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Items: 19


Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112.

Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV.

Mol Microbiol. 2019 Dec;112(6):1847-1862. doi: 10.1111/mmi.14398. Epub 2019 Oct 10.


ICEKp2: description of an integrative and conjugative element in Klebsiella pneumoniae, co-occurring and interacting with ICEKp1.

Farzand R, Rajakumar K, Zamudio R, Oggioni MR, Barer MR, O'Hare HM.

Sci Rep. 2019 Sep 25;9(1):13892. doi: 10.1038/s41598-019-50456-x.


Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division.

Iswahyudi, Mukamolova GV, Straatman-Iwanowska AA, Allcock N, Ajuh P, Turapov O, O'Hare HM.

Sci Rep. 2019 Jun 6;9(1):8337. doi: 10.1038/s41598-019-44841-9.


Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

Wagner T, André-Leroux G, Hindie V, Barilone N, Lisa MN, Hoos S, Raynal B, Vulliez-Le Normand B, O'Hare HM, Bellinzoni M, Alzari PM.

Sci Signal. 2019 May 7;12(580). pii: eaav9504. doi: 10.1126/scisignal.aav9504.


An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.

Bhattacharyya N, Nkumama IN, Newland-Smith Z, Lin LY, Yin W, Cullen RE, Griffiths JS, Jarvis AR, Price MJ, Chong PY, Wallis R, O'Hare HM.

mBio. 2018 Jul 31;9(4). pii: e00931-18. doi: 10.1128/mBio.00931-18.


PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar-Adler NR, Bottrill AR, le Chevalier F, Frigui W, Bellinzoni M, Lisa MN, Alzari PM, Nguyen L, Brosch R, Sauer U, Manganelli R, O'Hare HM.

PLoS Pathog. 2017 May 17;13(5):e1006399. doi: 10.1371/journal.ppat.1006399. eCollection 2017 May.


Tuberculosis: feeding the enemy.

Garton NJ, O'Hare HM.

Chem Biol. 2013 Aug 22;20(8):971-2. doi: 10.1016/j.chembiol.2013.08.001.


GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O'Hare HM.

Mol Microbiol. 2013 Oct;90(2):356-66. doi: 10.1111/mmi.12368. Epub 2013 Sep 8.


Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.

Bortoluzzi A, Muskett FW, Waters LC, Addis PW, Rieck B, Munder T, Schleier S, Forti F, Ghisotti D, Carr MD, O'Hare HM.

J Biol Chem. 2013 May 17;288(20):14438-50. doi: 10.1074/jbc.M113.459883. Epub 2013 Apr 2.


Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.

Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM.

Chem Biol. 2011 Aug 26;18(8):1011-20. doi: 10.1016/j.chembiol.2011.06.004.


An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ.

Sci Signal. 2009 Mar 24;2(63):ra12. doi: 10.1126/scisignal.2000212.


Regulation of glutamate metabolism by protein kinases in mycobacteria.

O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM.

Mol Microbiol. 2008 Dec;70(6):1408-23. doi: 10.1111/j.1365-2958.2008.06489.x. Epub 2008 Oct 17.


Chemical probes shed light on protein function.

O'Hare HM, Johnsson K, Gautier A.

Curr Opin Struct Biol. 2007 Aug;17(4):488-94. Epub 2007 Sep 11. Review.


The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffé M, Bäckbro K, Quémard A.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14628-33. Epub 2007 Sep 5.


Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution.

O'Hare HM, Huang F, Holding A, Choroba OW, Spencer JB.

FEBS Lett. 2006 Jun 12;580(14):3445-50. Epub 2006 May 15.


Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF.

Chem Biol. 2006 Mar;13(3):277-85.


Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

Bali S, O'Hare HM, Weissman KJ.

Chembiochem. 2006 Mar;7(3):478-84.


The laboratory in a droplet.

O'Hare HM, Johnsson K.

Chem Biol. 2005 Dec;12(12):1255-7. Review.

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