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Items: 1 to 50 of 68

1.

Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.

Haselmayer P, Camps M, Liu-Bujalski L, Nguyen N, Morandi F, Head J, O'Mahony A, Zimmerli SC, Bruns L, Bender AT, Schroeder P, Grenningloh R.

J Immunol. 2019 May 15;202(10):2888-2906. doi: 10.4049/jimmunol.1800583. Epub 2019 Apr 15.

2.

Screening for Myositis Antibodies in Interstitial Lung Disease.

O'Mahony AM, Murphy GM, Henry MT.

Lung. 2019 Jun;197(3):395-397. doi: 10.1007/s00408-019-00226-3. Epub 2019 Apr 5. No abstract available.

PMID:
30953143
3.

Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.

O'Mahony A, John MR, Cho H, Hashizume M, Choy EH.

J Transl Med. 2018 Jun 7;16(1):156. doi: 10.1186/s12967-018-1532-5.

4.

Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation.

Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y, Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K, Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C, Pidala J, Anasetti C, Yu XZ.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1582-1587. doi: 10.1073/pnas.1712452115. Epub 2018 Jan 30.

5.

Conceptualising a model to guide nursing and midwifery in the community guided by an evidence review.

Leahy-Warren P, Mulcahy H, Benefield L, Bradley C, Coffey A, Donohoe A, Fitzgerald S, Frawley T, Healy E, Healy M, Kelly M, McCarthy B, McLoughlin K, Meagher C, O'Connell R, O'Mahony A, Paul G, Phelan A, Stokes D, Walsh J, Savage E.

BMC Nurs. 2017 Jun 29;16:35. doi: 10.1186/s12912-017-0225-3. eCollection 2017.

6.

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

Shah F, Stepan AF, O'Mahony A, Velichko S, Folias AE, Houle C, Shaffer CL, Marcek J, Whritenour J, Stanton R, Berg EL.

Cell Chem Biol. 2017 Jul 20;24(7):858-869.e5. doi: 10.1016/j.chembiol.2017.06.003. Epub 2017 Jun 29.

7.

Establishing Content Validity of the CLEFT-Q: A New Patient-reported Outcome Instrument for Cleft Lip/Palate.

Tsangaris E, Wong Riff KWY, Goodacre T, Forrest CR, Dreise M, Sykes J, de Chalain T, Harman K, O'Mahony A, Pusic AL, Thabane L, Thoma A, Klassen AF.

Plast Reconstr Surg Glob Open. 2017 Apr 25;5(4):e1305. doi: 10.1097/GOX.0000000000001305. eCollection 2017 Apr.

8.

Invasive cervical resorption and the oro-facial cleft patient: a review and case series.

O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J.

Br Dent J. 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. Review.

PMID:
28496230
9.

Six years of national mental health seclusion data: the Australian experience.

Allan JA, Hanson GD, Schroder NL, O'Mahony AJ, Foster RMP, Sara GE.

Australas Psychiatry. 2017 Jun;25(3):277-281. doi: 10.1177/1039856217700298. Epub 2017 Apr 4.

PMID:
28375028
10.

Normalising breastfeeding within a formula feeding culture: An Irish qualitative study.

Leahy-Warren P, Creedon M, O'Mahony A, Mulcahy H.

Women Birth. 2017 Apr;30(2):e103-e110. doi: 10.1016/j.wombi.2016.10.002. Epub 2016 Nov 5.

PMID:
27825777
11.

Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR.

J Med Chem. 2016 May 26;59(10):4800-11. doi: 10.1021/acs.jmedchem.6b00012. Epub 2016 May 3.

12.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O'Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S.

Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9.

13.

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Hammitzsch A, Tallant C, Fedorov O, O'Mahony A, Brennan PE, Hay DA, Martinez FO, Al-Mossawi MH, de Wit J, Vecellio M, Wells C, Wordsworth P, Müller S, Knapp S, Bowness P.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73. doi: 10.1073/pnas.1501956112. Epub 2015 Aug 10.

14.

Effectively engaging the private sector through vouchers and contracting - A case for analysing health governance and context.

Nachtnebel M, O'Mahony A, Pillai N, Hort K.

Soc Sci Med. 2015 Nov;145:193-200. doi: 10.1016/j.socscimed.2015.05.021. Epub 2015 May 14. Review.

PMID:
26004065
15.

Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Berg EL, Polokoff MA, O'Mahony A, Nguyen D, Li X.

Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.

16.

Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.

Mc Carthy DJ, Malhotra M, O'Mahony AM, Cryan JF, O'Driscoll CM.

Pharm Res. 2015 Apr;32(4):1161-85. doi: 10.1007/s11095-014-1545-6. Epub 2014 Dec 2. Review.

PMID:
25446769
17.

Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies.

Lawless E, Griffin BT, O'Mahony A, O'Driscoll CM.

Pharm Res. 2015 May;32(5):1817-29. doi: 10.1007/s11095-014-1578-x. Epub 2014 Nov 27.

PMID:
25428258
18.

Obstetric and perinatal outcomes of twin pregnancies conceived following IVF/ICSI treatment compared with spontaneously conceived twin pregnancies.

Geisler ME, O'Mahony A, Meaney S, Waterstone JJ, O'Donoghue K.

Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:78-83. doi: 10.1016/j.ejogrb.2014.07.033. Epub 2014 Aug 1.

PMID:
25129152
19.

Orthogonal identification of gunshot residue with complementary detection principles of voltammetry, scanning electron microscopy, and energy-dispersive X-ray spectroscopy: sample, screen, and confirm.

O'Mahony AM, Samek IA, Sattayasamitsathit S, Wang J.

Anal Chem. 2014 Aug 19;86(16):8031-6. doi: 10.1021/ac5016112. Epub 2014 Aug 8.

PMID:
25084547
20.

Early-stage development of novel cyclodextrin-siRNA nanocomplexes allows for successful postnebulization transfection of bronchial epithelial cells.

Hibbitts A, O'Mahony AM, Forde E, Nolan L, Ogier J, Desgranges S, Darcy R, MacLoughlin R, O'Driscoll CM, Cryan SA.

J Aerosol Med Pulm Drug Deliv. 2014 Dec;27(6):466-77. doi: 10.1089/jamp.2013.1045.

PMID:
24665866
21.

Biophysical and structural characterisation of nucleic acid complexes with modified cyclodextrins using circular dichroism.

O'Mahony AM, Cronin MF, McMahon A, Evans JC, Daly K, Darcy R, O'Driscoll CM.

J Pharm Sci. 2014 May;103(5):1346-55. doi: 10.1002/jps.23922. Epub 2014 Mar 6.

PMID:
24604260
22.

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.

Ciceri P, Müller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S.

Nat Chem Biol. 2014 Apr;10(4):305-12. doi: 10.1038/nchembio.1471. Epub 2014 Mar 2. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.

23.

Gastrointestinal gene delivery by cyclodextrins--in vitro quantification of extracellular barriers.

O'Neill MJ, O'Mahony AM, Byrne C, Darcy R, O'Driscoll CM.

Int J Pharm. 2013 Nov 18;456(2):390-9. doi: 10.1016/j.ijpharm.2013.08.073. Epub 2013 Sep 7.

PMID:
24016741
24.

Non-viral nanosystems for gene and small interfering RNA delivery to the central nervous system: formulating the solution.

O'Mahony AM, Godinho BM, Cryan JF, O'Driscoll CM.

J Pharm Sci. 2013 Oct;102(10):3469-84. doi: 10.1002/jps.23672. Epub 2013 Jul 26. Review.

PMID:
23893329
25.

Solid-state Forensic Finger sensor for integrated sampling and detection of gunshot residue and explosives: towards 'Lab-on-a-finger'.

Bandodkar AJ, O'Mahony AM, Ramírez J, Samek IA, Anderson SM, Windmiller JR, Wang J.

Analyst. 2013 Sep 21;138(18):5288-95. doi: 10.1039/c3an01179h. Epub 2013 Jul 18.

PMID:
23865089
26.

Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery.

O'Mahony AM, Ogier J, Darcy R, Cryan JF, O'Driscoll CM.

PLoS One. 2013 Jun 21;8(6):e66413. doi: 10.1371/journal.pone.0066413. Print 2013.

27.

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.

Melton AC, Melrose J, Alajoki L, Privat S, Cho H, Brown N, Plavec AM, Nguyen D, Johnston ED, Yang J, Polokoff MA, Plavec I, Berg EL, O'Mahony A.

PLoS One. 2013;8(3):e58966. doi: 10.1371/journal.pone.0058966. Epub 2013 Mar 7.

28.

Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: in vitro investigations.

Guo J, O'Mahony AM, Cheng WP, O'Driscoll CM.

Int J Pharm. 2013 Apr 15;447(1-2):150-7. doi: 10.1016/j.ijpharm.2013.02.050. Epub 2013 Mar 1.

PMID:
23467082
29.

Repair of anterior cleft palate fistulae with cancellous bone graft: a simple technique that facilitates dental reconstruction.

Martin-Smith JD, O'Sullivan JB, Duggan L, O'Mahony A, Orr DJ.

Plast Reconstr Surg. 2013 Mar;131(3):380e-7e. doi: 10.1097/PRS.0b013e31827c7027.

PMID:
23446588
30.

In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery.

O'Mahony AM, Desgranges S, Ogier J, Quinlan A, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM.

Pharm Res. 2013 Apr;30(4):1086-98. doi: 10.1007/s11095-012-0945-8. Epub 2012 Nov 29.

PMID:
23192687
31.

Rapid field identification of subjects involved in firearm-related crimes based on electroanalysis coupled with advanced chemometric data treatment.

Cetó X, O'Mahony AM, Samek IA, Windmiller JR, del Valle M, Wang J.

Anal Chem. 2012 Dec 4;84(23):10306-14. doi: 10.1021/ac302361z. Epub 2012 Nov 12.

PMID:
23121395
32.

Click-modified cyclodextrins as nonviral vectors for neuronal siRNA delivery.

O'Mahony AM, Godinho BM, Ogier J, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM.

ACS Chem Neurosci. 2012 Oct 17;3(10):744-52. doi: 10.1021/cn3000372. Epub 2012 Aug 3.

33.

Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications.

O'Mahony AM, Doyle D, Darcy R, Cryan JF, O'Driscoll CM.

Eur J Pharm Sci. 2012 Dec 18;47(5):896-903. doi: 10.1016/j.ejps.2012.08.020. Epub 2012 Sep 25.

PMID:
23022516
34.

Simultaneous electrochemical measurement of metal and organic propellant constituents of gunshot residues.

Vuki M, Shiu KK, Galik M, O'Mahony AM, Wang J.

Analyst. 2012 Jul 21;137(14):3265-70. doi: 10.1039/c2an35379b. Epub 2012 May 31.

PMID:
22649790
35.

A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.

O'Mahony AM, Ogier J, Desgranges S, Cryan JF, Darcy R, O'Driscoll CM.

Org Biomol Chem. 2012 Jul 7;10(25):4954-60. doi: 10.1039/c2ob25490e. Epub 2012 May 21.

PMID:
22614240
36.

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.

Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Müller K, Perrin J, Rau C, Ellard K, Hopf C, Doce C, Leggate D, Mangano R, Mathieson T, O'Mahony A, Plavec I, Rharbaoui F, Reinhard F, Savitski MM, Ramsden N, Hirsch E, Drewes G, Rausch O, Bantscheff M, Neubauer G.

Nat Chem Biol. 2012 Apr 29;8(6):576-82. doi: 10.1038/nchembio.957. Erratum in: Nat Chem Biol. 2012 Aug;8(8):737.

PMID:
22544264
37.

RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents.

Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, O'Mahony A, Owens TD, Lou Y, Hill RJ, Narula S, DeMartino J, Fine JS.

J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6.

PMID:
22228807
38.

Toward membrane-free amperometric gas sensors: a microelectrode array approach.

Huang XJ, Aldous L, O'Mahony AM, del Campo FJ, Compton RG.

Anal Chem. 2010 Jun 15;82(12):5238-45. doi: 10.1021/ac1006359.

PMID:
20469834
39.

Modification and implications of changes in electrochemical responses encountered when undertaking deoxygenation in ionic liquids.

Zhao C, Bond AM, Compton RG, O'Mahony AM, Rogers EI.

Anal Chem. 2010 May 1;82(9):3856-61. doi: 10.1021/ac100378g.

PMID:
20392069
40.

Voltammetry in room temperature ionic liquids: comparisons and contrasts with conventional electrochemical solvents.

Barrosse-Antle LE, Bond AM, Compton RG, O'Mahony AM, Rogers EI, Silvester DS.

Chem Asian J. 2010 Feb 1;5(2):202-30. doi: 10.1002/asia.200900191. Review.

PMID:
20013990
41.

Microarrays of ring-recessed disk electrodes in transient generator-collector mode: theory and experiment.

Menshykau D, O'Mahony AM, del Campo FJ, Munõz FX, Compton RG.

Anal Chem. 2009 Nov 15;81(22):9372-82. doi: 10.1021/ac9017633.

PMID:
19835354
42.

Microelectrode arrays for electrochemistry: approaches to fabrication.

Huang XJ, O'Mahony AM, Compton RG.

Small. 2009 Apr;5(7):776-88. doi: 10.1002/smll.200801593. Review.

PMID:
19340821
43.

Delayed allergic reactions to omalizumab: are patients reporting all cases?

Barry PJ, O'Mahony A, Finnegan C, O'Connor TM.

J Allergy Clin Immunol. 2008 Mar;121(3):785-6; author reply 786. doi: 10.1016/j.jaci.2007.12.1184. No abstract available.

PMID:
18328902
44.

Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection.

Lee AW, Sharp ER, O'Mahony A, Rosenberg MG, Israelski DM, Nolan GP, Nixon DF.

J Virol. 2008 Apr;82(7):3702-12. doi: 10.1128/JVI.01582-07. Epub 2008 Jan 23.

45.

NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity.

O'Mahony A, Raber J, Montano M, Foehr E, Han V, Lu SM, Kwon H, LeFevour A, Chakraborty-Sett S, Greene WC.

Mol Cell Biol. 2006 Oct;26(19):7283-98.

46.

Promoting the positive aspects of dentistry.

O'Mahony A.

J Ir Dent Assoc. 2005 Spring;51(1):5. No abstract available.

PMID:
15789983
48.

Will dental insurance affect the quality of dental care?

O'Mahony A.

J Ir Dent Assoc. 2004 Fall;50(3):101. No abstract available.

PMID:
15481518
49.

Make health and safety a priority.

O'Mahony A.

J Ir Dent Assoc. 2004 Summer;50(2):52. No abstract available.

PMID:
15239577
50.

Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.

O'Mahony AM, Montano M, Van Beneden K, Chen LF, Greene WC.

J Biol Chem. 2004 Apr 30;279(18):18137-45. Epub 2004 Feb 12.

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