurobiol Dis. 2016 Jan;85:111-121. doi: 10.1016/j.nbd.2015.10.019. Epub 2015 Oct 22.


Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier.

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M.

Sci Adv. 2015 Sep 4;1(8):e1500472.


IgG Conformer's Binding to Amyloidogenic Aggregates.

Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B.

PLoS One. 2015 Sep 14;10(9):e0137344. doi: 10.1371/journal.pone.0137344. eCollection 2015.


Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates.

Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P.

Adv Healthc Mater. 2015 Oct;4(14):2100-2109. doi: 10.1002/adhm.201500487. Epub 2015 Aug 19.


C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM.

J Neurosci. 2015 Jul 29;35(30):10851-65. doi: 10.1523/JNEUROSCI.0387-15.2015.


The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.

Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM 3rd, Frosch MP, Walsh DM.

Alzheimers Dement. 2015 Nov;11(11):1286-305. doi: 10.1016/j.jalz.2015.01.005. Epub 2015 Apr 4.


A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.

Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.


Isolation and characterization of compound-resistant isolates of Mycobacterium tuberculosis.

O'Malley T, Melief E.

Methods Mol Biol. 2015;1285:317-28. doi: 10.1007/978-1-4939-2450-9_19.


Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, Parish T.

Bioorg Med Chem. 2014 Dec 15;22(24):6965-79. doi: 10.1016/j.bmc.2014.10.007. Epub 2014 Oct 22.


Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements.

Putterman C, Furie R, Ramsey-Goldman R, Askanase A, Buyon J, Kalunian K, Chatham WW, Massarotti E, Kirou K, Jordan N, Blanco I, Weinstein A, Chitkara P, Manzi S, Ahearn J, O'Malley T, Conklin J, Ibarra C, Barken D, Dervieux T.

Lupus Sci Med. 2014 Oct 1;1(1):e000056. doi: 10.1136/lupus-2014-000056. eCollection 2014.


A patient-centered longitudinal care plan: vision versus reality.

Dykes PC, Samal L, Donahue M, Greenberg JO, Hurley AC, Hasan O, O'Malley TA, Venkatesh AK, Volk LA, Bates DW.

J Am Med Inform Assoc. 2014 Nov-Dec;21(6):1082-90. doi: 10.1136/amiajnl-2013-002454. Epub 2014 Jul 4.


APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.

Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I.

Cell Rep. 2014 Jun 12;7(5):1560-1576. doi: 10.1016/j.celrep.2014.04.024. Epub 2014 May 15.


Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.

O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM.

Biochem J. 2014 Aug 1;461(3):413-26. doi: 10.1042/BJ20140219.


Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ.

Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27.


mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo.

Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ.

Nat Commun. 2014 Mar 4;5:3374. doi: 10.1038/ncomms4374.


Progressive change of intra-islet GLP-1 production during diabetes development.

O'Malley TJ, Fava GE, Zhang Y, Fonseca VA, Wu H.

Diabetes Metab Res Rev. 2014 Nov;30(8):661-8. doi: 10.1002/dmrr.2534.


Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.

Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC.

PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013.


Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J.

Nat Commun. 2013;4:2416. doi: 10.1038/ncomms3416.


Getting from here to there with longitudinal quality metrics.

Derr JF, O'Malley TA.

J AHIMA. 2013 Feb;84(2):48-9. No abstract available.


New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF.

Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ.

Alzheimers Dement. 2013 Mar;9(2):99-112. doi: 10.1016/j.jalz.2012.11.005. Epub 2013 Jan 30.

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