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Items: 1 to 50 of 87

1.

GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila.

Pérez-Moreno JJ, O'Kane CJ.

G3 (Bethesda). 2019 Feb 7;9(2):453-462. doi: 10.1534/g3.118.200809.

2.

NaCl-saturated brines are thermodynamically moderate, rather than extreme, microbial habitats.

Lee CJD, McMullan PE, O'Kane CJ, Stevenson A, Santos IC, Roy C, Ghosh W, Mancinelli RL, Mormile MR, McMullan G, Banciu HL, Fares MA, Benison KC, Oren A, Dyall-Smith ML, Hallsworth JE.

FEMS Microbiol Rev. 2018 Sep 1;42(5):672-693. doi: 10.1093/femsre/fuy026.

PMID:
29893835
3.

Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins.

Yalçın B, Zhao L, Stofanko M, O'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O'Kane CJ.

Elife. 2017 Jul 25;6. pii: e23882. doi: 10.7554/eLife.23882.

4.

CCT complex restricts neuropathogenic protein aggregation via autophagy.

Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC.

Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821.

5.

Aspergillus penicillioides differentiation and cell division at 0.585 water activity.

Stevenson A, Hamill PG, O'Kane CJ, Kminek G, Rummel JD, Voytek MA, Dijksterhuis J, Hallsworth JE.

Environ Microbiol. 2017 Feb;19(2):687-697. doi: 10.1111/1462-2920.13597. Epub 2017 Jan 30.

PMID:
27871132
6.

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.

Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, Stelzl U, Loll B, Walter AM, Sigrist SJ.

Nat Neurosci. 2016 Oct;19(10):1311-20. doi: 10.1038/nn.4364. Epub 2016 Aug 15.

PMID:
27526206
7.

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC.

Nat Chem Biol. 2015 May;11(5):347-354. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6.

8.

Virtual Fly Brain - Using OWL to support the mapping and genetic dissection of the Drosophila brain.

Osumi-Sutherland D, Costa M, Court R, O'Kane CJ.

CEUR Workshop Proc. 2014 Oct;1265:85-96.

9.

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC.

Cell Death Differ. 2015 Mar;22(3):433-44. doi: 10.1038/cdd.2014.151. Epub 2014 Sep 26.

10.

PICALM modulates autophagy activity and tau accumulation.

Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC.

Nat Commun. 2014 Sep 22;5:4998. doi: 10.1038/ncomms5998.

11.

A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila.

Masuda-Nakagawa LM, Ito K, Awasaki T, O'Kane CJ.

Front Neural Circuits. 2014 Apr 9;8:35. doi: 10.3389/fncir.2014.00035. eCollection 2014.

12.

NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases.

Na D, Rouf M, O'Kane CJ, Rubinsztein DC, Gsponer J.

BMC Med Genomics. 2013 Nov 14;6:52. doi: 10.1186/1755-8794-6-52.

13.

Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor.

O'Sullivan NC, Dräger N, O'Kane CJ.

J Genet Genomics. 2013 Jun 20;40(6):297-306. doi: 10.1016/j.jgg.2013.04.008. Epub 2013 May 9.

PMID:
23790629
14.

Emergency department presentations during the State of Origin rugby league series: a retrospective statewide analysis.

Furyk JS, Lawlor JM, Franklin R, O'Kane CJ, Kault DA, Banks CJ, Aitken PJ.

Med J Aust. 2012 Dec 10;197(11):663-6.

PMID:
23230946
15.

Multiple spectral inputs improve motion discrimination in the Drosophila visual system.

Wardill TJ, List O, Li X, Dongre S, McCulloch M, Ting CY, O'Kane CJ, Tang S, Lee CH, Hardie RC, Juusola M.

Science. 2012 May 18;336(6083):925-31. doi: 10.1126/science.1215317.

16.

Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons.

O'Sullivan NC, Jahn TR, Reid E, O'Kane CJ.

Hum Mol Genet. 2012 Aug 1;21(15):3356-65. doi: 10.1093/hmg/dds167. Epub 2012 Apr 27.

17.

Complex inhibitory effects of nitric oxide on autophagy.

Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC.

Mol Cell. 2011 Jul 8;43(1):19-32. doi: 10.1016/j.molcel.2011.04.029.

18.

A phagocytic route for uptake of double-stranded RNA in RNAi.

Rocha JJ, Korolchuk VI, Robinson IM, O'Kane CJ.

PLoS One. 2011 Apr 29;6(4):e19087. doi: 10.1371/journal.pone.0019087.

19.
20.

Lysosomal positioning coordinates cellular nutrient responses.

Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC.

Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.

21.

Drosophila as a model organism for the study of neuropsychiatric disorders.

O'Kane CJ.

Curr Top Behav Neurosci. 2011;7:37-60. doi: 10.1007/7854_2010_110.

PMID:
21225410
22.

Hereditary spastic paraplegias: membrane traffic and the motor pathway.

Blackstone C, O'Kane CJ, Reid E.

Nat Rev Neurosci. 2011 Jan;12(1):31-42. doi: 10.1038/nrn2946. Review. Erratum in: Nat Rev Neurosci. 2011 Feb;12(2):118.

23.

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein DC.

J Cell Biol. 2010 Sep 20;190(6):1023-37. doi: 10.1083/jcb.201003122.

24.

Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila.

Masuda-Nakagawa LM, Awasaki T, Ito K, O'Kane CJ.

Gene Expr Patterns. 2010 Oct-Dec;10(7-8):328-37. doi: 10.1016/j.gep.2010.07.004. Epub 2010 Jul 24.

PMID:
20659588
25.

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC.

Hum Mol Genet. 2010 Sep 1;19(17):3413-29. doi: 10.1093/hmg/ddq253. Epub 2010 Jun 21.

26.

The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila.

Lone M, Kungl T, Koper A, Bottenberg W, Kammerer R, Klein M, Sweeney ST, Auburn RP, O'Kane CJ, Prokop A.

J Cell Sci. 2010 Jul 15;123(Pt 14):2369-74. doi: 10.1242/jcs.060582. Epub 2010 Jun 15.

27.

Fast versus slow bandaid removal: a randomised trial.

Furyk JS, O'Kane CJ, Aitken PJ, Banks CJ, Kault DA.

Med J Aust. 2009 Dec 7-21;191(11-12):682-3.

PMID:
20028307
28.

The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E.

Hum Mol Genet. 2009 Oct 15;18(20):3805-21. doi: 10.1093/hmg/ddp324. Epub 2009 Jul 20.

29.

Automated measurement of Drosophila jump reflex habituation and its use for mutant screening.

Sharma P, Keane J, O'Kane CJ, Asztalos Z.

J Neurosci Methods. 2009 Aug 30;182(1):43-8. doi: 10.1016/j.jneumeth.2009.05.024. Epub 2009 Jun 9.

PMID:
19520114
30.

Localized olfactory representation in mushroom bodies of Drosophila larvae.

Masuda-Nakagawa LM, Gendre N, O'Kane CJ, Stocker RF.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10314-9. doi: 10.1073/pnas.0900178106. Epub 2009 Jun 5.

31.

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

Raghu P, Coessens E, Manifava M, Georgiev P, Pettitt T, Wood E, Garcia-Murillas I, Okkenhaug H, Trivedi D, Zhang Q, Razzaq A, Zaid O, Wakelam M, O'Kane CJ, Ktistakis N.

J Cell Biol. 2009 Apr 6;185(1):129-45. doi: 10.1083/jcb.200807027.

32.

Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics.

Zheng L, Nikolaev A, Wardill TJ, O'Kane CJ, de Polavieja GG, Juusola M.

PLoS One. 2009;4(1):e4307. doi: 10.1371/journal.pone.0004307. Epub 2009 Jan 30.

33.

Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms.

Nikolaev A, Zheng L, Wardill TJ, O'Kane CJ, de Polavieja GG, Juusola M.

PLoS One. 2009;4(1):e4306. doi: 10.1371/journal.pone.0004306. Epub 2009 Jan 30.

34.

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.

Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC.

J Cell Sci. 2008 May 15;121(Pt 10):1649-60. doi: 10.1242/jcs.025726. Epub 2008 Apr 22.

35.

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC.

Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79.

36.

Hereditary spastic paraplegia genes in Drosophila: dissecting their roles in axonal degeneration and intracellular traffic.

Wang X, O'Kane CJ.

SEB Exp Biol Ser. 2008;60:161-82. Review. No abstract available.

PMID:
18309792
37.

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.

Korolchuk VI, Schütz MM, Gómez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM, O'Kane CJ.

J Cell Sci. 2007 Dec 15;120(Pt 24):4367-76.

38.

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2008 Jan 15;17(2):170-8. Epub 2007 Oct 6.

PMID:
17921520
39.

Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.

Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ.

J Cell Biol. 2007 Jul 16;178(2):309-22. Epub 2007 Jul 9.

40.

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC.

Nat Chem Biol. 2007 Jun;3(6):331-8. Epub 2007 May 7.

41.

Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules.

Wang X, Shaw WR, Tsang HT, Reid E, O'Kane CJ.

Nat Neurosci. 2007 Feb;10(2):177-85. Epub 2007 Jan 14.

42.

Dyneins, autophagy, aggregation and neurodegeneration.

Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD.

Autophagy. 2005 Oct-Dec;1(3):177-8. Epub 2005 Oct 21. Review.

PMID:
16874055
43.

Rapamycin pre-treatment protects against apoptosis.

Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2006 Apr 1;15(7):1209-16. Epub 2006 Feb 23.

PMID:
16497721
44.

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.

Berger Z, Davies JE, Luo S, Pasco MY, Majoul I, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2006 Feb 1;15(3):453-65. Epub 2005 Dec 21.

PMID:
16371423
45.

Rapamycin alleviates toxicity of different aggregate-prone proteins.

Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2006 Feb 1;15(3):433-42. Epub 2005 Dec 20.

PMID:
16368705
46.

Stereotypic and random patterns of connectivity in the larval mushroom body calyx of Drosophila.

Masuda-Nakagawa LM, Tanaka NK, O'Kane CJ.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19027-32. Epub 2005 Dec 15.

47.

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

Berger Z, Ttofi EK, Michel CH, Pasco MY, Tenant S, Rubinsztein DC, O'Kane CJ.

Hum Mol Genet. 2005 Oct 15;14(20):3003-11. Epub 2005 Sep 2.

PMID:
16141285
48.

Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster.

Sharma P, Asztalos Z, Ayyub C, de Bruyne M, Dornan AJ, Gomez-Hernandez A, Keane J, Killeen J, Kramer S, Madhavan M, Roe H, Sherkhane PD, Siddiqi K, Silva E, Carlson JR, Goodwin SF, Heisenberg M, Krishnan K, Kyriacou CP, Partridge L, Riesgo-Escovar J, Rodrigues V, Tully T, O'Kane CJ.

J Neurogenet. 2005 Apr-Jun;19(2):57-85.

PMID:
16024440
49.

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC.

Nat Genet. 2005 Jul;37(7):771-6. Epub 2005 Jun 26.

PMID:
15980862
50.

Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights.

Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ, Kelly DA, Maher ER.

Hum Mol Genet. 2005 May 15;14(10):1261-70. Epub 2005 Mar 24.

PMID:
15790593

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