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Items: 1 to 50 of 83

1.

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base.

White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL.

J Glob Oncol. 2018 Sep;(4):1-10. doi: 10.1200/JGO.17.00099. Epub 2017 Nov 16.

PMID:
30241135
2.

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14.

PMID:
30106296
3.

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7854-E7862. doi: 10.1073/pnas.1806022115. Epub 2018 Jul 30.

4.

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR.

ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13.

PMID:
29812901
5.

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6.

PMID:
29624062
6.

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Org Chem. 2018 Jan 19;83(2):951-963. doi: 10.1021/acs.joc.7b02951. Epub 2018 Jan 10.

PMID:
29286245
7.

US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer.

Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji T, White JD.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx007.

PMID:
29140488
8.

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).

Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR.

SLAS Discov. 2017 Jul 1:2472555217717200. doi: 10.1177/2472555217717200. [Epub ahead of print]

PMID:
28697309
9.

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.

Zlotkowski K, Hewitt WM, Yan P, Bokesch HR, Peach ML, Nicklaus MC, O'Keefe BR, McMahon JB, Gustafson KR, Schneekloth JS Jr.

Org Lett. 2017 Apr 7;19(7):1726-1729. doi: 10.1021/acs.orglett.7b00496. Epub 2017 Mar 27.

PMID:
28345939
10.

Antiviral lectins: Selective inhibitors of viral entry.

Mitchell CA, Ramessar K, O'Keefe BR.

Antiviral Res. 2017 Jun;142:37-54. doi: 10.1016/j.antiviral.2017.03.007. Epub 2017 Mar 18. Review.

11.

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa.

Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151. Epub 2017 Mar 14.

12.

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.

Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2017 Jan 27;80(1):220-224. doi: 10.1021/acs.jnatprod.6b01153. Epub 2017 Jan 18.

13.

Acetophenone Monomers from Acronychia trifoliolata.

Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K.

J Nat Prod. 2016 Nov 23;79(11):2883-2889. Epub 2016 Oct 24.

14.

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.

Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G.

Viruses. 2016 Jun 6;8(6). pii: E158. doi: 10.3390/v8060158.

15.

Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro.

Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T.

Plant Cell Rep. 2016 Jun;35(6):1309-19. doi: 10.1007/s00299-016-1963-5. Epub 2016 Mar 23.

PMID:
27007716
16.

The canSAR data hub for drug discovery.

Chau CH, O'Keefe BR, Figg WD.

Lancet Oncol. 2016 Mar;17(3):286. doi: 10.1016/S1470-2045(16)00095-4. Epub 2016 Mar 2. No abstract available.

PMID:
26972856
17.

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T.

Plant Biotechnol J. 2016 Jun;14(6):1427-37. doi: 10.1111/pbi.12507. Epub 2016 Jan 23.

18.

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR.

J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4.

PMID:
26538432
19.

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).

Jakób M, Lubkowski J, O'Keefe BR, Wlodawer A.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1429-36. doi: 10.1107/S2053230X15019858. Epub 2015 Oct 24.

20.

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus.

Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7290-8. doi: 10.1128/AAC.01816-15. Epub 2015 Sep 14.

21.

Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model.

Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, Samuelson J.

PLoS One. 2015 Aug 7;10(8):e0135340. doi: 10.1371/journal.pone.0135340. eCollection 2015.

22.

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus.

Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LR, Constantine B, Wilson J, Buckheit RW Jr, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR.

Retrovirology. 2015 Jan 23;12:6. doi: 10.1186/s12977-014-0127-3.

23.

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV.

O'Keefe BR, Murad AM, Vianna GR, Ramessar K, Saucedo CJ, Wilson J, Buckheit KW, da Cunha NB, Araújo AC, Lacorte CC, Madeira L, McMahon JB, Rech EL.

Plant Biotechnol J. 2015 Sep;13(7):884-92. doi: 10.1111/pbi.12309. Epub 2015 Jan 9.

24.

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus.

Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG Jr, McMahon JB, Huggins J, O'Keefe BR.

Antiviral Res. 2014 Dec;112:1-7. doi: 10.1016/j.antiviral.2014.09.012. Epub 2014 Oct 5.

25.

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.

Sztuba-Solinska J, Shenoy SR, Gareiss P, Krumpe LR, Le Grice SF, O'Keefe BR, Schneekloth JS Jr.

J Am Chem Soc. 2014 Jun 11;136(23):8402-10. doi: 10.1021/ja502754f. Epub 2014 May 28.

26.

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.

Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, Jones KS.

J Virol. 2014 Feb;88(4):2327-32. doi: 10.1128/JVI.02553-13. Epub 2013 Nov 27.

27.

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models.

Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE.

Antimicrob Agents Chemother. 2014;58(1):120-7. doi: 10.1128/AAC.01407-13. Epub 2013 Oct 21.

28.

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.

Alexandre KB, Moore PL, Nonyane M, Gray ES, Ranchobe N, Chakauya E, McMahon JB, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2013 Nov;446(1-2):66-76. doi: 10.1016/j.virol.2013.07.019. Epub 2013 Aug 15.

29.

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

Takebe Y, Saucedo CJ, Lund G, Uenishi R, Hase S, Tsuchiura T, Kneteman N, Ramessar K, Tyrrell DL, Shirakura M, Wakita T, McMahon JB, O'Keefe BR.

PLoS One. 2013 May 21;8(5):e64449. doi: 10.1371/journal.pone.0064449. Print 2013.

30.

Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors.

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.

J Med Chem. 2012 Aug 23;55(16):7297. Epub 2012 Aug 14. No abstract available.

31.

Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.

J Med Chem. 2012 May 10;55(9):4457-78. doi: 10.1021/jm300335n. Epub 2012 Apr 26. Erratum in: J Med Chem. 2012 Aug 23;55(16):7297. Bermingam, Alun [corrected to Bermingham, Alun].

32.

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells.

Alexandre KB, Gray ES, Mufhandu H, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

Virology. 2012 Feb 20;423(2):175-86. doi: 10.1016/j.virol.2011.12.001. Epub 2011 Dec 29.

33.

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate.

Kouokam JC, Huskens D, Schols D, Johannemann A, Riedell SK, Walter W, Walker JM, Matoba N, O'Keefe BR, Palmer KE.

PLoS One. 2011;6(8):e22635. doi: 10.1371/journal.pone.0022635. Epub 2011 Aug 2.

34.

Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site.

Alexandre KB, Gray ES, Pantophlet R, Moore PL, McMahon JB, Chakauya E, O'Keefe BR, Chikwamba R, Morris L.

J Virol. 2011 Sep;85(17):9039-50. doi: 10.1128/JVI.02675-10. Epub 2011 Jun 22.

35.

Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.

Moulaei T, Shenoy SR, Giomarelli B, Thomas C, McMahon JB, Dauter Z, O'Keefe BR, Wlodawer A.

Structure. 2010 Sep 8;18(9):1104-15. doi: 10.1016/j.str.2010.05.016.

36.

Topology of the disulfide bonds in the antiviral lectin scytovirin.

Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, Lu W, Haugh-Krumpe L, O'Keefe BR, Wlodawer A.

Protein Sci. 2010 Sep;19(9):1649-61. doi: 10.1002/pro.445.

37.

Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF.

Antimicrob Agents Chemother. 2010 Sep;54(9):3913-21. doi: 10.1128/AAC.00434-10. Epub 2010 Jun 14.

38.

Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.

O'Keefe BR, Giomarelli B, Barnard DL, Shenoy SR, Chan PK, McMahon JB, Palmer KE, Barnett BW, Meyerholz DK, Wohlford-Lenane CL, McCray PB Jr.

J Virol. 2010 Mar;84(5):2511-21. doi: 10.1128/JVI.02322-09. Epub 2009 Dec 23. Erratum in: J Virol. 2010 May;84(10):5456.

39.

Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.

Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J.

Eukaryot Cell. 2010 Feb;9(2):228-41. doi: 10.1128/EC.00197-09. Epub 2009 Sep 25.

40.

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component.

O'Keefe BR, Vojdani F, Buffa V, Shattock RJ, Montefiori DC, Bakke J, Mirsalis J, d'Andrea AL, Hume SD, Bratcher B, Saucedo CJ, McMahon JB, Pogue GP, Palmer KE.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104. doi: 10.1073/pnas.0901506106. Epub 2009 Mar 30.

41.

Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer.

Weissman AM, Yang Y, Kitagaki J, Sasiela CA, Beutler JA, O'Keefe BR.

Ernst Schering Found Symp Proc. 2008;(1):171-90.

PMID:
19202599
42.

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

Clement JA, Kitagaki J, Yang Y, Saucedo CJ, O'Keefe BR, Weissman AM, McKee TC, McMahon JB.

Bioorg Med Chem. 2008 Dec 1;16(23):10022-8. doi: 10.1016/j.bmc.2008.10.024. Epub 2008 Oct 14.

43.

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.

Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, Götte M, Kvaratskhelia M, Le Grice S.

ACS Chem Biol. 2008 Oct 17;3(10):635-44. doi: 10.1021/cb8001039. Epub 2008 Oct 3.

44.

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

Smee DF, Bailey KW, Wong MH, O'Keefe BR, Gustafson KR, Mishin VP, Gubareva LV.

Antiviral Res. 2008 Dec;80(3):266-71. doi: 10.1016/j.antiviral.2008.06.003. Epub 2008 Jul 2.

45.

Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor.

Smee DF, Wandersee MK, Checketts MB, O'Keefe BR, Saucedo C, Boyd MR, Mishin VP, Gubareva LV.

Antivir Chem Chemother. 2007;18(6):317-27.

PMID:
18320936
46.

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.

Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR.

J Biomol Screen. 2008 Mar;13(3):229-37. doi: 10.1177/1087057108315038. Epub 2008 Feb 12.

PMID:
18270365
47.

Atomic-resolution crystal structure of the antiviral lectin scytovirin.

Moulaei T, Botos I, Ziółkowska NE, Bokesch HR, Krumpe LR, McKee TC, O'Keefe BR, Dauter Z, Wlodawer A.

Protein Sci. 2007 Dec;16(12):2756-60. Epub 2007 Oct 26.

48.

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.

Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB.

J Nat Prod. 2007 Oct;70(10):1647-9. Epub 2007 Oct 13.

PMID:
17935297
49.

Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.

Emau P, Tian B, O'keefe BR, Mori T, McMahon JB, Palmer KE, Jiang Y, Bekele G, Tsai CC.

J Med Primatol. 2007 Aug;36(4-5):244-53.

PMID:
17669213
50.

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine.

Ziółkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A.

Protein Sci. 2007 Jul;16(7):1485-9. Epub 2007 Jun 13.

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