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Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS.

Lancet Respir Med. 2020 Mar;8(3):247-257. doi: 10.1016/S2213-2600(19)30369-8. Epub 2020 Jan 13.


Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.

Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S, Dark P, Roy AI, Perkins GD, McMullan R, Emerson LM, Blackwood B, Wright SE, Kefala K, O'Kane CM, Baudouin SV, Paterson RL, Rostron AJ, Agus A, Bannard-Smith J, Robin NM, Welters ID, Bassford C, Yates B, Spencer C, Laha SK, Hulme J, Bonner S, Linnett V, Sonksen J, Van Den Broeck T, Boschman G, Keenan DJ, Scott J, Allen AJ, Phair G, Parker J, Bowett SA, Simpson AJ.

Lancet Respir Med. 2020 Feb;8(2):182-191. doi: 10.1016/S2213-2600(19)30367-4. Epub 2019 Dec 3.


A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis.

Dumigan A, Fitzgerald M, Santos JSG, Hamid U, O'Kane CM, McAuley DF, Bengoechea JA.

mBio. 2019 Dec 3;10(6). pii: e02802-19. doi: 10.1128/mBio.02802-19.


Emerging drugs for treating the acute respiratory distress syndrome.

Shaw TD, McAuley DF, O'Kane CM.

Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41. doi: 10.1080/14728214.2019.1591369. Epub 2019 Mar 18. Review.


Where next for cell-based therapy in ARDS.

Boyle AJ, O'Kane CM, McAuley DF.

Thorax. 2019 Jan;74(1):13-15. doi: 10.1136/thoraxjnl-2018-212272. Epub 2018 Nov 12. No abstract available.


Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.


Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group.

Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.


Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT.

McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, Murphy L, McNally C, Agus AM, McDowell C, Jackson C.

Southampton (UK): NIHR Journals Library; 2018 Jan.


Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF.

Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29.


Oxytocin reduces alcohol consumption in prairie voles.

Stevenson JR, Wenner SM, Freestone DM, Romaine CC, Parian MC, Christian SM, Bohidar AE, Ndem JR, Vogel IR, O'Kane CM.

Physiol Behav. 2017 Oct 1;179:411-421. doi: 10.1016/j.physbeh.2017.07.021. Epub 2017 Jul 14.


Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.


Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, O'Kane CM, Krasnodembskaya AD.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286. doi: 10.1164/rccm.201701-0170OC.


Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.

McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM.

Lancet Respir Med. 2017 Jun;5(6):484-491. doi: 10.1016/S2213-2600(17)30171-6. Epub 2017 May 16.


Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial.

Agus A, Hulme C, Verghis RM, McDowell C, Jackson C, O'Kane CM, Laffey JG, McAuley DF.

Crit Care. 2017 May 17;21(1):108. doi: 10.1186/s13054-017-1695-0.


Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol.

Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF.

Trials. 2017 May 11;18(1):214. doi: 10.1186/s13063-017-1930-7. No abstract available.


Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM.

Thorax. 2017 Nov;72(11):971-980. doi: 10.1136/thoraxjnl-2016-208571. Epub 2017 Jan 12.


Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD.

Stem Cells. 2016 Aug;34(8):2210-23. doi: 10.1002/stem.2372. Epub 2016 Apr 29.


Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS.

Thorax. 2016 Dec;71(12):1130-1136. doi: 10.1136/thoraxjnl-2015-207886. Epub 2016 Feb 2.


Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome.

Muir R, Osbourn M, Dubois AV, Doran E, Small DM, Monahan A, O'Kane CM, McAllister K, Fitzgerald DC, Kissenpfennig A, McAuley DF, Ingram RJ.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):407-16. doi: 10.1164/rccm.201410-1782OC.


Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ.

Sci Transl Med. 2015 Sep 2;7(303):303ra140. doi: 10.1126/scitranslmed.aab3459.


A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair.

Duffy MJ, O'Kane CM, Stevenson M, Young IS, Harkin DW, Mullan BA, McAuley DF.

Intensive Care Med Exp. 2015 Dec;3(1):50. doi: 10.1186/s40635-015-0050-5. Epub 2015 Jul 1.


Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D.

J Immunol. 2015 Jul 1;195(1):87-95. doi: 10.4049/jimmunol.1500054. Epub 2015 May 22.


Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis.

Boyle AJ, Di Gangi S, Hamid UI, Mottram LJ, McNamee L, White G, Cross LJ, McNamee JJ, O'Kane CM, McAuley DF.

Crit Care. 2015 Mar 23;19:109. doi: 10.1186/s13054-015-0846-4.


Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.

Hellyer TP, Morris AC, McAuley DF, Walsh TS, Anderson NH, Singh S, Dark P, Roy AI, Baudouin SV, Wright SE, Perkins GD, Kefala K, Jeffels M, McMullan R, O'Kane CM, Spencer C, Laha S, Robin N, Gossain S, Gould K, Ruchaud-Sparagano MH, Scott J, Browne EM, MacFarlane JG, Wiscombe S, Widdrington JD, Dimmick I, Laurenson IF, Nauwelaers F, Simpson AJ.

Thorax. 2015 Jan;70(1):41-7. doi: 10.1136/thoraxjnl-2014-205766. Epub 2014 Oct 8.


Simvastatin in the acute respiratory distress syndrome.

McAuley DF, Laffey JG, O'Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C; HARP-2 Investigators; Irish Critical Care Trials Group.

N Engl J Med. 2014 Oct 30;371(18):1695-703. doi: 10.1056/NEJMoa1403285. Epub 2014 Sep 30. Erratum in: N Engl J Med. 2016 Nov 17;375(20):2010.


SMAD inhibition attenuates epithelial to mesenchymal transition by primary keratinocytes in vitro.

O'Kane D, Jackson MV, Kissenpfennig A, Spence S, Damkat-Thomas L, Tolland JP, Smyth AE, Denton CP, Stuart Elborn J, McAuley DF, O'Kane CM.

Exp Dermatol. 2014 Jul;23(7):497-503. doi: 10.1111/exd.12452.


Reply to Letter: "Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial".

Shyamsundar M, McAuley DF, O'Kane CM.

Ann Surg. 2015 Dec;262(6):e95-6. doi: 10.1097/SLA.0000000000000670. No abstract available.


Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.

Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM.

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1520-9. doi: 10.1164/rccm.201310-1892OC.


Validation of an MRI-based method to assess patellofemoral joint contact areas in loaded knee flexion in vivo.

McWalter EJ, O'Kane CM, Fitzpatrick DP, Wilson DR.

J Magn Reson Imaging. 2014 Apr;39(4):978-87. doi: 10.1002/jmri.24240. Epub 2013 Sep 4.


Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.

McAuley DF, O'Kane CM, Craig TR, Shyamsundar M, Herwald H, Dib K.

BMC Pulm Med. 2013 Jul 19;13:47. doi: 10.1186/1471-2466-13-47.


Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.

Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, OʼKane CM.

Ann Surg. 2014 Jan;259(1):26-31. doi: 10.1097/SLA.0b013e31829d686b.


Statins and sepsis: potential benefit but more unanswered questions.

O'Kane CM, Perkins GD, McAuley DF.

Am J Respir Crit Care Med. 2013 Apr 1;187(7):672-4. No abstract available.


Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol.

Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF.

Trials. 2013 Feb 18;14:51. doi: 10.1186/1745-6215-14-51. Erratum in: Trials. 2017 May 11;18(1):214.


Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury.

Kerrin A, Weldon S, Chung AH, Craig T, Simpson AJ, O'Kane CM, McAuley DF, Taggart CC.

Thorax. 2013 Apr;68(4):315-21. doi: 10.1136/thoraxjnl-2012-202536. Epub 2012 Dec 14.


Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial.

McAuley DF, Laffey JG, O'Kane CM, Cross M, Perkins GD, Murphy L, McNally C, Crealey G, Stevenson M; HARP-2 investigators; Irish Critical Care Trials Group.

Trials. 2012 Sep 17;13:170. doi: 10.1186/1745-6215-13-170.


Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.

Wilkinson TS, Conway Morris A, Kefala K, O'Kane CM, Moore NR, Booth NA, McAuley DF, Dhaliwal K, Walsh TS, Haslett C, Sallenave JM, Simpson AJ.

Chest. 2012 Dec;142(6):1425-1432. doi: 10.1378/chest.11-3273.


Benefits of statins in the critically ill: promising but not proven.

McGuigan PJ, O'Kane CM, McAuley DF.

Crit Care Med. 2011 Jun;39(6):1599-600. doi: 10.1097/CCM.0b013e31821489fd. No abstract available.


Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair.

Davey A, McAuley DF, O'Kane CM.

Eur Respir J. 2011 Oct;38(4):959-70. doi: 10.1183/09031936.00032111. Epub 2011 May 12. Review.


A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study).

Craig TR, Duffy MJ, Shyamsundar M, McDowell C, O'Kane CM, Elborn JS, McAuley DF.

Am J Respir Crit Care Med. 2011 Mar 1;183(5):620-6. doi: 10.1164/rccm.201003-0423OC. Epub 2010 Sep 24. Erratum in: Am J Respir Crit Care Med. 2014 Nov 15;190(10):1199-200.


Novel pulmonary biomarkers in the diagnosis of VAP.

Johnston P, McAuley DF, O'Kane CM.

Thorax. 2010 Mar;65(3):190-2. doi: 10.1136/thx.2009.127308. No abstract available.


A potential role for keratinocyte growth factor and clarithromycin in the treatment of paraquat overdose.

Browne G, Bhavsar M, O'kane CM, Cross M, Leggett J, Mullan B, McAuley DF.

QJM. 2010 Aug;103(8):611-3. doi: 10.1093/qjmed/hcq004. Epub 2010 Feb 12. No abstract available.


STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.

O'Kane CM, Elkington PT, Jones MD, Caviedes L, Tovar M, Gilman RH, Stamp G, Friedland JS.

Am J Respir Cell Mol Biol. 2010 Oct;43(4):465-74. doi: 10.1165/rcmb.2009-0211OC. Epub 2009 Nov 13.


Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome.

O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF.

Crit Care Med. 2009 Jul;37(7):2242-9. doi: 10.1097/CCM.0b013e3181a5506c.


Keratinocyte growth factor in acute lung injury--a work in progress.

O'Kane CM, Thickett DR, McAuley DF.

Crit Care Med. 2009 May;37(5):1813-4. doi: 10.1097/CCM.0b013e3181a1a927. No abstract available.


Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.

Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF.

Am J Respir Crit Care Med. 2009 Jun 15;179(12):1107-14. doi: 10.1164/rccm.200810-1584OC. Epub 2009 Mar 26.


High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation.

Sheen P, O'Kane CM, Chaudhary K, Tovar M, Santillan C, Sosa J, Caviedes L, Gilman RH, Stamp G, Friedland JS.

Eur Respir J. 2009 Jan;33(1):134-41. doi: 10.1183/09031936.00127807. Epub 2008 Aug 20.


Synergistic up-regulation of epithelial cell matrix metalloproteinase-9 secretion in tuberculosis.

Elkington PT, Green JA, Emerson JE, Lopez-Pascua LD, Boyle JJ, O'Kane CM, Friedland JS.

Am J Respir Cell Mol Biol. 2007 Oct;37(4):431-7. Epub 2007 Jun 15.


Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages.

O'Kane CM, Boyle JJ, Horncastle DE, Elkington PT, Friedland JS.

J Immunol. 2007 Mar 15;178(6):3767-76.


Mycobacterium tuberculosis up-regulates matrix metalloproteinase-1 secretion from human airway epithelial cells via a p38 MAPK switch.

Elkington PT, Emerson JE, Lopez-Pascua LD, O'Kane CM, Horncastle DE, Boyle JJ, Friedland JS.

J Immunol. 2005 Oct 15;175(8):5333-40.

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